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1543. Ceftaroline Model-based Dose Individualization in an Infant with Kidney Disease and Mediastinitis

A Pharmacokinetic and Pharmacodynamic Study of Maraviroc as Acute Graft-versus-Host Disease Prophylaxis in Pediatric Allogeneic Stem Cell Transplant Recipients with Nonmalignant Diagnoses.

artículo científico publicado en 2016

A Prospective Study of Alemtuzumab as a Second-Line Agent for Steroid-Refractory Acute Graft-versus-Host Disease in Pediatric and Young Adult Allogeneic Hematopoietic Stem Cell Transplantation.

artículo científico publicado en 2016

A Theoretical Physiologically-Based Pharmacokinetic Approach to Ascertain Covariates Explaining the Large Interpatient Variability in Tacrolimus Disposition

artículo científico publicado en 2019

ABCC3 and OCT1 genotypes influence pharmacokinetics of morphine in children

artículo científico publicado en 2014

ABCC3 genetic variants are associated with postoperative morphine-induced respiratory depression and morphine pharmacokinetics in children

artículo científico publicado en 2016

Acute Kidney Injury Biomarkers Predict an Increase in Serum Milrinone Concentration Earlier Than Serum Creatinine-Defined Acute Kidney Injury in Infants After Cardiac Surgery

artículo científico publicado en 2018

Age-dependent changes in sirolimus metabolite formation in patients with neurofibromatosis type 1.

artículo científico publicado en 2015

Alternate-day micafungin antifungal prophylaxis in pediatric patients undergoing hematopoietic stem cell transplantation: a pharmacokinetic study.

artículo científico publicado en 2010

An integrated population pharmacokinetic meta-analysis of propofol in morbidly obese and nonobese adults, adolescents, and children.

artículo científico publicado en 2013

Assessment of tacrolimus intrapatient variability in stable adherent transplant recipients: Establishing baseline values

artículo científico publicado en 2018

Better medicines for 300 million children in China: report on recent progress.

artículo científico publicado en 2011

Bioequivalence between innovator and generic tacrolimus in liver and kidney transplant recipients: A randomized, crossover clinical trial

artículo científico publicado en 2017

Busulfan Pharmacokinetics and Precision Dosing: Are Patients with Fanconi Anemia Different?

scientific article published on 18 July 2019

CYP2D6 pharmacogenetic and oxycodone pharmacokinetic association study in pediatric surgical patients

artículo científico publicado en 2017

Characteristics of Successful Recruitment in Prospective Pediatric Pharmacogenetic Studies ⬇️

artículo científico publicado el 2 de diciembre de 2011

Characterization of Contributing Factors to Variability in Morphine Clearance Through PBPK Modeling Implemented With OCT1 Transporter.

artículo científico publicado en 2016

Characterizing the Developmental Trajectory of Sirolimus Clearance in Neonates and Infants

artículo científico publicado en 2016

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing.

artículo científico publicado en 2015

Clinical Pharmacokinetics and Pharmacodynamics of Biologic Therapeutics for Treatment of Systemic Lupus Erythematosus

artículo científico publicado en 2016

Clinical Trial Simulations and Pharmacometric Analysis in Pediatrics: Application to Inhaled Loxapine in Children and Adolescents

artículo científico publicado en 2017

Clinical implementation of pharmacogenetics and model-informed precision dosing to improve patient care

artículo científico publicado en 2020

Clinical trial simulations in pediatric patients using realistic covariates: application to teduglutide, a glucagon-like peptide-2 analog in neonates and infants with short-bowel syndrome

artículo científico publicado en 2009

Coma due to an overdose of valnoctamide

artículo científico publicado el 18 de abril de 1992

Concentration-effect relationship of ceftazidime explains why the time above the MIC is 40 percent for a static effect in vivo.

artículo científico publicado en 2007

Continuous infusion of beta-lactams.

artículo científico publicado en 2007

Continuous infusion of ceftazidime in cystic fibrosis patients during home treatment: clinical outcome, microbiology and pharmacokinetics ⬇️

artículo científico publicado el 1 de julio de 1997

Cost-effectiveness of therapeutic drug monitoring: a systematic review.

artículo científico publicado en 2005

Current management of neonatal abstinence syndrome secondary to intrauterine opioid exposure

artículo científico publicado en 2014

Delayed methotrexate clearance in patients with acute lymphoblastic leukemia concurrently receiving dasatinib

scientific article published on 24 January 2019

Design and anticipated outcomes of the eMERGE-PGx project: a multicenter pilot for preemptive pharmacogenomics in electronic health record systems

artículo científico publicado en 2014

Determination of risperidone and enantiomers of 9-hydroxyrisperidone in plasma by LC-MS/MS.

artículo científico publicado en 2007

Development and Implementation of Electronic Health Record-Integrated Model-Informed Clinical Decision Support Tools for the Precision Dosing of Drugs

scientific article published on 16 October 2019

Development of a Pediatric Physiologically Based Pharmacokinetic Model for Sirolimus: Applying Principles of Growth and Maturation in Neonates and Infants.

artículo científico publicado en 2015

Development of a Physiologically-Based Pharmacokinetic Model for Sirolimus: Predicting Bioavailability Based on Intestinal CYP3A Content.

artículo científico publicado en 2013

Development of a pharmacokinetic-guided dose individualization strategy for hydroxyurea treatment in children with sickle cell anaemia

artículo científico publicado en 2015

Development of an optimal sampling strategy for clinical pharmacokinetic studies of the novel anthracycline disaccharide analogue MEN-10755.

artículo científico publicado en 2004

Development of population PK model with enterohepatic circulation for mycophenolic acid in patients with childhood-onset systemic lupus erythematosus.

artículo científico publicado en 2012

Developmental Changes in Hepatic Organic Cation Transporter OCT1 Protein Expression from Neonates to Children.

artículo científico publicado en 2016

Developmental Pharmacokinetics and Age-Appropriate Dosing Design of Milrinone in Neonates and Infants with Acute Kidney Injury Following Cardiac Surgery

scientific article published on 01 June 2019

Developmental changes in morphine clearance across the entire paediatric age range are best described by a bodyweight-dependent exponent model.

artículo científico publicado en 2013

Developmental pharmacokinetics of sirolimus: Implications for precision dosing in neonates and infants with complicated vascular anomalies.

artículo científico publicado en 2017

Developmental trajectory of intestinal MDR1/ABCB1 mRNA expression in children

artículo científico publicado en 2014

Do not give paraffin to packers.

artículo científico publicado en 1998

Does intranasal dexmedetomidine provide adequate plasma concentrations for sedation in children: a pharmacokinetic study

artículo científico publicado en 2018

Dose modifications and pharmacokinetics of adjuvant cisplatin monotherapy while on hemodialysis for patients with hepatoblastoma

artículo científico publicado en 2018

Dose optimisation of antibiotics in children: application of pharmacokinetics/pharmacodynamics in paediatrics

artículo científico publicado en 2014

Drug Dosing in Obese Children: Challenges and Evidence-Based Strategies

artículo científico publicado en 2017

Drug-metabolizing enzyme genotypes and aggressive behavior treatment response in hospitalized pediatric psychiatric patients.

artículo científico publicado en 2009

Eculizumab therapy in children with severe hematopoietic stem cell transplantation-associated thrombotic microangiopathy.

artículo científico publicado en 2013

Effects of unbound mycophenolic acid on inosine monophosphate dehydrogenase inhibition in pediatric kidney transplant patients

artículo científico publicado en 2014

Efficacy and Safety of Sirolimus in the Treatment of Complicated Vascular Anomalies

artículo científico publicado en 2016

Electronic Health Record-Embedded Decision Support Platform for Morphine Precision Dosing in Neonates

scientific article published on 16 October 2019

Evaluation of Clinical and Safety Outcomes Following Uncontrolled Tacrolimus Conversion in Adult Transplant Recipients

scientific article published on 15 April 2019

Evaluation of Target Attainment of Vancomycin Area Under the Curve in Children With Methicillin-Resistant Staphylococcus Aureus Bacteremia

artículo científico publicado en 2015

Evaluation of propofol anesthesia in morbidly obese children and adolescents ⬇️

artículo científico publicado el 21 de abril de 2013

Evidence of a clinically significant drug-drug interaction between cannabidiol and tacrolimus

scientific article published on 21 May 2019

Fatty acid amide hydrolase-morphine interaction influences ventilatory response to hypercapnia and postoperative opioid outcomes in children.

artículo científico publicado en 2016

Federal legislation and the advancement of neonatal drug studies

artículo científico publicado en 2012

From Molecule to Patient and Ways to Get the Dose Precisely Right

scientific article published on 01 March 2019

Genotype-Directed Dosing Leads to Optimized Voriconazole Levels in Pediatric Patients Receiving Hematopoietic Stem Cell Transplantation.

artículo científico publicado en 2015

Hydroxyurea Pharmacokinetics in Pediatric Patients After Total Pancreatectomy With Islet Autotransplantation

artículo científico publicado en 2020

Implementation of Pharmacogenetics at Cincinnati Children's Hospital Medical Center: Lessons Learned Over 14 Years of Personalizing Medicine

scientific article published on 29 July 2018

Important role of population pharmacokinetic/pharmacodynamic modeling in pediatric therapeutics

scientific article published on 20 July 2011

Improved Population Pharmacokinetic Model for Predicting Optimized Infliximab Exposure in Pediatric Inflammatory Bowel Disease

scientific article published on 01 February 2020

Increased Vancomycin Exposure and Nephrotoxicity in Children: Therapeutic Does Not Mean Safe

artículo científico publicado en 2014

Individually Tailored Immunosuppression: Is There a Role for Biomarkers?

scientific article published on 12 January 2011

Influence of OCT1 ontogeny and genetic variation on morphine disposition in critically ill neonates: lessons from PBPK modeling and clinical study

artículo científico publicado en 2018

Inosine monophosphate dehydrogenase (IMPDH) activity as a pharmacodynamic biomarker of mycophenolic acid effects in pediatric kidney transplant recipients.

artículo científico publicado en 2010

Intermediate term thrombotic risk in contemporary total cavo-pulmonary connection for single ventricle circulations.

artículo científico publicado en 2017

Learning Health Systems as Facilitators of Precision Medicine.

artículo científico publicado en 2016

Letter: stool adalimumab detection in ulcerative colitis and Crohn's disease--authors' reply

artículo científico publicado en 2015

Longitudinal comparison of thyroxine pharmacokinetics between pregnant and nonpregnant women: a stable isotope study.

artículo científico publicado en 2010

Lower vancomycin serum trough concentrations might not be the answer.

artículo científico publicado en 2013

Measuring Medication Adherence in Pediatric Cancer: An Approach to Validation.

artículo científico publicado en 2016

Meropenem in children receiving continuous renal replacement therapy: clinical trial simulations using realistic covariates

artículo científico publicado en 2014

Micafungin antifungal prophylaxis in children undergoing HSCT: can we give higher doses, less frequently? A pharmacokinetic study

scientific article published on 01 June 2018

Milrinone Dosing Issues in Critically Ill Children With Kidney Injury: A Review.

artículo científico

Model-based dosing with concentration feedback as an integral part of personalized hydroxycarbamide management

artículo científico publicado en 2018

Model-based precision dosing of sirolimus in pediatric patients with vascular anomalies.

artículo científico publicado en 2017

Modeling and simulation in pediatric drug therapy: Application of pharmacometrics to define the right dose for children

artículo científico

Monitoring of inosine monophosphate dehydrogenase activity as a biomarker for mycophenolic acid effect: potential clinical implications.

artículo científico publicado en 2007

Morphine clearance in children: does race or genetics matter?

artículo científico publicado en 2012

Mycophenolate mofetil-related leukopenia in children and young adults following kidney transplantation: Influence of genes and drugs

artículo científico publicado en 2017

Mycophenolate, clinical pharmacokinetics, formulations, and methods for assessing drug exposure.

artículo científico publicado en 2010

NFM-06. NF106: PHASE 2 TRIAL OF THE MEK INHIBITOR PD-0325901 IN ADOLESCENTS AND ADULTS WITH NF1-RELATED PLEXIFORM NEUROFIBROMAS: AN NF CLINICAL TRIALS CONSORTIUM STUDY

Next Challenge From the Variance in Individual Physiologically-Based Pharmacokinetic Model-Predicted to Observed Morphine Concentration in Critically Ill Neonates

artículo científico publicado en 2019

Nonsteroidal Anti-Inflammatory Drugs May Reduce Enterohepatic Recirculation of Mycophenolic Acid in Patients With Childhood-Onset Systemic Lupus Erythematosus ⬇️

artículo científico publicado el 1 de octubre de 2011

OCT1 genetic variants are associated with postoperative morphine-related adverse effects in children

artículo científico publicado en 2017

OCT1 genetic variants influence the pharmacokinetics of morphine in children.

artículo científico publicado en 2013

Obesity and overweight as CAE comorbidities and differential drug response modifiers

artículo científico publicado en 2016

Opportunities for model-based precision dosing in the treatment of sickle cell anemia

artículo científico

Optimal study design for pioglitazone in septic pediatric patients ⬇️

artículo científico publicado el 11 de junio de 2011

Optimization of mycophenolic acid therapy using clinical pharmacometrics

artículo científico publicado en 2013

PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants

artículo científico publicado en 2018

Pediatric aspects of therapeutic drug monitoring of mycophenolic acid in renal transplantation ⬇️

artículo científico publicado el 30 de marzo de 2011

Personalizing Drug Selection Using Advanced Clinical Decision Support

artículo científico publicado en 2009

Pharmacogenetics and Anesthetic Drugs ⬇️

artículo científico publicado el 1 de mayo de 2012

Pharmacogenetics in perioperative medicine.

artículo científico

Pharmacokinetic and pharmacogenetic analysis of immunosuppressive agents after laparoscopic sleeve gastrectomy

artículo científico publicado en 2017

Pharmacokinetic modeling of therapies for systemic lupus erythematosus.

artículo científico

Pharmacokinetic modelling of intravenous tobramycin in adolescent and adult patients with cystic fibrosis using the nonparametric expectation maximization (NPEM) algorithm

artículo científico publicado el 1 de junio de 1997

Pharmacokinetic optimisation of antibacterial treatment in patients with cystic fibrosis. Current practice and suggestions for future directions.

artículo científico publicado en 1998

Pharmacokinetic/pharmacodynamic modelling of antibacterials in vitro and in vivo using bacterial growth and kill kinetics: the minimum inhibitory concentration versus stationary concentration.

artículo científico publicado en 2005

Pharmacokinetics and Safety of Single-Dose Inhaled Loxapine in Children and Adolescents.

artículo científico publicado en 2017

Pharmacokinetics and pharmacogenomics of β-lactam-induced neutropenia

artículo científico publicado en 2016

Pharmacokinetics of IGF-1 in PAPP-A2-Deficient Patients, Growth Response, and Effects on Glucose and Bone Density.

artículo científico publicado en 2017

Pharmacokinetics of Oral Methadone in the Treatment of Neonatal Abstinence Syndrome: A Pilot Study

artículo científico publicado en 2015

Pharmacokinetics of amantadine in children with impaired consciousness due to acquired brain injury: preliminary findings using a sparse-sampling technique.

artículo científico publicado en 2010

Pharmacokinetics of glycerol phenylbutyrate in pediatric patients 2 months to 2 years of age with urea cycle disorders

artículo científico publicado en 2018

Pharmacokinetics of levetiracetam in neonates with seizures

artículo científico publicado en 2011

Pharmacokinetics of meropenem in children receiving continuous renal replacement therapy: Validation of clinical trial simulations

artículo científico publicado en 2015

Pharmacokinetics of once-daily amikacin dosing in patients with cystic fibrosis ⬇️

artículo científico publicado el 1 de enero de 1998

Pharmacokinetics of prednisolone at steady state in young patients with systemic lupus erythematosus on prednisone therapy: an open-label, single-dose study.

artículo científico publicado en 2011

Pharmacokinetics of ranitidine in a homogeneous population of intensive care unit patients during intermittent and continuous administration

artículo científico publicado el 1 de enero de 1992

Phase 1 safety and pharmacokinetic study on the use of pioglitazone in critically ill patients with sepsis: a randomized clinical trial

scientific article published on 25 September 2018

Population Pharmacokinetics and Optimal Sampling Strategy for Model-Based Precision Dosing of Melphalan in Patients Undergoing Hematopoietic Stem Cell Transplantation

artículo científico publicado en 2017

Population Pharmacokinetics of Sirolimus in Pediatric Patients With Neurofibromatosis Type 1 ⬇️

artículo científico publicado el 1 de junio de 2013

Population pharmacokinetic analysis of nonlinear behavior of piperacillin during intermittent or continuous infusion in patients with cystic fibrosis.

artículo científico publicado en 2003

Population pharmacokinetic modeling of risperidone and 9-hydroxyrisperidone to estimate CYP2D6 subpopulations in children and adolescents.

artículo científico publicado en 2012

Population pharmacokinetic modelling of busulfan and the influence of body composition in paediatric Fanconi anaemia patients

scientific article published on 23 January 2020

Population pharmacokinetic-pharmacodynamic modeling and dosing simulation of propofol maintenance anesthesia in severely obese adolescents

artículo científico publicado en 2015

Population pharmacokinetic-pharmacodynamic modelling of mycophenolic acid in paediatric renal transplant recipients in the early post-transplant period

artículo científico publicado en 2014

Population pharmacokinetics of sirolimus in pediatric patients with neurofibromatosis type 1-Erratum

artículo científico publicado en 2016

Precision Medicine-Nobody Is Average.

artículo científico publicado en 2017

Pretransplant Absolute Lymphocyte Counts Impact the Pharmacokinetics of Alemtuzumab.

artículo científico publicado en 2017

Propofol Clearance in Morbidly Obese Children and Adolescents : Influence of Age and Body Size.

artículo científico publicado en 2012

Propofol Pharmacokinetics and Estimation of Fetal Propofol Exposure during Mid-Gestational Fetal Surgery: A Maternal-Fetal Sheep Model

artículo científico publicado en 2016

Quantification of the 5-lipoxygenase inhibitor zileuton in human plasma using high performance liquid chromatography-tandem mass spectrometry

artículo científico publicado en 2013

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS.

artículo científico publicado en 2015

Recommendations for the design of therapeutic trials for neonatal seizures

scientific article published on 24 December 2018

Relationship between minimum inhibitory concentration and stationary concentration revisited: growth rates and minimum bactericidal concentrations

artículo científico publicado en 2005

Retrospective Evaluation of Milrinone Pharmacokinetics in Children With Kidney Injury

artículo científico

Review article: applying pharmacokinetics to optimise dosing of anti-TNF biologics in acute severe ulcerative colitis

artículo científico publicado en 2015

Risk Assessment of Drug-Drug Interactions of Calcineurin Inhibitors Affecting Sirolimus Pharmacokinetics in Renal Transplant Patients

artículo científico publicado en 2016

Risk of tacrolimus toxicity in CYP3A5 nonexpressors treated with intravenous nicardipine after kidney transplantation

artículo científico publicado en 2012

Robust clinical and laboratory response to hydroxyurea using pharmacokinetically guided dosing for young children with sickle cell anemia

artículo científico publicado en 2019

Safety and Dose Escalation Study of Intravenous Zinc Supplementation in Pediatric Critical Illness.

artículo científico publicado en 2015

Significant effect of infection and food intake on sirolimus pharmacokinetics and exposure in pediatric patients with acute lymphoblastic leukemia

artículo científico publicado en 2018

Similar MPA exposure on modified release and regular tacrolimus

scientific article published on 01 June 2014

Sirolimus for non-progressive NF1-associated plexiform neurofibromas: an NF clinical trials consortium phase II study.

artículo científico publicado en 2014

Sirolimus for progressive neurofibromatosis type 1-associated plexiform neurofibromas: a neurofibromatosis Clinical Trials Consortium phase II study.

artículo científico publicado en 2014

Some international approaches to aminoglycoside monitoring in the extended dosing interval era.

artículo científico publicado en 1999

Suggestions for Model-Informed Precision Dosing to Optimize Neonatal Drug Therapy

scientific article published on 11 September 2018

Summary of the National Institute of Child Health and Human Development–Best Pharmaceuticals for Children Act Pediatric Formulation Initiatives Workshop–Pediatric Biopharmaceutics Classification System Working Group ⬇️

artículo científico publicado el 1 de noviembre de 2012

The application of population pharmacokinetic modeling to individualized antibiotic therapy.

artículo científico publicado en 2002

The effect of ABCG2 genotype on the population pharmacokinetics of sunitinib in patients with renal cell carcinoma.

artículo científico publicado en 2014

The evolution of population pharmacokinetic models to describe the enterohepatic recycling of mycophenolic acid in solid organ transplantation and autoimmune disease

artículo científico publicado en 2011

The future of physiologically based pharmacokinetic modeling to predict drug exposure in pregnant women.

artículo científico publicado en 2013

The impact of CYP3A5*3 polymorphism on sirolimus pharmacokinetics: insights from predictions with a physiologically-based pharmacokinetic model

artículo científico publicado en 2015

Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy: Second Consensus Report

scientific article published on 01 June 2019

Therapeutic Optimization as Part of the Precision Medicine Paradigm

artículo científico publicado en 2016

Time in therapeutic range as a marker for thrombotic and bleeding outcomes in Fontan patients.

artículo científico publicado en 2017

Trend in therapeutic monitoring of immunosuppressive drugs

scientific article published on 01 July 2007

UGT1A9, UGT2B7, and MRP2 genotypes can predict mycophenolic acid pharmacokinetic variability in pediatric kidney transplant recipients

artículo científico publicado en 2012

Update in fetal anesthesia for the ex utero intrapartum treatment (EXIT) procedure

scientific article published on January 2012

Urinary kidney injury biomarkers and tobramycin clearance among children and young adults with cystic fibrosis: a population pharmacokinetic analysis.

artículo científico publicado en 2016

Using a vancomycin PBPK model in special populations to elucidate case-based clinical PK observations

artículo científico publicado en 2018

Utilization of optimal study design for maternal and fetal sheep propofol pharmacokinetics study: a preliminary study

artículo científico publicado en 2014

Validation of a pediatric population pharmacokinetic model for vancomycin.

artículo científico publicado en 2015

Variable Eculizumab Clearance Requires Pharmacodynamic Monitoring to Optimize Therapy for Thrombotic Microangiopathy after Hematopoietic Stem Cell Transplantation.

artículo científico publicado en 2015

Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future.

artículo científico publicado en 2017

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