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2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization.

artículo científico publicado en 2018

A derivative of Mycobacterium smegmatis mc(2)155 that lacks the duplicated chromosomal region

artículo científico publicado en 2005

A pseudokinase debut at the mycobacterial cell wall

artículo científico

A riboswitch regulates expression of the coenzyme B12-independent methionine synthase in Mycobacterium tuberculosis: implications for differential methionine synthase function in strains H37Rv and CDC1551.

artículo científico publicado en 2007

A vitamin B₁₂ transporter in Mycobacterium tuberculosis

artículo científico publicado en 2013

Addressing Latent Tuberculosis: New Advances in Mimicking the Disease, Discovering Key Targets, and Designing Hit Compounds

artículo científico publicado en 2020

Aminopyrazolo[1,5-a]pyrimidines as potential inhibitors of Mycobacterium tuberculosis: Structure activity relationships and ADME characterization

artículo científico publicado en 2015

Antimicrobial activity of organometallic isonicotinyl and pyrazinyl ferrocenyl-derived complexes

artículo científico publicado en 2017

Antiplasmodial and antimycobacterial activities of crude and lead-like enhanced extracts from Namibian medicinal plants

artículo científico publicado en 2022

Approaches to target identification and validation for tuberculosis drug discovery: a UCT perspective.

artículo científico

Arrayed CRISPRi and quantitative imaging describe the morphotypic landscape of essential mycobacterial genes

artículo científico publicado en 2020

Azaaurones as Potent Antimycobacterial Agents Active against MDR- and XDR-TB

scientific article published on 25 July 2019

Beyond the lab: Eh!woza and knowing tuberculosis

scholarly article by Bianca Masuku et al published December 2018 in Medical Humanities

Bioisosteric ferrocenyl aminoquinoline-benzimidazole hybrids: Antimicrobial evaluation and mechanistic insights

scientific article published on 26 June 2019

Bioluminescent Reporters for Rapid Mechanism of Action Assessment in Tuberculosis Drug Discovery

artículo científico publicado en 2016

Cell Wall Proteomics Reveal Phenotypic Adaption of Drug-Resistant <i>Mycobacterium smegmatis</i> to Subinhibitory Rifampicin Exposure

artículo científico publicado en 2021

Cinnamoyl-Oxaborole Amides: Synthesis and Their in Vitro Biological Activity

artículo científico publicado en 2018

Complex genetics of drug resistance in Mycobacterium tuberculosis.

artículo científico publicado en 2013

Corrigendum to “Aminopyrazolo[1,5-a]pyrimidines as potential inhibitors of Mycobacterium tuberculosis: Structure activity relationships and ADME characterization” [Bioorg. Med. Chem. 23 (2015) 7240–7250]

scholarly article by Candice Soares de Melo et al published January 2016 in Bioorganic & Medicinal Chemistry

DNA Replication Fidelity in the Mycobacterium tuberculosis Complex

artículo científico publicado en 2017

DNA Replication in Mycobacterium tuberculosis

artículo científico publicado en 2017

DNA metabolism in mycobacterial pathogenesis

artículo científico

DNA-Dependent Binding of Nargenicin to DnaE1 Inhibits Replication in <i>Mycobacterium tuberculosis</i>

artículo científico publicado en 2022

Death of Mycobacterium tuberculosis by L-arginine starvation

article published in the Proceedings of the National Academy of Sciences of the United States of America

Defining a diagnostic gene signature for tuberculosis

artículo científico publicado en 2016

Design, Synthesis, and Evaluation of Novel Hybrid Efflux Pump Inhibitors for Use against Mycobacterium tuberculosis

artículo científico publicado en 2016

Design, synthesis, and antimycobacterial activity of novel ciprofloxacin derivatives

scientific article published on 17 June 2019

Detection and treatment of subclinical tuberculosis

article

Detection of Mycobacterium tuberculosis bacilli in bio-aerosols from untreated TB patients

scholarly article by Benjamin Patterson et al published 8 June 2018 in Gates Open Research

Detection of bacilli in bio-aerosols from untreated TB patients

Detection, survival and infectious potential of Mycobacterium tuberculosis in the environment: a review of the evidence and epidemiological implications

scientific article published on 27 June 2019

Diversity and disease pathogenesis in Mycobacterium tuberculosis

artículo científico publicado en 2014

Drug permeation and metabolism in Mycobacterium tuberculosis: Prioritising local exposure as essential criterion in new TB drug development

scientific article published on 22 June 2018

Editorial overview: Tuberculosis, malaria and schistosomiasis; understanding resistance and development of new drugs

scientific article published on 24 September 2018

Environmental air sampling for detection and quantification of <i>Mycobacterium tuberculosis</i> in clinical settings: Proof of concept

artículo científico publicado en 2022

Essential roles for imuA'- and imuB-encoded accessory factors in DnaE2-dependent mutagenesis in Mycobacterium tuberculosis

scientific journal article

Expanding the anti-TB arsenal

artículo científico publicado en 2019

Flow cytometry method for absolute counting and single-cell phenotyping of mycobacteria

artículo científico publicado en 2021

Function and regulation of class I ribonucleotide reductase-encoding genes in mycobacteria

scientific journal article

Functional characterization of a vitamin B12-dependent methylmalonyl pathway in Mycobacterium tuberculosis: implications for propionate metabolism during growth on fatty acids

scientific journal article

Genome-Wide Transposon Mutagenesis in Mycobacterium tuberculosis and Mycobacterium smegmatis.

