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A C-terminal mutant of CCAAT-enhancer-binding protein α (C/EBPα-Cm) downregulates Csf1r, a potent accelerator in the progression of acute myeloid leukemia with C/EBPα-Cm.

artículo científico

A mouse model reveals that Mfsd2a is critical for unfolded protein response upon exposure to tunicamycin

artículo científico publicado en 2016

Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia

scientific article published on 25 October 2019

Axitinib for the treatment of advanced renal cell carcinoma.

artículo científico

Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development

artículo científico publicado en 2006

Discrimination of Dormant and Active Hematopoietic Stem Cells by G0 Marker Reveals Dormancy Regulation by Cytoplasmic Calcium

scientific article published on 01 December 2019

Genetic interaction between mutations in c-Myb and the KIX domains of CBP and p300 affects multiple blood cell lineages and influences both gene activation and repression

artículo científico publicado en 2013

Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells

artículo científico publicado en 2006

High expression of ABCG2 induced by EZH2 disruption has pivotal roles in MDS pathogenesis

artículo científico publicado en 2017

Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development

scientific article published on 11 May 2009

Immunophenotypic analysis of cerebrospinal fluid reveals concurrent development of ATL in the CNS of a HAM/TSP patient

scientific article published on 13 January 2020

MYND-less splice variants of AML1-MTG8 (RUNX1-CBFA2T1) are expressed in leukemia with t(8;21).

artículo científico publicado en 2005

Novel working hypothesis for pathogenesis of hematological malignancies: combination of mutations-induced cellular phenotypes determines the disease (cMIP-DD).

artículo científico publicado en 2015

Opposing effects of acute versus chronic inhibition of p53 on decitabine's efficacy in myeloid neoplasms

scientific article published on 03 June 2019

T-cells null for the MED23 subunit of mediator express decreased levels of KLF2 and inefficiently populate the peripheral lymphoid organs

scientific journal article

Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases.

artículo científico publicado en 2010

The first case of elderly TCF3-HLF-positive B-cell acute lymphoblastic leukemia

artículo científico publicado en 2019

The molecular basis of myeloid malignancies

artículo científico publicado en 2014

The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1.

artículo científico publicado en 2017