Lista de obras - Nils Y. Lycke - Dominio Público Uruguay

A novel concept in mucosal adjuvanticity: The CTA1‐DD adjuvant is a B cell‐targeted fusion protein that incorporates the enzymatically active cholera toxin A1 subunit ⬇️

artículo científico publicado el 1 de junio de 1998

A novel non-toxic combined CTA1-DD and ISCOMS adjuvant vector for effective mucosal immunization against influenza virus ⬇️

artículo científico publicado el 8 de abril de 2011

A unique role of the cholera toxin A1-DD adjuvant for long-term plasma and memory B cell development

artículo científico publicado en 2011

ADP-ribosylating bacterial enzymes for the targeted control of mucosal tolerance and immunity

artículo científico publicado en 2004

ADP-ribosylation controls the outcome of tolerance or enhanced priming following mucosal immunization

artículo científico publicado en 2010

Accelerated acute rejection of the intestinal graft in CD28-deficient mice

artículo científico publicado en 2005

Adjuvanticity of the cholera toxin A1-based gene fusion protein, CTA1-DD, is critically dependent on the ADP-ribosyltransferase and Ig-binding activity.

artículo científico publicado en 1999

Adoptive transfer of gut mucosal antitoxin memory by isolated B cells 1 year after oral immunization with cholera toxin.

artículo científico publicado en 1989

Analysis of the second messenger systems involved in the synergistic effect of cholera toxin and interleukin-4 on B cell isotype-switching.

artículo científico publicado en 1995

Antigen-specific and polyclonal CD4+ lamina propria T-cell lines: phenotypic and functional characterization ⬇️

artículo científico publicado el 1 de enero de 1992

Blockade of the B7-CD28 pathway by CTLA4-Ig counteracts rejection and prolongs survival in small bowel transplantation

artículo científico publicado en 2000

B‐cell‐deficient mice develop complete immune protection against genital tract infection with Chlamydia trachomatis ⬇️

artículo científico publicado el 1 de diciembre de 1997

CD19-deficient mice exhibit poor responsiveness to oral immunization despite evidence of unaltered total IgA levels, germinal centers and IgA-isotype switching in Peyer's patches

artículo científico publicado en 2000

CD4+ T‐cell immunity in the female genital tract is critically dependent on local mucosal immunization ⬇️

artículo científico publicado el 1 de septiembre de 2011

CD8-deficient mice exhibit augmented mucosal immune responses and intact adjuvant effects to cholera toxin

artículo científico publicado en 1996

CTA1-DD adjuvant promotes strong immunity against human immunodeficiency virus type 1 envelope glycoproteins following mucosal immunization

artículo científico publicado en 2008

CTA1-DD-immune stimulating complexes: a novel, rationally designed combined mucosal vaccine adjuvant effective with nanogram doses of antigen

scientific article published on 01 September 2001

CTA1-M2e-DD: a novel mucosal adjuvant targeted influenza vaccine.

artículo científico publicado en 2008

Cellular basis of immunomodulation by cholera toxin in vitro with possible association to the adjuvant function in vivo

artículo científico publicado en 1989

Cholera antibody production in vitro by peripheral blood lymphocytes following oral immunization of humans and mice

artículo científico publicado en 1985

Cholera toxin adjuvant greatly promotes antigen priming of T cells

artículo científico publicado en 1993

Cholera toxin adjuvant promotes long-term immunological memory in the gut mucosa to unrelated immunogens after oral immunization ⬇️

artículo científico publicado el 1 de marzo de 1992

Cholera toxin and cholera B subunit as oral-mucosal adjuvant and antigen vector systems

artículo científico publicado en 1993

Cholera toxin enhances alloantigen presentation by cultured intestinal epithelial cells

artículo científico publicado en 1993

Cholera toxin enhances antigen presentation.

artículo científico publicado en 1995

Cholera toxin stimulates IL-1 production and enhances antigen presentation by macrophages in vitro.

artículo científico publicado en 1991

Circulating cholera antitoxin memory cells in the blood one year after oral cholera vaccination in humans

artículo científico publicado en 1987

Complement Activation and Complement Receptors on Follicular Dendritic Cells Are Critical for the Function of a Targeted Adjuvant ⬇️

artículo científico publicado el 31 de agosto de 2011

Cutting Edge: Retinoic Acid Signaling in B Cells Is Essential for Oral Immunization and Microflora Composition

artículo científico publicado en 2015

Differential CD28 and inducible costimulatory molecule signaling requirements for protective CD4+ T-cell-mediated immunity against genital tract Chlamydia trachomatis infection

artículo científico publicado en 2007

Feeding transgenic plants that express a tolerogenic fusion protein effectively protects against arthritis

artículo científico publicado en 2015

From toxin to adjuvant: basic mechanisms for the control of mucosal IgA immunity and tolerance

artículo científico publicado en 2005

Gene expression profiling identifies STAT3 as a novel pathway for immunomodulation by cholera toxin adjuvant

artículo científico publicado en 2010

Genetically engineered nontoxic vaccine adjuvant that combines B cell targeting with immunomodulation by cholera toxin A1 subunit.

artículo científico publicado en 1997

Genital tract infection with Chlamydia trachomatis fails to induce protective immunity in gamma interferon receptor-deficient mice despite a strong local immunoglobulin A response

artículo científico publicado en 1997

Graft mucosal blood flow is reduced prior to histologic evidence of rejection in mouse small bowel transplantation: a murine model

artículo científico publicado en 2003

Gut IgA class switch recombination in the absence of CD40 does not occur in the lamina propria and is independent of germinal centers.

artículo científico publicado en 2006

Helicobacter pylori-specific antibodies impair the development of gastritis, facilitate bacterial colonization, and counteract resistance against infection

artículo científico publicado en 2004

Host defense against cholera toxin is strongly CD4+ T cell dependent.

artículo científico publicado en 1991

IL-6-deficient mice exhibit normal mucosal IgA responses to local immunizations and Helicobacter felis infection

artículo científico publicado en 1996

IgA B Cell Responses to Gut Mucosal Antigens: Do We Know it all?

artículo científico publicado en 2013

IgA antibodies impair resistance against Helicobacter pylori infection: studies on immune evasion in IL-10-deficient mice

artículo científico publicado en 2005

IgA isotype restriction in the mucosal but not in the extramucosal immune response after oral immunizations with cholera toxin or cholera B subunit

scientific article published on 01 January 1983

Immunity against a Chlamydia infection and disease may be determined by a balance of IL-17 signaling.

artículo científico publicado en 2013

Immunization with a MOMP-based vaccine protects mice against a pulmonary Chlamydia challenge and identifies a disconnection between infection and pathology

artículo científico publicado en 2013

Impaired CD40-signalling in CD19-deficient mice selectively affects Th2-dependent isotype switching

artículo científico publicado en 2001

Impaired mucosal immune responses in interleukin 4-targeted mice

artículo científico publicado en 1995

Improved design and intranasal delivery of an M2e-based human influenza A vaccine

artículo científico publicado en 2006

Induction of gut IgA production through T cell-dependent and T cell-independent pathways

artículo científico publicado en 2012

Induction of gut mucosal immune responses: importance of genetic background and Th1/Th2 cross-regulation.

artículo científico publicado en 1998

Interferon‐γ receptor‐deficient mice exhibit impaired gut mucosal immune responses but intact oral tolerance ⬇️

artículo científico publicado el 1 de septiembre de 1997

Intestinal mucosal memory and presence of memory cells in lamina propria and Peyer's patches in mice 2 years after oral immunization with cholera toxin

artículo científico publicado en 1986

Intrarectal immunization of mice with VP6 and either LT(R192G) or CTA1-DD as adjuvant protects against fecal rotavirus shedding after EDIM challenge

artículo científico publicado en 2007

Lack of local suppression in orally tolerant CD8-deficient mice reveals a critical regulatory role of CD8+ T cells in the normal gut mucosa ⬇️

artículo científico publicado el 15 de enero de 1998

Laser-Doppler flowmetry is reliable for early diagnosis of small-bowel acute rejection in the mouse

