Lista de obras -

A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells ⬇️

artículo científico publicado el 13 de septiembre de 2010

A methotrexate insensitive variant of folate reductase present in two lines of methotrexate-resistant L5178Y cells ⬇️

artículo científico publicado el 1 de diciembre de 1980

A novel inhibitory effect of oxazol-5-one compounds on ROCKII signaling in human coronary artery vascular smooth muscle cells.

artículo científico publicado en 2016

Addition of carbonic anhydrase 9 inhibitor SLC-0111 to temozolomide treatment delays glioblastoma growth in vivo.

artículo científico publicado en 2017

Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells.

artículo científico publicado en 2005

Alterations in integrin receptor expression on chemically transformed human cells: specific enhancement of laminin and collagen receptor complexes ⬇️

artículo científico publicado el 1 de febrero de 1990

An essential role for the integrin-linked kinase-glycogen synthase kinase-3 beta pathway during dendrite initiation and growth

scientific journal article

Aortic aneurysm generation in mice with targeted deletion of integrin-linked kinase in vascular smooth muscle cells

artículo científico publicado en 2011

BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways ⬇️

artículo científico publicado en 2011

Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment

scientific article published on 14 October 2020

Carbonic anhydrase IX (CAIX) as a mediator of hypoxia-induced stress response in cancer cells.

artículo científico

Carbonic anhydrase IX promotes myeloid-derived suppressor cell mobilization and establishment of a metastatic niche by stimulating G-CSF production

artículo científico publicado en 2015

Carving out its niche: A role for carbonic anhydrase IX in pre-metastatic niche development.

artículo científico publicado en 2015

Cell adhesion and the integrin-linked kinase regulate the LEF-1 and β-catenin signaling pathways ⬇️

artículo científico publicado el 14 de abril de 1998

Combined inhibition of integrin linked kinase and FMS-like tyrosine kinase 3 is cytotoxic to acute myeloid leukemia progenitor cells.

artículo científico publicado en 2009

Combined inhibition of the phosphatidylinositol 3-kinase/Akt and Ras/mitogen-activated protein kinase pathways results in synergistic effects in glioblastoma cells.

artículo científico publicado en 2006

Coordinated Regulation of Metabolic Transporters and Migration/Invasion by Carbonic Anhydrase IX.

artículo científico publicado en 2018

Deep sequence analysis of gene expression identifies osteopontin as a downstream effector of integrin-linked kinase (ILK) in cardiac-specific ILK knockout mice

artículo científico publicado en 2013

Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX

artículo científico publicado en 2018

Divergence in patterns of invasion among subpopulations derived from a human carcinoma clone: roles of intercellular contacts and of cell-substratum adhesion

artículo científico publicado el 1 de enero de 1992

EXTH-44. ADDITION OF THE CARBONIC ANHYDRASE IX INHIBITOR SLC-0111 TO TEMOZOLOMIDE EXTENDS SURVIVAL OF MICE BEARING ORTHOTOPIC GLIOBLASTOMAS

Effects of hematopoietic growth factors on nonhematopoietic cells

artículo científico publicado el 1 de enero de 1992

Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells

scientific article published on 01 December 2005

Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

artículo científico publicado en 2017

Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.

artículo científico publicado en 2011

Harnessing Induced Essentiality: Targeting Carbonic Anhydrase IX and Angiogenesis Reduces Lung Metastasis of Triple Negative Breast Cancer Xenografts

scientific article published on 17 July 2019

Identification and characterization of a novel high-molecular-weight form of the integrin alpha 3 subunit

artículo científico publicado el 1 de noviembre de 1992

Identification of novel small molecule inhibitors of centrosome clustering in cancer cells

artículo científico publicado en 2013

Immunostaining of human brain capillaries by antibodies to very late antigens ⬇️

artículo científico publicado el 1 de marzo de 1990

Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase.

artículo científico publicado en 2013

Inactivation of the integrin-linked kinase (ILK) in osteoblasts increases mineralization.

artículo científico publicado en 2013

Induction of the intestinal stem cell signature gene SMOC-2 is required for L1-mediated colon cancer progression.

artículo científico publicado en 2015

Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth.

artículo científico publicado en 2005

Inhibition of the phosphatidylinositol 3'-kinase pathway promotes autocrine Fas-induced death of phosphatase and tensin homologue-deficient prostate cancer cells.

artículo científico publicado en 2006

Insulin attenuates apoptosis in neuronal cells by an integrin-linked kinase-dependent mechanism

scientific article published on 16 August 2019

Integrin linked kinase (ILK) is required for lens epithelial cell survival, proliferation and differentiation

artículo científico publicado en 2014

Integrin-linked Protein Kinase Regulates Fibronectin Matrix Assembly, E-cadherin Expression, and Tumorigenicity ⬇️

artículo científico publicado el 2 de enero de 1998

Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes

artículo científico publicado en 2001

Integrin-linked kinase (ILK) in combination molecular targeting.

artículo científico publicado en 2004

Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling.

artículo científico publicado en 1999

Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via alpha-PIX.

artículo científico publicado en 2005

Integrin-linked kinase as a target for ERG-mediated invasive properties in prostate cancer models

artículo científico publicado en 2012

Integrin-linked kinase at the heart of cardiac contractility, repair, and disease.

artículo científico publicado en 2007

Integrin-linked kinase deletion from mouse cortex results in cortical lamination defects resembling cobblestone lissencephaly.

artículo científico publicado en 2005

Integrin-linked kinase deletion in the developing lens leads to capsule rupture, impaired fiber migration and non-apoptotic epithelial cell death.

artículo científico publicado en 2012

Integrin-linked kinase functions as a downstream mediator of endothelin-1 to promote invasive behavior in ovarian carcinoma.

artículo científico publicado en 2006

Integrin-linked kinase functions as a downstream signal of platelet-derived growth factor to regulate actin polymerization and vascular smooth muscle cell migration.

artículo científico publicado en 2010

Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer.

artículo científico publicado en 2010

Integrin-linked kinase is an essential link between integrins and uptake of bacterial pathogens by epithelial cells.

artículo científico publicado en 2006

Integrin-linked kinase links dynactin-1/dynactin-2 with cortical integrin receptors to orient the mitotic spindle relative to the substratum ⬇️

artículo científico publicado en 2015

Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization

artículo científico publicado en 2008

Integrin-linked kinase regulates E-cadherin expression through PARP-1.

artículo científico publicado en 2008

Integrin-linked kinase regulates cell proliferation and tumour growth in murine colitis-associated carcinogenesis.

artículo científico publicado en 2008

Integrin-linked kinase regulates endothelial cell survival and vascular development.

artículo científico publicado en 2004

Integrin-linked kinase regulates integrin signaling in human trabecular meshwork cells.

artículo científico publicado en 2011

Integrin-linked kinase regulates interphase and mitotic microtubule dynamics

artículo científico publicado en 2013

Integrin-linked kinase regulates tubular aquaporin-2 content and intracellular location: a link between the extracellular matrix and water reabsorption

artículo científico publicado en 2014

Integrin-linked kinase--essential roles in physiology and cancer biology.

scientific article published on October 2008

Integrin-linked kinase: not so 'pseudo' after all.

scientific article published on 23 May 2011

Integrin-mediated signal transduction in transgenic mouse models of human breast cancer.

artículo científico publicado en 2003

Integrins and signal transduction

artículo científico publicado en 1999

Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know?

artículo científico publicado en 2005

Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling

artículo científico publicado en 2013

Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling

Isolation and characterization of monoclonal antibodies against human carbonic anhydrase-IX

publication published on 01 January 2021

Isolation of a novel integrin receptor mediating Arg-Gly-Asp-directed cell adhesion to fibronectin and type I collagen from human neuroblastoma cells. Association of a novel beta 1-related subunit with alpha v ⬇️

artículo científico publicado el 1 de junio de 1990

Loss of integrin linked kinase from mouse hepatocytes in vitro and in vivo results in apoptosis and hepatitis.

artículo científico

Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice.

artículo científico publicado en 2001

Mapping the integrin-linked kinase interactome using SILAC.

artículo científico publicado en 2008

Molecular pathways regulating EGF-induced epithelio-mesenchymal transition in human ovarian surface epithelium

artículo científico publicado en 2006

NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC

scientific journal article

Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons.

artículo científico publicado en 2008

Neurotrophins support regenerative axon assembly over CSPGs by an ECM-integrin-independent mechanism

artículo científico publicado en 2006

Novel matrix metalloproteinase inhibitor [18F]marimastat-aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer.

artículo científico publicado en 2010

Osteoclast-specific inactivation of the integrin-linked kinase (ILK) inhibits bone resorption.

artículo científico publicado en 2010

Overcoming Hypoxia-Mediated Tumor Progression: Combinatorial Approaches Targeting pH Regulation, Angiogenesis and Immune Dysfunction

artículo científico publicado en 2016

Overproduction of two antigenically distinct forms of dihydrofolate reductase in a highly methotrexate-resistant mouse leukemia cell line ⬇️

artículo científico publicado el 1 de octubre de 1983

PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer

artículo científico publicado en 2006

Paxillin phosphorylation: bifurcation point downstream of integrin-linked kinase (ILK) in streptococcal invasion.

artículo científico publicado en 2007

Podocyte-specific deletion of integrin-linked kinase results in severe glomerular basement membrane alterations and progressive glomerulosclerosis.

artículo científico publicado en 2006

Properties of a methotrexate-insensitive variant of dihydrofolate reductase derived from methotrexate-resistant L5178Y cells ⬇️

artículo científico publicado el 25 de noviembre de 1981

Reciprocal Interactions between Human Ovarian Surface Epithelial Cells and Adjacent Extracellular Matrix ⬇️

artículo científico publicado el 1 de noviembre de 1994

Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology

artículo científico publicado en 1998

Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.

artículo científico publicado en 2004

Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells

artículo científico publicado en 2004

Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia

scientific article published on 09 May 2019

Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival

artículo científico publicado en 2008

Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire.

artículo científico publicado en 2011

Role of integrin-linked kinase in leukocyte recruitment.

artículo científico publicado en 2002

Role of the integrin-linked kinase (ILK) in determining neuronal polarity

scientific journal article

Role of the integrin-linked kinase (ILK)/Rictor complex in TGFβ-1-induced epithelial-mesenchymal transition (EMT).

artículo científico publicado en 2012

Specific and sensitive combined high-performance liquid chromatographic—flow fluorometric assay for intracellular 6-thioguanine nucleotide metabolites of 6-mercaptopurine and 6-thioguanine ⬇️

artículo científico publicado el 1 de marzo de 1978

Stat3 in mitosis: A new role in clustering excess centrosomes

artículo científico publicado en 2017

Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1.

artículo científico publicado en 2017

Suppression of Her2/neu expression through ILK inhibition is regulated by a pathway involving TWIST and YB-1

artículo científico publicado en 2010

Suppression of VEGF secretion and changes in glioblastoma multiforme microenvironment by inhibition of integrin-linked kinase (ILK).

artículo científico publicado en 2008

Synthesis and evaluation of 18F-labeled carbonic anhydrase IX inhibitors for imaging with positron emission tomography

scientific article published on 07 March 2013

Targeting Hypoxia-Induced Carbonic Anhydrase IX Enhances Immune-Checkpoint Blockade Locally and Systemically

scientific article published on 14 May 2019

Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche.

artículo científico publicado en 2012

Targeting hypoxic response for cancer therapy

artículo científico publicado en 2016

Targeting hypoxic tumour cells to overcome metastasis.

artículo científico publicado en 2011

Targeting integrin linked kinase and FMS-like tyrosine kinase-3 is cytotoxic to acute myeloid leukemia stem cells but spares normal progenitors.

artículo científico publicado en 2010

Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.

artículo científico publicado en 2011

Tetraspanin 8 is a novel regulator of ILK-driven β1 integrin adhesion and signaling in invasive melanoma cells.

artículo científico publicado en 2017

The importance of integrin‐linked kinase in the regulation of bladder cancer invasion ⬇️

artículo científico publicado el 28 de mayo de 2011

The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion.

artículo científico publicado en 2017

The mitotic functions of integrin-linked kinase.

artículo científico publicado en 2009

The receptor for the basement membrane glycoprotein entactin is the integrin alpha 3/beta 1 ⬇️

artículo científico publicado el 15 de septiembre de 1992

The role of integrin-linked kinase in melanoma cell migration, invasion, and tumor growth.

artículo científico publicado en 2007

Tubular epithelial cell dedifferentiation is driven by the helix-loop-helix transcriptional inhibitor Id1.

artículo científico

Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis.

artículo científico publicado en 2011

Lista de obras de

A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells ⬇️

A methotrexate insensitive variant of folate reductase present in two lines of methotrexate-resistant L5178Y cells ⬇️

A novel inhibitory effect of oxazol-5-one compounds on ROCKII signaling in human coronary artery vascular smooth muscle cells.

Addition of carbonic anhydrase 9 inhibitor SLC-0111 to temozolomide treatment delays glioblastoma growth in vivo.

Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells.

Alterations in integrin receptor expression on chemically transformed human cells: specific enhancement of laminin and collagen receptor complexes ⬇️

An essential role for the integrin-linked kinase-glycogen synthase kinase-3 beta pathway during dendrite initiation and growth

Aortic aneurysm generation in mice with targeted deletion of integrin-linked kinase in vascular smooth muscle cells

BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways ⬇️

Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment

Carbonic anhydrase IX (CAIX) as a mediator of hypoxia-induced stress response in cancer cells.

Carbonic anhydrase IX promotes myeloid-derived suppressor cell mobilization and establishment of a metastatic niche by stimulating G-CSF production

Carving out its niche: A role for carbonic anhydrase IX in pre-metastatic niche development.

Cell adhesion and the integrin-linked kinase regulate the LEF-1 and β-catenin signaling pathways ⬇️

Combined inhibition of integrin linked kinase and FMS-like tyrosine kinase 3 is cytotoxic to acute myeloid leukemia progenitor cells.

Combined inhibition of the phosphatidylinositol 3-kinase/Akt and Ras/mitogen-activated protein kinase pathways results in synergistic effects in glioblastoma cells.

Coordinated Regulation of Metabolic Transporters and Migration/Invasion by Carbonic Anhydrase IX.

Deep sequence analysis of gene expression identifies osteopontin as a downstream effector of integrin-linked kinase (ILK) in cardiac-specific ILK knockout mice

Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX

Divergence in patterns of invasion among subpopulations derived from a human carcinoma clone: roles of intercellular contacts and of cell-substratum adhesion

EXTH-44. ADDITION OF THE CARBONIC ANHYDRASE IX INHIBITOR SLC-0111 TO TEMOZOLOMIDE EXTENDS SURVIVAL OF MICE BEARING ORTHOTOPIC GLIOBLASTOMAS

Effects of hematopoietic growth factors on nonhematopoietic cells

Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells

Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.

Harnessing Induced Essentiality: Targeting Carbonic Anhydrase IX and Angiogenesis Reduces Lung Metastasis of Triple Negative Breast Cancer Xenografts

Identification and characterization of a novel high-molecular-weight form of the integrin alpha 3 subunit

Identification of novel small molecule inhibitors of centrosome clustering in cancer cells

Immunostaining of human brain capillaries by antibodies to very late antigens ⬇️

Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase.

Inactivation of the integrin-linked kinase (ILK) in osteoblasts increases mineralization.

Induction of the intestinal stem cell signature gene SMOC-2 is required for L1-mediated colon cancer progression.

Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth.

Inhibition of the phosphatidylinositol 3'-kinase pathway promotes autocrine Fas-induced death of phosphatase and tensin homologue-deficient prostate cancer cells.

Insulin attenuates apoptosis in neuronal cells by an integrin-linked kinase-dependent mechanism

Integrin linked kinase (ILK) is required for lens epithelial cell survival, proliferation and differentiation

Integrin-linked Protein Kinase Regulates Fibronectin Matrix Assembly, E-cadherin Expression, and Tumorigenicity ⬇️

Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes

Integrin-linked kinase (ILK) in combination molecular targeting.

Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling.

Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via alpha-PIX.

Integrin-linked kinase as a target for ERG-mediated invasive properties in prostate cancer models

Integrin-linked kinase at the heart of cardiac contractility, repair, and disease.

Integrin-linked kinase deletion from mouse cortex results in cortical lamination defects resembling cobblestone lissencephaly.

Integrin-linked kinase deletion in the developing lens leads to capsule rupture, impaired fiber migration and non-apoptotic epithelial cell death.

Integrin-linked kinase functions as a downstream mediator of endothelin-1 to promote invasive behavior in ovarian carcinoma.

Integrin-linked kinase functions as a downstream signal of platelet-derived growth factor to regulate actin polymerization and vascular smooth muscle cell migration.

Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer.

Integrin-linked kinase is an essential link between integrins and uptake of bacterial pathogens by epithelial cells.

Integrin-linked kinase links dynactin-1/dynactin-2 with cortical integrin receptors to orient the mitotic spindle relative to the substratum ⬇️

Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization

Integrin-linked kinase regulates E-cadherin expression through PARP-1.

Integrin-linked kinase regulates cell proliferation and tumour growth in murine colitis-associated carcinogenesis.

Integrin-linked kinase regulates endothelial cell survival and vascular development.

Integrin-linked kinase regulates integrin signaling in human trabecular meshwork cells.

Integrin-linked kinase regulates interphase and mitotic microtubule dynamics

Integrin-linked kinase regulates tubular aquaporin-2 content and intracellular location: a link between the extracellular matrix and water reabsorption

Integrin-linked kinase--essential roles in physiology and cancer biology.

Integrin-linked kinase: not so 'pseudo' after all.

Integrin-mediated signal transduction in transgenic mouse models of human breast cancer.

Integrins and signal transduction

Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know?

Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling

Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling

Isolation and characterization of monoclonal antibodies against human carbonic anhydrase-IX

Isolation of a novel integrin receptor mediating Arg-Gly-Asp-directed cell adhesion to fibronectin and type I collagen from human neuroblastoma cells. Association of a novel beta 1-related subunit with alpha v ⬇️

Loss of integrin linked kinase from mouse hepatocytes in vitro and in vivo results in apoptosis and hepatitis.

Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice.

Mapping the integrin-linked kinase interactome using SILAC.

Molecular pathways regulating EGF-induced epithelio-mesenchymal transition in human ovarian surface epithelium

NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC

Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons.

Neurotrophins support regenerative axon assembly over CSPGs by an ECM-integrin-independent mechanism

Novel matrix metalloproteinase inhibitor [18F]marimastat-aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer.

Osteoclast-specific inactivation of the integrin-linked kinase (ILK) inhibits bone resorption.

Overcoming Hypoxia-Mediated Tumor Progression: Combinatorial Approaches Targeting pH Regulation, Angiogenesis and Immune Dysfunction

Overproduction of two antigenically distinct forms of dihydrofolate reductase in a highly methotrexate-resistant mouse leukemia cell line ⬇️

PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer

Paxillin phosphorylation: bifurcation point downstream of integrin-linked kinase (ILK) in streptococcal invasion.