Lista de obras -

A new tumour suppression mechanism by p27Kip1: EGFR down-regulation mediated by JNK/c-Jun pathway inhibition.

artículo científico publicado en 2014

ATG7 Promotes Bladder Cancer Invasion via Autophagy-Mediated Increased ARHGDIB mRNA Stability

artículo científico publicado en 2019

Acrolein- and 4-Aminobiphenyl-DNA adducts in human bladder mucosa and tumor tissue and their mutagenicity in human urothelial cells.

artículo científico publicado en 2014

Aldehydes are the predominant forces inducing DNA damage and inhibiting DNA repair in tobacco smoke carcinogenesis

artículo científico publicado en 2018

Anatomy and Physiology of the Urinary Tract: Relation to Host Defense and Microbial Infection

artículo científico publicado en 2015

Attention to Detail by Single-cell Sequencing.

artículo científico publicado en 2016

Bladder cancers arise from distinct urothelial sub-populations.

artículo científico publicado en 2014

Chemoprevention of urothelial cell carcinoma growth and invasion by the dual COX-LOX inhibitor licofelone in UPII-SV40T transgenic mice

artículo científico publicado en 2014

Cigarette side-stream smoke lung and bladder carcinogenesis: inducing mutagenic acrolein-DNA adducts, inhibiting DNA repair and enhancing anchorage-independent-growth cell transformation.

artículo científico publicado en 2015

Circulating uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel

artículo científico publicado en 2019

Comparison of the pathology of interstitial plaque in human ICSF stone patients to NHERF-1 and THP-null mice ⬇️

artículo científico publicado el 10 de noviembre de 2010

Conformational inactivation induces immunogenicity of the receptor-binding pocket of a bacterial adhesin

artículo científico publicado en 2013

Cyclin d1 downregulation contributes to anticancer effect of isorhapontigenin on human bladder cancer cells.

artículo científico publicado en 2013

DNMT3A/miR-129-2-5p/Rac1 Is an Effector Pathway for SNHG1 to Drive Stem-Cell-like and Invasive Behaviors of Advanced Bladder Cancer Cells

artículo científico publicado en 2022

Decreased tumorigenesis and mortality from bladder cancer in mice lacking urothelial androgen receptor.

artículo científico publicado en 2013

Deficiency of pRb family proteins and p53 in invasive urothelial tumorigenesis.

scientific article published on December 2009

Distinct Glycan Structures of Uroplakins Ia and Ib

scientific article published in Journal of Biological Chemistry

Downregulation of miR-200c stabilizes XIAP mRNA and contributes to invasion and lung metastasis of bladder cancer

scientific article published on 01 December 2019

Dual ligand/receptor interactions activate urothelial defenses against uropathogenic E. coli

artículo científico publicado en 2015

E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells.

artículo científico publicado en 2018

E3 ligase activity of XIAP RING domain is required for XIAP-mediated cancer cell migration, but not for its RhoGDI binding activity

artículo científico publicado en 2012

Early detection and measurement of urothelial tumors in mice.

artículo científico publicado en 2006

Effect of CpG methylation at different sequence context on acrolein- and BPDE-DNA binding and mutagenesis

artículo científico publicado en 2012

Electronic-cigarette smoke induces lung adenocarcinoma and bladder urothelial hyperplasia in mice

artículo científico publicado en 2019

Estrogen receptor alpha prevents bladder cancer via INPP4B inhibited akt pathway in vitro and in vivo

artículo científico publicado en 2014

FGFR3b Extracellular Loop Mutation Lacks Tumorigenicity In Vivo but Collaborates with p53/pRB Deficiency to Induce High-grade Papillary Urothelial Carcinoma

artículo científico publicado en 2016

High Sensitivity of an Ha-RAS Transgenic Model of Superficial Bladder Cancer to Metformin Is Associated with ∼240-Fold Higher Drug Concentration in Urine than Serum

artículo científico publicado en 2016

Hypermethylation of FOXA1 and allelic loss of PTEN drive squamous differentiation and promote heterogeneity in bladder cancer

scientific article published on 21 October 2019

Inhibition and Reversal of Microbial Attachment by an Antibody with Parasteric Activity against the FimH Adhesin of Uropathogenic E. coli

artículo científico publicado en 2015

Inhibition of PHLPP2/cyclin D1 protein translation contributes to the tumor suppressive effect of NFκB2 (p100).

scientific article published on 15 April 2016

Inhibition of Pyruvate Kinase M2 Markedly Reduces Chemoresistance of Advanced Bladder Cancer to Cisplatin.

artículo científico publicado en 2017

Interstitial calcinosis in renal papillae of genetically engineered mouse models: relation to Randall's plaques

artículo científico publicado en 2014

K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder.