artículo científico publicado en 2003

Local intravaginal vaccination of the female genital tract

artículo científico publicado en 1996

Long-term cholera antitoxin memory in the gut can be triggered to antibody formation associated with protection within hours of an oral challenge immunization

artículo científico publicado en 1987

MHC class I-restricted cytotoxic lymphocyte responses induced by enterotoxin-based mucosal adjuvants

article

Mast cells contribute to the mucosal adjuvant effect of CTA1-DD after IgG-complex formation

artículo científico publicado en 2010

Migration of host and donor T cells in small bowel transplantation

artículo científico publicado en 1997

Monoclonal antibodies to cholera toxin with special reference to cross-reactions with Escherichia coli heat-labile enterotoxin

artículo científico publicado en 1983

Mucosal Vaccine Development Based on Liposome Technology

artículo científico publicado en 2016

Mucosal adjuvants and long-term memory development with special focus on CTA1-DD and other ADP-ribosylating toxins

scientific article published on 15 September 2010

Mucosal immune response to cholera toxin--cellular basis of memory and adjuvant action

artículo científico publicado en 1988

Mucosal immunity: implications for vaccine development

artículo científico publicado en 1992

Mucosal immunization of piglets with purified F18 fimbriae does not protect against F18+ Escherichia coli infection.

artículo científico publicado en 2007

Mucosal memory B cells retain the ability to produce IgM antibodies 2 years after oral immunization.

artículo científico publicado en 1995

Oral administration of a streptococcal antigen coupled to cholera toxin B subunit evokes strong antibody responses in salivary glands and extramucosal tissues

artículo científico publicado en 1989

Oral vaccination with immune stimulating complexes.

artículo científico publicado en 1999

Paradoxical IgA immunity in CD4-deficient mice. Lack of cholera toxin-specific protective immunity despite normal gut mucosal IgA differentiation.

artículo científico publicado en 1995

Per Brandtzaeg: patron of mucosal immunology

artículo científico publicado en 2017

Porous Nanoparticles With Self-Adjuvanting M2e-Fusion Protein and Recombinant Hemagglutinin Provide Strong and Broadly Protective Immunity Against Influenza Virus Infections

Presence of antigen-specific long-term memory cells in systemic lymphoid tissues as well as locally in the gut lamina propria following oral immunization with cholera toxin adjuvant.

artículo científico publicado en 1995

Protection against Helicobacter pylori infection following immunization is IL-12-dependent and mediated by Th1 cells

artículo científico publicado en 2002

Protection against cholera toxin after oral immunization is thymus-dependent and associated with intestinal production of neutralizing IgA antitoxin

scientific article published on 01 April 1987

Protection against genital tract Chlamydia trachomatis infection following intranasal immunization with a novel recombinant MOMP VS2/4 antigen

artículo científico publicado en 2016

Recent progress in mucosal vaccine development: potential and limitations ⬇️

artículo científico publicado el 25 de julio de 2012

Recombinant cholera toxin B subunit is not an effective mucosal adjuvant for oral imm_unization of mice against Helicobacter felis ⬇️

artículo científico publicado el 1 de mayo de 1998

Requirements for B7-CD28 costimulation in mucosal IgA responses: paradoxes observed in CTLA4-H gamma 1 transgenic mice ⬇️

artículo científico publicado el 1 de julio de 1998

Role of CTA1R7K-COL-DD as a novel therapeutic mucosal tolerance-inducing vector for treatment of collagen-induced arthritis.

artículo científico publicado en 2009

Role of local IgA antitoxin-producing cells for intestinal protection against cholera toxin challenge

scientific article published on 01 January 1989

Splenic marginal zone dendritic cells mediate the cholera toxin adjuvant effect: dependence on the ADP-ribosyltransferase activity of the holotoxin

artículo científico publicado en 2005

Stimulation of antigen-specific T- and B-cell memory in local as well as systemic lymphoid tissues following oral immunization with cholera toxin adjuvant

artículo científico publicado en 1993

Strategies for the induction of immune responses at mucosal surfaces making use of cholera toxin B subunit as immunogen, carrier, and adjuvant.

artículo científico publicado en 1994

Strong adjuvant properties of cholera toxin on gut mucosal immune responses to orally presented antigens

artículo científico publicado en 1986

Strong biotype and serotype cross-protective antibacterial and antitoxic immunity in rabbits after cholera infection

artículo científico publicado en 1986

Strong differential regulation of serum and mucosal IgA responses as revealed in CD28-deficient mice using cholera toxin adjuvant

article

Studies in Knockout Mice Reveal that Anti‐Chlamydial Protection Requires TH1 Cells Producing IFN‐γ: Is this True for Humans? ⬇️

artículo científico publicado el 1 de diciembre de 1997

Subcomponent vaccine based on CTA1-DD adjuvant with incorporated UreB class II peptides stimulates protective Helicobacter pylori immunity

artículo científico publicado en 2013

T and B cell responses to chimeric proteins containing heterologous T helper epitopes inserted at different positions

artículo científico publicado el 1 de octubre de 1992

T cell-independent IgA class switch recombination is restricted to the GALT and occurs prior to manifest germinal center formation.

artículo científico publicado en 2010

Tandem repeats of t helper epitopes enhance immunogenicity of fusion proteins by promoting processing and presentation ⬇️

artículo científico publicado el 1 de junio de 1997

The ADP-Ribosylating CTA1-DD Adjuvant Enhances T Cell-Dependent and Independent Responses by Direct Action on B Cells Involving Anti-Apoptotic Bcl-2- and Germinal Center-Promoting Effects

article

The B cell targeted adjuvant, CTA1-DD, exhibits potent mucosal immunoenhancing activity despite pre-existing anti-toxin immunity

scientific article published on 01 March 2001

The B-cell targeted CTA1-DD vaccine adjuvant is highly effective at enhancing antibody as well as CTL responses

artículo científico publicado en 2001

The Female Lower Genital Tract Is a Privileged Compartment with IL-10 Producing Dendritic Cells and Poor Th1 Immunity following Chlamydia trachomatis Infection ⬇️

artículo científico publicado el 4 de noviembre de 2010

The Influence of Costimulation and Regulatory Cd4+ T Cells on Intestinal Iga Immune Responses ⬇️

artículo científico publicado el 1 de enero de 1998

The adjuvant action of cholera toxin is associated with an increased intestinal permeability for luminal antigens

artículo científico publicado en 1991

The adjuvant effect of Vibrio cholerae and Escherichia coli heat-labile enterotoxins is linked to their ADP-ribosyltransferase activity

artículo científico publicado el 1 de septiembre de 1992

The immune complex CTA1-DD/IgG adjuvant specifically targets connective tissue mast cells through FcγRIIIA and augments anti-HPV immunity after nasal immunization

artículo científico publicado en 2013

The level of protection against rotavirus shedding in mice following immunization with a chimeric VP6 protein is dependent on the route and the coadministered adjuvant

artículo científico publicado en 2002

The mechanism of cholera toxin adjuvanticity ⬇️

artículo científico publicado el 1 de octubre de 1997

The mucosal adjuvant effects of cholera toxin and immune-stimulating complexes differ in their requirement for IL-12, indicating different pathways of action

scientific article published on 01 June 1999

The nontoxic CTA1-DD adjuvant enhances protective immunity against Helicobacter pylori infection following mucosal immunization

artículo científico publicado en 2006

The regulation of gut mucosal IgA B-cell responses: recent developments

artículo científico publicado en 2017

The role of Peyer's patches in synchronizing gut IgA responses

artículo científico publicado en 2012

The universal influenza vaccine M2e-HBc administered intranasally in combination with the adjuvant CTA1-DD provides complete protection

artículo científico publicado en 2005

Vaccine-induced immunity against Helicobacter pylori infection is impaired in IL-18-deficient mice

artículo científico publicado en 2004

Lista de obras de Nils Y. Lycke

A novel concept in mucosal adjuvanticity: The CTA1‐DD adjuvant is a B cell‐targeted fusion protein that incorporates the enzymatically active cholera toxin A1 subunit ⬇️

A novel non-toxic combined CTA1-DD and ISCOMS adjuvant vector for effective mucosal immunization against influenza virus ⬇️

A unique role of the cholera toxin A1-DD adjuvant for long-term plasma and memory B cell development

ADP-ribosylating bacterial enzymes for the targeted control of mucosal tolerance and immunity

ADP-ribosylation controls the outcome of tolerance or enhanced priming following mucosal immunization

Accelerated acute rejection of the intestinal graft in CD28-deficient mice

Adjuvanticity of the cholera toxin A1-based gene fusion protein, CTA1-DD, is critically dependent on the ADP-ribosyltransferase and Ig-binding activity.

Adoptive transfer of gut mucosal antitoxin memory by isolated B cells 1 year after oral immunization with cholera toxin.

Analysis of the second messenger systems involved in the synergistic effect of cholera toxin and interleukin-4 on B cell isotype-switching.

Antigen-specific and polyclonal CD4+ lamina propria T-cell lines: phenotypic and functional characterization ⬇️

Blockade of the B7-CD28 pathway by CTLA4-Ig counteracts rejection and prolongs survival in small bowel transplantation

B‐cell‐deficient mice develop complete immune protection against genital tract infection with Chlamydia trachomatis ⬇️

CD19-deficient mice exhibit poor responsiveness to oral immunization despite evidence of unaltered total IgA levels, germinal centers and IgA-isotype switching in Peyer's patches

CD4+ T‐cell immunity in the female genital tract is critically dependent on local mucosal immunization ⬇️

CD8-deficient mice exhibit augmented mucosal immune responses and intact adjuvant effects to cholera toxin

CTA1-DD adjuvant promotes strong immunity against human immunodeficiency virus type 1 envelope glycoproteins following mucosal immunization

CTA1-DD-immune stimulating complexes: a novel, rationally designed combined mucosal vaccine adjuvant effective with nanogram doses of antigen

CTA1-M2e-DD: a novel mucosal adjuvant targeted influenza vaccine.

Cellular basis of immunomodulation by cholera toxin in vitro with possible association to the adjuvant function in vivo

Cholera antibody production in vitro by peripheral blood lymphocytes following oral immunization of humans and mice

Cholera toxin adjuvant greatly promotes antigen priming of T cells

Cholera toxin adjuvant promotes long-term immunological memory in the gut mucosa to unrelated immunogens after oral immunization ⬇️

Cholera toxin and cholera B subunit as oral-mucosal adjuvant and antigen vector systems

Cholera toxin enhances alloantigen presentation by cultured intestinal epithelial cells

Cholera toxin enhances antigen presentation.

Cholera toxin stimulates IL-1 production and enhances antigen presentation by macrophages in vitro.

Circulating cholera antitoxin memory cells in the blood one year after oral cholera vaccination in humans

Complement Activation and Complement Receptors on Follicular Dendritic Cells Are Critical for the Function of a Targeted Adjuvant ⬇️

Cutting Edge: Retinoic Acid Signaling in B Cells Is Essential for Oral Immunization and Microflora Composition

Differential CD28 and inducible costimulatory molecule signaling requirements for protective CD4+ T-cell-mediated immunity against genital tract Chlamydia trachomatis infection

Feeding transgenic plants that express a tolerogenic fusion protein effectively protects against arthritis

From toxin to adjuvant: basic mechanisms for the control of mucosal IgA immunity and tolerance

Gene expression profiling identifies STAT3 as a novel pathway for immunomodulation by cholera toxin adjuvant

Genetically engineered nontoxic vaccine adjuvant that combines B cell targeting with immunomodulation by cholera toxin A1 subunit.

Genital tract infection with Chlamydia trachomatis fails to induce protective immunity in gamma interferon receptor-deficient mice despite a strong local immunoglobulin A response

Graft mucosal blood flow is reduced prior to histologic evidence of rejection in mouse small bowel transplantation: a murine model

Gut IgA class switch recombination in the absence of CD40 does not occur in the lamina propria and is independent of germinal centers.

Helicobacter pylori-specific antibodies impair the development of gastritis, facilitate bacterial colonization, and counteract resistance against infection

Host defense against cholera toxin is strongly CD4+ T cell dependent.

IL-6-deficient mice exhibit normal mucosal IgA responses to local immunizations and Helicobacter felis infection

IgA B Cell Responses to Gut Mucosal Antigens: Do We Know it all?

IgA antibodies impair resistance against Helicobacter pylori infection: studies on immune evasion in IL-10-deficient mice

IgA isotype restriction in the mucosal but not in the extramucosal immune response after oral immunizations with cholera toxin or cholera B subunit

Immunity against a Chlamydia infection and disease may be determined by a balance of IL-17 signaling.

Immunization with a MOMP-based vaccine protects mice against a pulmonary Chlamydia challenge and identifies a disconnection between infection and pathology

Impaired CD40-signalling in CD19-deficient mice selectively affects Th2-dependent isotype switching

Impaired mucosal immune responses in interleukin 4-targeted mice

Improved design and intranasal delivery of an M2e-based human influenza A vaccine

Induction of gut IgA production through T cell-dependent and T cell-independent pathways

Induction of gut mucosal immune responses: importance of genetic background and Th1/Th2 cross-regulation.

Interferon‐γ receptor‐deficient mice exhibit impaired gut mucosal immune responses but intact oral tolerance ⬇️

Intestinal mucosal memory and presence of memory cells in lamina propria and Peyer's patches in mice 2 years after oral immunization with cholera toxin

Intrarectal immunization of mice with VP6 and either LT(R192G) or CTA1-DD as adjuvant protects against fecal rotavirus shedding after EDIM challenge

Lack of local suppression in orally tolerant CD8-deficient mice reveals a critical regulatory role of CD8+ T cells in the normal gut mucosa ⬇️

Laser-Doppler flowmetry is reliable for early diagnosis of small-bowel acute rejection in the mouse

Local intravaginal vaccination of the female genital tract

Long-term cholera antitoxin memory in the gut can be triggered to antibody formation associated with protection within hours of an oral challenge immunization

MHC class I-restricted cytotoxic lymphocyte responses induced by enterotoxin-based mucosal adjuvants

Mast cells contribute to the mucosal adjuvant effect of CTA1-DD after IgG-complex formation

Migration of host and donor T cells in small bowel transplantation

Monoclonal antibodies to cholera toxin with special reference to cross-reactions with Escherichia coli heat-labile enterotoxin

Mucosal Vaccine Development Based on Liposome Technology

Mucosal adjuvants and long-term memory development with special focus on CTA1-DD and other ADP-ribosylating toxins

Mucosal immune response to cholera toxin--cellular basis of memory and adjuvant action

Mucosal immunity: implications for vaccine development

Mucosal immunization of piglets with purified F18 fimbriae does not protect against F18+ Escherichia coli infection.

Mucosal memory B cells retain the ability to produce IgM antibodies 2 years after oral immunization.

Oral administration of a streptococcal antigen coupled to cholera toxin B subunit evokes strong antibody responses in salivary glands and extramucosal tissues

Oral vaccination with immune stimulating complexes.

Paradoxical IgA immunity in CD4-deficient mice. Lack of cholera toxin-specific protective immunity despite normal gut mucosal IgA differentiation.

Per Brandtzaeg: patron of mucosal immunology

Porous Nanoparticles With Self-Adjuvanting M2e-Fusion Protein and Recombinant Hemagglutinin Provide Strong and Broadly Protective Immunity Against Influenza Virus Infections

Presence of antigen-specific long-term memory cells in systemic lymphoid tissues as well as locally in the gut lamina propria following oral immunization with cholera toxin adjuvant.

Protection against Helicobacter pylori infection following immunization is IL-12-dependent and mediated by Th1 cells

Protection against cholera toxin after oral immunization is thymus-dependent and associated with intestinal production of neutralizing IgA antitoxin

Protection against genital tract Chlamydia trachomatis infection following intranasal immunization with a novel recombinant MOMP VS2/4 antigen

Recent progress in mucosal vaccine development: potential and limitations ⬇️

Recombinant cholera toxin B subunit is not an effective mucosal adjuvant for oral imm_unization of mice against Helicobacter felis ⬇️

Requirements for B7-CD28 costimulation in mucosal IgA responses: paradoxes observed in CTLA4-H gamma 1 transgenic mice ⬇️