Lista de obras -

A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC).

artículo científico publicado en 2017

A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1-/- mice is correlated to increased cellular senescence

artículo científico publicado en 2016

A novel approach for screening the proteome for changes in protein conformation

artículo científico publicado en 2006

A strategy for the ubiquitous overexpression of human catalase and CuZn superoxide dismutase genes in transgenic mice

artículo científico publicado en 2003

Ablation of the mitochondrial complex IV assembly protein Surf1 leads to increased expression of the UPR(MT) and increased resistance to oxidative stress in primary cultures of fibroblasts

artículo científico publicado en 2016

Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy

scientific journal article

Absence of insulin signalling in skeletal muscle is associated with reduced muscle mass and function: evidence for decreased protein synthesis and not increased degradation

artículo científico publicado en 2010

Accelerated sarcopenia in Cu/Zn superoxide dismutase knockout mice

artículo científico publicado en 2018

Age-associated alterations of the neuromuscular junction ⬇️

artículo científico publicado el 18 de septiembre de 2010

Age-dependent increases in interstitial collagenase and MAP Kinase levels are exacerbated by superoxide dismutase deficiencies

artículo científico publicado en 2009

Age-related cardiac muscle sarcopenia: Combining experimental and mathematical modeling to identify mechanisms

artículo científico publicado en 2007

Age-related cataract progression in five mouse models for anti-oxidant protection or hormonal influence

artículo científico publicado en 2005

Age-related loss of the DNA repair response following exposure to oxidative stress

artículo científico publicado en 2006

Butyrate prevents muscle atrophy after sciatic nerve crush

artículo científico publicado en 2015

Catalase transgenic mice: characterization and sensitivity to oxidative stress

artículo científico publicado en 2004

Comparative proteomics: characterization of a two-dimensional gel electrophoresis system to study the effect of aging on mitochondrial proteins

scientific article published on 01 January 2003

Comparative studies of oxidative stress and mitochondrial function in aging

artículo científico publicado en 2010

Complex I generated, mitochondrial matrix-directed superoxide is released from the mitochondria through voltage dependent anion channels ⬇️

artículo científico publicado el 18 de mayo de 2012

Complex III releases superoxide to both sides of the inner mitochondrial membrane

scientific journal article

Complex IV-deficient Surf1(-/-) mice initiate mitochondrial stress responses

artículo científico publicado en 2014

Continuous overexpression of thioredoxin 1 enhances cancer development and does not extend maximum lifespan in male C57BL/6 mice

CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life

artículo científico publicado en 2005

CuZnSOD gene deletion targeted to skeletal muscle leads to loss of contractile force but does not cause muscle atrophy in adult mice

artículo científico publicado en 2013

Current thoughts on the role of mitochondria and free radicals in the biology of aging

artículo científico publicado en 2009

Decreased in vitro mitochondrial function is associated with enhanced brain metabolism, blood flow, and memory in Surf1-deficient mice

artículo científico publicado en 2013

Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance

artículo científico publicado en 2008

Denervation induces cytosolic phospholipase A2-mediated fatty acid hydroperoxide generation by muscle mitochondria

artículo científico publicado en 2008

Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD.

artículo científico publicado en 2012

Dietary restriction attenuates the accelerated aging phenotype of Sod1−/− mice ⬇️

artículo científico publicado el 28 de febrero de 2013

Dietary restriction but not rapamycin extends disease onset and survival of the H46R/H48Q mouse model of ALS

artículo científico publicado en 2012

Different death stimuli evoke apoptosis via multiple pathways in retinal pigment epithelial cells

artículo científico publicado en 2006

Downregulation of Grb2 contributes to the insulin-sensitizing effect of calorie restriction

artículo científico publicado en 2009

Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levels

artículo científico publicado en 2005

Elevated protein carbonylation, and misfolding in sciatic nerve from db/db and Sod1(-/-) mice: plausible link between oxidative stress and demyelination

artículo científico publicado en 2013

Embryonic fibroblasts from Gpx4+/- mice: a novel model for studying the role of membrane peroxidation in biological processes

