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A new paradigm for aptamer therapeutic AS1411 action: uptake by macropinocytosis and its stimulation by a nucleolin-dependent mechanism ⬇️

artículo científico publicado en 2010

A novel small molecule that induces oxidative stress and selectively kills malignant cells.

artículo científico publicado en 2013

AS1411-conjugated gold nanospheres and their potential for breast cancer therapy

artículo científico publicado en 2015

Cell-surface nucleolin is a signal transducing P-selectin binding protein for human colon carcinoma cells.

artículo científico publicado en 2008

Characterizing Oligonucleotide Uptake in Cultured Cells: A Case Study Using AS1411 Aptamer

artículo científico publicado en 2019

G-quadruplex oligonucleotide AS1411 as a cancer-targeting agent: Uses and mechanisms.

artículo científico publicado en 2016

LINE-1 couples EMT programming with acquisition of oncogenic phenotypes in human bronchial epithelial cells.

artículo científico publicado en 2017

Line-1: Implications in the etiology of cancer, clinical applications, and pharmacologic targets

artículo científico publicado en 2018

Mechanistic studies of anticancer aptamer AS1411 reveal a novel role for nucleolin in regulating Rac1 activation.

artículo científico publicado en 2015

Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways.

artículo científico publicado en 2014

Physangulidine A, a withanolide from Physalis angulata, perturbs the cell cycle and induces cell death by apoptosis in prostate cancer cells.

artículo científico publicado en 2012

Plagiochiline A Inhibits Cytokinetic Abscission and Induces Cell Death.

artículo científico publicado en 2018

The aryl hydrocarbon receptor agonist benzo(a)pyrene reactivates LINE-1 in HepG2 cells through canonical TGF-β1 signaling: implications in hepatocellular carcinogenesis

artículo científico publicado en 2016

mTOR/AMPK signaling in the brain: Cell metabolism, proteostasis and survival

scientific article published on 01 April 2018

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