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A Pediatric Covariate Function for CYP3A-Mediated Midazolam Clearance Can Scale Clearance of Selected CYP3A Substrates in Children

scientific article published on 27 June 2019

A Prospective Clinical Study Characterizing the Influence of Morbid Obesity on the Pharmacokinetics of Gentamicin: Towards Individualized Dosing in Obese Patients

artículo científico publicado en 2019

A bodyweight-dependent allometric exponent for scaling clearance across the human life-span.

artículo científico publicado en 2012

A neonatal amikacin covariate model can be used to predict ontogeny of other drugs eliminated through glomerular filtration in neonates

artículo científico publicado en 2013

A novel maturation function for clearance of the cytochrome P450 3A substrate midazolam from preterm neonates to adults

artículo científico publicado en 2013

A randomized controlled trial of daily sedation interruption in critically ill children.

artículo científico publicado en 2015

Advances in paediatric pharmacokinetics

artículo científico publicado en 2010

Allometric Scaling of Clearance in Paediatric Patients: When Does the Magic of 0.75 Fade?

artículo científico publicado en 2016

Allometric relationships between the pharmacokinetics of propofol in rats, children and adults

artículo científico publicado en 2005

Amikacin Pharmacokinetics To Optimize Dosing in Neonates with Perinatal Asphyxia Treated with Hypothermia.

artículo científico publicado en 2017

Anti-Xa Levels 4 h After Subcutaneous Administration of 5,700 IU Nadroparin Strongly Correlate with Lean Body Weight in Morbidly Obese Patients

artículo científico publicado en 2012

Association between anti-thymocyte globulin exposure and CD4+ immune reconstitution in paediatric haemopoietic cell transplantation: a multicentre, retrospective pharmacodynamic cohort analysis

scientific article published on 21 April 2015

Association between anti-thymocyte globulin exposure and survival outcomes in adult unrelated haemopoietic cell transplantation: a multicentre, retrospective, pharmacodynamic cohort analysis

artículo científico publicado en 2017

Association between busulfan exposure and outcome in children receiving intravenous busulfan before hematologic stem cell transplantation

artículo científico publicado en 2009

Asthma medication in children who are overweight/obese: justified treatment?

scientific article published on 11 May 2019

Augmented Renal Clearance in Critically Ill Pediatric Patients: Does It Impact the Outcome of Pharmacotherapy?

artículo científico publicado en 2017

Author's Reply to Reith: "Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults"

artículo científico publicado en 2018

Author's Reply to Reith: "Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen"

artículo científico publicado en 2018

Beyond the Randomized Clinical Trial: Innovative Data Science to Close the Pediatric Evidence Gap

scientific article published on 22 January 2020

Big data analyses for continuous evaluation of pharmacotherapy: A proof of principle with doxapram in preterm infants

artículo científico publicado en 2017

Body weight, gender and pregnancy affect enantiomer-specific ketorolac pharmacokinetics.

artículo científico publicado en 2017

Body weight-dependent pharmacokinetics of busulfan in paediatric haematopoietic stem cell transplantation patients: towards individualized dosing

artículo científico publicado en 2012

Can Population Modelling Principles be Used to Identify Key PBPK Parameters for Paediatric Clearance Predictions? An Innovative Application of Optimal Design Theory

scholarly article by Elisa A M Calvier et al published 14 September 2018 in Pharmaceutical Research

Characterization of Intestinal and Hepatic CYP3A-Mediated Metabolism of Midazolam in Children Using a Physiological Population Pharmacokinetic Modelling Approach

artículo científico publicado en 2018

Children Are Not Small Adults, but Can We Treat Them As Such?

scientific article published on 28 January 2019

Children in clinical trials: towards evidence-based pediatric pharmacotherapy using pharmacokinetic-pharmacodynamic modeling.

artículo científico publicado en 2016

Chloroquine for SARS-CoV-2: Implications of Its Unique Pharmacokinetic and Safety Properties

scientific article published on 18 April 2020

Comment on "Effect of Age-Related Factors on the Pharmacokinetics of Lamotrigine and Potential Implications for Maintenance Dose Optimisation in Future Clinical Trials"

artículo científico publicado en 2018

Commentary on the EMA Reflection Paper on the use of extrapolation in the development of medicines for paediatrics

artículo científico publicado en 2019

Comparative evaluation of atracurium dosed on ideal body weight vs. total body weight in morbidly obese patients ⬇️

artículo científico publicado el 1 de enero de 2011

Comparative evaluation of propofol 350 and 200 mg for induction of anaesthesia in morbidly obese patients: a randomized double-blind pilot study

artículo científico publicado en 2010

Comparison of different pain scoring systems in critically ill patients in a general ICU.

artículo científico publicado en 2008

Correction to: Tobramycin Clearance Is Best Described by Renal Function Estimates in Obese and Nonobese Individuals: Results of a Prospective Rich Sampling Pharmacokinetic Study

scientific article published on 09 January 2020

Covariates in Pharmacometric Repeated Time-to-Event Models: Old and New (Pre)Selection Tools

artículo científico publicado en 2018

Critical Illness Is a Major Determinant of Midazolam Clearance in Children Aged 1 Month to 17 Years ⬇️

artículo científico publicado el 1 de agosto de 2012

Daily interruption of sedation in critically ill children: study protocol for a randomized controlled trial.

artículo científico publicado en 2014

Defining off-label and unlicensed use of medicines for children: results of a Delphi survey

artículo científico publicado en 2008

Development and Stability Study of an Omeprazole Suppository for Infants

artículo científico publicado en 2020

Development of Human Membrane Transporters: Drug Disposition and Pharmacogenetics

artículo científico publicado en 2016

Developmental Changes in the Expression and Function of Cytochrome P450 3A Isoforms: Evidence from In Vitro and In Vivo Investigations ⬇️

artículo científico publicado el 1 de mayo de 2013

Developmental changes in morphine clearance across the entire paediatric age range are best described by a bodyweight-dependent exponent model.

artículo científico publicado en 2013

Developmental changes rather than repeated administration drive paracetamol glucuronidation in neonates and infants.

artículo científico publicado en 2015

Developmental pharmacokinetics of propylene glycol in preterm and term neonates

artículo científico publicado en 2013

Dose evaluation of lamivudine in human immunodeficiency virus-infected children aged 5 months to 18 years based on a population pharmacokinetic analysis.

artículo científico publicado en 2017

Dose recommendations for gentamicin in the real-world obese population with varying body weight and renal (dys)function

artículo científico publicado en 2020

Dose-linearity of the pharmacokinetics of an intravenous [14 C]midazolam microdose in children

scientific article published on 30 July 2019

Drug Dosing in Obese Children: Challenges and Evidence-Based Strategies

artículo científico publicado en 2017

Drug disposition in obesity: toward evidence-based dosing

artículo científico publicado en 2014

Drugs Being Eliminated via the Same Pathway Will Not Always Require Similar Pediatric Dose Adjustments

artículo científico publicado en 2018

Effect of intravenous paracetamol on postoperative morphine requirements in neonates and infants undergoing major noncardiac surgery: a randomized controlled trial

artículo científico

Efficacy of Metformin Treatment with Respect to Weight Reduction in Children and Adults with Obesity: A Systematic Review

scientific article published on 01 December 2018

Enteral Acetaminophen Bioavailability in Pediatric Intensive Care Patients Determined With an Oral Microtracer and Pharmacokinetic Modeling to Optimize Dosing

artículo científico publicado en 2019

Estimation of Ontogeny Functions for Renal Transporters Using a Combined Population Pharmacokinetic and Physiology-Based Pharmacokinetic Approach: Application to OAT1,3

artículo científico publicado en 2021

Evidence-based drug treatment for special patient populations through model-based approaches.

artículo científico publicado en 2017

Evidence-based morphine dosing for postoperative neonates and infants

artículo científico publicado en 2014

Exploring the Relationship Between Morphine Concentration and Oversedation in Children After Cardiac Surgery

scientific article published on 20 May 2020

Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg/kg intravenous acetaminophen in very-preterm infants.

artículo científico publicado en 2017

First-Pass CYP3A-Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates.

artículo científico publicado en 2018

Fixed Dosing of Liposomal Amphotericin B in Morbidly Obese Individuals

scientific article published on 07 September 2019

From Pediatric Covariate Model to Semiphysiological Function for Maturation: Part II-Sensitivity to Physiological and Physicochemical Properties

artículo científico publicado en 2012

From Pediatric Covariate Model to Semiphysiological Function for Maturation: Part I–Extrapolation of a Covariate Model From Morphine to Zidovudine ⬇️

artículo científico publicado el 3 de octubre de 2012

Gas chromatography-mass spectrometric assay for propofol in cerebrospinal fluid of traumatic brain patients

artículo científico publicado en 2007

Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults.

artículo científico

How to screen obese children at risk for type 2 diabetes mellitus?

artículo científico publicado en 2013

Immune reconstitution kinetics as an early predictor for mortality using various hematopoietic stem cell sources in children.

artículo científico publicado en 2012

Impact of Obesity on Drug Metabolism and Elimination in Adults and Children

artículo científico publicado el 1 de mayo de 2012

Implications for IV posaconazole dosing in the era of obesity

scientific article published on 01 April 2020

Increased Arterial Stiffness in Adolescents With Obesity

artículo científico publicado en 2019

Increased Metformin Clearance in Overweight and Obese Adolescents: A Pharmacokinetic Substudy of a Randomized Controlled Trial

artículo científico publicado en 2018

Increasing trends in the incidence and prevalence rates of type 1 diabetes among children and adolescents in the Netherlands

artículo científico publicado en 2014

Individualized dosing regimens in children based on population PKPD modelling: Are we ready for it? ⬇️

artículo científico publicado el 3 de marzo de 2011

Infants Operated on for Necrotizing Enterocolitis: Towards Evidence-Based Pain Guidelines

artículo científico publicado en 2016

Inflammation and Organ Failure Severely Affect Midazolam Clearance in Critically Ill Children

artículo científico publicado en 2016

Influence of Morbid Obesity on the Pharmacokinetics of Morphine, Morphine-3-Glucuronide, and Morphine-6-Glucuronide

artículo científico

Intravenous paracetamol dosing guidelines for pain management in (pre)term neonates using the paediatric study decision tree.

artículo científico publicado en 2017

Is Intraoperative Remifentanil Associated With Acute or Chronic Postoperative Pain After Prolonged Surgery? An Update of the Literature

artículo científico publicado en 2015

Is indirect hyperbilirubinemia a useful biomarker of reduced propofol clearance in neonates?

artículo científico publicado en 2012

Kernel-Based Visual Hazard Comparison (kbVHC): a Simulation-Free Diagnostic for Parametric Repeated Time-to-Event Models

artículo científico publicado en 2017

Knowledge of developmental pharmacology and modeling approaches should be used to avoid useless trials in children

artículo científico publicado en 2009

Larger Dose Reductions of Vancomycin Required in Neonates with Patent Ductus Arteriosus Receiving Indomethacin versus Ibuprofen

scientific article published on 25 July 2019

Long-term metformin treatment in adolescents with obesity and insulin resistance, results of an open label extension study

scientific article published on 10 September 2018

Low but inducible contribution of renal elimination to clearance of propylene glycol in preterm and term neonates

artículo científico publicado en 2014

Low-dose recombinant factor VIIa in the management of uncontrolled postoperative hemorrhage in cardiac surgery patients

artículo científico publicado en 2006

Maturation of the glomerular filtration rate in neonates, as reflected by amikacin clearance.

artículo científico publicado en 2012

Midazolam pharmacokinetics in morbidly obese patients following semi-simultaneous oral and intravenous administration: a comparison with healthy volunteers

artículo científico publicado en 2014

Model-based clinical dose optimization for phenobarbital in neonates: An illustration of the importance of data sharing and external validation.

artículo científico publicado en 2017

Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen

artículo científico publicado en 2016

Morphine Glucuronidation and Elimination in Intensive Care Patients: A Comparison with Healthy Volunteers

artículo científico publicado en 2015

Morphine Pharmacodynamics in Mechanically Ventilated Preterm Neonates Undergoing Endotracheal Suctioning

artículo científico publicado en 2017

Morphine glucuronidation in preterm neonates, infants and children younger than 3 years

artículo científico publicado en 2009

Novel model-based dosing guidelines for gentamicin and tobramycin in preterm and term neonates

artículo científico publicado en 2015

Obesity and drug pharmacology: a review of the influence of obesity on pharmacokinetic and pharmacodynamic parameters.

artículo científico publicado en 2018

Ontogeny of hepatic glucuronidation; methods and results

artículo científico publicado en 2012

Pain and distress caused by endotracheal suctioning in neonates is better quantified by behavioural than physiological items: a comparison based on item response theory modelling

artículo científico publicado en 2016

Paracetamol and morphine for infant and neonatal pain; still a long way to go?

artículo científico publicado en 2016

Paracetamol pharmacokinetics and metabolism in young women.

artículo científico publicado en 2015

Pediatric microdose study of [(14)C]paracetamol to study drug metabolism using accelerated mass spectrometry: proof of concept

artículo científico publicado en 2014

Pediatric pharmacokinetics and dose predictions: a report of a satellite meeting to the 10th Juvenile Toxicity Symposium

scientific article published on 23 July 2020

Pediatric pharmacology: current efforts and future goals to improve clinical practice

artículo científico publicado en 2015

Perioperative antibiotic prophylaxis in the treatment of acute cholecystitis (PEANUTS II trial): study protocol for a randomized controlled trial

artículo científico publicado en 2017

Pharmacodynamics and Pharmacokinetics of Morphine After Cardiac Surgery in Children With and Without Down Syndrome.

artículo científico publicado en 2016

Pharmacogenetics and paediatric drug development: issues and consequences to labelling and dosing recommendations.

artículo científico publicado en 2007

Pharmacokinetic considerations for pediatric patients receiving analgesia in the intensive care unit; targeting postoperative, ECMO and hypothermia patients.

artículo científico publicado en 2018

Pharmacokinetics and Pharmacodynamics of Drugs in Obese Pediatric Patients: How to Map Uncharted Clinical Territories

artículo científico publicado en 2019

Pharmacokinetics and Pharmacodynamics of Posaconazole

scientific article published on 22 April 2020

Pharmacokinetics and effects of propofol 6% for short-term sedation in paediatric patients following cardiac surgery

artículo científico publicado en 2002

Pharmacokinetics and pharmacodynamics of midazolam and metabolites in nonventilated infants after craniofacial surgery.

artículo científico publicado en 2006

Pharmacokinetics and probability of target attainment for micafungin in normal-weight and morbidly obese adults

scientific article published on 01 April 2019

Pharmacokinetics of Anidulafungin in Obese and Normal-Weight Adults.

artículo científico publicado en 2018

Pharmacokinetics of paracetamol and its metabolites in women at delivery and post-partum.

artículo científico publicado en 2013

Pharmacological sedation management in the paediatric intensive care unit

artículo científico publicado en 2016

Pilot study on the influence of liver blood flow and cardiac output on the clearance of propofol in critically ill patients

artículo científico publicado en 2007

Population Pharmacokinetic Modeling of Acetaminophen and Metabolites in Children After Cardiac Surgery With Cardiopulmonary Bypass

scientific article published on 11 January 2019

Population Pharmacokinetics and Pharmacodynamics of Propofol in Morbidly Obese Patients

artículo científico publicado el 1 de noviembre de 2011

Population Pharmacokinetics of Alemtuzumab (Campath) in Pediatric Hematopoietic Cell Transplantation: Towards Individualized Dosing to Improve Outcome

artículo científico publicado en 2019

Population Pharmacokinetics of Intravenous Salbutamol in Children with Refractory Status Asthmaticus

scientific article published on 01 February 2020

Population pharmacodynamic model for low molecular weight heparin nadroparin in morbidly obese and non-obese patients using anti-Xa levels as endpoint

artículo científico publicado en 2014

Population pharmacokinetic and pharmacodynamic modeling of propofol for long-term sedation in critically ill patients: a comparison between propofol 6% and propofol 1%.

artículo científico publicado en 2002

Population pharmacokinetic modeling of Thymoglobulin(®) in children receiving allogeneic-hematopoietic cell transplantation: towards improved survival through individualized dosing

artículo científico publicado en 2015

Population pharmacokinetic-pharmacodynamic model of propofol in adolescents undergoing scoliosis surgery with intraoperative wake-up test: a study using Bispectral index and composite auditory evoked potentials as pharmacodynamic endpoints

artículo científico publicado en 2019

Population pharmacokinetics of midazolam and its metabolites in overweight and obese adolescents

artículo científico publicado en 2015

Population pharmacokinetics of oxycodone in plasma and cerebrospinal fluid after epidural and intravenous administration

scientific article published on 22 May 2019

Population pharmacokinetics of paracetamol across the human age-range from (pre)term neonates, infants, children to adults

scientific article published on 23 January 2014

Population pharmacokinetics of vancomycin in obesity: Finding the optimal dose for (morbidly) obese individuals

scientific article published on 07 January 2020

Precision Dosing of Doxapram in Preterm Infants Using Continuous Pharmacodynamic Data and Model-Based Pharmacokinetics: An Illustrative Case Series

artículo científico publicado en 2020

Predicting CYP3A-mediated midazolam metabolism in critically ill neonates, infants, children and adults with inflammation and organ failure.

artículo científico publicado en 2017

Predicting Unacceptable Pain in Cardiac Surgery Patients Receiving Morphine Maintenance and Rescue Doses: A Model-Based Pharmacokinetic-Pharmacodynamic Analysis

artículo científico publicado en 2020

Prediction of morphine clearance in the paediatric population : how accurate are the available pharmacokinetic models?

artículo científico

Prediction of propofol clearance in children from an allometric model developed in rats, children and adults versus a 0.75 fixed-exponent allometric model

artículo científico publicado en 2010

Predictive Performance of a Recently Developed Population Pharmacokinetic Model for Morphine and its Metabolites in New Datasets of (Preterm) Neonates, Infants and Children

artículo científico publicado en 2011

Predictive performance of a busulfan pharmacokinetic model in children and young adults.

artículo científico publicado en 2012

Predictors of Insulin Resistance in Children versus Adolescents with Obesity

artículo científico publicado en 2017

Propofol clearance in morbidly obese children and adolescents: influence of age and body size

artículo científico publicado en 2012

Propofol in (pre)term neonates: consider the extensive interindividual variability in clearance within the neonatal population.

artículo científico publicado en 2011

Propofol pharmacokinetics and pharmacodynamics for depth of sedation in nonventilated infants after major craniofacial surgery.

artículo científico publicado en 2006

Psychostimulants: Influence on Body Mass Index and Height in a Pediatric Population with Attention-Deficit/Hyperactivity Disorder?

scientific article published on 16 May 2018

Randomized Controlled Trial on the Influence of Intraoperative Remifentanil versus Fentanyl on Acute and Chronic Pain after Cardiac Surgery

artículo científico publicado en 2017

Rapid Increase in Clearance of Phenobarbital in Neonates on Extracorporeal Membrane Oxygenation: A Pilot Retrospective Population Pharmacokinetic Analysis

artículo científico publicado en 2020

Rapidly maturing fentanyl clearance in preterm neonates

scientific article published on 01 February 2019

Recently Registered Midazolam Doses for Preterm Neonates Do Not Lead to Equal Exposure: A Population Pharmacokinetic Model

scientific article published on 15 May 2019

Rectal Omeprazole in Infants With Gastroesophageal Reflux Disease: A Randomized Pilot Trial

artículo científico publicado en 2020

Reduced subcutaneous tissue distribution of cefazolin in morbidly obese versus non-obese patients determined using clinical microdialysis.

