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A Phase 1 study evaluating AMG 337 in Asian patients with advanced solid tumors

artículo científico publicado en 2017

A Phase 1/1b tolerability study of rilotumumab alone or in combination with cisplatin and capecitabine in Japanese patients with gastric cancer

artículo científico publicado en 2017

A Phase I study of intravenous PI3K inhibitor copanlisib in Japanese patients with advanced or refractory solid tumors

artículo científico publicado en 2016

A multicenter phase II study of TAS-102 monotherapy in patients with pre-treated advanced gastric cancer (EPOC1201).

artículo científico publicado en 2016

A multicenter retrospective study of endoscopic resection for early gastric cancer

artículo científico publicado en 2006

A non-randomized, open-label, single-arm, Phase 2 study of emibetuzumab in Asian patients with MET diagnostic positive, advanced gastric cancer

artículo científico publicado en 2017

A phase 1 study of crenigacestat (LY3039478), the Notch inhibitor, in Japanese patients with advanced solid tumors

scientific article published on 16 September 2020

A phase 1 study of oral ASP5878, a selective small-molecule inhibitor of fibroblast growth factor receptors 1-4, as a single dose and multiple doses in patients with solid malignancies

scientific article published on 30 April 2019

A phase 2 clinical trial of panitumumab monotherapy in Japanese patients with metastatic colorectal cancer

artículo científico publicado en 2009

A phase I dose-escalation study of LY2875358, a bivalent MET antibody, given as monotherapy or in combination with erlotinib or gefitinib in Japanese patients with advanced malignancies

artículo científico publicado en 2016

A phase I study evaluating cixutumumab, a type 1 insulin-like growth factor receptor inhibitor, given every 2 or 3 weeks in Japanese patients with advanced solid tumors

artículo científico

A phase I study of intravenous aflibercept with FOLFIRI in Japanese patients with previously treated metastatic colorectal cancer ⬇️

artículo científico publicado el 20 de noviembre de 2012

A phase I study of the human anti-activin receptor-like kinase 1 antibody PF-03446962 in Asian patients with advanced solid tumors

artículo científico publicado en 2016

A phase II Study of the global dose and schedule of capecitabine in Japanese patients with metastatic colorectal cancer

artículo científico publicado en 2006

A phase ib study of safety and pharmacokinetics of ramucirumab in combination with paclitaxel in patients with advanced gastric adenocarcinomas

artículo científico publicado en 2015

A retrospective observational study of clinicopathological features of KRAS, NRAS, BRAF and PIK3CA mutations in Japanese patients with metastatic colorectal cancer

artículo científico publicado en 2015

A retrospective study of definitive chemoradiotherapy for elderly patients with esophageal cancer

artículo científico publicado en 2007

A retrospective study of the safety and efficacy of paclitaxel plus ramucirumab in patients with advanced or recurrent gastric cancer with ascites

artículo científico publicado en 2018

Adjuvant therapy with imatinib mesylate after resection of primary high-risk gastrointestinal stromal tumors in Japanese patients ⬇️

artículo científico publicado el 23 de noviembre de 2011

Amrubicin for the treatment of neuroendocrine carcinoma of the gastrointestinal tract: a retrospective analysis of five cases

artículo científico publicado en 2011

Analysis of esophagogastric cancer patients enrolled in the National Cancer Institute Cancer Therapy Evaluation Program sponsored phase 1 trials

artículo científico publicado en 2016

Application of a combination of a knowledge-based algorithm and 2-stage screening to hypothesis-free genomic data on irinotecan-treated patients for identification of a candidate single nucleotide polymorphism related to an adverse effect

artículo científico publicado en 2014

Bevacizumab safety in Japanese patients with colorectal cancer

artículo científico publicado en 2016

Chemotherapy for GI and pancreatic NETs

artículo científico publicado el 1 de julio de 2013

Clinical and molecular factors for selection of nivolumab or irinotecan as third-line treatment for advanced gastric cancer

scientific article published on 17 July 2020

Clinical outcomes in 66 patients with advanced gastric cancer treated in phase I trials: the NCCHE experience

artículo científico publicado en 2015

Clinical outcomes of patients with gastrointestinal stromal tumor in phase I clinical trials

artículo científico publicado en 2016

Clinicopathological and molecular features of responders to nivolumab for patients with advanced gastric cancer

scholarly article by Saori Mishima et al published 31 January 2019 in Journal for Immunotherapy of Cancer

Clinicopathological features of 22C3 PD-L1 expression with mismatch repair, Epstein-Barr virus status, and cancer genome alterations in metastatic gastric cancer.

artículo científico publicado en 2018

Clinicopathological features of PD-L1 expression with MMR, EBV status and cancer genome alterations in MGC

artículo científico publicado en 2017

Clinicopathological features of programmed death ligand 1 expression with tumor-infiltrating lymphocyte, mismatch repair, and Epstein-Barr virus status in a large cohort of gastric cancer patients

artículo científico publicado en 2016

Comparison of HER2 gene amplification assessed by fluorescence in situ hybridization and HER2 protein expression assessed by immunohistochemistry in gastric cancer.

artículo científico publicado en 2006

Complete resection of alpha-fetoprotein-producing early gastric cancer by using endoscopic submucosal dissection

artículo científico publicado en 2009

Comprehensive immunohistochemical analysis of tumor microenvironment immune status in esophageal squamous cell carcinoma

artículo científico publicado en 2016

Concordance between PIK3CA mutations in endoscopic biopsy and surgically resected specimens of esophageal squamous cell carcinoma

artículo científico publicado en 2017

Construction of possible integrated predictive index based on EGFR and ANXA3 polymorphisms for chemotherapy response in fluoropyrimidine-treated Japanese gastric cancer patients using a bioinformatic method

artículo científico publicado en 2015

Correlation between overall survival and other endpoints in clinical trials of second-line chemotherapy for patients with advanced gastric cancer

artículo científico publicado en 2013

Dose-escalation study for the targeting of CD44v+ cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205).

artículo científico publicado en 2016

Dose-finding study of the checkpoint kinase 1 inhibitor, prexasertib, in Japanese patients with advanced solid tumors

artículo científico publicado en 2018

EMR as salvage treatment for patients with locoregional failure of definitive chemoradiotherapy for esophageal cancer

artículo científico publicado en 2003

Early clinical outcomes of anal squamous cell carcinoma treated with concurrent chemoradiotherapy with 5-Fluorouracil plus mitomycin C in Japanese patients: experience at a single institution

scientific article published on 19 June 2012

Effect of RECIST revision on classification of target lesions and overall response in advanced gastric cancer patients.

artículo científico publicado en 2012

Effect of food on the pharmacokinetics of TAS-102 and its efficacy and safety in patients with advanced solid tumors

artículo científico publicado en 2016

Efficacy and safety of capecitabine plus cisplatin in Japanese patients with advanced or metastatic gastric cancer: subset analyses of the AVAGAST study and the ToGA study ⬇️

artículo científico publicado el 11 de julio de 2012

Efficacy and safety of ramucirumab-containing chemotherapy in patients with pretreated metastatic gastric neuroendocrine carcinoma

scientific article published on 01 November 2018

Efficacy and safety profile of S-1 in patients with metastatic gastric cancer in clinical practice: results from a post-marketing survey

artículo científico publicado en 2003

Efficacy of concurrent chemoradiotherapy as a palliative treatment in stage IVB esophageal cancer patients with dysphagia

artículo científico publicado en 2011

Endoscopic submucosal dissection using a new scissors-type electrosurgical knife: a first-in-human feasibility study

artículo científico publicado en 2014

Erratum to: Efficacy and safety of capecitabine plus cisplatin in Japanese patients with advanced or metastatic gastric cancer: subset analyses of the AVAGAST study and the ToGA study.

artículo científico publicado en 2012

Evaluation of safety, pharmacokinetics, and efficacy of vorinostat, a histone deacetylase inhibitor, in the treatment of gastrointestinal (GI) cancer in a phase I clinical trial ⬇️

artículo científico publicado el 11 de enero de 2012

Expression profiles of HER2, EGFR, MET and FGFR2 in a large cohort of patients with gastric adenocarcinoma

artículo científico publicado en 2014

Extensive liver metastasis of gastric cancer effectively treated by hepatic arterial infusion of 5-fluorouracil/cisplatin

artículo científico publicado en 2000

Feasibility of oxaliplatin and infusional fluorouracil/leucovorin (FOLFOX4) for Japanese patients with unresectable metastatic colorectal cancer

artículo científico publicado en 2007

First-in-human phase 1 study of novel dUTPase inhibitor TAS-114 in combination with S-1 in Japanese patients with advanced solid tumors

scientific article published on 04 December 2018

Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study

artículo científico publicado en 2009

Gastrointestinal Perforation and Fistula Formation in 5 Patients With Colorectal Cancer During Treatment With Regorafenib.

artículo científico publicado en 2016

Genetic polymorphisms of FCGR2A encoding Fcγ receptor IIa in a Japanese population and functional analysis of the L273P variant.

artículo científico publicado en 2012

Genetic polymorphisms of FCGRT encoding FcRn in a Japanese population and their functional analysis

artículo científico publicado en 2010

Genetic polymorphisms of copper- and platinum drug-efflux transporters ATP7A and ATP7B in Japanese cancer patients

artículo científico publicado en 2009

Immunotherapy for Esophageal Squamous Cell Carcinoma

artículo científico publicado en 2017

Induction chemotherapy with docetaxel, cisplatin and S-1 followed by proton beam therapy concurrent with cisplatin in patients with T4b nasal and sinonasal malignancies

artículo científico publicado en 2012

Lapatinib plus paclitaxel versus paclitaxel alone in the second-line treatment of HER2-amplified advanced gastric cancer in Asian populations: TyTAN--a randomized, phase III study

artículo científico publicado en 2014

Large-scale comprehensive immunohistochemical biomarker analyses in esophageal squamous cell carcinoma

artículo científico publicado en 2017

Local efficacy and survival outcome of salvage endoscopic therapy for local recurrent lesions after definitive chemoradiotherapy for esophageal cancer

artículo científico publicado en 2016

Molecular Subtypes of Gastric Cancer

artículo científico publicado en 2016

Multicenter phase II study of everolimus in patients with previously treated metastatic gastric cancer

artículo científico publicado en 2010

Non-surgical approach to small cell carcinoma of the esophagus: does this rare disease have the same tumor behavior as SCLC?

artículo científico publicado en 2011

Novel molecular-targeted agents for GIST(Regorafenib etc.)

artículo científico publicado el 1 de enero de 2013

Pembrolizumab for the Treatment of Advanced Salivary Gland Carcinoma: Findings of the Phase 1b KEYNOTE-028 Study

artículo científico publicado en 2018

Pharmacodynamic Studies of Gefitinib in Tumor Biopsy Specimens From Patients With Advanced Gastric Carcinoma

artículo científico publicado en 2006

Pharmacokinetics, safety, and efficacy of FOLFIRI plus bevacizumab in Japanese colorectal cancer patients with UGT1A1 gene polymorphisms.

artículo científico publicado en 2014

Phase 1 pharmacokinetic study of MK-0646 (dalotuzumab), an anti-insulin-like growth factor-1 receptor monoclonal antibody, in combination with cetuximab and irinotecan in Japanese patients with advanced colorectal cancer

artículo científico publicado en 2013

Phase 1 pharmacokinetic study of the oral pan-AKT inhibitor MK-2206 in Japanese patients with advanced solid tumors

artículo científico publicado en 2015

Phase 1 study of ganitumab (AMG 479), a fully human monoclonal antibody against the insulin-like growth factor receptor type I (IGF1R), in Japanese patients with advanced solid tumors

artículo científico publicado en 2012

Phase 1 study of sulfasalazine and cisplatin for patients with CD44v-positive gastric cancer refractory to cisplatin (EPOC1407).

artículo científico publicado en 2017

Phase 1 study of trebananib (AMG 386), an angiogenesis targeting angiopoietin-1/2 antagonist, in Japanese patients with advanced solid tumors

artículo científico publicado en 2012

Phase 2 study of nilotinib as third-line therapy for patients with gastrointestinal stromal tumor.

artículo científico publicado en 2011

Phase I Study of Axitinib in Combination with Cisplatin and Capecitabine in Patients with Previously Untreated Advanced Gastric Cancer

artículo científico publicado en 2015

Phase I Study of NK012, a Novel SN-38–Incorporating Micellar Nanoparticle, in Adult Patients with Solid Tumors ⬇️

artículo científico publicado el 13 de octubre de 2010

Phase I Study of Single-Agent Utomilumab (PF-05082566), a 4-1BB/CD137 Agonist, in Patients with Advanced Cancer

artículo científico publicado en 2018

Phase I Study of the Focal Adhesion Kinase Inhibitor BI 853520 in Japanese and Taiwanese Patients with Advanced or Metastatic Solid Tumors

Phase I clinical and pharmacokinetic study of RAD001 (everolimus) administered daily to Japanese patients with advanced solid tumors

artículo científico publicado en 2009

Phase I dose-escalation study of buparlisib (BKM120), an oral pan-class I PI3K inhibitor, in Japanese patients with advanced solid tumors

artículo científico publicado en 2014

Phase I dose-escalation study of the HSP90 inhibitor AUY922 in Japanese patients with advanced solid tumors

artículo científico publicado en 2014

Phase I dose-escalation study of the safety, tolerability, and pharmacokinetics of aflibercept in combination with S-1 in Japanese patients with advanced solid malignancies

artículo científico publicado en 2020

Phase I dose-escalation trial of Sym004, an anti-EGFR antibody mixture, in Japanese patients with advanced solid tumors

Phase I study of LY2603618, a CHK1 inhibitor, in combination with gemcitabine in Japanese patients with solid tumors

artículo científico publicado en 2015

Phase I study of TAS-102 and irinotecan combination therapy in Japanese patients with advanced colorectal cancer

artículo científico publicado en 2015

Phase I study of TAS-115, a novel oral multi-kinase inhibitor, in patients with advanced solid tumors

scientific article published on 10 December 2019

Phase I study of ipatasertib as a single agent and in combination with abiraterone plus prednisolone in Japanese patients with advanced solid tumors

scientific article published on 21 June 2019

Phase I study of olaratumab in Japanese patients with advanced solid tumors

artículo científico publicado en 2014

Phase I study of single-agent ribociclib in Japanese patients with advanced solid tumors

artículo científico publicado en 2017

Phase I/II study of capecitabine plus oxaliplatin (XELOX) plus bevacizumab as first-line therapy in Japanese patients with metastatic colorectal cancer

artículo científico publicado en 2010

Phase I/II study of oxaliplatin with weekly bolus fluorouracil and high-dose leucovorin (ROX) as first-line therapy for patients with colorectal cancer

artículo científico publicado en 2006

Phase I/II study of sunitinib malate in Japanese patients with gastrointestinal stromal tumor after failure of prior treatment with imatinib mesylate

artículo científico publicado en 2010

Phase II study of motesanib in Japanese patients with advanced gastrointestinal stromal tumors with prior exposure to imatinib mesylate

artículo científico publicado en 2009

Phase II study of sunitinib as second-line treatment for advanced gastric cancer

artículo científico publicado en 2010

Phase Ia Study of FoxP3+ CD4 Treg Depletion by Infusion of a Humanized Anti-CCR4 Antibody, KW-0761, in Cancer Patients

artículo científico publicado en 2015

Photodynamic therapy as salvage treatment for local failure after chemoradiotherapy in patients with esophageal squamous cell carcinoma: a phase II study.

artículo científico publicado en 2012

Predictive factors for hyperprogressive disease during nivolumab as anti-PD1 treatment in patients with advanced gastric cancer

scientific article published on 09 January 2019

Present status of chemotherapy for colorectal cancer in countries outside of Japan

artículo científico publicado el 1 de septiembre de 2003

Prognostic significance of tumor regression grade for patients with esophageal squamous cell carcinoma after neoadjuvant chemotherapy followed by surgery

artículo científico publicado en 2016

Progression-free survival and post-progression survival in patients with advanced gastric cancer treated with first-line chemotherapy

artículo científico publicado en 2013

Prophylactic Use of Oral Dexamethasone to Alleviate Fatigue During Regorafenib Treatment for Patients With Metastatic Colorectal Cancer

artículo científico publicado en 2016

Pulmonary tumor thrombotic microangiopathy associated with esophageal squamous cell carcinoma

artículo científico publicado en 2011

Randomized Phase III KEYNOTE-181 Study of Pembrolizumab Versus Chemotherapy in Advanced Esophageal Cancer

artículo científico publicado en 2020

Randomized Phase III study of 5-fluorouracil continuous infusion vs. sequential methotrexate and 5-fluorouracil therapy in far advanced gastric cancer with peritoneal metastasis (JCOG0106).

artículo científico publicado en 2013

Rechallenge of drugs in the era of targeted therapy

artículo científico publicado en 2013

Regional differences in advanced gastric cancer: exploratory analyses of the AVAGAST placebo arm.

artículo científico publicado en 2017

Regorafenib for advanced gastrointestinal stromal tumors following imatinib and sunitinib treatment: a subgroup analysis evaluating Japanese patients in the phase III GRID trial

artículo científico publicado en 2015

Relationship between the immune microenvironment of different locations in a primary tumour and clinical outcomes of oesophageal squamous cell carcinoma

scientific article published on 25 November 2019

Safety and Antitumor Activity of the Anti-Programmed Death-1 Antibody Pembrolizumab in Patients With Advanced Esophageal Carcinoma

artículo científico publicado en 2017

Safety and Efficacy of Pembrolizumab Monotherapy in Patients With Previously Treated Advanced Gastric and Gastroesophageal Junction Cancer: Phase 2 Clinical KEYNOTE-059 Trial

artículo científico publicado en 2018

Safety and Efficacy of Trifluridine/Tipiracil Monotherapy in Clinical Practice for Patients With Metastatic Colorectal Cancer: Experience at a Single Institution

artículo científico publicado en 2015

Safety and Tolerability of Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF-β and PD-L1, in Asian Patients with Pretreated Recurrent or Refractory Gastric Cancer

scientific article published on 16 April 2020

Safety and antitumor activity of the anti-PD-1 antibody pembrolizumab in patients with advanced, PD-L1-positive papillary or follicular thyroid cancer

article published in 2019

Safety and efficacy of radium-223 dichloride in Japanese patients with castration-resistant prostate cancer and bone metastases

artículo científico publicado en 2017

Safety of irinotecan and infusional fluorouracil/leucovorin (FOLFIRI) in Japan: a retrospective review of 48 patients with metastatic colorectal cancer

artículo científico publicado en 2008

Safety, pharmacokinetic, and pharmacodynamics of erdafitinib, a pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor, in patients with advanced or refractory solid tumors

artículo científico publicado en 2017

Safety, pharmacokinetics, and antitumour activity of trastuzumab deruxtecan (DS-8201), a HER2-targeting antibody-drug conjugate, in patients with advanced breast and gastric or gastro-oesophageal tumours: a phase 1 dose-escalation study

artículo científico publicado en 2017

Salvage photodynamic therapy for local failure after chemoradiotherapy for esophageal squamous cell carcinoma

artículo científico publicado en 2015

Serum HER2 levels and HER2 status in tumor cells in advanced gastric cancer patients

artículo científico publicado en 2014

Subgroup analyses of the safety and efficacy of ramucirumab in Japanese and Western patients in RAINBOW: a randomized clinical trial in second-line treatment of gastric cancer

artículo científico

Sunitinib-resistant gastrointestinal stromal tumors harbor cis-mutations in the activation loop of the KIT gene.

artículo científico publicado en 2009

TAK-264 (MLN0264) in Previously Treated Asian Patients with Advanced Gastrointestinal Carcinoma Expressing Guanylyl Cyclase C: Results from an Open-Label, Non-randomized Phase 1 Study.

artículo científico publicado en 2017

TAS-102 plus bevacizumab for patients with metastatic colorectal cancer refractory to standard therapies (C-TASK FORCE): an investigator-initiated, open-label, single-arm, multicentre, phase 1/2 study

artículo científico publicado en 2017

Targeting VEGFR2 with Ramucirumab strongly impacts effector/ activated regulatory T cells and CD8 T cells in the tumor microenvironment

scholarly article by Yasuko Tada et al published 11 October 2018 in Journal for Immunotherapy of Cancer

The Nationwide Cancer Genome Screening Project in Japan SCRUM-Japan GI-SCREEN: Efficient identification of cancer genome alterations in advanced non-colorectal (Non-CRC) gastrointestinal cancer

The Nationwide Cancer Genome Screening Project in Japan, SCRUM-Japan GI-SCREEN: Efficient identification of cancer genome alterations in advanced colorectal cancer

The Nationwide Cancer Genome Screening Projects for Gastrointestinal Cancer in Japan (SCRUM-Japan GI-SCREEN): Efficient identification of actionable cancer genome alterations in advanced colorectal and non-colorectal gastrointestinal cancer (GI Scree

The Recommended Chemotherapy Duration-From the Viewpoint of Drug Resistance

artículo científico publicado en 2016

The impact of molecular subtype on efficacy of chemotherapy and checkpoint inhibition in advanced gastric cancer

scientific article published on 10 March 2020

The safety and tolerability of epacadostat alone and in combination with pembrolizumab in patients with advanced solid tumors: results from a first-in-Japanese phase I study (KEYNOTE-434)

scientific article published on 20 June 2020

Therapeutic significance of a D-dimer cut-off level of >3 µg/ml in colorectal cancer patients treated with standard chemotherapy plus bevacizumab

artículo científico publicado en 2010

Trastuzumab deruxtecan (DS-8201a) in patients with advanced HER2-positive breast cancer previously treated with trastuzumab emtansine: a dose-expansion, phase 1 study

article published in 2019

Trastuzumab deruxtecan (DS-8201a) in patients with advanced HER2-positive gastric cancer: a dose-expansion, phase 1 study

artículo científico publicado en 2019

Trastuzumab deruxtecan (DS-8201a) in subjects with HER2-expressing solid tumors: Long-term results of a large phase 1 study with multiple expansion cohorts

Trifluridine/tipiracil versus placebo in patients with heavily pretreated metastatic gastric cancer (TAGS): a randomised, double-blind, placebo-controlled, phase 3 trial

artículo científico publicado en 2018

Tumor KRAS Status Predicts Responsiveness to Panitumumab in Japanese Patients with Metastatic Colorectal Cancer ⬇️

artículo científico publicado el 17 de diciembre de 2010

Tyrosine kinase inhibitors in the treatment of unresectable or metastatic gastrointestinal stromal tumors

artículo científico publicado en 2014

[Two cases of KRAS wild-type unresectable or recurrent colorectal cancer effectively treated by cetuximab after progression of prior chemotherapy].

artículo científico publicado en 2009

[VEGFR inhibitor (multi-target kinase inhibitors)].

artículo científico publicado en 2015

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