artículo científico publicado en 2017

IS1096-mediated DNA rearrangements play a key role in genome evolution of Mycobacterium smegmatis

Identification of Antimycobacterial Natural Products from a Library of Marine Invertebrate Extracts

artículo científico publicado en 2022

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria

artículo científico publicado en 2016

In Vitro Efficacies, ADME, and Pharmacokinetic Properties of Phenoxazine Derivatives Active against Mycobacterium tuberculosis

scientific article published on 22 October 2019

Isolation and characterization of new phenolic siderophores with antimicrobial properties from <i>Pseudomonas</i> sp. UIAU-6B

artículo científico publicado en 2021

Making ends meet in mycobacteria ⬇️

artículo científico publicado el 24 de noviembre de 2010

Mono- and polynuclear ferrocenylthiosemicarbazones: Synthesis, characterisation and antimicrobial evaluation

Mutation rate and the emergence of drug resistance in Mycobacterium tuberculosis.

artículo científico

Mycobacterial genetics in target validation.

artículo científico publicado en 2004

Mycobacterium tuberculosis metabolism

artículo científico publicado en 2014

New Quinolone-Based Thiosemicarbazones Showing Activity Against Plasmodium falciparum and Mycobacterium tuberculosis ⬇️

scientific article published on 04 May 2019

Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure-Activity Relationship and Target Identification Studies.

artículo científico publicado en 2017

Novel South African Rare Actinomycete Kribbella speibonae Strain SK5: A Prolific Producer of Hydroxamate Siderophores Including New Dehydroxylated Congeners

artículo científico publicado en 2020

Nucleotide Metabolism and DNA Replication

artículo científico

Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery

artículo científico publicado en 2014

Proteomic comparison of three clinical diarrhoeagenic drug-resistant Escherichia coli isolates grown on CHROMagar™STEC media

artículo científico publicado en 2017

Pyrrolo[3,4-c]pyridine-1,3(2H)-diones: A Novel Antimycobacterial Class Targeting Mycobacterial Respiration

artículo científico publicado en 2015

Quinolone-isoniazid hybrids: synthesis and preliminary in vitro cytotoxicity and anti-tuberculosis evaluation

artículo científico publicado en 2019

Real-Time Investigation of Tuberculosis Transmission: Developing the Respiratory Aerosol Sampling Chamber (RASC)

artículo científico publicado en 2016

Ribonucleotide Reduction in Mycobacterium tuberculosis : Function and Expression of Genes Encoding Class Ib and Class II Ribonucleotide Reductases ⬇️

artículo científico publicado el 1 de noviembre de 2003

Role of the DinB homologs Rv1537 and Rv3056 in Mycobacterium tuberculosis

artículo científico publicado en 2010

Shortening treatment for tuberculosis--to basics

artículo científico publicado en 2014

Single-step synthesis and in vitro anti-mycobacterial activity of novel nitrofurantoin analogues

artículo científico publicado en 2020

Susceptibility of Mycobacterium tuberculosis cytochrome bd oxidase mutants to compounds targeting the terminal respiratory oxidase, cytochrome c.

artículo científico publicado en 2017

Synthesis and antiplasmodial and antimycobacterial evaluation of new nitroimidazole and nitroimidazooxazine derivatives

artículo científico publicado en 2012

Synthesis and biological evaluation of 2-aminothiazole derivatives as antimycobacterial and antiplasmodial agents

artículo científico publicado en 2013

Synthesis and biological evaluation of 2-chloro-3-[(thiazol-2-yl)amino]-1,4-naphthoquinones

scientific article published on 03 May 2019

Synthesis and synergistic antimycobacterial screening of chlorpromazine and its metabolites

Synthesis of new verapamil analogues and their evaluation in combination with rifampicin against Mycobacterium tuberculosis and molecular docking studies in the binding site of efflux protein Rv1258c

artículo científico publicado en 2014

Synthesis, Characterization, and Pharmacological Evaluation of Silicon-Containing Aminoquinoline Organometallic Complexes As Antiplasmodial, Antitumor, and Antimycobacterial Agents

scholarly article by Yiqun Li et al published 31 December 2012 in Organometallics

Synthesis, characterization and antimicrobial evaluation of mono- and polynuclear ferrocenyl-derived amino and imino complexes

Targeted gene knockout and essentiality testing by homologous recombination

artículo científico publicado en 2015

Targeting DNA Replication and Repair for the Development of Novel Therapeutics against Tuberculosis

artículo científico publicado en 2017

The Influence of HIV on the Evolution of Mycobacterium tuberculosis

artículo científico publicado en 2017

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis

artículo científico publicado en 2016

The complex mechanism of antimycobacterial action of 5-fluorouracil

artículo científico publicado en 2014

The impact of drug resistance on Mycobacterium tuberculosis physiology: what can we learn from rifampicin?

artículo científico publicado en 2014

Translating genomics research into control of tuberculosis: lessons learned and future prospects

artículo científico publicado en 2014

Tuberculosis chemotherapy: the influence of bacillary stress and damage response pathways on drug efficacy

artículo científico publicado en 2006

Versatility of 7-Substituted Coumarin Molecules as Antimycobacterial Agents, Neuronal Enzyme Inhibitors and Neuroprotective Agents.

artículo científico publicado en 2017

Vitamin B(12) metabolism in Mycobacterium tuberculosis

artículo científico publicado en 2013

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