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A Transcriptomic Immunologic Signature Predicts Favorable Outcome in Neoadjuvant Chemotherapy Treated Triple Negative Breast Tumors

artículo científico publicado en 2019

A dominant-negative N-terminal fragment of HER2 frequently expressed in breast cancers.

artículo científico publicado en 2012

A modular approach to trim cellular targets in anticancer drug discovery

artículo científico publicado en 2011

A new method for detecting TNF-alpha-secreting cells using direct-immunofluorescence surface membrane stainings

artículo científico publicado en 2002

A new simple whole blood flow cytometry-based method for simultaneous identification of activated cells and quantitative evaluation of cytokines released during activation.

artículo científico publicado en 2004

A phase I study of the SRC kinase inhibitor dasatinib with trastuzumab and paclitaxel as first line therapy for patients with HER2-overexpressing advanced breast cancer. GEICAM/2010-04 study

artículo científico publicado en 2017

Achilles' heel of triple negative cancer

artículo científico publicado en 2014

Activation of ErbB2 by overexpression or by transmembrane neuregulin results in differential signaling and sensitivity to herceptin

artículo científico publicado en 2005

Activation of the PI3K/mTOR/AKT pathway and survival in solid tumors: systematic review and meta-analysis

artículo científico publicado en 2014

Active kinase profiling, genetic and pharmacological data define mTOR as an important common target in triple-negative breast cancer

artículo científico publicado en 2012

Activity of BET-proteolysis targeting chimeric (PROTAC) compounds in triple negative breast cancer

artículo científico publicado en 2019

Adaptive resistance to trastuzumab impairs response to neratinib and lapatinib through deregulation of cell death mechanisms

scientific article published on 22 November 2019

Adoptive Cell Therapy in Breast Cancer: A Current Perspective of Next-Generation Medicine

scientific article published on 27 October 2020

An Overview of Antibody Conjugated Polymeric Nanoparticles for Breast Cancer Therapy

artículo científico publicado en 2020

An update into the pathophysiological role of HER2 in cancer: therapeutic implications

scientific article published on 01 September 2007

Androgen-independent prostate cancer cells circumvent EGFR inhibition by overexpression of alternative HER receptors and ligands

artículo científico publicado en 2012

Antibody Conjugation of Nanoparticles as Therapeutics for Breast Cancer Treatment

artículo científico publicado en 2020

Antiproliferative Effect of Synadenium grantii Hook f. stems (Euphorbiaceae) and a Rare Phorbol Diterpene Ester

scientific article published on 27 July 2016

Antitumor activity of the novel multi-kinase inhibitor EC-70124 in triple negative breast cancer

artículo científico publicado en 2015

Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies

scientific article published on 01 August 1993

Antitumoral activity of the mithralog EC-8042 in triple negative breast cancer linked to cell cycle arrest in G2

artículo científico publicado en 2015

Antitumoral effect of Ocoxin in hepatocellular carcinoma.

artículo científico publicado en 2017

Antitumoral effect of Ocoxin on acute myeloid leukemia.

artículo científico publicado en 2016

Antitumoral effect of Ocoxin, a natural compound-containing nutritional supplement, in small cell lung cancer.

artículo científico publicado en 2018

Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo

artículo científico publicado en 2008

Autocrine regulation of membrane transforming growth factor-alpha cleavage

scientific article published on 01 February 1996

Autophagy inhibition sensitizes multiple myeloma cells to 17-dimethylaminoethylamino-17-demethoxygeldanamycin-induced apoptosis

artículo científico publicado en 2010

BET inhibitors as novel therapeutic agents in breast cancer.

artículo científico publicado en 2017

Biological insights into effective and antagonistic combinations of targeted agents with chemotherapy in solid tumors

artículo científico publicado en 2014

Bortezomib induces selective depletion of alloreactive T lymphocytes and decreases the production of Th1 cytokines

artículo científico publicado en 2005

Bortezomib is an efficient agent in plasma cell leukemias

artículo científico publicado en 2005

Breast Cancer Heterogeneity and Response to Novel Therapeutics

artículo científico publicado en 2020

Breast cancer dissemination promoted by a neuregulin-collagenase 3 signalling node.

