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Analysis of the overall structure of the multi-domain amyloid precursor protein (APP).

artículo científico publicado en 2013

Crystal structure of the antimicrobial peptidase lysostaphin fromStaphylococcus simulans

artículo científico publicado en 2014

Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin

scientific article published on 20 February 2019

Engineering a Constrained Peptidic Scaffold towards Potent and Selective Furin Inhibitors

artículo científico publicado en 2015

Heparin induced dimerization of APP is primarily mediated by E1 and regulated by its acidic domain

scientific article published on 22 May 2014

Localization and orientation of heavy-atom cluster compounds in protein crystals using molecular replacement.

artículo científico publicado en 2013

OFF-State-Specific Inhibition of the Proprotein Convertase Furin

artículo científico publicado en 2021

Optimization of Substrate-Analogue Furin Inhibitors

artículo científico publicado en 2017

Sirtilins - the new old members of the vitamin K-dependent coagulation factor family

scientific article published on 13 February 2019

Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor.

artículo científico publicado en 2017

Structural and functional analysis of cystatin E reveals enzymologically relevant dimer and amyloid fibril states

artículo científico publicado en 2018

Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein

artículo científico publicado en 2010

Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism

artículo científico publicado en 2016

The Crystal Structure of Death Receptor 6 (DR6): A Potential Receptor of the Amyloid Precursor Protein (APP)

artículo científico publicado el 2 de abril de 2011

The amyloid precursor protein shows a pH-dependent conformational switch in its E1 domain

artículo científico publicado en 2015

The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers.

artículo científico publicado en 2016

X-ray Structures of Human Furin in Complex with Competitive Inhibitors

artículo científico publicado en 2014

X-ray structures of the proprotein convertase furin bound with substrate analog inhibitors reveal substrate specificity determinants beyond the S4 pocket.

artículo científico publicado en 2018