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A trapped human PPM1A-phosphopeptide complex reveals structural features critical for regulation of PPM protein phosphatase activity

artículo científico publicado en 2018

Binding of a third metal ion by the human phosphatases PP2Cα and Wip1 is required for phosphatase activity

artículo científico publicado en 2013

Chemical Features Important for Activity in a Class of Inhibitors Targeting the Wip1 Flap Subdomain

artículo científico publicado en 2018

Cooperative assembly of a four-molecule signaling complex formed upon T cell antigen receptor activation

artículo científico publicado en 2018

Design of pentapeptidic BACE1 inhibitors with carboxylic acid bioisosteres at P1' and P4 positions.

artículo científico publicado en 2010

Intensity and duration of TCR signaling is limited by p38 phosphorylation of ZAP-70T293 and destabilization of the signalosome.

artículo científico publicado en 2018

Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens

scientific article published on 03 September 2019

Structure-guided design and synthesis of P1' position 1-phenylcycloalkylamine-derived pentapeptidic BACE1 inhibitors

artículo científico publicado en 2011

Tetrapeptides, as small-sized peptidic inhibitors; synthesis and their inhibitory activity against BACE1.

artículo científico publicado en 2010

Tripeptidic BACE1 inhibitors devised by in-silico conformational structure-based design

scientific article published on 01 December 2011

Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation

artículo científico publicado en 2018

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