Lista de obras - Mattia Mori - Dominio Público Uruguay

(Thia)calixarenephosphonic Acids as Potent Inhibitors of the Nucleic Acid Chaperone Activity of the HIV-1 Nucleocapsid Protein with a New Binding Mode and Multitarget Antiviral Activity

artículo científico publicado en 2020

1H-NMR metabolomics reveals the Glabrescione B exacerbation of glycolytic metabolism beside the cell growth inhibitory effect in glioma

scientific article published on 28 August 2019

2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors.

artículo científico publicado en 2010

A Molecular Tool Targeting the Base-Flipping Activity of Human UHRF1

artículo científico publicado en 2019

A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth

artículo científico publicado en 2019

A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors.

artículo científico publicado en 2013

A deadly spillover: SARS-CoV-2 outbreak

scientific article published on 23 April 2020

A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer

artículo científico publicado en 2017

A unique high-diversity natural product collection as a reservoir of new therapeutic leads

artículo científico publicado en 2021

Alvaxanthone, a Thymidylate Synthase Inhibitor with Nematocidal and Tumoricidal Activities

artículo científico publicado en 2020

Chalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T-cell Acute Lymphoblastic Leukemia

scientific article published on 26 February 2019

Challenging Organic Syntheses and Pharmacological Applications of Natural Products and their Derivatives - Part II

artículo científico publicado en 2016

Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61.

artículo científico publicado en 2018

Chemically stable inhibitors of 14-3-3 protein-protein interactions derived from BV02

scientific article published on 01 December 2019

Click Reaction as a Tool to Combine Pharmacophores: The Case of Vismodegib

artículo científico publicado en 2015

Current trends in Hedgehog signaling pathway inhibition by small molecules

artículo científico publicado en 2018

Design, Palladium-Catalyzed Synthesis, and Biological Investigation of 2-Substituted 3-Aroylquinolin-4(1H)-ones as Inhibitors of the Hedgehog Signaling Pathway.

artículo científico publicado en 2017

Design, synthesis, SAR and biological investigation of 3-(carboxymethyl)rhodanine and aminothiazole inhibitors of Mycobacterium tuberculosis Zmp1.

artículo científico publicado en 2018

Differentially activated Src kinase in chemo-naïve human primary osteosarcoma cells and effects of a Src kinase inhibitor.

artículo científico publicado en 2017

Discovery of 14-3-3 protein-protein interaction inhibitors that sensitize multidrug-resistant cancer cells to doxorubicin and the Akt inhibitor GSK690693.

artículo científico publicado en 2014

Discovery of a New Class of Potent MMP Inhibitors by Structure-Based Optimization of the Arylsulfonamide Scaffold

artículo científico publicado en 2013

Discovery of in vitro antitubercular agents through in silico ligand-based approaches.

artículo científico publicado en 2016

Discovery of small molecule inhibitors of Leishmania braziliensis Hsp90 chaperone

artículo científico publicado en 2020

Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor

artículo científico publicado en 2014

Dual SMO/BRAF Inhibition by Flavonolignans from Silybum marianum †

artículo científico publicado en 2020

Editorial: Challenging Organic Syntheses and Pharmacological Applications of Natural Products and their Derivatives

artículo científico publicado en 2015

Evaluation of sofosbuvir activity and resistance profile against West Nile virus in vitro

scientific article published on 10 January 2020

Excited-State Dynamics of Thienoguanosine, an Isomorphic Highly Fluorescent Analogue of Guanosine

artículo científico publicado en 2019

Experimental and Computational Druggability Exploration of the 14-3-3ζ/SOS1pS1161 PPI Interface

artículo científico publicado en 2020

Exploring Oxidovanadium(IV) Complexes as YopH Inhibitors: Mechanism of Action and Modeling Studies.

artículo científico publicado en 2015

Fragment docking to S100 proteins reveals a wide diversity of weak interaction sites.

artículo científico publicado en 2007

Free Energy Profile and Kinetics Studies of Paclitaxel Internalization from the Outer to the Inner Wall of Microtubules.

artículo científico publicado en 2012

Functional and structural characterization of 2-amino-4-phenylthiazole inhibitors of the HIV-1 nucleocapsid protein with antiviral activity.

artículo científico publicado en 2014

Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors.

artículo científico publicado en 2014

Green Routes for the Production of Enantiopure Benzylisoquinoline Alkaloids.

artículo científico publicado en 2017

Hedgehog signaling pathway inhibitors: an updated patent review (2015-present)

artículo científico publicado en 2020

High-Affinity "Click" RGD Peptidomimetics as Radiolabeled Probes for Imaging αv β3 Integrin.

artículo científico publicado en 2017

Hit Recycling: Discovery of a Potent Carbonic Anhydrase Inhibitor by in Silico Target Fishing.

artículo científico publicado en 2015

Hydrolytic inhibition of α-chymotrypsin by 2,8,14,20-tetrakis(D-leucyl-D-valinamido)resorc[4]arenecarboxylic acid: a spectroscopic NMR and computational combined approach

artículo científico publicado en 2015

Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein-Protein Interaction

artículo científico publicado en 2020

Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines

scientific article published on 18 July 2019

Identification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemia

artículo científico publicado en 2017

Identification of novel 2-benzoxazolinone derivatives with specific inhibitory activity against the HIV-1 nucleocapsid protein

artículo científico publicado en 2017

In Memory of Maurizio Botta: His Contribution to the Development of Computer-Aided Drug Design

scientific article published on 05 December 2019

Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype

artículo científico publicado en 2016

Inhibition of Melanoma Cell Migration and Invasion Targeting the Hypoxic Tumor Associated CAXII

artículo científico publicado en 2020

Inhibitory Effect of Lithospermic Acid on the HIV-1 Nucleocapsid Protein

artículo científico publicado en 2020

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis.

artículo científico publicado en 2018

Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions

artículo científico publicado en 2015

Molecular dynamics and DFT study on HIV-1 nucleocapsid protein-7 in complex with viral genome.

artículo científico publicado en 2010

Molecular insights to the bioactive form of BV02, a reference inhibitor of 14-3-3σ protein-protein interactions

artículo científico publicado en 2015

Mycobacterial carbonic anhydrase inhibition with phenolic acids and esters: kinetic and computational investigations

artículo científico publicado en 2016

Mycobacterium tuberculosis-Secreted Tyrosine Phosphatases as Targets Against Tuberculosis: Exploring Natural Sources in Searching for New Drugs

artículo científico publicado en 2016

Natural Products Inspired Modulators of Cancer Stem Cells-specific Signaling Pathways Notch and Hedgehog

artículo científico publicado en 2018

Natural modulators of nonalcoholic fatty liver disease: Mode of action analysis and in silico ADME-Tox prediction.

artículo científico publicado en 2017

Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B.

artículo científico publicado en 2017

Nigritanine as a New Potential Antimicrobial Alkaloid for the Treatment of Staphylococcus aureus-Induced Infections

artículo científico publicado en 2019

Novel Insights on Human Carbonic Anhydrase Inhibitors Based on Coumalic Acid: Design, Synthesis, Molecular Modeling Investigation, and Biological Studies

artículo científico publicado en 2022

Novel Sulfamide-Containing Compounds as Selective Carbonic Anhydrase I Inhibitors.

artículo científico publicado en 2017

Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells.

artículo científico publicado en 2017

Nucleocapsid Protein: A Desirable Target for Future Therapies Against HIV-1.

artículo científico publicado en 2015

Occurrence of Enantioselectivity in Nature: The Case of (S)-Norcoclaurine

artículo científico

Oregonin from Alnus incana bark affects DNA methyltransferases expression and mitochondrial DNA copies in mouse embryonic fibroblasts.

artículo científico publicado en 2018

P300/CBP-associated factor regulates transcription and function of isocitrate dehydrogenase 2 during muscle differentiation

artículo científico publicado en 2018

Potent and Selective Carboxylic Acid Inhibitors of Tumor-Associated Carbonic Anhydrases IX and XII.

artículo científico publicado en 2017

Predicting the binding mode of known NCp7 inhibitors to facilitate the design of novel modulators.

artículo científico publicado en 2010

Repurposing drugs for the management of COVID-19

scientific article published on 06 December 2020

Small molecules modulation of 14-3-3 protein-protein interactions.

artículo científico

Sofosbuvir Selects for Drug-Resistant Amino Acid Variants in the Zika Virus RNA-Dependent RNA-Polymerase Complex In Vitro

artículo científico publicado en 2021

Stable Oxidative Cytosine Modifications Accumulate in Cardiac Mesenchymal Cells from Type2 Diabetes Patients: Rescue by Alpha-Ketoglutarate and TET-TDG Functional Reactivation.

artículo científico publicado en 2017

Statins interfere with the attachment of S. cerevisiae mtDNA to the inner mitochondrial membrane

scientific article published on 01 December 2020

Structure prediction and validation of the ERK8 kinase domain

artículo científico publicado en 2013

Structure, function, involvement in diseases and targeting of 14-3-3 proteins: an update

artículo científico publicado en 2017

Structure-Based Identification of HIV-1 Nucleocapsid Protein Inhibitors Active against Wild-Type and Drug-Resistant HIV-1 Strains.

artículo científico publicado en 2017

Synergistic effects of trace amounts of water in the enantiodiscrimination processes by lipodex E: a spectroscopic and computational investigation.

artículo científico publicado en 2014

Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold

scientific article published on 09 July 2018

Synthesis and Evaluation of Bifunctional Aminothiazoles as Antiretrovirals Targeting the HIV-1 Nucleocapsid Protein

article

Synthesis of distal and proximal fleximer base analogues and evaluation in the nucleocapsid protein of HIV-1

scientific article published on 15 May 2019

Synthesis, biological evaluation and molecular modeling studies on novel quinonoid inhibitors of CDC25 phosphatases.

artículo científico publicado en 2016

Synthetic thiosemicarbazones as a new class of Mycobacterium tuberculosis protein tyrosine phosphatase A inhibitors

artículo científico publicado en 2018

Targeting GLI factors to inhibit the Hedgehog pathway.

artículo científico

Targeting the RdRp of Emerging RNA Viruses: The Structure-Based Drug Design Challenge

artículo científico publicado en 2020

Tautomers of a Fluorescent G Surrogate and Their Distinct Photophysics Provide Additional Information Channels.

artículo científico publicado en 2016

The plant-derived triterpenoid tingenin B is a potent anticancer agent due to its cytotoxic activity on cancer stem cells of breast cancer in vitro.

artículo científico publicado en 2016

Use of virtual screening for discovering antiretroviral compounds interacting with the HIV-1 nucleocapsid protein.

artículo científico publicado en 2012

Yeast as a tool to select inhibitors of the cullin deneddylating enzyme Csn5.

artículo científico publicado en 2016

ent-Beyerane Diterpenes as a Key Platform for the Development of ArnT-Mediated Colistin Resistance Inhibitors

artículo científico publicado en 2020

Lista de obras de Mattia Mori

(Thia)calixarenephosphonic Acids as Potent Inhibitors of the Nucleic Acid Chaperone Activity of the HIV-1 Nucleocapsid Protein with a New Binding Mode and Multitarget Antiviral Activity

1H-NMR metabolomics reveals the Glabrescione B exacerbation of glycolytic metabolism beside the cell growth inhibitory effect in glioma

2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors.

A Molecular Tool Targeting the Base-Flipping Activity of Human UHRF1

A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth

A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors.

A deadly spillover: SARS-CoV-2 outbreak

A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer

A unique high-diversity natural product collection as a reservoir of new therapeutic leads

Alvaxanthone, a Thymidylate Synthase Inhibitor with Nematocidal and Tumoricidal Activities

Chalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T-cell Acute Lymphoblastic Leukemia

Challenging Organic Syntheses and Pharmacological Applications of Natural Products and their Derivatives - Part II

Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61.

Chemically stable inhibitors of 14-3-3 protein-protein interactions derived from BV02

Click Reaction as a Tool to Combine Pharmacophores: The Case of Vismodegib

Current trends in Hedgehog signaling pathway inhibition by small molecules

Design, Palladium-Catalyzed Synthesis, and Biological Investigation of 2-Substituted 3-Aroylquinolin-4(1H)-ones as Inhibitors of the Hedgehog Signaling Pathway.

Design, synthesis, SAR and biological investigation of 3-(carboxymethyl)rhodanine and aminothiazole inhibitors of Mycobacterium tuberculosis Zmp1.

Differentially activated Src kinase in chemo-naïve human primary osteosarcoma cells and effects of a Src kinase inhibitor.

Discovery of 14-3-3 protein-protein interaction inhibitors that sensitize multidrug-resistant cancer cells to doxorubicin and the Akt inhibitor GSK690693.

Discovery of a New Class of Potent MMP Inhibitors by Structure-Based Optimization of the Arylsulfonamide Scaffold

Discovery of in vitro antitubercular agents through in silico ligand-based approaches.

Discovery of small molecule inhibitors of Leishmania braziliensis Hsp90 chaperone

Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor

Dual SMO/BRAF Inhibition by Flavonolignans from Silybum marianum †

Editorial: Challenging Organic Syntheses and Pharmacological Applications of Natural Products and their Derivatives

Evaluation of sofosbuvir activity and resistance profile against West Nile virus in vitro

Excited-State Dynamics of Thienoguanosine, an Isomorphic Highly Fluorescent Analogue of Guanosine

Experimental and Computational Druggability Exploration of the 14-3-3ζ/SOS1pS1161 PPI Interface

Exploring Oxidovanadium(IV) Complexes as YopH Inhibitors: Mechanism of Action and Modeling Studies.

Fragment docking to S100 proteins reveals a wide diversity of weak interaction sites.

Free Energy Profile and Kinetics Studies of Paclitaxel Internalization from the Outer to the Inner Wall of Microtubules.

Functional and structural characterization of 2-amino-4-phenylthiazole inhibitors of the HIV-1 nucleocapsid protein with antiviral activity.

Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors.

Green Routes for the Production of Enantiopure Benzylisoquinoline Alkaloids.

Hedgehog signaling pathway inhibitors: an updated patent review (2015-present)

High-Affinity "Click" RGD Peptidomimetics as Radiolabeled Probes for Imaging αv β3 Integrin.

Hit Recycling: Discovery of a Potent Carbonic Anhydrase Inhibitor by in Silico Target Fishing.

Hydrolytic inhibition of α-chymotrypsin by 2,8,14,20-tetrakis(D-leucyl-D-valinamido)resorc[4]arenecarboxylic acid: a spectroscopic NMR and computational combined approach

Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein-Protein Interaction

Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines

Identification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemia

Identification of novel 2-benzoxazolinone derivatives with specific inhibitory activity against the HIV-1 nucleocapsid protein

In Memory of Maurizio Botta: His Contribution to the Development of Computer-Aided Drug Design

Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype

Inhibition of Melanoma Cell Migration and Invasion Targeting the Hypoxic Tumor Associated CAXII

Inhibitory Effect of Lithospermic Acid on the HIV-1 Nucleocapsid Protein

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis.

Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions

Molecular dynamics and DFT study on HIV-1 nucleocapsid protein-7 in complex with viral genome.

Molecular insights to the bioactive form of BV02, a reference inhibitor of 14-3-3σ protein-protein interactions

Mycobacterial carbonic anhydrase inhibition with phenolic acids and esters: kinetic and computational investigations

Mycobacterium tuberculosis-Secreted Tyrosine Phosphatases as Targets Against Tuberculosis: Exploring Natural Sources in Searching for New Drugs

Natural Products Inspired Modulators of Cancer Stem Cells-specific Signaling Pathways Notch and Hedgehog

Natural modulators of nonalcoholic fatty liver disease: Mode of action analysis and in silico ADME-Tox prediction.

Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B.

Nigritanine as a New Potential Antimicrobial Alkaloid for the Treatment of Staphylococcus aureus-Induced Infections

Novel Insights on Human Carbonic Anhydrase Inhibitors Based on Coumalic Acid: Design, Synthesis, Molecular Modeling Investigation, and Biological Studies

Novel Sulfamide-Containing Compounds as Selective Carbonic Anhydrase I Inhibitors.

Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells.

Nucleocapsid Protein: A Desirable Target for Future Therapies Against HIV-1.

Occurrence of Enantioselectivity in Nature: The Case of (S)-Norcoclaurine

Oregonin from Alnus incana bark affects DNA methyltransferases expression and mitochondrial DNA copies in mouse embryonic fibroblasts.

P300/CBP-associated factor regulates transcription and function of isocitrate dehydrogenase 2 during muscle differentiation

Potent and Selective Carboxylic Acid Inhibitors of Tumor-Associated Carbonic Anhydrases IX and XII.

Predicting the binding mode of known NCp7 inhibitors to facilitate the design of novel modulators.

Repurposing drugs for the management of COVID-19

Small molecules modulation of 14-3-3 protein-protein interactions.

Sofosbuvir Selects for Drug-Resistant Amino Acid Variants in the Zika Virus RNA-Dependent RNA-Polymerase Complex In Vitro

Stable Oxidative Cytosine Modifications Accumulate in Cardiac Mesenchymal Cells from Type2 Diabetes Patients: Rescue by Alpha-Ketoglutarate and TET-TDG Functional Reactivation.

Statins interfere with the attachment of S. cerevisiae mtDNA to the inner mitochondrial membrane

Structure prediction and validation of the ERK8 kinase domain

Structure, function, involvement in diseases and targeting of 14-3-3 proteins: an update

Structure-Based Identification of HIV-1 Nucleocapsid Protein Inhibitors Active against Wild-Type and Drug-Resistant HIV-1 Strains.

Synergistic effects of trace amounts of water in the enantiodiscrimination processes by lipodex E: a spectroscopic and computational investigation.

Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold

Synthesis and Evaluation of Bifunctional Aminothiazoles as Antiretrovirals Targeting the HIV-1 Nucleocapsid Protein

Synthesis of distal and proximal fleximer base analogues and evaluation in the nucleocapsid protein of HIV-1

Synthesis, biological evaluation and molecular modeling studies on novel quinonoid inhibitors of CDC25 phosphatases.