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A new mechanism for cannabidiol in regulating the one-carbon cycle and methionine levels in Dictyostelium and in mammalian epilepsy models

scientific article published on 03 January 2020

A novel human receptor involved in bitter tastant detection identified using Dictyostelium discoideum.

artículo científico publicado en 2013

An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum.

artículo científico publicado en 2014

An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA2 dependent signalling.

artículo científico publicado en 2015

Bitter tastant responses in the amoeba Dictyostelium correlate with rat and human taste assays.

artículo científico publicado en 2015

Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds.

artículo científico publicado en 2011

Curcumin and derivatives function through protein phosphatase 2A and presenilin orthologues in Dictyostelium discoideum

artículo científico publicado en 2017

Decanoic acid inhibits mTORC1 activity independent of glucose and insulin signaling

scientific article published on 02 September 2020

Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid in

artículo científico publicado en 2018

Employing Dictyostelium as an Advantageous 3Rs Model for Pharmacogenetic Research

artículo científico publicado en 2016

Epilepsy research methods update: Understanding the causes of epileptic seizures and identifying new treatments using non-mammalian model organisms.

artículo científico

Gamma secretase orthologs are required for lysosomal activity and autophagic degradation in Dictyostelium discoideum, independent of PSEN (presenilin) proteolytic function

scientific article published on 21 March 2019

Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a TRPP2 (polycystin-2)-dependent manner

artículo científico publicado en 2014

New experimental therapies for status epilepticus in preclinical development.

artículo científico

Non-Catalytic Roles of Presenilin Throughout Evolution.

artículo científico publicado en 2016

Phytocannabinoid-dependent mTORC1 regulation is dependent upon IPMK activity

scientific article published on 21 December 2020

Seizure control by ketogenic diet-associated medium chain fatty acids

artículo científico publicado en 2013

Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid

artículo científico publicado en 2013

Structural basis of AMPA receptor inhibition by 4-BCCA

scientific article published on 22 September 2020

Synapsin I phosphorylation is dysregulated by beta-amyloid oligomers and restored by valproic acid

artículo científico publicado en 2017

The Inositol-3-Phosphate Synthase Biosynthetic Enzyme Has Distinct Catalytic and Metabolic Roles.

artículo científico publicado en 2016

Tipping the scales: Lessons from simple model systems on inositol imbalance in neurological disorders

artículo científico publicado en 2017

Valproic acid and its congener propylisopropylacetic acid reduced the amount of soluble amyloid-β oligomers released from 7PA2 cells.

artículo científico publicado en 2017

Valproic acid protects against haemorrhagic shock-induced signalling changes via PPARγ activation in an in vitro model

scientific article published on September 2015

Zizimin and Dock guanine nucleotide exchange factors in cell function and disease.

artículo científico publicado en 2012

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