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A New CDK9 Inhibitor on the Block to Treat Hematologic Malignancies

scientific article published on 16 December 2019

BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response

artículo científico publicado en 2013

Blastic Plasmacytoid Dendritic Cell Neoplasm Is Dependent on BCL2 and Sensitive to Venetoclax.

artículo científico publicado en 2016

Cell Line–Specific Network Models of ER+ Breast Cancer Identify Potential PI3Kα Inhibitor Resistance Mechanisms and Drug Combinations

scientific article published on 13 July 2021

Complementary dynamic BH3 profiles predict co-operativity between the multi-kinase inhibitor TG02 and the BH3 mimetic ABT-199 in acute myeloid leukaemia cells

artículo científico publicado en 2017

DNA methyltransferase inhibition overcomes diphthamide pathway deficiencies underlying CD123-targeted treatment resistance

artículo científico publicado en 2019

Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies

scientific article published on 14 November 2019

Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.

artículo científico publicado en 2015

Dual inhibition of MDM2 and MDM4 in virus-positive Merkel cell carcinoma enhances the p53 response

scientific article published on 31 December 2018

Dynamic BH3 profiling-poking cancer cells with a stick

artículo científico publicado en 2016

KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.

artículo científico publicado en 2013

Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma.

artículo científico publicado en 2008

Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer

scientific article published on 28 August 2019

Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors.

artículo científico publicado en 2012

Sequential combinations of chemotherapeutic agents with BH3 mimetics to treat rhabdomyosarcoma and avoid resistance

scientific article published on 15 August 2020

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

artículo científico publicado en 2017

The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading

artículo científico publicado en 2017

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

artículo científico publicado en 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

artículo científico publicado en 2016

iBH3: simple, fixable BH3 profiling to determine apoptotic priming in primary tissue by flow cytometry

artículo científico publicado en 2016

p53 regulates a non-apoptotic death induced by ROS.

artículo científico publicado en 2013

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