artículo científico publicado en 2015

Bryonia dioica aqueous extract induces apoptosis and G2/M cell cycle arrest in MDA‑MB 231 breast cancer cells

artículo científico publicado en 2019

CD20 positive cells are undetectable in the majority of multiple myeloma cell lines and are not associated with a cancer stem cell phenotype

artículo científico publicado en 2012

CM363, a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemia

artículo científico publicado en 2016

Cellular plasticity confers migratory and invasive advantages to a population of glioblastoma-initiating cells that infiltrate peritumoral tissue.

artículo científico publicado en 2013

Central Role of Cell Cycle Regulation in the Antitumoral Action of Ocoxin

scientific article published on 14 May 2019

Checkpoint Kinase 1 Pharmacological Inhibition Synergizes with DNA-Damaging Agents and Overcomes Platinum Resistance in Basal-Like Breast Cancer

artículo científico publicado en 2020

Circulating DNA and Survival in Solid Tumors

artículo científico publicado en 2015

Cleavage of the TrkA neurotrophin receptor by multiple metalloproteases generates signalling-competent truncated forms

scientific article published on 01 April 1999

Clinical significance of CD81 expression by clonal plasma cells in high-risk smoldering and symptomatic multiple myeloma patients

artículo científico publicado en 2012

Colorectal cancer and medicinal plants: Principle findings from recent studies

artículo científico publicado en 2018

Correction: CM363, a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemia

article

DNA-damage related genes and clinical outcome in hormone receptor positive breast cancer

artículo científico publicado en 2016

Dasatinib as a bone-modifying agent: anabolic and anti-resorptive effects

artículo científico publicado en 2012

Defective cyclin B1 induction in trastuzumab-emtansine (T-DM1) acquired resistance in HER2-positive breast cancer.

artículo científico publicado en 2017

Deficient spindle assembly checkpoint in multiple myeloma

artículo científico publicado en 2011

Differential shedding of transmembrane neuregulin isoforms by the tumor necrosis factor-alpha-converting enzyme

artículo científico publicado en 2000

Do we have to change the way targeted drugs are developed?

scientific article published on 21 June 2010

Dual targeting of HER2-positive breast cancer with trastuzumab emtansine and pertuzumab: understanding clinical trial results

artículo científico publicado en 2018

ERK2, but not ERK1, mediates acquired and "de novo" resistance to imatinib mesylate: implication for CML therapy

artículo científico publicado en 2009

ERK5 activates NF-kappaB in leukemic T cells and is essential for their growth in vivo.

artículo científico publicado en 2006

ERK5/BMK1 is a novel target of the tumor suppressor VHL: implication in clear cell renal carcinoma.

artículo científico publicado en 2013

Effect of Oncoxin Oral Solution in HER2-Overexpressing Breast Cancer

artículo científico publicado en 2015

Effect of multikinase inhibitors on caspase-independent cell death and DNA damage in HER2-overexpressing breast cancer cells

artículo científico publicado en 2010

Effect of p95HER2/611CTF on the response to trastuzumab and chemotherapy.

artículo científico publicado en 2014

Efficacy and safety of dasatinib with trastuzumab and paclitaxel in first line HER2-positive metastatic breast cancer: results from the phase II GEICAM/2010-04 study

artículo científico publicado en 2019

Endoglin expression regulates basal and TGF-beta1-induced extracellular matrix synthesis in cultured L6E9 myoblasts.

artículo científico publicado en 2004

Endoglin modulation of TGF-beta1-induced collagen synthesis is dependent on ERK1/2 MAPK activation

artículo científico publicado en 2006

Enhancement of antiproliferative activity by molecular simplification of catalpol

artículo científico publicado en 2010

Epigenetic modulation of FOXM1-gene interacting network by BET inhibitors in breast cancer

scientific article published on 11 September 2018

Erk5 is activated and acts as a survival factor in mitosis.

artículo científico publicado en 2007

Erk5 nuclear location is independent on dual phosphorylation, and favours resistance to TRAIL-induced apoptosis

artículo científico publicado en 2007

Erk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2

artículo científico publicado en 2002

Erratum: Achilles' heel of triple negative cancer

artículo científico publicado en 2014

Evaluation of transcriptionally regulated genes identifies NCOR1 in hormone receptor negative breast tumors and lung adenocarcinomas as a potential tumor suppressor gene

artículo científico publicado en 2018

Expression of Erk5 in early stage breast cancer and association with disease free survival identifies this kinase as a potential therapeutic target

scientific article published on 15 May 2009

Expression of MHC class I, HLA-A and HLA-B identifies immune-activated breast tumors with favorable outcome

artículo científico publicado en 2019

Expression of c-Kit isoforms in multiple myeloma: differences in signaling and drug sensitivity.

artículo científico publicado en 2008

Expression of the beta-isoforms of Na,K-ATPase in the renal cortex of rats

artículo científico publicado en 1997

Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding.

artículo científico publicado en 2002

Functional transcriptomic annotation and protein-protein interaction analysis identify EZH2 and UBE2C as key upregulated proteins in ovarian cancer.

artículo científico publicado en 2018

Genetic Abnormalities and Patterns of Antigenic Expression in Multiple Myeloma

artículo científico publicado en 2005

Genetic and pharmacologic evidence that mTOR targeting outweighs mTORC1 inhibition as an antimyeloma strategy

artículo científico publicado en 2014

Genetic mutational status of genes regulating epigenetics: Role of the histone methyltransferase KMT2D in triple negative breast tumors

article

Genomic Mapping Identifies Mutations in RYR2 and AHNAK as Associated with Favorable Outcome in Basal-Like Breast Tumors Expressing PD1/PD-L1

artículo científico publicado en 2020

Genomic Signatures of Immune Activation Predict Outcome in Advanced Stages of Ovarian Cancer and Basal-Like Breast Tumors

scientific article published on 01 January 2019

HER2 heterogeneity and resistance to anti-HER2 antibody-drug conjugates

artículo científico publicado en 2020

HER3 overexpression and survival in solid tumors: a meta-analysis

artículo científico publicado en 2012

HER3 targeting with an antibody-drug conjugate bypasses resistance to anti-HER2 therapies

scientific article published on 24 April 2020

Identification of therapeutic targets in ovarian cancer through active tyrosine kinase profiling

artículo científico publicado en 2015

Identifying breast cancer druggable oncogenic alterations: lessons learned and future targeted options.

scientific article published on February 2008

Imatinib mesylate (STI571) inhibits multiple myeloma cell proliferation and potentiates the effect of common antimyeloma agents

artículo científico publicado en 2003

Impact of Availability of Companion Diagnostics on the Clinical Development of Anticancer Drugs

artículo científico publicado en 2017

Impaired trafficking and activation of tumor necrosis factor-alpha-converting enzyme in cell mutants defective in protein ectodomain shedding.

artículo científico publicado en 2003

In Silico Analysis Guides Selection of BET Inhibitors for Triple-Negative Breast Cancer Treatment.

artículo científico publicado en 2016

In silico analyses identify gene-sets, associated with clinical outcome in ovarian cancer: role of mitotic kinases.

artículo científico publicado en 2016

In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma

artículo científico publicado en 2009

In vivo murine model of acquired resistance in myeloma reveals differential mechanisms for lenalidomide and pomalidomide in combination with dexamethasone.

artículo científico publicado en 2014

Induction of B-chronic lymphocytic leukemia cell apoptosis by arsenic trioxide involves suppression of the phosphoinositide 3-kinase/Akt survival pathway via c-jun-NH2 terminal kinase activation and PTEN upregulation.

artículo científico publicado en 2010

Influence of companion diagnostics on efficacy and safety of targeted anti-cancer drugs: systematic review and meta-analyses

artículo científico publicado en 2015

Inhibition of SRC family kinases and receptor tyrosine kinases by dasatinib: possible combinations in solid tumors.

artículo científico publicado en 2011

Inhibition of the mitotic kinase PLK1 overcomes therapeutic resistance to BET inhibitors in triple negative breast cancer

artículo científico publicado en 2020

Integrin ανβ6 Protein Expression and Prognosis in Solid Tumors: A Meta-Analysis

artículo científico publicado en 2020

Interaction between Hormonal Receptor Status, Age and Survival in Patients with BRCA1/2 Germline Mutations: A Systematic Review and Meta-Regression

artículo científico publicado en 2016

MEK5 promotes lung adenocarcinoma

artículo científico publicado en 2019

Mapping Bromodomains in breast cancer and association with clinical outcome

scientific article published on 05 April 2019

Mechanism of apoptosis induced by IFN-alpha in human myeloma cells: role of Jak1 and Bim and potentiation by rapamycin.

artículo científico publicado en 2006

Medicinal Plants as Sources of Active Molecules Against COVID-19

scientific article published on 07 August 2020

Mesenchymal stem cells from multiple myeloma patients display distinct genomic profile as compared with those from normal donors

scientific article published on 09 April 2009

Mitogen-activated protein kinase routes as targets in the action of diaza-anthracene compounds with a potent growth-inhibitory effect on cancer cells

artículo científico publicado en 2002

Mitogen-activated protein kinase-dependent and -independent routes control shedding of transmembrane growth factors through multiple secretases.

artículo científico publicado en 2002

Mitotic arrest induced by a novel family of DNA topoisomerase II inhibitors.

artículo científico publicado en 2010

Mitotic read-out genes confer poor outcome in luminal A breast cancer tumors.

artículo científico publicado en 2017

Modulation of cereblon levels by anti-myeloma agents.

artículo científico publicado en 2015

Molecular pathways: P-Rex in cancer.

artículo científico publicado en 2013

Multifunctional role of Erk5 in multiple myeloma

artículo científico publicado en 2005

Multisite phosphorylation of Erk5 in mitosis

artículo científico publicado en 2010

Multisite phosphorylation of P-Rex1 by protein kinase C.

artículo científico publicado en 2016

N-terminal cleavage of proTGFalpha occurs at the cell surface by a TACE-independent activity.

artículo científico publicado en 2005

NADPH oxidases as therapeutic targets in chronic myelogenous leukemia.

artículo científico publicado en 2014

Neuregulin expression in solid tumors: prognostic value and predictive role to anti-HER3 therapies

artículo científico publicado en 2016

Neuregulin expression modulates clinical response to trastuzumab in patients with metastatic breast cancer

scientific article published on 01 July 2007

Neuregulins and cancer.

artículo científico publicado en 2008

Neutrophils in cancer: prognostic role and therapeutic strategies.

artículo científico publicado en 2017

New drugs in multiple myeloma: mechanisms of action and phase I/II clinical findings.

artículo científico publicado en 2008

Novel Synthetic Lethality Approaches for Drug Combinations and Early Drug Development

artículo científico publicado en 2015

Novel tyrosine kinase inhibitors in the treatment of cancer.

artículo científico publicado en 2009

ODZ1 allows glioblastoma to sustain invasiveness through a Myc-dependent transcriptional upregulation of RhoA.

artículo científico publicado en 2016

Oncogenic targets, magnitude of benefit, and market pricing of antineoplastic drugs

scientific article published on 23 May 2011

Overexpression of HER2 signaling to WAVE2-Arp2/3 complex activates MMP-independent migration in breast cancer

artículo científico publicado en 2010

Overexpression of RasN17 fails to neutralize endogenous Ras in MCF7 breast cancer cells

artículo científico publicado en 2005

P-Rex1 participates in Neuregulin-ErbB signal transduction and its expression correlates with patient outcome in breast cancer.

artículo científico publicado en 2010

PDCD4 limits prooncogenic neuregulin-ErbB signaling

artículo científico publicado en 2020

Paclitaxel-Trastuzumab Mixed Nanovehicle to Target HER2-Overexpressing Tumors

artículo científico publicado en 2019

Pemetrexed acts as an antimyeloma agent by provoking cell cycle blockade and apoptosis.

artículo científico publicado en 2007

Personalized therapies in the cancer "omics" era

artículo científico publicado en 2010

Pharmacological screening and transcriptomic functional analyses identify a synergistic interaction between dasatinib and olaparib in triple-negative breast cancer

artículo científico publicado en 2020

Phospho-kinase profile of colorectal tumors guides in the selection of multi-kinase inhibitors.

artículo científico publicado en 2015

Phospho-kinase profile of triple negative breast cancer and androgen receptor signaling.

artículo científico publicado en 2014

Phosphorylation of P-Rex1 at serine 1169 participates in IGF-1R signaling in breast cancer cells.

artículo científico publicado en 2013

Potent antimyeloma activity of a novel ERK5/CDK inhibitor

artículo científico publicado en 2013

Preclinical development of molecular-targeted agents for cancer

scientific article published on 07 December 2010

Predominance of mTORC1 over mTORC2 in the regulation of proliferation of ovarian cancer cells: therapeutic implications.

artículo científico publicado en 2012

Prognostic Value of Lymphocyte-Activation Gene 3 (LAG3) in Cancer: A Meta-Analysis

scientific article published on 15 October 2019

Prognostic relevance of receptor tyrosine kinase expression in breast cancer: a meta-analysis.

artículo científico publicado en 2014

Prognostic value of receptor tyrosine kinase-like orphan receptor (ROR) family in cancer: A meta-analysis

scientific article published on 29 May 2019

Proteolysis targeting chimeras (PROTACs) in cancer therapy

scientific article published on 15 September 2020

RAF265, a dual BRAF and VEGFR2 inhibitor, prevents osteoclast formation and resorption. Therapeutic implications.

artículo científico publicado en 2012

Refining Early Antitumoral Drug Development

article

Regulation of the prometastatic neuregulin-MMP13 axis by SRC family kinases: therapeutic implications.

artículo científico publicado en 2017

Resistance to Antibody-Drug Conjugates.

artículo científico publicado en 2018

Resistance to the Antibody-Drug Conjugate T-DM1 Is Based in a Reduction in Lysosomal Proteolytic Activity

artículo científico publicado en 2017

Role of metalloproteinases MMP-9 and MT1-MMP in CXCL12-promoted myeloma cell invasion across basement membranes

artículo científico publicado en 2006

Screening and Preliminary Biochemical and Biological Studies of [RuCl(p-cymene)(N,N-bis(diphenylphosphino)-isopropylamine)][BF4] in Breast Cancer Models

artículo científico publicado en 2019

Synergic antitumoral effect of an IGF-IR inhibitor and trastuzumab on HER2-overexpressing breast cancer cells.

artículo científico publicado en 2008

Synthetic lethality interaction between Aurora kinases and CHEK1 inhibitors in ovarian cancer.

artículo científico

TGF-beta1 induces COX-2 expression and PGE2 synthesis through MAPK and PI3K pathways in human mesangial cells

artículo científico publicado en 2006

TRAIL receptor activation overcomes resistance to trastuzumab in HER2 positive breast cancer cells

artículo científico publicado en 2019

Targeting HER receptors in cancer

artículo científico

Targeting basal-like breast tumors with bromodomain and extraterminal domain (BET) and polo-like kinase inhibitors

artículo científico publicado en 2017

Targeting oncogenic vulnerabilities in triple negative breast cancer: biological bases and ongoing clinical studies

artículo científico publicado en 2017

Targeting receptor tyrosine kinases and their signal transduction routes in head and neck cancer

artículo científico publicado en 2006

Targeting the EGF/HER Ligand-Receptor System in Cancer.

