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A Kinetic and Conformational Study on the Interaction of Tetrahydropteridines with Tyrosine Hydroxylase†

artículo científico publicado en 2000

A comparison of kinetic and regulatory properties of the tetrameric and dimeric forms of wild-type and Thr427-->Pro mutant human phenylalanine hydroxylase: contribution of the flexible hinge region Asp425-Gln429 to the tetramerization and cooperativ

artículo científico publicado en 2001

A general and rational approach to the optimal recovery of mitochondria by differential centrifugation in homogenous media ⬇️

artículo científico publicado el 26 de mayo de 1975

A low-cost integrator for preparative ultracentrifuges ⬇️

artículo científico publicado el 1 de marzo de 1974

Acyl-CoA synthetase activity of brown adipose tissue mitochondria substrate specificity and its relation to the endogenous pool of long-chain fatty acids ⬇️

artículo científico publicado el 14 de julio de 1980

Acyl-CoA synthetase activity of rat heart mitochondria. Substrate specificity with special reference to very-long-chain and isomeric fatty acids

artículo científico publicado en 1983

Acyl-CoA synthetase activity of rat liver microsomes. Substrate specificity with special reference to very-long-chain and isomeric fatty acids

scientific article published on 01 May 1981

Allosteric activation of human glucokinase by free polyubiquitin chains and its ubiquitin-dependent cotranslational proteasomal degradation

scientific article published on 08 June 2007

An adenosine 3':5'-monophosphate-adenosine binding protein from mouse liver: some physicochemical properties

artículo científico publicado en 1978

Anion- and pH-dependent activation of the soluble form of dopamine beta-hydroxylase

artículo científico publicado en 2003

Annexin A2 recognises a specific region in the 3'-UTR of its cognate messenger RNA

artículo científico publicado en 2006

Ascorbate as a natural constituent of chromaffin granules from the bovine adrenal medulla ⬇️

artículo científico publicado el 1 de noviembre de 1975

Binding of ATP at the active site of human pancreatic glucokinase – nucleotide‐induced conformational changes with possible implications for its kinetic cooperativity ⬇️

artículo científico publicado el 31 de mayo de 2011

Brown adipose tissue mitochondria ⬇️

artículo científico publicado el 31 de marzo de 1975

Catalytic activation of human glucokinase by substrate binding: residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions

artículo científico publicado en 2008

Characterization of a novel pterin intermediate formed in the catalytic cycle of tyrosine hydroxylase

artículo científico publicado en 1996

Characterization of phospholipase activities in chromaffin granule ghosts isolated from the bovine adrenal medulla

artículo científico publicado en 1987

Characterization of the iron environment in recombinant human tyrosine hydroxylase, using Mössbauer and EPR-spectroscopy

artículo científico publicado en 1993

Conformation and interaction of phenylalanine with the divalent cation at the active site of human recombinant tyrosine hydroxylase as determined by proton NMR

artículo científico publicado en 1993

Conformational properties and stability of tyrosine hydroxylase studied by infrared spectroscopy. Effect of iron/catecholamine binding and phosphorylation

scientific article published on 01 August 1996

Conjugation of phenylalanine hydroxylase with polyubiquitin chains catalysed by rat liver enzymes.

artículo científico publicado en 2001

Cooperative homotropic interaction of l-noradrenaline with the catalytic site of phenylalanine 4-monooxygenase

artículo científico publicado en 1990

Crystal structure and site-specific mutagenesis of pterin-bound human phenylalanine hydroxylase

artículo científico publicado en 2000

Crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuria

artículo científico publicado en 1997

Crystallization and preliminary diffraction analysis of a truncated homodimer of human phenylalanine hydroxylase

artículo científico publicado en 1997

Crystallographic analysis of the human phenylalanine hydroxylase catalytic domain with bound catechol inhibitors at 2.0 A resolution

artículo científico publicado en 1998

Cytochrome -561 of the bovine adrenal chromaffin granules. Molecular weight and hydrodynamic properties in micellar solutions of Triton X-100 ⬇️

artículo científico publicado el 16 de marzo de 1981

Cytochrome b 561 of the bovine adrenal chromaffin granules. A high potential b-type cytochrome

artículo científico publicado en 1971

Cytochrome b-561 as the single heme protein of the bovine adrenal chromaffin granule membrane

artículo científico publicado en 1974

Deamidations in recombinant human phenylalanine hydroxylase. Identification of labile asparagine residues and functional characterization of Asn --> Asp mutant forms

artículo científico publicado en 2003

Determination of CoASH by high-performance liquid chromatography and its application in the assay of long-chain acyl-CoA derivatives ⬇️

artículo científico publicado el 1 de julio de 1979

Determination of sedimentation coefficients of subcellular particles of rat liver homogenates. A theoretical and experimental approach

artículo científico publicado en 1973

Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY): a protein misfolding disease

artículo científico publicado en 2011

Domain structure and stability of human phenylalanine hydroxylase inferred from infrared spectroscopy

artículo científico publicado en 1998

Dopamine Oxidation Generates an Oxidative Stress Mediated by Dopamine Semiquinone and Unrelated to Reactive Oxygen Species ⬇️

artículo científico publicado el 1 de junio de 1997

Dopamine beta-monooxygenase. Binding to apoenzyme and rapid exchange in holoenzyme of 64Cu studied with high-performance size-exclusion gel chromatography

artículo científico publicado en 1983

Dopamine beta-monooxygenase: reduced enzyme needs additional reductant for completion of the catalytic cycle

artículo científico publicado el 14 de septiembre de 1978

EPR and 1H-NMR spectroscopic studies on the paramagnetic iron at the active site of phenylalanine hydroxylase and its interaction with substrates and inhibitors

artículo científico publicado en 1991

Effect of a high-fat diet with partially hydrogenated fish oil on long-chain fatty acid metabolizing enzymes in subcellular fractions of rat liver

artículo científico publicado en 1987

Effects of essential fatty acid deficiency on mitochondria and peroxisomes in rat hepatocytes with special reference to a partially hydrogenated fish oil diet

artículo científico publicado en 1986

Electron Paramagnetic Resonance of the Copper in Dopamine beta-Monooxygenase. Rapid Reduction by Ascorbate, the Steady-State Redox Level, Chelation with EDTA, and Reactivation of the Apoenzyme by Added Copper ⬇️

artículo científico publicado el 1 de enero de 1980

Electron carriers of the bovine adrenal chromaffin granules

artículo científico publicado en 1971

Electron carriers of the noradrenaline storage vesicles from bovine splenic nerves

scientific article published on 01 August 1971

Energy-dependent accumulation of calcium antagonists in catecholamine storage vesicles

artículo científico publicado en 2000

Energy-dependent accumulation of iron by isolated rat liver mitochondria V. Effect on factors controlling respiration and oxidative phosphorylation ⬇️

artículo científico publicado el 14 de abril de 1975

Energy-dependent accumulation of iron by isolated rat liver mitochondria. 3. Submitochondrial localization of the iron accumulated

artículo científico publicado en 1974

Energy-dependent accumulation of iron by isolated rat liver mitochondria. I. General features.

artículo científico publicado en 1973

Energy-dependent accumulation of iron by isolated rat liver mitochondria. II. Relationship to the active transport of Ca2+ ⬇️

artículo científico publicado el 19 de octubre de 1973

Energy-dependent redox reactions of two b-type cytochromes in brown adipose tissue mitochondria ⬇️

artículo científico publicado el 19 de octubre de 1973

Evidence for a negative modulating effect of erucic acid on the peroxisomal beta-oxidation enzyme system and biogenesis in rat liver

artículo científico publicado en 1983

Evidence from EPR spectroscopy that phosphorylation of Ser-40 in bovine adrenal tyrosine hydroxylase facilitates the reduction of high-spin Fe(III) under turnover conditions

artículo científico publicado en 1989

Expression of recombinant human phenylalanine hydroxylase as fusion protein in Escherichia coli circumvents proteolytic degradation by host cell proteases. Isolation and characterization of the wild-type enzyme

artículo científico publicado en 1995

Expression of wild type and mutant forms of human phenylalanine hydroxylase in E. coli.

artículo científico publicado en 1993

Fluorometric detection of tryptophan, 5-hydroxytryptophan, and 5-hydroxytryptamine (serotonin) in high-performance liquid chromatography

scientific article published on 01 September 1980

GCK-MODY diabetes as a protein misfolding disease: the mutation R275C promotes protein misfolding, self-association and cellular degradation

artículo científico publicado en 2013

GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation

artículo científico publicado en 2012

Generation of reactive oxygen species by tyrosine hydroxylase: a possible contribution to the degeneration of dopaminergic neurons?

artículo científico publicado en 1997

Heterotetrameric forms of human phenylalanine hydroxylase: Co-expression of wild-type and mutant forms in a bicistronic system ⬇️

artículo científico publicado el 17 de febrero de 2011

High resolution crystal structures of the catalytic domain of human phenylalanine hydroxylase in its catalytically active Fe(II) form and binary complex with tetrahydrobiopterin ⬇️

artículo científico publicado el 23 de noviembre de 2001

High-molecular-mass complexes of the regulatory subunits of cyclic AMP-dependent protein kinase

artículo científico publicado en 1991

Hydrodynamic parameters and isolation of mitochondria, microperoxisomes and microsomes of rat heart

scientific article published on 01 December 1982

Identification of protein phosphatase 2A as the major tyrosine hydroxylase phosphatase in adrenal medulla and corpus striatum: evidence from the effects of okadaic acid

artículo científico publicado en 1989

Inactivation of purified phenylalanine hydroxylase by dithiothreitol

artículo científico publicado en 1992

Increase in mitochondrial content of long-chain acyl-CoA in brown adipose tissue during cold-acclimation

artículo científico publicado en 1984

Inhibition byN-ethylmaleimide of the MgATP-driven proton pump of the chromaffin granules ⬇️

artículo científico publicado el 22 de noviembre de 1982

Inhibition of aromatic L-amino acid decarboxylase activity by human autoantibodies

artículo científico publicado en 2000

Inhibition of dopamine beta-mono-oxygenase by non-ionic detergents of the triton X-series

artículo científico publicado el 1 de abril de 1977

Inhibition of the H+-ATPase in bovine adrenal chromaffin granule ghosts by diethylstilbestrol. Evidence for a tight coupling between ATP hydrolysis and proton translocation

artículo científico publicado en 1988

Interaction of substrate and pterin cofactor with the metal of human tyrosine hydroxylase as determined by 1H-NMR

artículo científico publicado en 1993

Isolation and characterization of noradrenalin storage granules of bovine adrenal medulla ⬇️

artículo científico publicado el 2 de junio de 1979

Isolation and characterization of tetrahydropterin oxidation products generated in the tyrosine 3-monooxygenase (tyrosine hydroxylase) reaction

artículo científico publicado en 1987

Isolation from the microsomal fraction of rat liver of a subfraction highly enriched in uncoated endocytic vesicles with high H+-ATPase activity and a 50 kDa phosphoprotein

artículo científico publicado en 1985

Kinetic analysis and ligand-induced conformational changes in dimeric and tetrameric forms of human thymidine kinase 2.

artículo científico publicado en 2005

Long-chain acyl-CoA synthetase and "outer" carnitine long-chain acyltransferase activities of intact brown adipose tissue mitochondria

artículo científico publicado el 28 de septiembre de 1978

Microperoxisomes and mitochondria of brown adipose tissue. Hydrodynamic parameters, isolation and capacity of long-chain fatty acid oxidation

artículo científico publicado en 1982

Mitochondrial iron not bound in heme and iron-sulfur centers. Estimation, compartmentation and redox state ⬇️

artículo científico publicado el 8 de febrero de 1980

Modulation by pterins of the phosphorylation and phenylalanine activation of phenylalanine 4-mono-oxygenase

artículo científico publicado en 1987

NADH(NADPH): (acceptor) oxidoreductase activities of the bovine adrenal chromaffin granules

artículo científico publicado en 1973

NH2-terminal sequence of dopamine beta-hydroxylase from bovine adrenal medulla

artículo científico publicado el 21 de febrero de 1977

Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation

artículo científico publicado en 2017

On the mechanism of induction of the enzyme systems for peroxisomal beta-oxidation of fatty acids in rat liver by diets rich in partially hydrogenated fish oil

artículo científico publicado en 1988

On the mechanism of stimulation of peroxisomal beta-oxidation in rat heart by partially hydrogenated fish oil

artículo científico publicado en 1995

On the polydispersity of mitochondria in tissue homogenates and the determination of the average sedimentation coefficients of mixed populations of mitochondria ⬇️

artículo científico publicado el 15 de octubre de 1978

On the rate-limiting step in the transfer of long-chain acyl groups across the inner membrane of brown adipose tissue mitochondria ⬇️

artículo científico publicado el 9 de febrero de 1978

Oxidoreductase activities of chromaffin granule ghosts isolated from the bovine adrenal medulla

artículo científico publicado en 1980

Partial characterization and three-dimensional-structural localization of eight mutations in exon 7 of the human phenylalanine hydroxylase gene associated with phenylketonuria.

artículo científico publicado en 1998

Phenylalanine 4-monooxygenase from bovine and rat liver: some physical and chemical properties

scientific article published on 01 April 1982

Phenylalanine 4-monooxygenase from bovine liver

scientific article published on 01 January 1987

Phenylalanine as substrate for tyrosine hydroxylase in bovine adrenal chromaffin cells

artículo científico publicado en 1990

Phenylalanine positively modulates the cAMP‐dependent phosphorylation and negatively modulates the vasopressin‐induced and okadaic‐acid‐induced phosphorylation of phenylalanine 4‐monooxygenase in intact rat hepatocytes ⬇️

artículo científico publicado el 15 de mayo de 1992

Phenylketonuria as a protein misfolding disease: The mutation pG46S in phenylalanine hydroxylase promotes self-association and fibril formation

artículo científico publicado en 2010

Phosphatidylinositol kinase of bovine adrenal chromaffin granules. Modulation by hydrophilic and amphiphilic cations

artículo científico publicado en 1988

Phosphatidylinositol kinase of bovine adrenal chromaffin granules: kinetic properties and inhibition by low concentrations of Ca2+

scientific article published on 01 February 1988

Phosphorylation and mutations of Ser(16) in human phenylalanine hydroxylase. Kinetic and structural effects

artículo científico publicado en 2002

Phosphorylation of recombinant human phenylalanine hydroxylase: effect on catalytic activity, substrate activation and protection against non-specific cleavage of the fusion protein by restriction protease

artículo científico publicado en 1996

Probing the role of crystallographically defined/predicted hinge-bending regions in the substrate-induced global conformational transition and catalytic activation of human phenylalanine hydroxylase by single-site mutagenesis

artículo científico publicado en 2004

Purification and Characterization of Dopamine β ‐Hydroxylase from Bovine Adrenal Medulla ⬇️

artículo científico publicado el 15 de enero de 1976

Purification and characterization of the blue-green rat phaeochromocytoma (PC12) tyrosine hydroxylase with a dopamine-Fe(III) complex. Reversal of the endogenous feedback inhibition by phosphorylation of serine-40 ⬇️

artículo científico publicado el 15 de junio de 1992

Purification and kinetic properties of a membrane-bound phosphatidylinositol kinase of the bovine adrenal medulla

artículo científico publicado en 1990

Purification and kinetic properties of a soluble phosphatidylinositol-4-phosphate kinase of the bovine adrenal medulla with emphasis on its inhibition by calcium ions

scientific article published on 01 February 1989

Rapid and sensitive assay of tyrosine 3-monooxygenase activity by high-performance liquid chromatography using the native fluorescence of DOPA

artículo científico publicado en 1980

Recessively inherited L-DOPA-responsive dystonia caused by a point mutation (Q381K) in the tyrosine hydroxylase gene

artículo científico publicado en 1995

Recombinant human phenylalanine hydroxylase is a substrate for the ubiquitin-conjugating enzyme system

artículo científico publicado en 1996

Recombinant human tyrosine hydroxylase isozymes. Reconstitution with iron and inhibitory effect of other metal ions

artículo científico publicado en 1991

Regulation of recombinant human tyrosine hydroxylase isozymes by catecholamine binding and phosphorylation. Structure/activity studies and mechanistic implications.

artículo científico publicado en 1992

Relation between induction of ornithine decarboxylase and specific gene expression in rat liver in response to the tumor promoter agent clofibrate

scientific article published on 01 September 1986

Resonance Raman studies on the blue-green-colored bovine adrenal tyrosine 3-monooxygenase (tyrosine hydroxylase). Evidence that the feedback inhibitors adrenaline and noradrenaline are coordinated to iron

artículo científico publicado en 1988

SUMOylation of pancreatic glucokinase regulates its cellular stability and activity

artículo científico publicado en 2013

Sedimentation coefficient and buoyant density of brown adipose tissue mitochondria from guinea pigs ⬇️

artículo científico publicado el 12 de mayo de 1975

Soluble tyrosine hydroxylase (tyrosine 3-monooxygenase) from bovine adrenal medulla: large-scale purification and physicochemical properties.

artículo científico publicado en 1988

Some aspects of the phosphorylation of phenylalanine 4-monooxygenase by a calcium-dependent and calmodulin-dependent protein kinase

scientific article published on 01 November 1984

Stereoselective effects in the interactions of pterin cofactors with rat-liver phenylalanine 4-monooxygenase

scientific article published on 01 October 1986

Structure of Tetrameric Human Phenylalanine Hydroxylase and Its Implications for Phenylketonuria ⬇️

artículo científico publicado el 3 de julio de 1998

Structure/function relationships in human phenylalanine hydroxylase. Effect of terminal deletions on the oligomerization, activation and cooperativity of substrate binding to the enzyme.

artículo científico publicado en 1996

Studies on the energy state of isolated brown adipose tissue mitochondria the cytochrome b complex as a probe of the energy state of the mitochondrial inner membrane ⬇️

artículo científico publicado el 17 de agosto de 1972

Studies on the energy state of isolated brown adipose tissue mitochondria. Effect of adenine nucleotides and oligomycin on the generation and dissipation of the "energy potential".

artículo científico publicado en 1973

Studies on the ferrochelatase activity of isolated rat liver mitochondria with special reference to the effect of oxidizable substrates and oxygen concentration ⬇️

artículo científico publicado el 6 de diciembre de 1976

Subcellular distribution of ascorbate in bovine adrenal medulla. Evidence for accumulation in chromaffin granules against a concentration gradient

scientific article published on 01 March 1980

Substrate-induced conformational transition in human phenylalanine hydroxylase as studied by surface plasmon resonance analyses: the effect of terminal deletions, substrate analogues and phosphorylation

artículo científico publicado en 2003

Synergistic Antiproliferative Actions of Cyclic Adenosine 3′,5′-Monophosphate, Interleukin-1β, and Activators of Ca2+/Calmodulin-Dependent Protein Kinase in Primary Hepatocytes1 ⬇️

artículo científico publicado el 1 de octubre de 1997

The PKU mutation S349P causes complete loss of catalytic activity in the recombinant phenylalanine hydroxylase enzyme.

artículo científico publicado en 1995

The assignment of the Ca2+-ATPase activity of chromaffin granules to the proton translocating ATPase

scientific article published on 01 March 1985

The cooperative binding of phenylalanine to phenylalanine 4-monooxygenase studied by 1H-NMR paramagnetic relaxation. Changes in water accessibility to the iron at the active site upon substrate binding

artículo científico publicado en 1993

The effect of calcium channel blockers on the H+-ATPase and bioenergetics of catecholamine storage vesicles ⬇️

artículo científico publicado el 25 de mayo de 1991

The effect of ligands of phenylalanine 4-monooxygenase on the cAMP-dependent phosphorylation of the enzyme

artículo científico publicado en 1984

The effect of phosphorylation at Ser-40 on the structure and thermal stability of tyrosine hydroxylase

artículo científico publicado en 1998

The effect of prenylamine and organic nitrates on the bioenergetics of bovine catecholamine storage vesicles

artículo científico publicado en 1990

The effect of substrate, dihydrobiopterin, and dopamine on the EPR spectroscopic properties and the midpoint potential of the catalytic iron in recombinant human phenylalanine hydroxylase

artículo científico publicado en 2001

The incorporation of divalent metal ions into recombinant human tyrosine hydroxylase apoenzymes studied by intrinsic fluorescence and 1H-NMR spectroscopy

artículo científico publicado en 1992

The mRNA-binding site of annexin A2 resides in helices C-D of its domain IV

artículo científico publicado en 2007

Tight binding of deoxyribonucleotide triphosphates to human thymidine kinase 2 expressed in Escherichia coli. Purification and partial characterization of its dimeric and tetrameric forms

artículo científico publicado en 2003

Tyrosine hydroxylase binds tetrahydrobiopterin cofactor with negative cooperativity, as shown by kinetic analyses and surface plasmon resonance detection.

artículo científico publicado en 1999

Use of surface plasmon resonance for real-time measurements of the global conformational transition in human phenylalanine hydroxylase in response to substrate binding and catalytic activation

artículo científico publicado en 2001

pH-dependent release of catecholamines from tyrosine hydroxylase and the effect of phosphorylation of Ser-40

artículo científico publicado en 1990

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