Lista de obras -

A knockout of the Tsg101 gene leads to decreased expression of ErbB receptor tyrosine kinases and induction of autophagy prior to cell death.

artículo científico publicado en 2012

A mammary-specific, long-range deletion on mouse chromosome 11 accelerates Brca1-associated mammary tumorigenesis.

artículo científico publicado en 2008

AKT3 drives adenoid cystic carcinoma development in salivary glands

artículo científico publicado en 2017

Acceleration of Bcr-Abl+ leukemia induced by deletion of JAK2.

artículo científico publicado en 2014

Autocrine IGF1 Signaling Mediates Pancreatic Tumor Cell Dormancy in the Absence of Oncogenic Drivers

artículo científico publicado en 2017

Cancer cell dormancy in novel mouse models for reversible pancreatic cancer: a lingering challenge in the development of targeted therapies

artículo científico publicado en 2014

Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells.

artículo científico publicado en 2015

Casitas B-cell lymphoma (Cbl) proteins protect mammary epithelial cells from proteotoxicity of active c-Src accumulation.

artículo científico publicado en 2016

Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans

artículo científico publicado en 2013

Cre-mediated gene deletion in the mammary gland ⬇️

artículo científico publicado el 1 de noviembre de 1997

Critical role of Jak2 in the maintenance and function of adult hematopoietic stem cells.

artículo científico publicado en 2014

Crosstalk between STAT5 activation and PI3K/AKT functions in normal and transformed mammary epithelial cells.

artículo científico publicado en 2017

Cyclin D3 Compensates for the Loss of Cyclin D1 during ErbB2-Induced Mammary Tumor Initiation and Progression ⬇️

artículo científico publicado el 28 de octubre de 2011

Cyr61 as mediator of Src signaling in triple negative breast cancer cells.

artículo científico publicado en 2015

Differential effects of hydroxyurea and INC424 on mutant allele burden and myeloproliferative phenotype in a JAK2-V617F polycythemia vera mouse model.

artículo científico publicado en 2012

Disruption of JAK2 in adipocytes impairs lipolysis and improves fatty liver in mice with elevated GH.

artículo científico publicado en 2013

Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer.

artículo científico publicado en 2013

ESCRT proteins: Double-edged regulators of cellular signaling ⬇️

artículo científico publicado el 1 de enero de 2011

Efficient tissue-type specific expression of target genes in a tetracycline-controlled manner from the ubiquitously active Eef1a1 locus

scientific article published on 14 January 2020

Erythropoietin protects against diabetes through direct effects on pancreatic β cells ⬇️

artículo científico publicado el 13 de diciembre de 2010

Forced involution of the functionally differentiated mammary gland by overexpression of the pro-apoptotic protein bax

artículo científico publicado en 2011

G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells.

artículo científico publicado en 2013

Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung

artículo científico publicado en 2013

Generation of Janus kinase 1 (JAK1) conditional knockout mice.

artículo científico publicado en 2016

Generation of conditional knockout mice.

artículo científico publicado en 2014

Genetically engineered mucin mouse models for inflammation and cancer.

artículo científico publicado en 2015

Hepatic Deletion of Janus Kinase 2 Counteracts Oxidative Stress in Mice.

artículo científico publicado en 2016

Hepatic JAK2 protects against atherosclerosis through circulating IGF-1.

artículo científico

Human prolactin receptors are insensitive to mouse prolactin: implications for xenotransplant modeling of human breast cancer in mice.

artículo científico publicado en 2006

IRF4 is a suppressor of c-Myc induced B cell leukemia.

artículo científico publicado en 2011

Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice.

artículo científico publicado en 2011

Jak2 is necessary for neuroendocrine control of female reproduction

artículo científico publicado en 2011

Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling.

scientific article published on 04 April 2016

Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression

artículo científico publicado en 2018

Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice.

artículo científico publicado en 2017

Janus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancer

scientific journal article

Janus-kinase-2 relates directly to portal hypertension and to complications in rodent and human cirrhosis.

artículo científico publicado en 2015

Liver-derived IGF-I contributes to GH-dependent increases in lean mass and bone mineral density in mice with comparable levels of circulating GH.

artículo científico publicado en 2011

Longitudinal analysis of mammogenesis using a novel tetracycline-inducible mouse model and in vivo imaging.

artículo científico publicado en 2009

Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis

scientific journal article

Loss of Jak2 impairs endothelial function by attenuating Raf-1/MEK1/Sp-1 signaling along with altered eNOS activities.

artículo científico publicado en 2013

Loss of Jak2 protects cardiac allografts from chronic rejection by attenuating Th1 response along with increased regulatory T cells

artículo científico publicado en 2019

Macrophage JAK2 deficiency protects against high-fat diet-induced inflammation.

artículo científico publicado en 2017

Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents.

artículo científico publicado en 2017

Mouse models of breast cancer

artículo científico publicado en 2015

Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy.

artículo científico publicado en 2012

Multipotent PI-MECs are the true targets of MMTV-neu tumorigenesis

artículo científico publicado en 2012

Myocardial Hypertrophic Remodeling and Impaired Left Ventricular Function in Mice with a Cardiac-Specific Deletion of Janus Kinase 2.

artículo científico publicado en 2015

NSG-Pro mouse model for uncovering resistance mechanisms and unique vulnerabilities in human luminal breast cancers

artículo científico publicado en 2021

Novel transcripts from a distinct promoter that encode the full-length AKT1 in human breast cancer cells

artículo científico publicado en 2014

PAK4-NAMPT Dual Inhibition Sensitizes Pancreatic Neuroendocrine Tumors to Everolimus

artículo científico publicado en 2021

Regulation and New Treatment Strategies in Breast Cancer

artículo científico publicado en 2019

Selective deletion of Jak2 in adult mouse hematopoietic cells leads to lethal anemia and thrombocytopenia.

artículo científico publicado en 2014

Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells

artículo científico publicado en 2012

Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1.

artículo científico publicado en 2010

Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis.

scientific article published on 27 January 2014

Stimulation of Oncogene-Specific Tumor-Infiltrating T Cells through Combined Vaccine and αPD-1 Enable Sustained Antitumor Responses against Established HER2 Breast Cancer

artículo científico publicado en 2020

Temporally and spatially controlled expression of transgenes in embryonic and adult tissues.

artículo científico publicado en 2009

The Multifaceted Roles of the Tumor Susceptibility Gene 101 (TSG101) in Normal Development and Disease

artículo científico publicado en 2020

The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses

artículo científico publicado en 2013

Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7–induced signaling ⬇️

artículo científico publicado el 25 de octubre de 2010

Tsg101 Is Necessary for the Establishment and Maintenance of Mouse Retinal Pigment Epithelial Cell Polarity

artículo científico publicado en 2021

Tsg101 positively regulates physiologic-like cardiac hypertrophy through FIP3-mediated endosomal recycling of IGF-1R

artículo científico publicado en 2019

Vascular smooth muscle Jak2 deletion prevents angiotensin II-mediated neointima formation following injury in mice.

artículo científico publicado en 2011

Vascular smooth muscle Jak2 mediates angiotensin II-induced hypertension via increased levels of reactive oxygen species ⬇️

artículo científico publicado el 24 de febrero de 2011

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

artículo científico publicado en 2015

Lista de obras de

A knockout of the Tsg101 gene leads to decreased expression of ErbB receptor tyrosine kinases and induction of autophagy prior to cell death.

A mammary-specific, long-range deletion on mouse chromosome 11 accelerates Brca1-associated mammary tumorigenesis.

AKT3 drives adenoid cystic carcinoma development in salivary glands

Acceleration of Bcr-Abl+ leukemia induced by deletion of JAK2.

Autocrine IGF1 Signaling Mediates Pancreatic Tumor Cell Dormancy in the Absence of Oncogenic Drivers

Cancer cell dormancy in novel mouse models for reversible pancreatic cancer: a lingering challenge in the development of targeted therapies

Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells.

Casitas B-cell lymphoma (Cbl) proteins protect mammary epithelial cells from proteotoxicity of active c-Src accumulation.

Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans

Cre-mediated gene deletion in the mammary gland ⬇️

Critical role of Jak2 in the maintenance and function of adult hematopoietic stem cells.

