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Alkoxyamines Designed as Potential Drugs against Plasmodium and Schistosoma Parasites

artículo científico publicado en 2020

Alkylating ability of artemisinin after Cu(I)-induced activation.

artículo científico publicado en 2009

Antischistosomal activity of trioxaquines: in vivo efficacy and mechanism of action on Schistosoma mansoni

artículo científico publicado en 2012

Characterization of new specific copper chelators as potential drugs for the treatment of Alzheimer's disease

artículo científico publicado en 2014

Correlation between Plasmodium yoelii nigeriensis susceptibility to artemisinin and alkylation of heme by the drug.

artículo científico publicado en 2013

Endoperoxide-based compounds: cross-resistance with artemisinins and selection of a Plasmodium falciparum lineage with a K13 non-synonymous polymorphism.

artículo científico publicado en 2017

Heme as trigger and target for trioxane-containing antimalarial drugs.

artículo científico publicado en 2010

In vitro activities of trioxaquines against Schistosoma mansoni.

artículo científico publicado en 2009

Involvement of Pazopanib and Sunitinib Aldehyde Reactive Metabolites in Toxicity and Drug-Drug Interactions in Vitro and in Patient Samples

scientific article published on 26 September 2019

Magnetite Fe3 O4 Has no Intrinsic Peroxidase Activity, and Is Probably not Involved in Alzheimer's Oxidative Stress

artículo científico publicado en 2018

Metal Ions in Alzheimer's Disease: A Key Role or Not?

scientific article published on 05 July 2019

Metalloporphyrin-Catalyzed Oxidation of Sunitinib and Pazopanib, Two Anticancer Tyrosine Kinase Inhibitors: Evidence for New Potentially Toxic Metabolites

scientific article published on 24 August 2018

N4-Tetradentate chelators efficiently regulate copper homeostasis and prevent ROS production induced by copper-amyloid-β1-16, even in the presence of an excess of zinc.

artículo científico publicado en 2018

Peroxide bond strength of antimalarial drugs containing an endoperoxide cycle. Relation with biological activity.

artículo científico publicado en 2011

Preparation of new tetradentate copper chelators as potential anti-Alzheimer agents.

artículo científico publicado en 2018

Recent Advances in Malaria Chemotherapy

artículo científico publicado en 2002

Regulation of copper and iron homeostasis by metal chelators: a possible chemotherapy for Alzheimer's disease.

artículo científico publicado en 2015

Schistosomiasis chemotherapy.

artículo científico publicado en 2013

Small Molecules: The Past or the Future in Drug Innovation?

scientific article published on 01 January 2019

TDMQ20, a Specific Copper Chelator, Reduces Memory Impairments in Alzheimer's Disease Mouse Models

artículo científico publicado en 2020

The Necessity of Having a Tetradentate Ligand to Extract Copper(II) Ions from Amyloids.

artículo científico publicado en 2014

The antimalarial trioxaquine DU1301 alkylates heme in malaria-infected mice.

artículo científico publicado en 2008

Transfer of Copper from an Amyloid to a Natural Copper-Carrier Peptide with a Specific Mediating Ligand.

artículo científico publicado en 2015

Trioxaferroquines as new hybrid antimalarial drugs.

artículo científico publicado en 2010