artículo científico publicado en 2011

Kava chalcone, flavokawain A, inhibits urothelial tumorigenesis in the UPII-SV40T transgenic mouse model.

artículo científico publicado en 2013

Loss of FOXA1 Drives Sexually Dimorphic Changes in Urothelial Differentiation and Is an Independent Predictor of Poor Prognosis in Bladder Cancer

artículo científico publicado en 2015

Loss of p27 upregulates MnSOD in a STAT3-dependent manner, disrupts intracellular redox activity and enhances cell migration.

artículo científico publicado en 2014

Loss of the urothelial differentiation marker FOXA1 is associated with high grade, late stage bladder cancer and increased tumor proliferation.

artículo científico publicado en 2012

Maintenance of the bladder cancer precursor urothelial hyperplasia requires FOXA1 and persistent expression of oncogenic HRAS

artículo científico publicado en 2019

Mitochondrial lipid droplet formation as a detoxification mechanism to sequester and degrade excessive urothelial membranes ⬇️

artículo científico publicado en 2019

Molecular and Cellular Effects of Tamm-Horsfall Protein Mutations and Their Rescue by Chemical Chaperones ⬇️

artículo científico publicado el 22 de noviembre de 2011

Neuropilin-VEGF signaling pathway acts as a key modulator of vascular, lymphatic, and inflammatory cell responses of the bladder to intravesical BCG treatment.

artículo científico publicado en 2010

On a FOX hunt: functions of FOX transcriptional regulators in bladder cancer.

artículo científico publicado en 2016

Oncogenic HRAS Activates Epithelial-to-Mesenchymal Transition and Confers Stemness to p53-Deficient Urothelial Cells to Drive Muscle Invasion of Basal Subtype Carcinomas

artículo científico publicado en 2015

PHLPP2 stabilization by p27 mediates its inhibition of bladder cancer invasion by promoting autophagic degradation of MMP2 protein

scientific article published on 21 June 2018

Point mutation in D8C domain of Tamm-Horsfall protein/uromodulin in transgenic mice causes progressive renal damage and hyperuricemia.

artículo científico publicado en 2017

Progress made in the use of animal models for the study of high-risk, nonmuscle invasive bladder cancer

artículo científico publicado en 2014

Progressive renal papillary calcification and ureteral stone formation in mice deficient for Tamm-Horsfall protein

artículo científico publicado en 2010

Ras mutation cooperates with β-catenin activation to drive bladder tumourigenesis ⬇️

artículo científico publicado en 2011

Renal tubule-specific expression and urinary secretion of human growth hormone: a kidney-based transgenic bioreactor growth

artículo científico publicado el 1 de abril de 2003

RhoGDI SUMOylation at Lys-138 increases its binding activity to Rho GTPase and its inhibiting cancer cell motility.

artículo científico publicado en 2012

Role of isoenzyme M2 of pyruvate kinase in urothelial tumorigenesis

artículo científico publicado en 2016

SNX31: a novel sorting nexin associated with the uroplakin-degrading multivesicular bodies in terminally differentiated urothelial cells

scientific journal article

Sequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cells

artículo científico publicado en 2016

TP53 modulating agent, CP-31398 enhances antitumor effects of ODC inhibitor in mouse model of urinary bladder transitional cell carcinoma

artículo científico publicado en 2015

Tamm-Horsfall Protein Regulates Circulating and Renal Cytokines by Affecting Glomerular Filtration Rate and Acting as a Urinary Cytokine Trap ⬇️

artículo científico publicado el 27 de marzo de 2012

Tamm-Horsfall Protein Regulates Granulopoiesis and Systemic Neutrophil Homeostasis.

artículo científico publicado en 2015

Tamm-Horsfall Protein Regulates Mononuclear Phagocytes in the Kidney

artículo científico publicado en 2017

Tamm-Horsfall Protein/Uromodulin Deficiency Elicits Tubular Compensatory Responses Leading to Hypertension and Hyperuricemia.

artículo científico publicado en 2018

Tamm-Horsfall protein translocates to the basolateral domain of thick ascending limbs, interstitium, and circulation during recovery from acute kidney injury

artículo científico publicado en 2013

Tamm-Horsfall protein-deficient thick ascending limbs promote injury to neighboring S3 segments in an MIP-2-dependent mechanism.

artículo científico publicado en 2011

Targeting mTOR and p53 Signaling Inhibits Muscle Invasive Bladder Cancer In Vivo

artículo científico publicado en 2015

Temporally and spatially controllable gene expression and knockout in mouse urothelium.

