Lista de obras -

Acute unfolding of a single protein immediately stimulates recruitment of ubiquitin protein ligase E3C (UBE3C) to 26S proteasomes

artículo científico publicado en 2019

Balancing act

artículo científico publicado en 2014

Cyclin C is a haploinsufficient tumour suppressor

artículo científico publicado en 2014

Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy.

artículo científico publicado en 2015

Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson’s disease model

artículo científico publicado en 2024

Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.

artículo científico publicado en 2016

Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics.

artículo científico publicado en 2018

EDF1 coordinates cellular responses to ribosome collisions

artículo científico publicado en 2020

Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress

artículo científico publicado en 2015

Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes

artículo científico publicado en 2021

G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells

artículo científico publicado en 2017

Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling

artículo científico publicado en 2020

Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1

scientific article published on 12 November 2021

Highly Multiplexed Quantitative Mass Spectrometry Analysis of Ubiquitylomes.

artículo científico publicado en 2016

Pathogenic Pathways in Early-Onset Autosomal Recessive Parkinson's Disease Discovered Using Isogenic Human Dopaminergic Neurons

scientific article published on 02 January 2020

Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon β.

artículo científico publicado en 2011

Quantifying ubiquitin signaling

artículo científico publicado en 2015

Quantitative Phospho-proteomic Analysis of TNFα/NFκB Signaling Reveals a Role for RIPK1 Phosphorylation in Suppressing Necrotic Cell Death.

artículo científico publicado en 2017

Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.

artículo científico publicado en 2014

RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway

scientific article published on 21 November 2018

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes

artículo científico publicado en 2016

Systematic quantitative analysis of ribosome inventory during nutrient stress

artículo científico publicado en 2020

TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL

artículo científico publicado en 2019

TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress

scientific article published on 18 April 2019

TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling.

artículo científico publicado en 2017

The BioPlex Network: A Systematic Exploration of the Human Interactome

artículo científico publicado en 2015

The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1.

artículo científico publicado en 2008

The PINK1 kinase-driven ubiquitin ligase Parkin promotes mitochondrial protein import through the presequence pathway in living cells

artículo científico publicado en 2019

The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

artículo científico publicado en 2015

The endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase

artículo científico publicado en 2020

Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming

scientific article published on 11 May 2020

Lista de obras de

Acute unfolding of a single protein immediately stimulates recruitment of ubiquitin protein ligase E3C (UBE3C) to 26S proteasomes

Balancing act

Cyclin C is a haploinsufficient tumour suppressor

Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy.

Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson’s disease model

Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.

Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics.

EDF1 coordinates cellular responses to ribosome collisions

Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress

Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes

G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells

Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling

Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1

Highly Multiplexed Quantitative Mass Spectrometry Analysis of Ubiquitylomes.

Pathogenic Pathways in Early-Onset Autosomal Recessive Parkinson's Disease Discovered Using Isogenic Human Dopaminergic Neurons

Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon β.

Quantifying ubiquitin signaling

Quantitative Phospho-proteomic Analysis of TNFα/NFκB Signaling Reveals a Role for RIPK1 Phosphorylation in Suppressing Necrotic Cell Death.

Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.

RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes

Systematic quantitative analysis of ribosome inventory during nutrient stress

TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL

TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress

TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling.

The BioPlex Network: A Systematic Exploration of the Human Interactome

The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1.

The PINK1 kinase-driven ubiquitin ligase Parkin promotes mitochondrial protein import through the presequence pathway in living cells

The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

The endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase

Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming