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Activation of tumor-promoting pathways implicated in hepatocellular adenoma/carcinoma, a long-term complication of glycogen storage disease type Ia

scientific article published on 15 November 2019

An evolutionary approach to optimizing glucose-6-phosphatase-α enzymatic activity for gene therapy of glycogen storage disease type Ia

artículo científico publicado en 2019

Downregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia.

artículo científico publicado en 2017

Downregulation of pathways implicated in liver inflammation and tumorigenesis of glycogen storage disease type Ia mice receiving gene therapy.

artículo científico publicado en 2017

Emerging roles of autophagy in hepatic tumorigenesis and therapeutic strategies in glycogen storage disease type Ia: a review

artículo científico publicado en 2020

Gene therapy prevents hepatic tumor initiation in murine glycogen storage disease type Ia at the tumor-developing stage

scientific article published on 06 March 2019

Glycogen storage disease type Ia mice with less than 2% of normal hepatic glucose-6-phosphatase-α activity restored are at risk of developing hepatic tumors

artículo científico publicado en 2017

Hepatic glucose-6-phosphatase-α deficiency leads to metabolic reprogramming in glycogen storage disease type Ia.

artículo científico publicado en 2018

Inhibition of apoptosis signal-regulating kinase 1 by nitric oxide through a thiol redox mechanism.

artículo científico publicado en 2003

Liver Glycogen Phosphorylase Deficiency Leads to Profibrogenic Phenotype in a Murine Model of Glycogen Storage Disease Type VI

scientific article published on 24 September 2019

Liver-directed gene therapy for murine glycogen storage disease type Ib.

artículo científico publicado en 2017

Mice expressing reduced levels of hepatic glucose-6-phosphatase-α activity do not develop age-related insulin resistance or obesity

artículo científico publicado en 2015

Molecular biology and gene therapy for glycogen storage disease type Ib.

artículo científico publicado en 2018

PRMT1 negatively regulates activation-induced cell death in macrophages by arginine methylation of GAPDH

artículo científico publicado en 2018

Positive regulation of ASK1-mediated c-Jun NH(2)-terminal kinase signaling pathway by the WD-repeat protein Gemin5

artículo científico publicado en 2007

Recent development and gene therapy for glycogen storage disease type Ia

artículo científico publicado en 2017

Sirtuin signaling controls mitochondrial function in glycogen storage disease type Ia

scientific article published on 08 May 2018