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(1-4)-Thiodisaccharides as anticancer agents. Part 5. Evaluation of anticancer activity and investigation of mechanism of action

artículo científico publicado en 2019

A preliminary study of apoptosis induction in glioma cells via alteration of the Bax/Bcl-2-p53 axis by transformed and non-transformed root extracts of Leonurus sibiricus L.

artículo científico publicado en 2016

An Evaluation of the DNA-Protective Effects of Extracts from Menyanthes trifoliata L. Plants Derived from In Vitro Culture Associated with Redox Balance and Other Biological Activities

scientific article published on 16 October 2019

An Extract of Transgenic Senna obtusifolia L. Hairy Roots with Overexpression of PgSS1 Gene in Combination with Chemotherapeutic Agent Induces Apoptosis in the Leukemia Cell Line

scientific article published on 27 March 2020

An In Vitro Estimation of the Cytotoxicity and Genotoxicity of Root Extract from L. Overexpressing AtPAP1 against Different Cancer Cell Lines

artículo científico publicado en 2018

An In Vitro Evaluation of the Molecular Mechanisms of Action of Medical Plants from the Lamiaceae Family as Effective Sources of Active Compounds against Human Cancer Cell Lines

artículo científico publicado en 2020

Anti-Inflammatory Activity of Extracts and Pure Compounds Derived from Plants via Modulation of Signaling Pathways, Especially PI3K/AKT in Macrophages

artículo científico publicado en 2020

Antibacterial, Anti-Inflammatory, Antioxidant, and Antiproliferative Properties of Essential Oils from Hairy and Normal Roots of Leonurus sibiricus L. and Their Chemical Composition

artículo científico publicado en 2017

Antioxidant and DNA Repair Stimulating Effect of Extracts from Transformed and Normal Roots of Rhaponticum carthamoides against Induced Oxidative Stress and DNA Damage in CHO Cells

artículo científico publicado en 2016

Association between Single-Nucleotide Polymorphisms of the hOGG1,NEIL1,APEX1, FEN1,LIG1, and LIG3 Genes and Alzheimer's Disease Risk

artículo científico publicado en 2016

Association between polymorphism of the NQO1, NOS3 and NFE2L2 genes and AMD

article

Association between single nucleotide polymorphisms of MUTYH, hOGG1 and NEIL1 genes, and depression

artículo científico publicado en 2015

Association between single nucleotide polymorphisms of TPH1 and TPH2 genes, and depressive disorders

artículo científico publicado en 2018

Associations between DNA Damage, DNA Base Excision Repair Gene Variability and Alzheimer's Disease Risk

artículo científico publicado en 2016

Base excision repair in Alzheimer's disease

artículo científico publicado en 2014

Benign Effect of Extremely Low-Frequency Electromagnetic Field on Brain Plasticity Assessed by Nitric Oxide Metabolism during Poststroke Rehabilitation.

artículo científico publicado en 2017

Common polymorphisms in the XPD and hOGG1 genes are not associated with the risk of colorectal cancer in a Polish population

artículo científico publicado en 2009

Cytotoxicity and genotoxicity of capecitabine in head and neck cancer and normal cells.

artículo científico publicado en 2010

DNA damage and repair in neuropsychiatric disorders. What do we know and what are the future perspectives?

scientific article published on 01 February 2020

DNA double strand break repair - related synthetic lethality.

artículo científico publicado en 2018

Decreased expression level of BER genes in Alzheimer's disease patients is not derivative of their DNA methylation status.

artículo científico publicado en 2017

Diterpenoids from Plectranthus spp. as Potential Chemotherapeutic Agents via Apoptosis

scientific article published on 16 June 2020

Effect of Rehabilitation with Extremely Low Frequency Electromagnetic Field on Molecular Mechanism of Apoptosis in Post-Stroke Patients

artículo científico publicado en 2020

Effects of venlafaxine on the expression level and methylation status of genes involved in oxidative stress in rats exposed to a chronic mild stress

scientific article published on 13 April 2020

Elevated level of DNA damage and impaired repair of oxidative DNA damage in patients with recurrent depressive disorder

artículo científico publicado en 2015

Enhanced Accumulation of Betulinic Acid in Transgenic Hairy Roots of Senna obtusifolia Growing in the Sprinkle Bioreactor and Evaluation of Their Biological Properties in Various Biological Models

scientific article published on 13 July 2021

Eradication of LIG4-deficient glioblastoma cells by the combination of PARP inhibitor and alkylating agent

artículo científico publicado en 2018

Ethylene glycol dimethacrylate and diethylene glycol dimethacrylate exhibits cytotoxic and genotoxic effect on human gingival fibroblasts via induction of reactive oxygen species.

artículo científico publicado en 2017

Evaluation of the effects of extremely low frequency electromagnetic field on the levels of some inflammatory cytokines in post-stroke patients

artículo científico publicado en 2019

Flavonolignans Inhibit IL1-β-Induced Cross-Talk between Blood Platelets and Leukocytes

artículo científico publicado en 2017

Genotoxicity and cytotoxicity of ZnO and Al2O3 nanoparticles.

artículo científico publicado en 2015

Imatinib mesylate (STI571) abrogates the resistance to doxorubicin in human K562 chronic myeloid leukemia cells by inhibition of BCR/ABL kinase-mediated DNA repair.

artículo científico publicado en 2006

Impact of Single Nucleotide Polymorphisms of Base Excision Repair Genes on DNA Damage and Efficiency of DNA Repair in Recurrent Depression Disorder

artículo científico publicado en 2016

In Vitro Assessment of Antimicrobial, Antioxidant, and Cytotoxic Properties of Saccharin-Tetrazolyl and -Thiadiazolyl Derivatives: The Simple Dependence of the pH Value on Antimicrobial Activity

scientific article published on 12 November 2019

Increase in Blood Levels of Growth Factors Involved in the Neuroplasticity Process by Using an Extremely Low Frequency Electromagnetic Field in Post-stroke Patients

artículo científico publicado en 2018

Induction of apoptosis by in vitro and in vivo plant extracts derived from Menyanthes trifoliata L. in human cancer cells

article

Induction of apoptosis in human glioma cell lines of various grades through the ROS-mediated mitochondrial pathway and caspase activation by Rhaponticum carthamoides transformed root extract.

artículo científico publicado en 2017

Inhibition of human glioma cell proliferation by altered Bax/Bcl-2-p53 expression and apoptosis induction by Rhaponticum carthamoides extracts from transformed and normal roots.

artículo científico publicado en 2016

Insight the Biological Activities of Selected Abietane Diterpenes Isolated from Plectranthus spp

artículo científico publicado en 2020

MUTYH Tyr165Cys, OGG1 Ser326Cys and XPD Lys751Gln polymorphisms and head neck cancer susceptibility: a case control study

artículo científico publicado en 2010

Major depressive disorders accompanying autoimmune diseases - Response to treatment

artículo científico publicado en 2019

Melittin-A Natural Peptide from Bee Venom Which Induces Apoptosis in Human Leukaemia Cells

scientific article published on 06 February 2020

Methyl Jasmonate Effect on Betulinic Acid Content and Biological Properties of Extract from Senna obtusifolia Transgenic Hairy Roots

artículo científico publicado en 2021

Mitochondrial DNA copy number, damage, repair and degradation in depressive disorder

artículo científico publicado en 2019

Modulation of antioxidant enzyme gene expression by extremely low frequency electromagnetic field in post-stroke patients

scientific article published on 01 November 2018

Non-NAD-like PARP1 inhibitor enhanced synthetic lethal effect of NAD-like PARP inhibitors against BRCA1-deficient leukemia

artículo científico publicado en 2018

Novel association between TGFA, TGFB1, IRF1, PTGS2 and IKBKB single-nucleotide polymorphisms and occurrence, severity and treatment response of major depressive disorder

artículo científico publicado en 2020

Orchidaceae-Derived Anticancer Agents: A Review

artículo científico publicado en 2022

Over-Expression of AtPAP1 Transcriptional Factor Enhances Phenolic Acid Production in Transgenic Roots of Leonurus sibiricus L. and Their Biological Activities

artículo científico publicado en 2017

Oxidative Damage of Blood Platelets Correlates with the Degree of Psychophysical Disability in Secondary Progressive Multiple Sclerosis

artículo científico publicado en 2020

Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders

artículo científico publicado en 2017

PARP1 inhibitor olaparib (Lynparza) exerts synthetic lethal effect against ligase 4-deficient melanomas.

artículo científico publicado en 2016

Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile

artículo científico publicado en 2013

Plant Extracts and Reactive Oxygen Species as Two Counteracting Agents with Anti- and Pro-Obesity Properties

artículo científico publicado en 2019

Plant Extracts as A Natural Source of Bioactive Compounds and Potential Remedy for The Treatment of Certain Skin Diseases

scientific article published on 17 April 2020

Polymorphism of the ERalpha and CYP1B1 genes in endometrial cancer in a Polish subpopulation.

artículo científico publicado en 2010

Polymorphisms in RAD51, XRCC2 and XRCC3 genes of the homologous recombination repair in colorectal cancer--a case control study.

artículo científico publicado en 2010

Polymorphisms of the BRCA2 and RAD51 genes in breast cancer.

artículo científico publicado en 2005

Polymorphisms of the DNA polymerase beta gene in breast cancer.

artículo científico publicado en 2006

Polymorphisms of the XRCC3 C722T and the RAD51 G135C genes and the risk of head and neck cancer in a Polish population

artículo científico publicado en 2010

Potential Synergistic Action of Bioactive Compounds from Plant Extracts against Skin Infecting Microorganisms

scientific article published on 19 July 2020

Preliminary Study of the Impact of Single-Nucleotide Polymorphisms of IL-1α, IL-1β and TNF-α Genes on the Occurrence, Severity and Treatment Effectiveness of the Major Depressive Disorder

scientific article published on 07 January 2020

Protective action of melatonin against oxidative DNA damage: chemical inactivation versus base-excision repair

scientific article published on 09 August 2007

RAD52 as a Potential Target for Synthetic Lethality-Based Anticancer Therapies

scientific article published on 14 October 2019

Rhaponticum carthamoides transformed root extract inhibits human glioma cells viability, induces double strand DNA damage, H2A.X phosphorylation, and PARP1 cleavage

scientific article published on 31 August 2018

Role of base-excision repair in the treatment of childhood acute lymphoblastic leukaemia with 6-mercaptopurine and high doses of methotrexate

artículo científico publicado en 2011

STI571 reduces NER activity in BCR/ABL-expressing cells.

artículo científico publicado en 2008

Screening Analysis of Platelet miRNA Profile Revealed miR-142-3p as a Potential Biomarker in Modeling the Risk of Acute Coronary Syndrome

artículo científico publicado en 2021

Single-Nucleotide Polymorphisms of Genes Involved in Repair of Oxidative DNA Damage and the Risk of Recurrent Depressive Disorder

artículo científico publicado en 2016

Single-nucleotide polymorphisms of uracil-processing genes affect the occurrence and the onset of recurrent depressive disorder.

artículo científico publicado en 2018

Synthetic lethality as a functional tool in basic research and in anticancer therapy

artículo científico publicado en 2014

The Changes of Expression and Methylation of Genes Involved in Oxidative Stress in Course of Chronic Mild Stress and Antidepressant Therapy with Agomelatine

artículo científico publicado en 2020

The Effect of Chronic Mild Stress and Escitalopram on the Expression and Methylation Levels of Genes Involved in the Oxidative and Nitrosative Stresses as Well as Tryptophan Catabolites Pathway in the Blood and Brain Structures

artículo científico publicado en 2020

The Effect of Chronic Mild Stress and Venlafaxine on the Expression and Methylation Levels of Genes Involved in the Tryptophan Catabolites Pathway in the Blood and Brain Structures of Rats

artículo científico publicado en 2020

The Effect of Leonurus sibiricus Plant Extracts on Stimulating Repair and Protective Activity against Oxidative DNA Damage in CHO Cells and Content of Phenolic Compounds

artículo científico publicado en 2015

The Essential Oils of Rhaponticum carthamoides Hairy Roots and Roots of Soil-Grown Plants: Chemical Composition and Antimicrobial, Anti-Inflammatory, and Antioxidant Activities

artículo científico publicado en 2016

The Extract of Leonurus sibiricus Transgenic Roots with AtPAP1 Transcriptional Factor Induces Apoptosis via DNA Damage and Down Regulation of Selected Epigenetic Factors in Human Cancer Cells.

artículo científico publicado en 2018

The Impact of Chronic Mild Stress and Agomelatine Treatment on the Expression Level and Methylation Status of Genes Involved in Tryptophan Catabolic Pathway in PBMCs and Brain Structures

scientific article published on 18 September 2020

The Influence of Hepatitis C Virus Therapy on the DNA Base Excision Repair System of Peripheral Blood Mononuclear Cells

artículo científico publicado en 2017

The Relationship Between Single-Nucleotide Polymorphisms, the Expression of DNA Damage Response Genes, and Hepatocellular Carcinoma in a Polish Population.

artículo científico publicado en 2017

The c.469+46_56del mutation in the homeobox MSX1 gene--a novel risk factor in breast cancer?

artículo científico publicado en 2010

The interplay between inflammation, oxidative stress, DNA damage, DNA repair and mitochondrial dysfunction in depression

artículo científico publicado en 2017

The levels of 7,8-dihydrodeoxyguanosine (8-oxoG) and 8-oxoguanine DNA glycosylase 1 (OGG1) - A potential diagnostic biomarkers of Alzheimer's disease.

artículo científico publicado en 2016

The molecular aspects of oxidative & nitrosative stress and the tryptophan catabolites pathway (TRYCATs) as potential causes of depression

artículo científico publicado en 2017

Transformed Root Extract Has Potent Anticancer Activity in Human Leukemia and Lung Adenocarcinoma Cell Lines

artículo científico publicado en 2018

Transformed Root Extract of Leonurus sibiricus Induces Apoptosis through Intrinsic and Extrinsic Pathways in Various Grades of Human Glioma Cells.

artículo científico publicado en 2016

Transgenesis as a Tool for the Efficient Production of Selected Secondary Metabolites from in Vitro Plant Cultures

scientific article published on 21 January 2020

Tyrosine kinase blockers: new hope for successful cancer therapy.

artículo científico publicado en 2009

Tyrosine kinase inhibitor-induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors.

artículo científico publicado en 2018

Variants of Base Excision Repair Genes MUTYH , PARP1 and XRCC1 in Alzheimer's Disease Risk.

artículo científico publicado en 2015

Variation of Genes Encoding Tryptophan Catabolites Pathway Enzymes in Stroke

scientific article published on 03 December 2019

Variation of genes encoding KAT1, AADAT and IDO1 as a potential risk of depression development

artículo científico publicado en 2018

Variation of genes involved in oxidative and nitrosative stresses in depression

artículo científico publicado en 2017

Zinc salts differentially modulate DNA damage in normal and cancer cells.

artículo científico publicado en 2009

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