artículo científico publicado en 2010

The Chinese herb isolate isorhapontigenin induces apoptosis in human cancer cells by down-regulating overexpression of antiapoptotic protein XIAP.

artículo científico publicado en 2012

The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis

scientific article published on 12 July 2013

The Epithelium—Molecular Landscaping for an Interactive Barrier ⬇️

artículo científico publicado el 1 de enero de 2010

The RING domain in the anti-apoptotic protein XIAP stabilizes c-Myc protein and preserves anchorage-independent growth of bladder cancer cells

artículo científico publicado en 2019

Tumorigenicity of RTK/RAS in urothelium

artículo científico publicado en 2015

Uromodulin (Tamm-Horsfall protein): guardian of urinary and systemic homeostasis

artículo científico publicado en 2020

Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy.

artículo científico publicado en 2018

Uromodulin in kidney injury: an instigator, bystander, or protector?

artículo científico publicado en 2012

Uromodulin regulates renal magnesium homeostasis through the ion channel transient receptor potential melastatin 6 (TRPM6)

scientific article published on 23 August 2018

Uromodulin-SlpA binding dictates Lactobacillus acidophilus uptake by intestinal epithelial M cells.

artículo científico publicado en 2017

β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation.

artículo científico publicado en 2010

Lista de obras de

A new tumour suppression mechanism by p27Kip1: EGFR down-regulation mediated by JNK/c-Jun pathway inhibition.

ATG7 Promotes Bladder Cancer Invasion via Autophagy-Mediated Increased ARHGDIB mRNA Stability

Acrolein- and 4-Aminobiphenyl-DNA adducts in human bladder mucosa and tumor tissue and their mutagenicity in human urothelial cells.

Aldehydes are the predominant forces inducing DNA damage and inhibiting DNA repair in tobacco smoke carcinogenesis

Anatomy and Physiology of the Urinary Tract: Relation to Host Defense and Microbial Infection

Attention to Detail by Single-cell Sequencing.

Bladder cancers arise from distinct urothelial sub-populations.

Chemoprevention of urothelial cell carcinoma growth and invasion by the dual COX-LOX inhibitor licofelone in UPII-SV40T transgenic mice

Cigarette side-stream smoke lung and bladder carcinogenesis: inducing mutagenic acrolein-DNA adducts, inhibiting DNA repair and enhancing anchorage-independent-growth cell transformation.

Circulating uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel

Comparison of the pathology of interstitial plaque in human ICSF stone patients to NHERF-1 and THP-null mice ⬇️

Conformational inactivation induces immunogenicity of the receptor-binding pocket of a bacterial adhesin

Cyclin d1 downregulation contributes to anticancer effect of isorhapontigenin on human bladder cancer cells.

DNMT3A/miR-129-2-5p/Rac1 Is an Effector Pathway for SNHG1 to Drive Stem-Cell-like and Invasive Behaviors of Advanced Bladder Cancer Cells

Decreased tumorigenesis and mortality from bladder cancer in mice lacking urothelial androgen receptor.

Deficiency of pRb family proteins and p53 in invasive urothelial tumorigenesis.

Distinct Glycan Structures of Uroplakins Ia and Ib

Downregulation of miR-200c stabilizes XIAP mRNA and contributes to invasion and lung metastasis of bladder cancer

Dual ligand/receptor interactions activate urothelial defenses against uropathogenic E. coli

E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells.

E3 ligase activity of XIAP RING domain is required for XIAP-mediated cancer cell migration, but not for its RhoGDI binding activity

Early detection and measurement of urothelial tumors in mice.

Effect of CpG methylation at different sequence context on acrolein- and BPDE-DNA binding and mutagenesis

Electronic-cigarette smoke induces lung adenocarcinoma and bladder urothelial hyperplasia in mice

Estrogen receptor alpha prevents bladder cancer via INPP4B inhibited akt pathway in vitro and in vivo

FGFR3b Extracellular Loop Mutation Lacks Tumorigenicity In Vivo but Collaborates with p53/pRB Deficiency to Induce High-grade Papillary Urothelial Carcinoma

High Sensitivity of an Ha-RAS Transgenic Model of Superficial Bladder Cancer to Metformin Is Associated with ∼240-Fold Higher Drug Concentration in Urine than Serum

Hypermethylation of FOXA1 and allelic loss of PTEN drive squamous differentiation and promote heterogeneity in bladder cancer

Inhibition and Reversal of Microbial Attachment by an Antibody with Parasteric Activity against the FimH Adhesin of Uropathogenic E. coli

Inhibition of PHLPP2/cyclin D1 protein translation contributes to the tumor suppressive effect of NFκB2 (p100).

