Lista de obras -

5-Benzamidoisoquinolin-1-ones and 5-(ω-Carboxyalkyl)isoquinolin-1-ones as Isoform-Selective Inhibitors of Poly(ADP-ribose) Polymerase 2 (PARP-2) ⬇️

artículo científico publicado el 18 de marzo de 2011

A fluorescent methylation-switchable probe for highly sensitive analysis of FTO -methyladenosine demethylase activity in cells

artículo científico publicado en 2018

A methylation-switchable conformational probe for the sensitive and selective detection of RNA demethylase activity

artículo científico publicado en 2016

A safe lithium mimetic for bipolar disorder

artículo científico publicado en 2013

A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N6-methyladenosine demethylase FTO.

artículo científico publicado en 2014

Doxorubicin-loaded cell-derived nanovesicles: an alternative targeted approach for anti-tumor therapy.

artículo científico publicado en 2017

Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.

artículo científico publicado en 2012

Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors.

artículo científico publicado en 2012

Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase

artículo científico publicado en 2012

Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro

artículo científico publicado en 2015

Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity

artículo científico publicado en 2016

Inhibition of Histone Demethylases by 4-Carboxy-2,2′-Bipyridyl Compounds

artículo científico publicado en 2011

Micro cell vesicle technology (mCVT): a novel hybrid system of gene delivery for hard-to-transfect (HTT) cells

artículo científico publicado en 2020

Multiprotein Dynamic Combinatorial Chemistry: A Strategy for the Simultaneous Discovery of Subfamily-Selective Inhibitors for Nucleic Acid Demethylases FTO and ALKBH3

article

N(6)-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5.

artículo científico publicado en 2016

Observations on the Deprotection of Pinanediol and Pinacol Boronate Esters via Fluorinated Intermediates

scientific article published on 01 January 2010

One-pot tandem Hurtley-retro-Claisen-cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs.

artículo científico publicado en 2013

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

artículo científico publicado en 2012

Poly(ADP-ribose)polymerase inhibition - where now?

artículo científico publicado en 2005

Solid-phase synthesis of chlorofusin analogues

artículo científico publicado en 2007

Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors.

artículo científico publicado en 2009

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

artículo científico publicado en 2011

Lista de obras de

5-Benzamidoisoquinolin-1-ones and 5-(ω-Carboxyalkyl)isoquinolin-1-ones as Isoform-Selective Inhibitors of Poly(ADP-ribose) Polymerase 2 (PARP-2) ⬇️

A fluorescent methylation-switchable probe for highly sensitive analysis of FTO -methyladenosine demethylase activity in cells

A methylation-switchable conformational probe for the sensitive and selective detection of RNA demethylase activity

A safe lithium mimetic for bipolar disorder

A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N6-methyladenosine demethylase FTO.

Doxorubicin-loaded cell-derived nanovesicles: an alternative targeted approach for anti-tumor therapy.

Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.

Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors.

Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase

Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro

Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity

Inhibition of Histone Demethylases by 4-Carboxy-2,2′-Bipyridyl Compounds

Micro cell vesicle technology (mCVT): a novel hybrid system of gene delivery for hard-to-transfect (HTT) cells

Multiprotein Dynamic Combinatorial Chemistry: A Strategy for the Simultaneous Discovery of Subfamily-Selective Inhibitors for Nucleic Acid Demethylases FTO and ALKBH3

N(6)-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5.

Observations on the Deprotection of Pinanediol and Pinacol Boronate Esters via Fluorinated Intermediates

One-pot tandem Hurtley-retro-Claisen-cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs.

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

Poly(ADP-ribose)polymerase inhibition - where now?

Solid-phase synthesis of chlorofusin analogues

Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors.

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases