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Application of PBPK modeling to predict human intestinal metabolism of CYP3A substrates - an evaluation and case study using GastroPlus.

artículo científico publicado en 2012

Combined treatment with a BACE inhibitor and anti-Aβ antibody gantenerumab enhances amyloid reduction in APPLondon mice.

artículo científico publicado en 2014

Modeling the activation of the alternative complement pathway and its effects on hemolysis in health and disease

scientific article published on 02 October 2020

Ocular Half-Life of Intravitreal Biologics in Humans and Other Species: Meta-Analysis and Model-Based Prediction

scientific article published on 16 January 2020

On the modeling of drug induced respiratory depression in the non-steady-state.

artículo científico publicado en 2008

PK/PD assessment in CNS drug discovery: Prediction of CSF concentration in rodents for P-glycoprotein substrates and application to in vivo potency estimation.

artículo científico publicado en 2013

Pharmacodynamic modelling of drug-induced ventilatory depression and automatic drug dosing in conscious sedation.

artículo científico publicado en 2006

Recent developments in using mechanistic cardiac modelling for drug safety evaluation

artículo científico publicado en 2016

The dynamics of Aβ distribution after γ-secretase inhibitor treatment, as determined by experimental and modelling approaches in a wild type rat.

artículo científico publicado en 2012

Theoretical Insights into the Retinal Dynamics of Vascular Endothelial Growth Factor in Patients Treated with Ranibizumab, Based on an Ocular Pharmacokinetic/Pharmacodynamic Model

artículo científico publicado en 2018

Translational PK/PD modeling for cardiovascular safety assessment of drug candidates: Methods and examples in drug development.

artículo científico publicado en 2014

Translational PK/PD modeling to increase probability of success in drug discovery and early development

artículo científico publicado en 2016

Understanding the Half-Life Extension of Intravitreally Administered Antibodies Binding to Ocular Albumin

artículo científico publicado en 2020

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