Lista de obras -

A non-transgenic mouse model (icv-STZ mouse) of Alzheimer's disease: similarities to and differences from the transgenic model (3xTg-AD mouse).

artículo científico publicado en 2012

Activation of Protein Phosphatase 2B and Hyperphosphorylation of Tau in Alzheimer's Disease ⬇️

artículo científico publicado el 1 de enero de 2011

Alzheimer Neurofibrillary Degeneration: Therapeutic Targets and High-Throughput Assays ⬇️

artículo científico publicado el 1 de enero de 2003

Alzheimer disease therapeutics: focus on the disease and not just plaques and tangles

artículo científico publicado en 2014

Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorial

artículo científico publicado en 2010

Anesthesia induces phosphorylation of tau

artículo científico publicado en 2009

Anesthesia with sevoflurane or isoflurane induces severe hypoglycemia in neonatal mice

scientific article published on 02 April 2020

Anesthetics and Tau Protein: Animal Model Studies ⬇️

artículo científico publicado el 1 de enero de 2010

Bilateral injection of isoproterenol into hippocampus induces Alzheimer-like hyperphosphorylation of tau and spatial memory deficit in rat.

artículo científico publicado en 2005

Brain gene expression of a sporadic (icv-STZ Mouse) and a familial mouse model (3xTg-AD mouse) of Alzheimer's disease

artículo científico publicado en 2012

Brain glucose transporters, O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer's disease

artículo científico publicado en 2009

C-terminal truncation of GSK-3β enhances its dephosphorylation by PP2A.

artículo científico publicado en 2017

CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer's disease

artículo científico publicado en 2013

Calpain I Activation Causes GLUT3 Proteolysis and Downregulation of O-GlcNAcylation in Alzheimer's Disease Brain

artículo científico publicado en 2018

Chronic cerebral hypoperfusion causes decrease of O-GlcNAcylation, hyperphosphorylation of tau and behavioral deficits in mice

artículo científico publicado en 2014

Concurrent alterations of O-GlcNAcylation and phosphorylation of tau in mouse brains during fasting

artículo científico publicado en 2006

Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation

artículo científico publicado en 2005

Corrigendum: Rapid alteration of protein phosphorylation during postmortem: implication in the study of protein phosphorylation

artículo científico publicado en 2016

Cross talk between PI3K-AKT-GSK-3β and PP2A pathways determines tau hyperphosphorylation

artículo científico publicado en 2014

Cyclic AMP-dependent protein kinase enhances SC35-promoted Tau exon 10 inclusion

artículo científico publicado en 2013

Cyclic AMP-dependent protein kinase regulates 9G8-mediated alternative splicing of tau exon 10.

artículo científico publicado en 2012

Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer disease

artículo científico publicado en 2011

Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome.

artículo científico publicado en 2008

Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

artículo científico publicado en 2008

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes ⬇️

artículo científico publicado el 19 de mayo de 2011

Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5

scientific journal article

Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease

artículo científico publicado en 2004

Deregulation of brain insulin signaling in Alzheimer's disease

artículo científico

Deregulation of sphingolipid metabolism in Alzheimer's disease

artículo científico publicado en 2008

Developmental Regulation of Protein O-GlcNAcylation, O-GlcNAc Transferase, and O-GlcNAcase in Mammalian Brain ⬇️

artículo científico publicado el 22 de agosto de 2012

Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases ⬇️

artículo científico publicado en 2009

Differential Effects of an O-GlcNAcase Inhibitor on Tau Phosphorylation ⬇️

artículo científico publicado el 19 de abril de 2012

Diverse regulation of AKT and GSK‐3β by O‐GlcNAcylation in various types of cells ⬇️

artículo científico publicado el 8 de junio de 2012

Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain

artículo científico publicado en 2007

Dual-specificity Tyrosine Phosphorylation-regulated Kinase 1A (Dyrk1A) Modulates Serine/Arginine-rich Protein 55 (SRp55)-promoted Tau Exon 10 Inclusion ⬇️

artículo científico publicado el 5 de julio de 2012

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) enhances tau expression

artículo científico publicado en 2013

Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice

artículo científico publicado en 2017

Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer's disease

artículo científico publicado en 2009

Dysregulation of protein phosphorylation/dephosphorylation in Alzheimer's disease: a therapeutic target

artículo científico publicado en 2006

Dysregulation of tau phosphorylation in mouse brain during excitotoxic damage

artículo científico publicado en 2009

Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain

artículo científico publicado en 2004

Expression of Tau Pathology-Related Proteins in Different Brain Regions: A Molecular Basis of Tau Pathogenesis

artículo científico publicado en 2017

From chronic cerebral hypoperfusion to Alzheimer-like brain pathology and neurodegeneration

artículo científico publicado en 2014

GSK-3β is Dephosphorylated by PP2A in a Leu309 Methylation-Independent Manner

artículo científico publicado en 2015

Hyperphosphorylation-induced tau oligomers

artículo científico publicado en 2013

Impaired brain glucose metabolism leads to Alzheimer neurofibrillary degeneration through a decrease in tau O-GlcNAcylation.

artículo científico publicado en 2006

Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome

artículo científico publicado en 2008

Inhibition of glycogen synthase kinase-3 reverses tau hyperphosphorylation induced by Pin1 down-regulation

artículo científico publicado en 2013

Inhibition of protein phosphatase 2A induces phosphorylation and accumulation of neurofilaments in metabolically active rat brain slices

artículo científico publicado en 2003

Inhibition of protein synthesis alters protein degradation through activation of protein kinase B (AKT)

scientific article published on 10 July 2013

Insulin sensitizers improve learning and attenuate tau hyperphosphorylation and neuroinflammation in 3xTg-AD mice

artículo científico publicado en 2014

Intracerebroventricular streptozotocin exacerbates Alzheimer-like changes of 3xTg-AD mice

artículo científico publicado en 2013

Intranasal Insulin Prevents Anesthesia-Induced Cognitive Impairment and Chronic Neurobehavioral Changes

artículo científico publicado en 2017

Intranasal Insulin Prevents Anesthesia-Induced Spatial Learning and Memory Deficit in Mice

artículo científico publicado en 2016

Intranasal insulin prevents anesthesia-induced hyperphosphorylation of tau in 3xTg-AD mice

artículo científico publicado en 2014

Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice

artículo científico publicado en 2014

Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta

artículo científico publicado en 2002

Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome

artículo científico publicado en 2011

Losartan-induced hypotension leads to tau hyperphosphorylation and memory deficit

artículo científico publicado en 2014

Mechanisms of tau-induced neurodegeneration

artículo científico publicado en 2009

Microtubule-associated protein tau as a therapeutic target in Alzheimer's disease

artículo científico

Multifactorial Hypothesis and Multi-Targets for Alzheimer's Disease

artículo científico publicado en 2018

NF-kappaB precursor, p105, and NF-kappaB inhibitor, IkappaBgamma, are both elevated in Alzheimer disease brain

artículo científico publicado en 2005

Neonatal Exposure to Anesthesia Leads to Cognitive Deficits in Old Age: Prevention with Intranasal Administration of Insulin in Mice

artículo científico publicado en 2020

O-GlcNAc cycling modulates neurodegeneration ⬇️

artículo científico publicado el 9 de octubre de 2012

O-GlcNAcylation Reduces Ischemia-Reperfusion-Induced Brain Injury

artículo científico publicado en 2017

O-GlcNAcylation modulates PKA-CREB signaling in a manner specific to PKA catalytic subunit isoforms

artículo científico publicado en 2018

O-GlcNAcylation of protein kinase A catalytic subunits enhances its activity: a mechanism linked to learning and memory deficits in Alzheimer's disease

artículo científico publicado en 2016

O-GlcNAcylation regulates ischemia-induced neuronal apoptosis through AKT signaling

artículo científico publicado en 2015

O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease

artículo científico publicado en 2004

O-GlcNAcylation: A regulator of tau pathology and neurodegeneration

artículo científico publicado en 2016

Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease

artículo científico publicado en 2003

Opposite effects of two estrogen receptors on tau phosphorylation through disparate effects on the miR-218/PTPA pathway

artículo científico publicado en 2015

Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome

artículo científico publicado en 2008

PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners

artículo científico publicado en 2006

PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta

artículo científico publicado en 2010

Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies

artículo científico publicado en 2014

Pathological Tau From Alzheimer's Brain Induces Site-Specific Hyperphosphorylation and SDS- and Reducing Agent-Resistant Aggregation of Tau

Protein Phosphatase 1 dephosphorylates TDP-43 and suppresses its function in tau exon 10 inclusion

artículo científico publicado en 2018

Rapid alteration of protein phosphorylation during postmortem: implication in the study of protein phosphorylation

artículo científico publicado en 2015

Recent developments with tau-based drug discovery

artículo científico publicado en 2018

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

artículo científico publicado en 2009

Regulation between O-GlcNAcylation and phosphorylation of neurofilament-M and their dysregulation in Alzheimer disease

artículo científico publicado en 2007

Regulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1A

artículo científico publicado en 2011

Regulation of microtubule-associated proteins, protein kinases and protein phosphatases during differentiation of SY5Y cells

artículo científico publicado en 2004

Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A ⬇️

artículo científico publicado el 5 de abril de 2011

Relevance of Phosphorylation and Truncation of Tau to the Etiopathogenesis of Alzheimer's Disease

artículo científico publicado en 2018

Significance and mechanism of Alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion

artículo científico publicado en 2002

Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation

artículo científico publicado en 2007

Splicing factor SC35 promotes tau expression through stabilization of its mRNA ⬇️

artículo científico publicado el 17 de febrero de 2011

Subacute to chronic Alzheimer-like alterations after controlled cortical impact in human tau transgenic mice

TDP-43 suppresses tau expression via promoting its mRNA instability

artículo científico publicado en 2017

Targeting Insulin Signaling for the Treatment of Alzheimer's Disease

artículo científico

Targeting tau protein in Alzheimer's disease

artículo científico publicado en 2010

Tau and neurodegenerative disease: the story so far.

artículo científico publicado en 2015

Tau exon 10 alternative splicing and tauopathies

artículo científico publicado en 2008

Tau passive immunization blocks seeding and spread of Alzheimer hyperphosphorylated Tau-induced pathology in 3 × Tg-AD mice

artículo científico publicado en 2018

Tau passive immunization inhibits not only tau but also Aβ pathology

artículo científico publicado en 2017

Tau pathology in Alzheimer disease and other tauopathies

artículo científico publicado en 2005

The role of DYRK1A in neurodegenerative diseases ⬇️

artículo científico publicado el 13 de diciembre de 2010

The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome

artículo científico publicado en 2008

Transactive response DNA-binding protein 43 (TDP-43) regulates alternative splicing of tau exon 10: Implications for the pathogenesis of tauopathies

artículo científico publicado en 2017

Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE.

artículo científico publicado en 2015

Truncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease

artículo científico publicado en 2015

Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain

artículo científico publicado en 2005

Truncation of tau selectively facilitates its pathological activities

artículo científico publicado en 2020

Up-regulation of casein kinase 1ε is involved in tau pathogenesis in Alzheimer's disease

artículo científico publicado en 2017

Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration

artículo científico publicado en 2002

Lista de obras de

A non-transgenic mouse model (icv-STZ mouse) of Alzheimer's disease: similarities to and differences from the transgenic model (3xTg-AD mouse).

Activation of Protein Phosphatase 2B and Hyperphosphorylation of Tau in Alzheimer's Disease ⬇️

Alzheimer Neurofibrillary Degeneration: Therapeutic Targets and High-Throughput Assays ⬇️

Alzheimer disease therapeutics: focus on the disease and not just plaques and tangles

Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorial

Anesthesia induces phosphorylation of tau

Anesthesia with sevoflurane or isoflurane induces severe hypoglycemia in neonatal mice

Anesthetics and Tau Protein: Animal Model Studies ⬇️

Bilateral injection of isoproterenol into hippocampus induces Alzheimer-like hyperphosphorylation of tau and spatial memory deficit in rat.

Brain gene expression of a sporadic (icv-STZ Mouse) and a familial mouse model (3xTg-AD mouse) of Alzheimer's disease

Brain glucose transporters, O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer's disease

C-terminal truncation of GSK-3β enhances its dephosphorylation by PP2A.

CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer's disease

Calpain I Activation Causes GLUT3 Proteolysis and Downregulation of O-GlcNAcylation in Alzheimer's Disease Brain

Chronic cerebral hypoperfusion causes decrease of O-GlcNAcylation, hyperphosphorylation of tau and behavioral deficits in mice

Concurrent alterations of O-GlcNAcylation and phosphorylation of tau in mouse brains during fasting

Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation

Corrigendum: Rapid alteration of protein phosphorylation during postmortem: implication in the study of protein phosphorylation

Cross talk between PI3K-AKT-GSK-3β and PP2A pathways determines tau hyperphosphorylation

Cyclic AMP-dependent protein kinase enhances SC35-promoted Tau exon 10 inclusion

Cyclic AMP-dependent protein kinase regulates 9G8-mediated alternative splicing of tau exon 10.

Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer disease

Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome.

Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes ⬇️

Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5

Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease

Deregulation of brain insulin signaling in Alzheimer's disease

Deregulation of sphingolipid metabolism in Alzheimer's disease

Developmental Regulation of Protein O-GlcNAcylation, O-GlcNAc Transferase, and O-GlcNAcase in Mammalian Brain ⬇️

Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases ⬇️

Differential Effects of an O-GlcNAcase Inhibitor on Tau Phosphorylation ⬇️

Diverse regulation of AKT and GSK‐3β by O‐GlcNAcylation in various types of cells ⬇️

Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain

Dual-specificity Tyrosine Phosphorylation-regulated Kinase 1A (Dyrk1A) Modulates Serine/Arginine-rich Protein 55 (SRp55)-promoted Tau Exon 10 Inclusion ⬇️

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) enhances tau expression

Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice

Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer's disease

Dysregulation of protein phosphorylation/dephosphorylation in Alzheimer's disease: a therapeutic target

Dysregulation of tau phosphorylation in mouse brain during excitotoxic damage

Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain

Expression of Tau Pathology-Related Proteins in Different Brain Regions: A Molecular Basis of Tau Pathogenesis

From chronic cerebral hypoperfusion to Alzheimer-like brain pathology and neurodegeneration

GSK-3β is Dephosphorylated by PP2A in a Leu309 Methylation-Independent Manner

Hyperphosphorylation-induced tau oligomers

Impaired brain glucose metabolism leads to Alzheimer neurofibrillary degeneration through a decrease in tau O-GlcNAcylation.

Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome

Inhibition of glycogen synthase kinase-3 reverses tau hyperphosphorylation induced by Pin1 down-regulation

Inhibition of protein phosphatase 2A induces phosphorylation and accumulation of neurofilaments in metabolically active rat brain slices

Inhibition of protein synthesis alters protein degradation through activation of protein kinase B (AKT)

Insulin sensitizers improve learning and attenuate tau hyperphosphorylation and neuroinflammation in 3xTg-AD mice

Intracerebroventricular streptozotocin exacerbates Alzheimer-like changes of 3xTg-AD mice

Intranasal Insulin Prevents Anesthesia-Induced Cognitive Impairment and Chronic Neurobehavioral Changes

Intranasal Insulin Prevents Anesthesia-Induced Spatial Learning and Memory Deficit in Mice

Intranasal insulin prevents anesthesia-induced hyperphosphorylation of tau in 3xTg-AD mice

Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice

Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta

Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome

Losartan-induced hypotension leads to tau hyperphosphorylation and memory deficit

Mechanisms of tau-induced neurodegeneration

Microtubule-associated protein tau as a therapeutic target in Alzheimer's disease

Multifactorial Hypothesis and Multi-Targets for Alzheimer's Disease

NF-kappaB precursor, p105, and NF-kappaB inhibitor, IkappaBgamma, are both elevated in Alzheimer disease brain

Neonatal Exposure to Anesthesia Leads to Cognitive Deficits in Old Age: Prevention with Intranasal Administration of Insulin in Mice

O-GlcNAc cycling modulates neurodegeneration ⬇️

O-GlcNAcylation Reduces Ischemia-Reperfusion-Induced Brain Injury

O-GlcNAcylation modulates PKA-CREB signaling in a manner specific to PKA catalytic subunit isoforms

O-GlcNAcylation of protein kinase A catalytic subunits enhances its activity: a mechanism linked to learning and memory deficits in Alzheimer's disease

O-GlcNAcylation regulates ischemia-induced neuronal apoptosis through AKT signaling

O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease

O-GlcNAcylation: A regulator of tau pathology and neurodegeneration

Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease

Opposite effects of two estrogen receptors on tau phosphorylation through disparate effects on the miR-218/PTPA pathway

Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome

PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners

PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta

Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies

Pathological Tau From Alzheimer's Brain Induces Site-Specific Hyperphosphorylation and SDS- and Reducing Agent-Resistant Aggregation of Tau

Protein Phosphatase 1 dephosphorylates TDP-43 and suppresses its function in tau exon 10 inclusion