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A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer's disease brain

scientific article published on 03 December 2019

A validated antibody panel for the characterization of tau post-translational modifications

artículo científico publicado en 2017

Caspase-6 and neurodegeneration.

artículo científico publicado en 2011

Constitutive ablation of caspase-6 reduces the inflammatory response and behavioural changes caused by peripheral pro-inflammatory stimuli.

artículo científico publicado en 2018

Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development.

artículo científico publicado en 2011

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

artículo científico publicado en 2008

EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity.

artículo científico publicado en 2010

Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression

artículo científico publicado en 2010

Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models

artículo científico publicado en 2006

HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.

artículo científico publicado en 2014

Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.

artículo científico publicado en 2016

Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease.

artículo científico publicado en 2011

Mouse models of Huntington disease: variations on a theme.

artículo científico publicado en 2009

Palmitoylation of caspase-6 by HIP14 regulates its activation

artículo científico publicado en 2016

SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer's disease

artículo científico publicado en 2021

Small changes, big impact: posttranslational modifications and function of huntingtin in Huntington disease.

scientific article published on 10 February 2011

p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin

artículo científico publicado en 2013