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Activation of legumain involves proteolytic and conformational events, resulting in a context- and substrate-dependent activity profile.

artículo científico publicado en 2011

Comparing Proteolytic Fingerprints of Antigen-Presenting Cells during Allergen Processing

artículo científico publicado en 2017

Cruzain structures: apocruzain and cruzain bound to S-methyl thiomethanesulfonate and implications for drug design

scientific article published on 13 May 2019

Crystal structure of plant legumain reveals a unique two-chain state with pH-dependent activity regulation.

artículo científico publicado en 2018

Distinct Roles of Catalytic Cysteine and Histidine in the Protease and Ligase Mechanisms of Human Legumain As Revealed by DFT-Based QM/MM Simulations

artículo científico publicado en 2017

Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.

artículo científico publicado en 2017

Protease recognition sites in Bet v 1a are cryptic, explaining its slow processing relevant to its allergenicity.

artículo científico publicado en 2015

Structural analyses of Arabidopsis thaliana legumain γ reveal the differential recognition and processing of proteolysis and ligation substrates.

artículo científico publicado en 2018

Structural and functional analysis of cystatin E reveals enzymologically relevant dimer and amyloid fibril states

artículo científico publicado en 2018

Structural and functional studies of Arabidopsis thaliana legumain beta reveal isoform specific mechanisms of activation and substrate recognition

artículo científico publicado en 2020

Structure and function of legumain in health and disease

artículo científico publicado en 2016

Structure and mechanism of an aspartimide-dependent peptide ligase in human legumain

artículo científico publicado en 2015

Two Distinct Conformations in Bet v 2 Determine Its Proteolytic Resistance to Cathepsin S.

artículo científico publicado en 2017

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