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A Role for Phosphodiesterase 11A (PDE11A) in the Formation of Social Memories and the Stabilization of Mood.

artículo científico publicado en 2017

Acquisition of a novel behavior induces higher levels of Arc mRNA than does overtrained performance

artículo científico publicado en 2002

Chronic Galphas signaling in the striatum increases anxiety-related behaviors independent of developmental effects

artículo científico publicado en 2008

Chronically increased Gsalpha signaling disrupts associative and spatial learning.

artículo científico publicado en 2006

Constitutive activation of Galphas within forebrain neurons causes deficits in sensorimotor gating because of PKA-dependent decreases in cAMP.

artículo científico publicado en 2006

Constitutive activation of the G-protein subunit Galphas within forebrain neurons causes PKA-dependent alterations in fear conditioning and cortical Arc mRNA expression.

artículo científico publicado en 2008

Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain.

artículo científico publicado en 2017

Differential function of phosphodiesterase families in the brain: gaining insights through the use of genetically modified animals

artículo científico publicado en 2009

Does phosphodiesterase 11A (PDE11A) hold promise as a future therapeutic target?

artículo científico publicado en 2015

Identification of new PDE9A isoforms and how their expression and subcellular compartmentalization in the brain change across the life span.

artículo científico publicado en 2018

Loss of Function of Phosphodiesterase 11A4 Shows that Recent and Remote Long-Term Memories Can Be Uncoupled

scientific article published on 11 July 2019

Mice expressing constitutively active Gsalpha exhibit stimulus encoding deficits similar to those observed in schizophrenia patients.

artículo científico publicado en 2006

PDE11A negatively regulates lithium responsivity

scientific article published on 20 September 2016

PDE11A regulates social behaviors and is a key mechanism by which social experience sculpts the brain.

artículo científico publicado en 2016

Phosphodiesterase 11A (PDE11A), Enriched in Ventral Hippocampus Neurons, is Required for Consolidation of Social but not Nonsocial Memories in Mice.

artículo científico publicado en 2016

Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes.

artículo científico publicado en 2010

Phosphodiesterases PDE2A and PDE10A both change mRNA expression in the human brain with age, but only PDE2A changes in a region-specific manner with psychiatric disease

artículo científico publicado en 2020

Rolipram: a specific phosphodiesterase 4 inhibitor with potential antipsychotic activity.

artículo científico publicado en 2006

The distribution of phosphodiesterase 2A in the rat brain.

artículo científico publicado en 2012

The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function.

artículo científico publicado en 2010

Therapeutic targeting of 3',5'-cyclic nucleotide phosphodiesterases: inhibition and beyond

artículo científico publicado en 2019

Transcriptional regulation of neurodevelopmental and metabolic pathways by NPAS3.

artículo científico publicado en 2011