artículo científico publicado en 2003

Emerging roles for histone deacetylases in age-related muscle atrophy

artículo científico publicado en 2016

Formation of 3-nitrotyrosines in carbonic anhydrase III is a sensitive marker of oxidative stress in skeletal muscle

artículo científico publicado en 2007

GAPDH is conformationally and functionally altered in association with oxidative stress in mouse models of amyotrophic lateral sclerosis

artículo científico publicado en 2008

Genetic ablation of 12/15-lipoxygenase but not 5-lipoxygenase protects against denervation-induced muscle atrophy

artículo científico publicado en 2013

Genetic disruption of SOD1 gene causes glucose intolerance and impairs β-cell function

artículo científico publicado en 2013

Glutathione peroxidase 4 differentially regulates the release of apoptogenic proteins from mitochondria

artículo científico publicado en 2009

Glutathione peroxidase 4 protects cortical neurons from oxidative injury and amyloid toxicity

artículo científico publicado en 2006

Glutathione-peroxidase-1 null muscle progenitor cells are globally defective

scientific journal article

Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain ⬇️

artículo científico publicado el 6 de marzo de 2012

High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates

artículo científico publicado en 2008

Immune cell Toll-like receptor 4 is required for cardiac myocyte impairment during endotoxemia

artículo científico publicado en 2004

Increased mitochondrial matrix-directed superoxide production by fatty acid hydroperoxides in skeletal muscle mitochondria ⬇️

artículo científico publicado el 21 de diciembre de 2010

Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration

artículo científico publicado en 2009

Insulin resistance is a cellular antioxidant defense mechanism

artículo científico publicado en 2009

Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes

artículo científico publicado en 2018

Is the oxidative stress theory of aging dead?

artículo científico publicado en 2009

Isocitrate dehydrogenase 1 is downregulated during early skin tumorigenesis which can be inhibited by overexpression of manganese superoxide dismutase ⬇️

artículo científico publicado el 7 de junio de 2012

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

artículo científico publicado en 2003

Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice

artículo científico publicado en 2018

Lifespan extension in genetically modified mice

artículo científico publicado en 2009

Liver specific expression of Cu/ZnSOD extends the lifespan of Sod1 null mice

artículo científico publicado en 2016

Loss of manganese superoxide dismutase leads to abnormal growth and signal transduction in mouse embryonic fibroblasts

artículo científico publicado en 2010

Loss of the antioxidant enzyme CuZnSOD (Sod1) mimics an age-related increase in absolute mitochondrial DNA copy number in the skeletal muscle

artículo científico publicado en 2016

Metabolic and Stress Response Changes Precede Disease Onset in the Spinal Cord of Mutant SOD1 ALS Mice.

artículo científico publicado en 2019

Methionine oxidation and aging

artículo científico publicado en 2005

Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity

scientific article published on 23 September 2009

Microwave & Magnetic (M2) Proteomics of a Mouse Model of Mild Traumatic Brain Injury

artículo científico publicado en 2014

Mitochondrial Dysfunction in Aging and Longevity: A Causal or Protective Role? ⬇️

artículo científico publicado el 12 de noviembre de 2012

Mitochondrial stress signaling in longevity: a new role for mitochondrial function in aging

artículo científico publicado en 2014

MnSOD deficiency has a differential effect on disease progression in two different ALS mutant mouse models

artículo científico publicado en 2008

MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging

artículo científico publicado en 2011

MnSOD overexpression reduces fibrosis and pro-apoptotic signaling in the aging mouse heart

artículo científico publicado en 2014

Moderate modulation of disease in the G93A model of ALS by the compound 2-(2-hydroxyphenyl)-benzoxazole (HBX).

artículo científico publicado en 2016

Modulation of Lon protease activity and aconitase turnover during aging and oxidative stress.

artículo científico publicado en 2002

Molecular changes associated with spinal cord aging

artículo científico publicado en 2020

Molecular events in matrix protein metabolism in the aging kidney

artículo científico publicado en 2012

Mouse Models of Oxidative Stress Indicate a Role for Modulating Healthy Aging

artículo científico publicado en 2012

Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress

scientific journal article

Muscle fiber type diversification during exercise and regeneration

artículo científico publicado en 2016

Muscle mitochondrial catalase expression prevents neuromuscular junction disruption, atrophy, and weakness in a mouse model of accelerated sarcopenia

scientific article published on 24 September 2021

Neuron-specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice

artículo científico publicado en 2020

Neuron-specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD-knockout mice

artículo científico publicado en 2013

Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass

artículo científico publicado en 2018

Overexpression of Mn superoxide dismutase does not increase life span in mice

artículo científico publicado en 2009

Overexpression of antioxidant enzymes in diaphragm muscle does not alter contraction-induced fatigue or recovery

artículo científico publicado en 2009

Overexpression of human SOD1 improves survival of mice susceptible to endotoxic shock ⬇️

artículo científico publicado el 24 de julio de 2012

Oxidative damage associated with obesity is prevented by overexpression of CuZn- or Mn-superoxide dismutase

artículo científico publicado en 2013

Oxidative damage to DNA and aging

artículo científico publicado en 2003

Oxidative stress and diabetes: What can we learn about insulin resistance from antioxidant mutant mouse models? ⬇️

artículo científico publicado el 20 de octubre de 2011

Processing of data generated by 2-dimensional gel electrophoresis for statistical analysis: missing data, normalization, and statistics

artículo científico publicado en 2004

Prolonged ethanol administration depletes mitochondrial DNA in MnSOD-overexpressing transgenic mice, but not in their wild type littermates

artículo científico publicado en 2008

Protein imbalance in the development of skeletal muscle wasting in tumour-bearing mice

article

Protein misfolding, mitochondrial dysfunction and muscle loss are not directly dependent on soluble and aggregation state of mSOD1 protein in skeletal muscle of ALS ⬇️

artículo científico publicado el 3 de enero de 2012

Raising the antioxidant levels within mouse muscle fibres does not affect contraction-induced injury

artículo científico publicado en 2006

Rapamycin Modulates Markers of Mitochondrial Biogenesis and Fatty Acid Oxidation in the Adipose Tissue of db/db Mice ⬇️

artículo científico publicado el 1 de junio de 2013

Reactive Oxygen Species Differentially Regulate Bone Turnover in an Age-Specific Manner in Catalase Transgenic Female Mice

artículo científico publicado en 2016

Reduced coupling of oxidative phosphorylation in vivo precedes electron transport chain defects due to mild oxidative stress in mice

artículo científico publicado en 2011

Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts ⬇️

artículo científico publicado el 30 de julio de 2013

Reduced mitochondrial ROS, enhanced antioxidant defense, and distinct age-related changes in oxidative damage in muscles of long-lived Peromyscus leucopus ⬇️

artículo científico publicado el 16 de enero de 2013

Reduction in Reactive Oxygen Species Production by Mitochondria From Elderly Subjects With Normal and Impaired Glucose Tolerance ⬇️

artículo científico publicado el 15 de junio de 2011

Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis

artículo científico publicado en 2007

Reduction of glucose intolerance with high fat feeding is associated with anti-inflammatory effects of thioredoxin 1 overexpression in mice ⬇️

artículo científico publicado el 17 de mayo de 2012

Reduction of mitochondrial H2O2 by overexpressing peroxiredoxin 3 improves glucose tolerance in mice

artículo científico publicado en 2008

Role of superoxide-nitric oxide interactions in the accelerated age-related loss of muscle mass in mice lacking Cu,Zn superoxide dismutase

artículo científico publicado en 2011

Sco2 deficient mice develop increased adiposity and insulin resistance

artículo científico publicado en 2017

Sod1 gene ablation in adult mice leads to physiological changes at the neuromuscular junction similar to changes that occur in old wild-type mice

artículo científico publicado en 2015

Sod2 overexpression preserves myoblast mitochondrial mass and function, but not muscle mass with aging

artículo científico publicado en 2009

Sustained NFκB inhibition improves insulin sensitivity but is detrimental to muscle health

artículo científico publicado en 2017

The age-related failure of adaptive responses to contractile activity in skeletal muscle is mimicked in young mice by deletion of Cu,Zn superoxide dismutase

artículo científico publicado en 2010

The effects of dietary restriction on oxidative stress in rodents ⬇️

artículo científico publicado el 4 de junio de 2013

The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging

artículo científico publicado en 2015

The in vivo gene expression signature of oxidative stress

artículo científico publicado en 2008

The lack of CuZnSOD leads to impaired neurotransmitter release, neuromuscular junction destabilization and reduced muscle strength in mice

artículo científico publicado en 2014

The mitochondrial theory of aging: insight from transgenic and knockout mouse models

artículo científico publicado en 2009

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

artículo científico publicado en 2008

The role of insulin and insulin-like growth factor-I in mammalian ageing

artículo científico publicado en 2004

The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults

scientific journal article

Thioredoxin 1 Overexpression Extends Mainly the Earlier Part of Life Span in Mice ⬇️

artículo científico publicado el 26 de agosto de 2011

Thioredoxin 2 haploinsufficiency in mice results in impaired mitochondrial function and increased oxidative stress

artículo científico publicado en 2007

Transcriptional profiling of the age-related response to genotoxic stress points to differential DNA damage response with age.

artículo científico publicado en 2009

Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis

artículo científico publicado en 2004

Trends in oxidative aging theories

artículo científico publicado en 2007

Use of Nerve Conduction Velocity to Assess Peripheral Nerve Health in Aging Mice

artículo científico publicado en 2014

p53 Regulates Oxidative Stress-Mediated Retrograde Signaling: A Novel Mechanism for Chemotherapy-Induced Cardiac Injury ⬇️

artículo científico publicado el 30 de marzo de 2011

Lista de obras de

A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC).

A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1-/- mice is correlated to increased cellular senescence

A novel approach for screening the proteome for changes in protein conformation

A strategy for the ubiquitous overexpression of human catalase and CuZn superoxide dismutase genes in transgenic mice

Ablation of the mitochondrial complex IV assembly protein Surf1 leads to increased expression of the UPR(MT) and increased resistance to oxidative stress in primary cultures of fibroblasts

Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy

Absence of insulin signalling in skeletal muscle is associated with reduced muscle mass and function: evidence for decreased protein synthesis and not increased degradation

Accelerated sarcopenia in Cu/Zn superoxide dismutase knockout mice

Age-associated alterations of the neuromuscular junction ⬇️

Age-dependent increases in interstitial collagenase and MAP Kinase levels are exacerbated by superoxide dismutase deficiencies

Age-related cardiac muscle sarcopenia: Combining experimental and mathematical modeling to identify mechanisms

Age-related cataract progression in five mouse models for anti-oxidant protection or hormonal influence

Age-related loss of the DNA repair response following exposure to oxidative stress

Butyrate prevents muscle atrophy after sciatic nerve crush

Catalase transgenic mice: characterization and sensitivity to oxidative stress

Comparative proteomics: characterization of a two-dimensional gel electrophoresis system to study the effect of aging on mitochondrial proteins

Comparative studies of oxidative stress and mitochondrial function in aging

Complex I generated, mitochondrial matrix-directed superoxide is released from the mitochondria through voltage dependent anion channels ⬇️

Complex III releases superoxide to both sides of the inner mitochondrial membrane

Complex IV-deficient Surf1(-/-) mice initiate mitochondrial stress responses

Continuous overexpression of thioredoxin 1 enhances cancer development and does not extend maximum lifespan in male C57BL/6 mice

CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life

CuZnSOD gene deletion targeted to skeletal muscle leads to loss of contractile force but does not cause muscle atrophy in adult mice

Current thoughts on the role of mitochondria and free radicals in the biology of aging

Decreased in vitro mitochondrial function is associated with enhanced brain metabolism, blood flow, and memory in Surf1-deficient mice

Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance

Denervation induces cytosolic phospholipase A2-mediated fatty acid hydroperoxide generation by muscle mitochondria

Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD.

Dietary restriction attenuates the accelerated aging phenotype of Sod1−/− mice ⬇️

Dietary restriction but not rapamycin extends disease onset and survival of the H46R/H48Q mouse model of ALS

Different death stimuli evoke apoptosis via multiple pathways in retinal pigment epithelial cells

Downregulation of Grb2 contributes to the insulin-sensitizing effect of calorie restriction

Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levels

Elevated protein carbonylation, and misfolding in sciatic nerve from db/db and Sod1(-/-) mice: plausible link between oxidative stress and demyelination

Embryonic fibroblasts from Gpx4+/- mice: a novel model for studying the role of membrane peroxidation in biological processes

Emerging roles for histone deacetylases in age-related muscle atrophy

Formation of 3-nitrotyrosines in carbonic anhydrase III is a sensitive marker of oxidative stress in skeletal muscle

GAPDH is conformationally and functionally altered in association with oxidative stress in mouse models of amyotrophic lateral sclerosis

Genetic ablation of 12/15-lipoxygenase but not 5-lipoxygenase protects against denervation-induced muscle atrophy

Genetic disruption of SOD1 gene causes glucose intolerance and impairs β-cell function

Glutathione peroxidase 4 differentially regulates the release of apoptogenic proteins from mitochondria

Glutathione peroxidase 4 protects cortical neurons from oxidative injury and amyloid toxicity

Glutathione-peroxidase-1 null muscle progenitor cells are globally defective

Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain ⬇️

High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates

Immune cell Toll-like receptor 4 is required for cardiac myocyte impairment during endotoxemia

Increased mitochondrial matrix-directed superoxide production by fatty acid hydroperoxides in skeletal muscle mitochondria ⬇️

Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration

Insulin resistance is a cellular antioxidant defense mechanism

Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes

Is the oxidative stress theory of aging dead?

Isocitrate dehydrogenase 1 is downregulated during early skin tumorigenesis which can be inhibited by overexpression of manganese superoxide dismutase ⬇️

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice

Lifespan extension in genetically modified mice

Liver specific expression of Cu/ZnSOD extends the lifespan of Sod1 null mice

Loss of manganese superoxide dismutase leads to abnormal growth and signal transduction in mouse embryonic fibroblasts

Loss of the antioxidant enzyme CuZnSOD (Sod1) mimics an age-related increase in absolute mitochondrial DNA copy number in the skeletal muscle

Metabolic and Stress Response Changes Precede Disease Onset in the Spinal Cord of Mutant SOD1 ALS Mice.

Methionine oxidation and aging

Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity

Microwave & Magnetic (M2) Proteomics of a Mouse Model of Mild Traumatic Brain Injury

Mitochondrial Dysfunction in Aging and Longevity: A Causal or Protective Role? ⬇️

Mitochondrial stress signaling in longevity: a new role for mitochondrial function in aging

MnSOD deficiency has a differential effect on disease progression in two different ALS mutant mouse models

MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging

MnSOD overexpression reduces fibrosis and pro-apoptotic signaling in the aging mouse heart

Moderate modulation of disease in the G93A model of ALS by the compound 2-(2-hydroxyphenyl)-benzoxazole (HBX).

Modulation of Lon protease activity and aconitase turnover during aging and oxidative stress.

Molecular changes associated with spinal cord aging

Molecular events in matrix protein metabolism in the aging kidney

Mouse Models of Oxidative Stress Indicate a Role for Modulating Healthy Aging

Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress

Muscle fiber type diversification during exercise and regeneration

Muscle mitochondrial catalase expression prevents neuromuscular junction disruption, atrophy, and weakness in a mouse model of accelerated sarcopenia

Neuron-specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice

Neuron-specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD-knockout mice

Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass

Overexpression of Mn superoxide dismutase does not increase life span in mice