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Aerobic sn-glycerol-3-phosphate dehydrogenase from Escherichia coli binds to the cytoplasmic membrane through an amphipathic alpha-helix

artículo científico publicado en 2002

Combining Nonclinical Experiments with Translational PKPD Modeling to Differentiate Erlotinib and Gefitinib.

artículo científico publicado en 2016

Developing Exposure/Response Models for Anticancer Drug Treatment: Special Considerations

artículo científico

First-in-human phase I clinical trial of RG7356, an anti-CD44 humanized antibody, in patients with advanced, CD44-expressing solid tumors.

artículo científico publicado en 2016

Influence of molecular size on tissue distribution of antibody fragments

artículo científico publicado en 2015

Model-based assessment of erlotinib effect in vitro measured by real-time cell analysis.

artículo científico publicado en 2015

No dose adjustment on coadministration of the PDE4 inhibitor roflumilast with a weak CYP3A, CYP1A2, and CYP2C19 inhibitor: an investigation using cimetidine

artículo científico publicado en 2010

PKPD modeling of acquired resistance to anti-cancer drug treatment.

artículo científico publicado en 2017

Preclinical optimization of MDM2 antagonist scheduling for cancer treatment by using a model-based approach

artículo científico publicado en 2014

Predicting In Vivo Efficacy from In Vitro Data: Quantitative Systems Pharmacology Modeling for an Epigenetic Modifier Drug in Cancer

scientific article published on 16 January 2020

Predicting tumor killing and T-cell activation by T-Cell Bispecific antibodies as a function of target expression: combining in vitro experiments with systems modeling

scientific article published on 09 December 2020

Recent developments in using mechanistic cardiac modelling for drug safety evaluation

artículo científico publicado en 2016

Translational PK/PD modeling to increase probability of success in drug discovery and early development

artículo científico publicado en 2016

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