Crosstalk between STAT5 activation and PI3K/AKT functions in normal and transformed mammary epithelial cells.

Cyclin D3 Compensates for the Loss of Cyclin D1 during ErbB2-Induced Mammary Tumor Initiation and Progression ⬇️

Cyr61 as mediator of Src signaling in triple negative breast cancer cells.

Differential effects of hydroxyurea and INC424 on mutant allele burden and myeloproliferative phenotype in a JAK2-V617F polycythemia vera mouse model.

Disruption of JAK2 in adipocytes impairs lipolysis and improves fatty liver in mice with elevated GH.

Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer.

ESCRT proteins: Double-edged regulators of cellular signaling ⬇️

Efficient tissue-type specific expression of target genes in a tetracycline-controlled manner from the ubiquitously active Eef1a1 locus

Erythropoietin protects against diabetes through direct effects on pancreatic β cells ⬇️

Forced involution of the functionally differentiated mammary gland by overexpression of the pro-apoptotic protein bax

G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells.

Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung

Generation of Janus kinase 1 (JAK1) conditional knockout mice.

Generation of conditional knockout mice.

Genetically engineered mucin mouse models for inflammation and cancer.

Hepatic Deletion of Janus Kinase 2 Counteracts Oxidative Stress in Mice.

Hepatic JAK2 protects against atherosclerosis through circulating IGF-1.

Human prolactin receptors are insensitive to mouse prolactin: implications for xenotransplant modeling of human breast cancer in mice.

IRF4 is a suppressor of c-Myc induced B cell leukemia.

Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice.

Jak2 is necessary for neuroendocrine control of female reproduction

Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling.

Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression

Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice.

Janus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancer

Janus-kinase-2 relates directly to portal hypertension and to complications in rodent and human cirrhosis.

Liver-derived IGF-I contributes to GH-dependent increases in lean mass and bone mineral density in mice with comparable levels of circulating GH.

Longitudinal analysis of mammogenesis using a novel tetracycline-inducible mouse model and in vivo imaging.

Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis

Loss of Jak2 impairs endothelial function by attenuating Raf-1/MEK1/Sp-1 signaling along with altered eNOS activities.

Loss of Jak2 protects cardiac allografts from chronic rejection by attenuating Th1 response along with increased regulatory T cells

Macrophage JAK2 deficiency protects against high-fat diet-induced inflammation.

Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents.

Mouse models of breast cancer

Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy.

Multipotent PI-MECs are the true targets of MMTV-neu tumorigenesis

Myocardial Hypertrophic Remodeling and Impaired Left Ventricular Function in Mice with a Cardiac-Specific Deletion of Janus Kinase 2.

NSG-Pro mouse model for uncovering resistance mechanisms and unique vulnerabilities in human luminal breast cancers

Novel transcripts from a distinct promoter that encode the full-length AKT1 in human breast cancer cells

PAK4-NAMPT Dual Inhibition Sensitizes Pancreatic Neuroendocrine Tumors to Everolimus

Regulation and New Treatment Strategies in Breast Cancer

Selective deletion of Jak2 in adult mouse hematopoietic cells leads to lethal anemia and thrombocytopenia.

Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells

Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1.

Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis.

Stimulation of Oncogene-Specific Tumor-Infiltrating T Cells through Combined Vaccine and αPD-1 Enable Sustained Antitumor Responses against Established HER2 Breast Cancer

Temporally and spatially controlled expression of transgenes in embryonic and adult tissues.

The Multifaceted Roles of the Tumor Susceptibility Gene 101 (TSG101) in Normal Development and Disease

The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses

Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7–induced signaling ⬇️

Tsg101 Is Necessary for the Establishment and Maintenance of Mouse Retinal Pigment Epithelial Cell Polarity

Tsg101 positively regulates physiologic-like cardiac hypertrophy through FIP3-mediated endosomal recycling of IGF-1R

Vascular smooth muscle Jak2 deletion prevents angiotensin II-mediated neointima formation following injury in mice.

Vascular smooth muscle Jak2 mediates angiotensin II-induced hypertension via increased levels of reactive oxygen species ⬇️

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets