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A Phase I Study of Concurrent Chemotherapy (Paclitaxel and Carboplatin) and Thoracic Radiotherapy with Swallowed Manganese Superoxide Dismutase Plasmid Liposome Protection in Patients with Locally Advanced Stage III Non-Small-Cell Lung Cancer

artículo científico publicado el 2 de febrero de 2011

A Small Molecule Screen Exposes mTOR Signaling Pathway Involvement in Radiation-Induced Apoptosis

artículo científico publicado en 2016

A Topical Mitochondria-Targeted Redox-Cycling Nitroxide Mitigates Oxidative Stress-Induced Skin Damage

artículo científico publicado en 2016

A manganese-porphyrin complex decomposes H(2)O(2), inhibits apoptosis, and acts as a radiation mitigator in vivo

artículo científico publicado en 2011

A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death

artículo científico publicado en 2011

A mitochondria-targeted nitroxide/hemigramicidin S conjugate protects mouse embryonic cells against gamma irradiation

artículo científico publicado en 2008

A mitochondrial pathway for biosynthesis of lipid mediators

artículo científico publicado en 2014

Adipocyte differentiation in Sod2(-/-) and Sod2(+/+) murine bone marrow stromal cells is associated with low antioxidant pools

scientific journal article

Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts

artículo científico publicado en 2008

Amelioration of radiation-induced oral cavity mucositis and distant bone marrow suppression in fanconi anemia Fancd2-/- (FVB/N) mice by intraoral GS-nitroxide JP4-039.

artículo científico publicado en 2014

Amelioration of radiation-induced pulmonary fibrosis by a water-soluble bifunctional sulfoxide radiation mitigator (MMS350).

artículo científico publicado en 2013

Antioxidant Approaches to Management of Ionizing Irradiation Injury

artículo científico publicado en 2015

Antioxidant-Chemoprevention Diet Ameliorates Late Effects of Total-Body Irradiation and Supplements Radioprotection by MnSOD-Plasmid Liposome Administration

artículo científico publicado el 5 de abril de 2011

Ascorbate as a "redox sensor" and protector against irradiation-induced oxidative stress in 32D CL 3 hematopoietic cells and subclones overexpressing human manganese superoxide dismutase

artículo científico publicado en 2004

Blocking the formation of radiation-induced breast cancer stem cells

artículo científico publicado en 2014

Bone marrow from CD18-/- (MAC-1-/-) homozygous deletion recombinant negative mice demonstrates increased longevity in long-term bone marrow culture and decreased contribution to irradiation pulmonary damage

artículo científico publicado en 2006

Bone marrow origin of cells with capacity for homing and differentiation to esophageal squamous epithelium

artículo científico publicado en 2004

Bone marrow origin of myofibroblasts in irradiation pulmonary fibrosis

artículo científico publicado en 2003

Bone marrow-derived stem cells and radiation response.

artículo científico publicado en 2009

Can Radiosensitivity Associated with Defects in DNA Repair be Overcome by Mitochondrial-Targeted Antioxidant Radioprotectors

artículo científico publicado en 2014

Cardiolipin-specific peroxidase reactions of cytochrome C in mitochondria during irradiation-induced apoptosis

artículo científico publicado en 2007

Conditional radioresistance of Tet-inducible manganese superoxide dismutase bone marrow stromal cell lines

artículo científico publicado en 2013

Correction to "Design and Synthesis of a Mitochondria-Targeted Mimic of Glutathione Peroxidase, MitoEbselen-2, as a Radiation Mitigator"

artículo científico publicado en 2016

Correlation of ionizing irradiation-induced late pulmonary fibrosis with long-term bone marrow culture fibroblast progenitor cell biology in mice homozygous deletion recombinant negative for endothelial cell adhesion molecules.

artículo científico publicado en 2004

Design and Synthesis of a Mitochondria-Targeted Mimic of Glutathione Peroxidase, MitoEbselen-2, as a Radiation Mitigator

artículo científico publicado en 2014

Development of Small-Molecule PUMA Inhibitors for Mitigating Radiation-Induced Cell Death

artículo científico publicado el 1 de enero de 2011

Differences in irradiated lung gene transcription between fibrosis-prone C57BL/6NHsd and fibrosis-resistant C3H/HeNHsd mice

artículo científico publicado en 2014

Differing roles of mitochondrial nitric oxide synthase in cardiomyocytes and urothelial cells

artículo científico publicado en 2004

Effect of EGFR antagonists gefitinib (Iressa) and C225 (Cetuximab) on MnSOD-plasmid liposome transgene radiosensitization of a murine squamous cell carcinoma cell line.

artículo científico publicado en 2006

Effectiveness of Analogs of the GS-Nitroxide, JP4-039, as Total Body Irradiation Mitigators

artículo científico publicado en 2017

Effectiveness of combined modality radiotherapy of orthotopic human squamous cell carcinomas in Nu/Nu mice using cetuximab, tirapazamine and MnSOD-plasmid liposome gene therapy

artículo científico publicado en 2010

Effects of MnSOD-plasmid liposome gene therapy on antioxidant levels in irradiated murine oral cavity orthotopic tumors

artículo científico publicado en 2007

Effects of the bifunctional sulfoxide MMS350, a radiation mitigator, on hematopoiesis in long-term bone marrow cultures and on radioresistance of marrow stromal cell lines

artículo científico publicado en 2014

Effects of thoracic irradiation on pulmonary endothelial compared to alveolar type-II cells in fibrosis-prone C57BL/6NTac mice

scientific article published on May 2013

Ethyl pyruvate, a potentially effective mitigator of damage after total-body irradiation

artículo científico publicado en 2007

Evaluation of Different Formulations and Routes for the Delivery of the Ionizing Radiation Mitigator GS-Nitroxide (JP4-039)

scholarly article published in In Vivo

Evaluation of potential ionizing irradiation protectors and mitigators using clonogenic survival of human umbilical cord blood hematopoietic progenitor cells

artículo científico publicado en 2013

Evolution of malignant plasmacytoma cell lines from K14E7 Fancd2-/- mouse long-term bone marrow cultures

artículo científico publicado en 2016

FANCD2 protects against bone marrow injury from ferroptosis

artículo científico publicado en 2016

GS-Nitroxide (JP4-039)-Mediated Radioprotection of Human Fanconi Anemia Cell Lines

artículo científico publicado el 22 de septiembre de 2011

Gene transfer of human manganese superoxide dismutase protects small intestinal villi from radiation injury

scientific article published on 01 February 2003

Graduating During a Time of War

artículo científico publicado el 1 de abril de 2003

Hematopoietic stem cell regeneration enhanced by ectopic expression of ROS-detoxifying enzymes in transplant mice

artículo científico publicado en 2013

Human in vivo radiation-induced biomarkers: gene expression changes in radiotherapy patients

artículo científico publicado en 2004

Identification of druggable targets for radiation mitigation using a small interfering RNA screening assay

artículo científico publicado en 2012

Improved Total-Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways

artículo científico publicado en 2017

Improved survival of mice after total body irradiation with 10 MV photon, 2400 MU/min SRS beam

artículo científico publicado en 2014

Increased longevity of hematopoiesis in continuous bone marrow cultures and adipocytogenesis in marrow stromal cells derived from Smad3(-/-) mice.

artículo científico publicado en 2005

Increased longevity of hematopoiesis in continuous bone marrow cultures derived from NOS1 (nNOS, mtNOS) homozygous recombinant negative mice correlates with radioresistance of hematopoietic and marrow stromal cells.

artículo científico publicado en 2007

Increased longevity of hematopoiesis in continuous marrow cultures and radiation resistance of marrow stromal and hematopoietic progenitor cells from caspase-1 homozygous recombinant-negative (knockout) mice

artículo científico publicado en 2013

Increased radioresistance, g(2)/m checkpoint inhibition, and impaired migration of bone marrow stromal cell lines derived from Smad3(-/-) mice

artículo científico publicado en 2006

Induction of TGF-β by Irradiation or Chemotherapy in Fanconi Anemia (FA) Mouse Bone Marrow Is Modulated by Small Molecule Radiation Mitigators JP4-039 and MMS350.

artículo científico publicado en 2017

Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice

artículo científico publicado en 2016

Intraesophageal Manganese Superoxide Dismutase-Plasmid Liposomes Ameliorates Novel Total-Body and Thoracic Radiation Sensitivity of NOS1−/−Mice

artículo científico publicado el 1 de septiembre de 2010

Intraoral Mitochondrial-Targeted GS-Nitroxide, JP4-039, Radioprotects Normal Tissue in Tumor-Bearing Radiosensitive Fancd2(-/-) (C57BL/6) Mice

artículo científico publicado en 2016

Intraoral manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) radioprotective gene therapy decreases ionizing irradiation-induced murine mucosal cell cycling and apoptosis.

artículo científico publicado en 2004

Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice

artículo científico publicado en 2014

Ionizing irradiation protection and mitigation of murine cells by carbamazepine is p53 and autophagy independent

artículo científico publicado en 2012

Irradiated esophageal cells are protected from radiation-induced recombination by MnSOD gene therapy

artículo científico publicado en 2010

Lack of DNA polymerase theta (POLQ) radiosensitizes bone marrow stromal cells in vitro and increases reticulocyte micronuclei after total-body irradiation

artículo científico publicado en 2009

Leukocyte-derived extracellular superoxide dismutase does not contribute to airspace EC-SOD after interstitial pulmonary injury

artículo científico publicado el 14 de octubre de 2011

Liquid chromatography-tandem mass spectrometric assay for the quantitation of the novel radiation protective agent and radiation mitigator JP4-039 in murine plasma

artículo científico publicado en 2017

Malignant Transformation of Fanconi Anemia Complementation Group D2-deficient () Hematopoietic Progenitor Cells by a Single HPV16 Oncogene

Manganese superoxide dismutase (SOD2) inhibits radiation-induced apoptosis by stabilization of the mitochondrial membrane

artículo científico publicado en 2002

Manganese superoxide dismutase gene therapy protects against irradiation-induced cystitis

artículo científico publicado en 2002

Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) intratracheal gene therapy reduction of irradiation-induced inflammatory cytokines does not protect orthotopic Lewis lung carcinomas.

artículo científico publicado en 2003

Mass-spectrometric characterization of phospholipids and their hydroperoxide derivatives in vivo: effects of total body irradiation

artículo científico publicado en 2009

Mitochondrial localization of superoxide dismutase is required for decreasing radiation-induced cellular damage

artículo científico publicado en 2003

Mitochondrial targeting of radioprotectants using peptidyl conjugates

artículo científico publicado en 2006

MnSOD-plasmid liposome gene therapy decreases ionizing irradiation-induced lipid peroxidation of the esophagus

artículo científico publicado en 2005

Modulation of radiation-induced life shortening by systemic intravenous MnSOD-plasmid liposome gene therapy

artículo científico publicado en 2008

Nanoassembly of surfactants with interfacial drug-interactive motifs as tailor-designed drug carriers

artículo científico publicado en 2012

Necrostatin-1 rescues mice from lethal irradiation

artículo científico publicado en 2016

Non-small cell lung cancer cells survived ionizing radiation treatment display cancer stem cell and epithelial-mesenchymal transition phenotypes

artículo científico publicado en 2013

Organ-specific responses of total body irradiated doxycycline-inducible manganese superoxide dismutase Tet/Tet mice

artículo científico publicado en 2014

Overexpression of the transgene for manganese superoxide dismutase (MnSOD) in 32D cl 3 cells prevents apoptosis induction by TNF-alpha, IL-3 withdrawal, and ionizing radiation

artículo científico publicado en 2003

Oxidative lipidomics of gamma-irradiation-induced intestinal injury

artículo científico publicado en 2007

Oxidative lipidomics of γ-radiation-induced lung injury: mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation

artículo científico publicado en 2011

Oxidized phospholipids as biomarkers of tissue and cell damage with a focus on cardiolipin

artículo científico publicado en 2012

PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome

artículo científico publicado en 2008

Pharmacologic profiling of phosphoinositide 3-kinase inhibitors as mitigators of ionizing radiation-induced cell death

artículo científico publicado en 2013

Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation

artículo científico publicado en 2015

Photodynamic therapy induced esophageal stricture--an animal model: from mouse to pig.

artículo científico publicado en 2005

Prevention of radiation-induced oral cavity mucositis by plasmid/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene

artículo científico publicado en 2003

Protection of esophageal multi-lineage progenitors of squamous epithelium (stem cells) from ionizing irradiation by manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy.

artículo científico publicado en 2005

Pulmonary irradiation-induced expression of VCAM-I and ICAM-I is decreased by manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy

artículo científico publicado en 2002

Pulmonary receptor for advanced glycation end-products promotes asthma pathogenesis through IL-33 and accumulation of group 2 innate lymphoid cells

artículo científico publicado en 2015

Radiologic differences between bone marrow stromal and hematopoietic progenitor cell lines from Fanconi Anemia (Fancd2(-/-)) mice

artículo científico

Radioprotection in vitro and in vivo by minicircle plasmid carrying the human manganese superoxide dismutase transgene

artículo científico publicado en 2008

Radioprotection of lung and esophagus by overexpression of the human manganese superoxide dismutase transgene.

artículo científico publicado en 2002

Radioresistance of bone marrow stromal and hematopoietic progenitor cell lines derived from Nrf2-/- homozygous deletion recombinant-negative mice

artículo científico publicado en 2013

Radioresistant human lung adenocarcinoma cells that survived multiple fractions of ionizing radiation are sensitive to HSP90 inhibition

artículo científico publicado en 2015

Reduced Competitive Repopulation Capacity of Multipotential Hematopoietic Stem Cells in the Bone Marrow of Friend Virus-infected Fv2-resistant Mice

artículo científico publicado en 2017

Reduced irradiation pulmonary fibrosis and stromal cell migration in Smad3-/- marrow chimeric mice

artículo científico publicado en 2006

Regulation of the anaphase-promoting complex-separase cascade by transforming growth factor-beta modulates mitotic progression in bone marrow stromal cells

artículo científico publicado en 2008

Repopulation of the irradiation damaged lung with bone marrow-derived cells

artículo científico publicado el 1 de enero de 2012

Review. Antioxidant gene therapeutic approaches to normal tissue radioprotection and tumor radiosensitization

artículo científico publicado en 2007

Screening of antimicrobial agents for in vitro radiation protection and mitigation capacity, including those used in supportive care regimens for bone marrow transplant recipients.

artículo científico publicado en 2010

Strategies for discovery of small molecule radiation protectors and radiation mitigators

artículo científico publicado en 2011

Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria

artículo científico publicado en 2013

Synthetic protection short interfering RNA screen reveals glyburide as a novel radioprotector

artículo científico publicado en 2009

Targeting Mitochondrial Oxidative Stress to Mitigate UV-Induced Skin Damage

scholarly article by Rhonda M Brand et al published 2018 in Frontiers in Pharmacology

Testicular recovery after irradiation differs in prepubertal and pubertal non-human primates, and can be enhanced by autologous germ cell transplantation

artículo científico publicado en 2011

Thalidomide radiosensitization of normal murine hematopoietic but not squamous cell carcinoma or multiple myeloma tumor cell lines.

artículo científico publicado en 2006

The GS-nitroxide JP4-039 improves intestinal barrier and stem cell recovery in irradiated mice

artículo científico publicado en 2018

The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung Adenocarcinoma Cells

artículo científico publicado en 2015

The Use of 3,5,4′-Tri-O-acetylresveratrol as a Potential Prodrug for Resveratrol Protects Mice from γ-Irradiation-Induced Death

artículo científico publicado el 25 de enero de 2011

The resistance of electron-transport chain Fe-S clusters to oxidative damage during the reaction of peroxynitrite with mitochondrial complex II and rat-heart pericardium

artículo científico publicado en 2008

The zebrafish--Danio rerio--is a useful model for measuring the effects of small-molecule mitigators of late effects of ionizing irradiation

artículo científico publicado en 2012

Two strategies for the development of mitochondrion-targeted small molecule radiation damage mitigators

artículo científico publicado en 2011