artículo científico publicado en 2016

The Activation of the Sox2 RR2 Pluripotency Transcriptional Reporter in Human Breast Cancer Cell Lines is Dynamic and Labels Cells with Higher Tumorigenic Potential

artículo científico publicado en 2014

The effect of the proteasome inhibitor bortezomib on acute myeloid leukemia cells and drug resistance associated with the CD34+ immature phenotype

artículo científico publicado en 2008

The epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable oprozomib have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects.

artículo científico publicado en 2012

The evolving landscape of protein kinases in breast cancer: clinical implications.

artículo científico

The extracellular linker of pro-neuregulin-alpha2c is required for efficient sorting and juxtacrine function.

artículo científico publicado en 2006

The histone deacetylase inhibitor LBH589 is a potent antimyeloma agent that overcomes drug resistance.

artículo científico publicado en 2006

The immunoglobulin-like domain of neuregulins potentiates ErbB3/HER3 activation and cellular proliferation.

artículo científico publicado en 2018

The insulin-like growth factor-I receptor inhibitor NVP-AEW541 provokes cell cycle arrest and apoptosis in multiple myeloma cells.

artículo científico publicado en 2008

The mitogen-activated protein kinase ERK5 regulates the development and growth of hepatocellular carcinoma.

artículo científico publicado en 2014

The mitogen-activated protein kinase Erk5 mediates human mesangial cell activation.

artículo científico publicado en 2008

Therapeutic potential of ERK5 targeting in triple negative breast cancer

artículo científico publicado en 2014

Transautocrine signaling by membrane neuregulins requires cell surface targeting, which is controlled by multiple domains

artículo científico publicado en 2011

Transcriptome evolution from breast epithelial cells to basal-like tumors.

artículo científico publicado en 2017

Transcriptomic analyses identify association between mitotic kinases, PDZ-binding kinase and BUB1, and clinical outcome in breast cancer

artículo científico publicado en 2016

Transcriptomic immunologic signature associated with favorable clinical outcome in basal-like breast tumors

artículo científico publicado en 2017

Transcriptomic profile induced in bone marrow mesenchymal stromal cells after interaction with multiple myeloma cells: implications in myeloma progression and myeloma bone disease

artículo científico publicado en 2014

Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab

artículo científico publicado en 2008

Transforming growth factor-beta1 induces collagen synthesis and accumulation via p38 mitogen-activated protein kinase (MAPK) pathway in cultured L(6)E(9) myoblasts

artículo científico publicado en 2002

Trastuzumab Emtansine: Mechanisms of Action and Resistance, Clinical Progress, and Beyond

scientific article published on 21 January 2020

Trastuzumab and antiestrogen therapy: focus on mechanisms of action and resistance.

artículo científico publicado en 2006

Tumor-infiltrating lymphocytes in breast cancer: ready for prime time?

artículo científico publicado en 2015

Ubiquitin-conjugating enzyme E2T (UBE2T) and denticleless protein homolog (DTL) are linked to poor outcome in breast and lung cancers.

artículo científico publicado en 2017

What about incorporating selenium in the therapeutic regimen of SARS-CoV-2?

scientific article published on 07 December 2020

Zalypsis has in vitro activity in acute myeloid blasts and leukemic progenitor cells through the induction of a DNA damage response.

artículo científico publicado en 2011

Zalypsis: a novel marine-derived compound with potent antimyeloma activity that reveals high sensitivity of malignant plasma cells to DNA double-strand breaks.

artículo científico publicado en 2008

β-Lapachone analogs with enhanced antiproliferative activity

artículo científico publicado en 2012

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