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Calsequestrin interacts directly with the cardiac ryanodine receptor luminal domain.

artículo científico publicado en 2016

Dantrolene rescues aberrant N-terminus intersubunit interactions in mutant pro-arrhythmic cardiac ryanodine receptors.

artículo científico publicado en 2014

Differential Ca2+ sensitivity of RyR2 mutations reveals distinct mechanisms of channel dysfunction in sudden cardiac death.

artículo científico publicado en 2005

Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor.

artículo científico publicado en 2016

FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease

artículo científico publicado en 2009

Functional heterogeneity of ryanodine receptor mutations associated with sudden cardiac death.

artículo científico publicado en 2004

Identification of an amino-terminus determinant critical for ryanodine receptor/Ca2+ release channel function

artículo científico publicado en 2020

Insights into the gating mechanism of the ryanodine-modified human cardiac Ca2+-release channel (ryanodine receptor 2).

artículo científico publicado en 2014

Questioning flecainide's mechanism of action in the treatment of catecholaminergic polymorphic ventricular tachycardia

artículo científico publicado en 2016

Role of ryanodine receptor mutations in cardiac pathology: more questions than answers?

scientific article published on 01 November 2006

Ryanodine receptor mutations in arrhythmia: The continuing mystery of channel dysfunction.

scientific article published on 02 February 2010

Ryanodine receptor mutations in arrhythmias: advances in understanding the mechanisms of channel dysfunction.

artículo científico publicado en 2007

Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains.

artículo científico publicado en 2004

Techniques and methodologies to study the ryanodine receptor at the molecular, subcellular and cellular level.

artículo científico

The mechanism of flecainide action in CPVT does not involve a direct effect on RyR2.

artículo científico publicado en 2015

Unambiguous observation of blocked states reveals altered, blocker-induced, cardiac ryanodine receptor gating

artículo científico publicado en 2016