Lista de obras -

ADP-regulation of mitochondrial free radical production is different with complex I- or complex II-linked substrates: implications for the exercise paradox and brain hypermetabolism

artículo científico publicado el 1 de junio de 1997

An evolutionary comparative scan for longevity-related oxidative stress resistance mechanisms in homeotherms ⬇️

artículo científico publicado el 14 de julio de 2011

Calorie restriction, oxidative stress and longevity

artículo científico publicado en 2008

Correlations with longevity and body size: to correct or not correct?

artículo científico publicado en 2014

Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction

artículo científico publicado en 2015

Deprenyl protects from MPTP-induced Parkinson-like syndrome and glutathione oxidation in rat striatum ⬇️

artículo científico publicado el 25 de enero de 2002

Dietary Protein Restriction Decreases Oxidative Protein Damage, Peroxidizability Index, and Mitochondrial Complex I Content in Rat Liver

artículo científico publicado en 2007

Dietary restriction at old age lowers mitochondrial oxygen radical production and leak at complex I and oxidative DNA damage in rat brain

artículo científico publicado en 2005

Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver.

artículo científico publicado en 2008

Effect of 8.5% and 25% caloric restriction on mitochondrial free radical production and oxidative stress in rat liver

artículo científico publicado en 2007

Effect of aging on mitochondrial and nuclear DNA oxidative damage in the heart and brain throughout the life-span of the rat

artículo científico publicado en 2001

Effect of graded corticosterone treatment on aging-related markers of oxidative stress in rat liver mitochondria

artículo científico publicado en 2006

Effect of insulin and growth hormone on rat heart and liver oxidative stress in control and caloric restricted animals

artículo científico publicado en 2005

Effect of lipid restriction on mitochondrial free radical production and oxidative DNA damage

artículo científico publicado en 2006

Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heart.

artículo científico publicado en 2009

Effect of short-term caloric restriction on H2O2 production and oxidative DNA damage in rat liver mitochondria and location of the free radical source

artículo científico publicado el 1 de agosto de 2001

Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria

artículo científico publicado en 2012

Formation of S-(carboxymethyl)-cysteine in rat liver mitochondrial proteins: effects of caloric and methionine restriction.

artículo científico publicado en 2012

Forty percent and eighty percent methionine restriction decrease mitochondrial ROS generation and oxidative stress in rat liver.

artículo científico publicado en 2008

Forty percent methionine restriction lowers DNA methylation, complex I ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart

artículo científico publicado en 2011

Free radicals and aging.

artículo científico publicado en 2004

H2O2 production of heart mitochondria and aging rate are slower in canaries and parakeets than in mice: sites of free radical generation and mechanisms involved ⬇️

artículo científico publicado el 15 de junio de 1998

Highly resistant macromolecular components and low rate of generation of endogenous damage: two key traits of longevity.

artículo científico publicado en 2007

Independent and additive effects of atenolol and methionine restriction on lowering rat heart mitochondria oxidative stress.

artículo científico publicado en 2013

Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity

artículo científico publicado en 2014

Localization at complex I and mechanism of the higher free radical production of brain nonsynaptic mitochondria in the short-lived rat than in the longevous pigeon

artículo científico publicado el 1 de junio de 1998

Localization of the site of oxygen radical generation inside the complex I of heart and nonsynaptic brain mammalian mitochondria.

artículo científico publicado en 2000

Long-lived Ames dwarf mice: Oxidative damage to mitochondrial DNA in heart and brain.

artículo científico publicado en 2002

Lowered methionine ingestion as responsible for the decrease in rodent mitochondrial oxidative stress in protein and dietary restriction possible implications for humans.

scientific article published on 18 January 2008

Membrane lipid unsaturation as physiological adaptation to animal longevity.

artículo científico publicado en 2013

Membrane peroxidation index and maximum lifespan are negatively correlated in fish of genus Nothobranchius

artículo científico publicado en 2020

Methionine and homocysteine modulate the rate of ROS generation of isolated mitochondria in vitro.

artículo científico publicado en 2011

Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins

scientific article published on 01 June 2006

Minireview: the role of oxidative stress in relation to caloric restriction and longevity.

artículo científico publicado en 2005

Mitochondrial base excision repair positively correlates with longevity in the liver and heart of mammals

artículo científico publicado en 2020

Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection.

artículo científico publicado en 2006

Mitochondrial oxygen consumption and reactive oxygen species production are independently modulated: implications for aging studies.

artículo científico publicado en 2007

Plasma long-chain free fatty acids predict mammalian longevity.

artículo científico publicado en 2013

Protein and lipid oxidative damage and complex I content are lower in the brain of budgerigar and canaries than in mice. Relation to aging rate

artículo científico publicado en 2005

Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice.

artículo científico publicado en 2016

Reduced apurinic/apyrimidinic endonuclease 1 activity and increased DNA damage in mitochondria are related to enhanced apoptosis and inflammation in the brain of senescence- accelerated P8 mice (SAMP8).

artículo científico publicado en 2015

Regulation of longevity and oxidative stress by nutritional interventions: role of methionine restriction.

artículo científico

Short-term caloric restriction and sites of oxygen radical generation in kidney and skeletal muscle mitochondria

scientific article published on 01 June 2004

Sites and mechanisms responsible for the low rate of free radical production of heart mitochondria in the long-lived pigeon ⬇️

artículo científico publicado el 1 de noviembre de 1997

Testing the vicious cycle theory of mitochondrial ROS production: effects of H2O2 and cumene hydroperoxide treatment on heart mitochondria

artículo científico publicado en 2006

The gene cluster hypothesis of aging and longevity

artículo científico publicado en 2007

The mitochondrial free radical theory of aging

artículo científico publicado en 2014

The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach ⬇️

artículo científico publicado el 1 de abril de 1998

The β-blocker atenolol lowers the longevity-related degree of fatty acid unsaturation, decreases protein oxidative damage, and increases extracellular signal-regulated kinase signaling in the heart of C57BL/6 mice.

artículo científico publicado en 2010

Thyroid hormone-induced oxidative damage on lipids, glutathione and DNA in the mouse heart ⬇️

artículo científico publicado el 1 de octubre de 2001

Towards a unified mechanistic theory of aging

artículo científico publicado en 2019

Updating the Mitochondrial Free Radical Theory of Aging: An Integrated View, Key Aspects, and Confounding Concepts ⬇️

artículo científico publicado el 3 de julio de 2013

Lista de obras de

ADP-regulation of mitochondrial free radical production is different with complex I- or complex II-linked substrates: implications for the exercise paradox and brain hypermetabolism

An evolutionary comparative scan for longevity-related oxidative stress resistance mechanisms in homeotherms ⬇️

Calorie restriction, oxidative stress and longevity

Correlations with longevity and body size: to correct or not correct?

Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction

Deprenyl protects from MPTP-induced Parkinson-like syndrome and glutathione oxidation in rat striatum ⬇️

Dietary Protein Restriction Decreases Oxidative Protein Damage, Peroxidizability Index, and Mitochondrial Complex I Content in Rat Liver

Dietary restriction at old age lowers mitochondrial oxygen radical production and leak at complex I and oxidative DNA damage in rat brain

Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver.

Effect of 8.5% and 25% caloric restriction on mitochondrial free radical production and oxidative stress in rat liver

Effect of aging on mitochondrial and nuclear DNA oxidative damage in the heart and brain throughout the life-span of the rat

Effect of graded corticosterone treatment on aging-related markers of oxidative stress in rat liver mitochondria

Effect of insulin and growth hormone on rat heart and liver oxidative stress in control and caloric restricted animals

Effect of lipid restriction on mitochondrial free radical production and oxidative DNA damage

Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heart.

Effect of short-term caloric restriction on H2O2 production and oxidative DNA damage in rat liver mitochondria and location of the free radical source

Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria

Formation of S-(carboxymethyl)-cysteine in rat liver mitochondrial proteins: effects of caloric and methionine restriction.

Forty percent and eighty percent methionine restriction decrease mitochondrial ROS generation and oxidative stress in rat liver.

Forty percent methionine restriction lowers DNA methylation, complex I ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart

Free radicals and aging.

H2O2 production of heart mitochondria and aging rate are slower in canaries and parakeets than in mice: sites of free radical generation and mechanisms involved ⬇️

Highly resistant macromolecular components and low rate of generation of endogenous damage: two key traits of longevity.

Independent and additive effects of atenolol and methionine restriction on lowering rat heart mitochondria oxidative stress.

Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity

Localization at complex I and mechanism of the higher free radical production of brain nonsynaptic mitochondria in the short-lived rat than in the longevous pigeon

Localization of the site of oxygen radical generation inside the complex I of heart and nonsynaptic brain mammalian mitochondria.

Long-lived Ames dwarf mice: Oxidative damage to mitochondrial DNA in heart and brain.

Lowered methionine ingestion as responsible for the decrease in rodent mitochondrial oxidative stress in protein and dietary restriction possible implications for humans.

Membrane lipid unsaturation as physiological adaptation to animal longevity.

Membrane peroxidation index and maximum lifespan are negatively correlated in fish of genus Nothobranchius

Methionine and homocysteine modulate the rate of ROS generation of isolated mitochondria in vitro.

Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins

Minireview: the role of oxidative stress in relation to caloric restriction and longevity.

Mitochondrial base excision repair positively correlates with longevity in the liver and heart of mammals

Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection.

Mitochondrial oxygen consumption and reactive oxygen species production are independently modulated: implications for aging studies.

Plasma long-chain free fatty acids predict mammalian longevity.

Protein and lipid oxidative damage and complex I content are lower in the brain of budgerigar and canaries than in mice. Relation to aging rate

Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice.

Reduced apurinic/apyrimidinic endonuclease 1 activity and increased DNA damage in mitochondria are related to enhanced apoptosis and inflammation in the brain of senescence- accelerated P8 mice (SAMP8).

Regulation of longevity and oxidative stress by nutritional interventions: role of methionine restriction.

Short-term caloric restriction and sites of oxygen radical generation in kidney and skeletal muscle mitochondria

Sites and mechanisms responsible for the low rate of free radical production of heart mitochondria in the long-lived pigeon ⬇️

Testing the vicious cycle theory of mitochondrial ROS production: effects of H2O2 and cumene hydroperoxide treatment on heart mitochondria

The gene cluster hypothesis of aging and longevity

The mitochondrial free radical theory of aging

The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach ⬇️

The β-blocker atenolol lowers the longevity-related degree of fatty acid unsaturation, decreases protein oxidative damage, and increases extracellular signal-regulated kinase signaling in the heart of C57BL/6 mice.

Thyroid hormone-induced oxidative damage on lipids, glutathione and DNA in the mouse heart ⬇️

Towards a unified mechanistic theory of aging

Updating the Mitochondrial Free Radical Theory of Aging: An Integrated View, Key Aspects, and Confounding Concepts ⬇️