artículo científico publicado en 2013

Remifentanil versus fentanyl during cardiac surgery on the incidence of chronic thoracic pain (REFLECT): study protocol for a randomized controlled trial

artículo científico publicado en 2014

Risk factors for chronic thoracic pain after cardiac surgery via sternotomy ⬇️

artículo científico publicado el 10 de mayo de 2011

Scaling Drug Clearance from Adults to the Young Children for Drugs Undergoing Hepatic Metabolism: A Simulation Study to Search for the Simplest Scaling Method

artículo científico publicado en 2019

Scaling of pharmacokinetics across paediatric populations: the lack of interpolative power of allometric models ⬇️

artículo científico publicado el 1 de septiembre de 2012

Sedation With Midazolam After Cardiac Surgery in Children With and Without Down Syndrome: A Pharmacokinetic-Pharmacodynamic Study

artículo científico publicado en 2020

Short- and long-term impact of remifentanil on thermal detection and pain thresholds after cardiac surgery: A randomised controlled trial

artículo científico publicado en 2019

Simulation-based suggestions to improve ibuprofen dosing for patent ductus arteriosus in preterm newborns

scientific article published on 28 July 2018

Simultaneous pharmacokinetic modeling of gentamicin, tobramycin and vancomycin clearance from neonates to adults: towards a semi-physiological function for maturation in glomerular filtration

artículo científico publicado en 2014

Skin autofluorescence in children with and without obesity

artículo científico publicado en 2019

Successful Use of [14C]Paracetamol Microdosing to Elucidate Developmental Changes in Drug Metabolism

artículo científico publicado en 2017

Supervised Multidimensional Item Response Theory Modeling of Pediatric Iatrogenic Withdrawal Symptoms

artículo científico publicado en 2019

Systematic evaluation of the descriptive and predictive performance of paediatric morphine population models

artículo científico publicado en 2010

Tailor-made drug treatment for children: creation of an infrastructure for data-sharing and population PK-PD modeling

artículo científico publicado en 2009

The Effect of Adult and Pediatric Cardiopulmonary Bypass on Pharmacokinetic and Pharmacodynamic Parameters ⬇️

artículo científico publicado el 1 de noviembre de 2013

The Effect of Eighteen-Month Metformin Treatment in Obese Adolescents: Comparison of Results Obtained in Daily Practice with Results from a Clinical Trial.

artículo científico publicado en 2016

The Influence of Normalization Weight in Population Pharmacokinetic Covariate Models.

artículo científico publicado en 2019

The Predictive Value of Glomerular Filtration Rate-Based Scaling of Pediatric Clearance and Doses for Drugs Eliminated by Glomerular Filtration with Varying Protein-Binding Properties

artículo científico publicado en 2020

The Val158Met polymorphism of the COMT gene is associated with increased pain sensitivity in morphine-treated patients undergoing a painful procedure after cardiac surgery.

artículo científico publicado en 2013

The allometric exponent for scaling clearance varies with age: a study on seven propofol datasets ranging from preterm neonates to adults

scientific article published on January 2014

The oral bioavailability and metabolism of midazolam in stable critically ill children: a pharmacokinetic microtracing study

artículo científico publicado en 2020

The role of population PK-PD modelling in paediatric clinical research.

artículo científico publicado en 2011

The use of the Behavioral Pain Scale to assess pain in conscious sedated patients

artículo científico publicado en 2009

Tobramycin Clearance Is Best Described by Renal Function Estimates in Obese and Non-obese Individuals: Results of a Prospective Rich Sampling Pharmacokinetic Study.

artículo científico publicado en 2019

Towards Rational Dosing Algorithms for Vancomycin in Neonates and Infants Based on Population Pharmacokinetic Modeling

artículo científico publicado en 2015

Towards evidence-based dosing regimens in children on the basis of population pharmacokinetic pharmacodynamic modelling

artículo científico publicado en 2013

Towards personalized treatment of pain using a quantitative systems pharmacology approach.

artículo científico publicado en 2017

Treatment of Peritoneal Dissemination in Stomach Cancer Patients With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC): Rationale and Design of the PERISCOPE Study

artículo científico publicado en 2017

Treatment of pulmonary embolism in an extremely obese patient.

artículo científico publicado en 2009

Vancomycin pharmacokinetic models: informing the clinical management of drug-resistant bacterial infections.

artículo científico publicado en 2014

What is the right dose for children? ⬇️

artículo científico publicado el 1 de octubre de 2010

[Individualized dosing guidelines for children]

artículo científico publicado en 2013

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