Inhibition of Pyruvate Kinase M2 Markedly Reduces Chemoresistance of Advanced Bladder Cancer to Cisplatin.

Interstitial calcinosis in renal papillae of genetically engineered mouse models: relation to Randall's plaques

K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder.

Kava chalcone, flavokawain A, inhibits urothelial tumorigenesis in the UPII-SV40T transgenic mouse model.

Loss of FOXA1 Drives Sexually Dimorphic Changes in Urothelial Differentiation and Is an Independent Predictor of Poor Prognosis in Bladder Cancer

Loss of p27 upregulates MnSOD in a STAT3-dependent manner, disrupts intracellular redox activity and enhances cell migration.

Loss of the urothelial differentiation marker FOXA1 is associated with high grade, late stage bladder cancer and increased tumor proliferation.

Maintenance of the bladder cancer precursor urothelial hyperplasia requires FOXA1 and persistent expression of oncogenic HRAS

Mitochondrial lipid droplet formation as a detoxification mechanism to sequester and degrade excessive urothelial membranes ⬇️

Molecular and Cellular Effects of Tamm-Horsfall Protein Mutations and Their Rescue by Chemical Chaperones ⬇️

Neuropilin-VEGF signaling pathway acts as a key modulator of vascular, lymphatic, and inflammatory cell responses of the bladder to intravesical BCG treatment.

On a FOX hunt: functions of FOX transcriptional regulators in bladder cancer.

Oncogenic HRAS Activates Epithelial-to-Mesenchymal Transition and Confers Stemness to p53-Deficient Urothelial Cells to Drive Muscle Invasion of Basal Subtype Carcinomas

PHLPP2 stabilization by p27 mediates its inhibition of bladder cancer invasion by promoting autophagic degradation of MMP2 protein

Point mutation in D8C domain of Tamm-Horsfall protein/uromodulin in transgenic mice causes progressive renal damage and hyperuricemia.

Progress made in the use of animal models for the study of high-risk, nonmuscle invasive bladder cancer

Progressive renal papillary calcification and ureteral stone formation in mice deficient for Tamm-Horsfall protein

Ras mutation cooperates with β-catenin activation to drive bladder tumourigenesis ⬇️

Renal tubule-specific expression and urinary secretion of human growth hormone: a kidney-based transgenic bioreactor growth

RhoGDI SUMOylation at Lys-138 increases its binding activity to Rho GTPase and its inhibiting cancer cell motility.

Role of isoenzyme M2 of pyruvate kinase in urothelial tumorigenesis

SNX31: a novel sorting nexin associated with the uroplakin-degrading multivesicular bodies in terminally differentiated urothelial cells

Sequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cells

TP53 modulating agent, CP-31398 enhances antitumor effects of ODC inhibitor in mouse model of urinary bladder transitional cell carcinoma

Tamm-Horsfall Protein Regulates Circulating and Renal Cytokines by Affecting Glomerular Filtration Rate and Acting as a Urinary Cytokine Trap ⬇️

Tamm-Horsfall Protein Regulates Granulopoiesis and Systemic Neutrophil Homeostasis.

Tamm-Horsfall Protein Regulates Mononuclear Phagocytes in the Kidney

Tamm-Horsfall Protein/Uromodulin Deficiency Elicits Tubular Compensatory Responses Leading to Hypertension and Hyperuricemia.

Tamm-Horsfall protein translocates to the basolateral domain of thick ascending limbs, interstitium, and circulation during recovery from acute kidney injury

Tamm-Horsfall protein-deficient thick ascending limbs promote injury to neighboring S3 segments in an MIP-2-dependent mechanism.

Targeting mTOR and p53 Signaling Inhibits Muscle Invasive Bladder Cancer In Vivo

Temporally and spatially controllable gene expression and knockout in mouse urothelium.

The Chinese herb isolate isorhapontigenin induces apoptosis in human cancer cells by down-regulating overexpression of antiapoptotic protein XIAP.

The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis

The Epithelium—Molecular Landscaping for an Interactive Barrier ⬇️

The RING domain in the anti-apoptotic protein XIAP stabilizes c-Myc protein and preserves anchorage-independent growth of bladder cancer cells

Tumorigenicity of RTK/RAS in urothelium

Uromodulin (Tamm-Horsfall protein): guardian of urinary and systemic homeostasis

Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy.

Uromodulin in kidney injury: an instigator, bystander, or protector?

Uromodulin regulates renal magnesium homeostasis through the ion channel transient receptor potential melastatin 6 (TRPM6)

Uromodulin-SlpA binding dictates Lactobacillus acidophilus uptake by intestinal epithelial M cells.

β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation.