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3-Deazaneplanocin A (DZNep), an inhibitor of the histone methyltransferase EZH2, induces apoptosis and reduces cell migration in chondrosarcoma cells

artículo científico publicado en 2014

Anti-inflammatory and chondroprotective effects of the S-adenosylhomocysteine hydrolase inhibitor 3-Deazaneplanocin A, in human articular chondrocytes.

artículo científico

Anti-inflammatory effects of an injectable copolymer of fatty acids (Ara 3000 beta®) in joint diseases.

artículo científico publicado en 2015

Antiproliferative effect of the histone demethylase inhibitor GSK-J4 in chondrosarcomas

artículo científico publicado en 2019

Asporin expression is highly regulated in human chondrocytes.

artículo científico publicado en 2011

Chondroitin sulfate modulation of matrix and inflammatory gene expression in IL-1beta-stimulated chondrocytes--study in hypoxic alginate bead cultures

artículo científico publicado en 2007

Development of a simple osteoarthritis model useful to predict in vitro the anti-hypertrophic action of drugs

artículo científico publicado en 2019

Enhanced hyaline cartilage matrix synthesis in collagen sponge scaffolds by using siRNA to stabilize chondrocytes phenotype cultured with bone morphogenetic protein-2 under hypoxia.

artículo científico publicado en 2013

Epigenetic dynamic during endochondral ossification and articular cartilage development

article

Evaluation of the impact of S-adenosylmethionine-dependent methyltransferase inhibitor, 3-deazaneplanocin A, on tissue injury and cognitive function in mice.

artículo científico publicado en 2018

Genetic Determinism of Primary Early-Onset Osteoarthritis.

artículo científico

Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation

artículo científico publicado en 2015

Histone methylases as novel drug targets: developing inhibitors of EZH2.

artículo científico publicado en 2014

Hypoxia inducible factor 1 alpha down-regulates type i collagen through Sp3 transcription factor in human chondrocytes

artículo científico publicado en 2016

Identification of an easy to use 3D culture model to investigate invasion and anticancer drug response in chondrosarcomas

artículo científico publicado en 2017

Interleukin-1beta impairment of transforming growth factor beta1 signaling by down-regulation of transforming growth factor beta receptor type II and up-regulation of Smad7 in human articular chondrocytes

artículo científico publicado en 2007

Interleukin-1beta up-regulation of Smad7 via NF-kappaB activation in human chondrocytes.

artículo científico publicado en 2008

Modulation of Skin Inflammatory Response by Active Components of Silymarin

artículo científico publicado en 2018

Modulation of transforming growth factor beta signalling pathway genes by transforming growth factor beta in human osteoarthritic chondrocytes: involvement of Sp1 in both early and late response cells to transforming growth factor beta ⬇️

artículo científico publicado el 15 de febrero de 2011

NFkappaB mediates IL-1beta-induced down-regulation of TbetaRII through the modulation of Sp3 expression.

artículo científico publicado en 2007

Regulation and Role of TGFβ Signaling Pathway in Aging and Osteoarthritis Joints

artículo científico publicado en 2013

Regulatory mechanism of transforming growth factor beta receptor type II degradation by interleukin-1 in primary chondrocytes.

artículo científico publicado en 2012

TOL19-001 reduces inflammation and MMP expression in monolayer cultures of tendon cells

artículo científico publicado en 2015

The Antitumoral Effect of the S-Adenosylhomocysteine Hydrolase Inhibitor, 3-Deazaneplanocin A, is Independent of EZH2 but is Correlated with EGFR Downregulation in Chondrosarcomas

artículo científico publicado en 2019

Use of Adult Stem Cells for Cartilage Tissue Engineering: Current Status and Future Developments

artículo científico publicado en 2015

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