Lista de obras -

A cross-sectional study exploring levels of physical activity and motivators and barriers towards physical activity in haemodialysis patients to inform intervention development

scientific article published on 24 October 2019

Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice

scientific journal article

Academic postgraduate medical education -- an Oxford view.

artículo científico publicado en 2014

Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases

artículo científico publicado en 2015

Cerebral ischemia during hemodialysis-finding the signal in the noise.

artículo científico publicado en 2018

Characterisation of functional domains within the mouse erythropoietin 3' enhancer conveying oxygen-regulated responses in different cell lines

artículo científico publicado en 1994

Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression.

artículo científico publicado en 2012

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

artículo científico publicado en 2005

Detection of BK virus in urine from renal transplant subjects by mass spectrometry.

artículo científico publicado en 2012

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity

scientific journal article

Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism.

artículo científico publicado en 2010

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

artículo científico publicado en 2015

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.

artículo científico publicado en 2006

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq.

artículo científico publicado en 2011

Hypoxia and HIF pathway in cancer and the placenta.

artículo científico publicado en 2017

Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing.

artículo científico publicado en 2009

Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.

artículo científico publicado en 2013

Hypoxia-inducible factors: where, when and why?

artículo científico publicado en 2006

Imaging of haemodialysis-associated amyloidosis with 123I-serum amyloid P component

artículo científico publicado en 1991

Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice.

artículo científico publicado en 2004

Insights into the role of the von Hippel-Lindau gene product. A key player in hypoxic regulation

article

Interaction of hydroxylated collagen IV with the von hippel-lindau tumor suppressor.

artículo científico publicado en 2007

Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control

scientific article published on 23 March 2020

Modulation of the Hypoxic Response.

artículo científico publicado en 2016

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

artículo científico publicado en 2017

Mutation of the von Hippel-Lindau gene alters human cardiopulmonary physiology.

artículo científico publicado en 2008

Neuroprotection by dimethyloxalylglycine following permanent and transient focal cerebral ischemia in rats.

artículo científico publicado en 2010

New horizons in hypoxia signaling pathways

artículo científico publicado en 2017

Non-contact video-based vital sign monitoring using ambient light and auto-regressive models.

artículo científico publicado en 2014

Non-lymphoid cells from rat intestinal lymph

scientific article published on 01 January 1982

Oxygen sensing

scientific article published on 01 January 2005

Oxygen sensing in cancer

artículo científico publicado en 2003

Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha.

artículo científico publicado en 1999

PHD2 inactivation in Type I cells drives HIF-2α-dependent multilineage hyperplasia and the formation of paraganglioma-like carotid bodies

artículo científico publicado en 2018

Photoplethysmographic derivation of respiratory rate: a review of relevant physiology.

artículo científico publicado en 2011

Postdoctoral progression is needed for doctors taking up clinical academic careers

artículo científico publicado en 2015

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

artículo científico publicado en 2006

Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain

artículo científico publicado en 2015

Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses

artículo científico

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice

artículo científico publicado en 2011

Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.

artículo científico publicado en 2001

Regulation of growth differentiation factor 15 expression by intracellular iron.

artículo científico publicado en 2008

Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF-2 pathway

artículo científico

Relationship between Hypotension and Cerebral Ischemia during Hemodialysis

artículo científico publicado en 2017

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.

artículo científico publicado en 2016

Systemic silencing of PHD2 causes reversible immune regulatory dysfunction

scientific article published on 04 June 2019

Target gene selectivity of hypoxia-inducible factor-alpha in renal cancer cells is conveyed by post-DNA-binding mechanisms.

artículo científico publicado en 2007

Targeting tumors through the HIF system.

artículo científico publicado en 2000

The HIF pathway: implications for patterns of gene expression in cancer.

artículo científico publicado en 2001

The Oxford Renal (OxRen) cross-sectional study of chronic kidney disease in the UK.

artículo científico publicado en 2013

The VHL tumor suppressor inhibits expression of the IGF1R and its loss induces IGF1R upregulation in human clear cell renal carcinoma

artículo científico publicado en 2007

The clinical academic workforce of the future: a cross-sectional study of factors influencing career decision-making among clinical PhD students at two research-intensive UK universities

artículo científico

The impact of renin–angiotensin–aldosterone system inhibitors on Type 1 and Type 2 diabetic patients with and without early diabetic nephropathy

artículo científico publicado en 2011

The pVHL-hIF-1 system. A key mediator of oxygen homeostasis.

artículo científico publicado en 2001

The prolyl hydroxylase enzymes that act as oxygen sensors regulating destruction of hypoxia-inducible factor alpha

artículo científico publicado en 2004

The relationship between symptoms and blood pressure during maintenance hemodialysis

artículo científico publicado en 2015

The role of hypoxia-inducible factors in organ donation and transplantation: the current perspective and future opportunities

artículo científico publicado en 2014

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

artículo científico publicado en 1999

The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.

artículo científico publicado en 2003

Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases

artículo científico publicado en 2016

Use of novel monoclonal antibodies to determine the expression and distribution of the hypoxia regulatory factors PHD-1, PHD-2, PHD-3 and FIH in normal and neoplastic human tissues.

artículo científico publicado en 2005

Using an Integrated -Omics Approach to Identify Key Cellular Processes That Are Disturbed in the Kidney After Brain Death.

artículo científico publicado en 2015

What lies downstream: Cellular oxygen delivery during hemodialysis

scientific article published on 04 December 2018

Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.

artículo científico publicado en 2002

Lista de obras de

A cross-sectional study exploring levels of physical activity and motivators and barriers towards physical activity in haemodialysis patients to inform intervention development

Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice

Academic postgraduate medical education -- an Oxford view.

Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases

Cerebral ischemia during hemodialysis-finding the signal in the noise.

Characterisation of functional domains within the mouse erythropoietin 3' enhancer conveying oxygen-regulated responses in different cell lines

Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression.

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

Detection of BK virus in urine from renal transplant subjects by mass spectrometry.

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity

Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism.

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq.

Hypoxia and HIF pathway in cancer and the placenta.

Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing.

Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.

Hypoxia-inducible factors: where, when and why?

Imaging of haemodialysis-associated amyloidosis with 123I-serum amyloid P component

Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice.

Insights into the role of the von Hippel-Lindau gene product. A key player in hypoxic regulation

Interaction of hydroxylated collagen IV with the von hippel-lindau tumor suppressor.

Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control

Modulation of the Hypoxic Response.

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

Mutation of the von Hippel-Lindau gene alters human cardiopulmonary physiology.

Neuroprotection by dimethyloxalylglycine following permanent and transient focal cerebral ischemia in rats.

New horizons in hypoxia signaling pathways

Non-contact video-based vital sign monitoring using ambient light and auto-regressive models.

Non-lymphoid cells from rat intestinal lymph

Oxygen sensing

Oxygen sensing in cancer

Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha.

PHD2 inactivation in Type I cells drives HIF-2α-dependent multilineage hyperplasia and the formation of paraganglioma-like carotid bodies

Photoplethysmographic derivation of respiratory rate: a review of relevant physiology.

Postdoctoral progression is needed for doctors taking up clinical academic careers

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain

Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice

Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.

Regulation of growth differentiation factor 15 expression by intracellular iron.

Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF-2 pathway

Relationship between Hypotension and Cerebral Ischemia during Hemodialysis

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.

Systemic silencing of PHD2 causes reversible immune regulatory dysfunction

Target gene selectivity of hypoxia-inducible factor-alpha in renal cancer cells is conveyed by post-DNA-binding mechanisms.

Targeting tumors through the HIF system.

The HIF pathway: implications for patterns of gene expression in cancer.

The Oxford Renal (OxRen) cross-sectional study of chronic kidney disease in the UK.

The VHL tumor suppressor inhibits expression of the IGF1R and its loss induces IGF1R upregulation in human clear cell renal carcinoma

The clinical academic workforce of the future: a cross-sectional study of factors influencing career decision-making among clinical PhD students at two research-intensive UK universities

The impact of renin–angiotensin–aldosterone system inhibitors on Type 1 and Type 2 diabetic patients with and without early diabetic nephropathy

The pVHL-hIF-1 system. A key mediator of oxygen homeostasis.

The prolyl hydroxylase enzymes that act as oxygen sensors regulating destruction of hypoxia-inducible factor alpha

The relationship between symptoms and blood pressure during maintenance hemodialysis

The role of hypoxia-inducible factors in organ donation and transplantation: the current perspective and future opportunities

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.

Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases

Use of novel monoclonal antibodies to determine the expression and distribution of the hypoxia regulatory factors PHD-1, PHD-2, PHD-3 and FIH in normal and neoplastic human tissues.

Using an Integrated -Omics Approach to Identify Key Cellular Processes That Are Disturbed in the Kidney After Brain Death.

What lies downstream: Cellular oxygen delivery during hemodialysis

Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.