Lista de obras -

2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-one-based HIV-1 integrase inhibitors

artículo científico publicado en 2007

4-amino-1-hydroxy-2-oxo-1,8-naphthyridine-containing compounds having high potency against raltegravir-resistant integrase mutants of HIV-1

artículo científico publicado en 2014

4′- C -Methyl-2′-Deoxyadenosine and 4′- C -Ethyl-2′-Deoxyadenosine Inhibit HIV-1 Replication ⬇️

artículo científico publicado el 22 de febrero de 2011

6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors ⬇️

artículo científico publicado el 27 de octubre de 2012

A 4'-C-ethynyl-2',3'-dideoxynucleoside analogue highlights the role of the 3'-OH in anti-HIV active 4'-C-ethynyl-2'-deoxy nucleosides

artículo científico publicado en 2004

A Homology Model of HIV-1 Integrase and Analysis of Mutations Designed to Test the Model ⬇️

artículo científico publicado el 27 de marzo de 2013

A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants

artículo científico publicado en 2012

A conformationally locked analogue of the anti-HIV agent stavudine. An important correlation between pseudorotation and maximum amplitude

artículo científico publicado en 2003

A novel mechanism for inhibition of HIV-1 reverse transcriptase

artículo científico publicado en 2002

Activities, Crystal Structures, and Molecular Dynamics of Dihydro-1 H -isoindole Derivatives, Inhibitors of HIV-1 Integrase

artículo científico publicado en 2013

Altering the RNase H primer grip of human immunodeficiency virus reverse transcriptase modifies cleavage specificity

artículo científico publicado en 2002

Alternate polypurine tracts (PPTs) affect the rous sarcoma virus RNase H cleavage specificity and reveal a preferential cleavage following a GA dinucleotide sequence at the PPT-U3 junction

artículo científico publicado en 2005

Alternate polypurine tracts affect rous sarcoma virus integration in vivo

artículo científico publicado en 2006

Analysis of amino acids in the beta7-beta8 loop of human immunodeficiency virus type 1 reverse transcriptase for their role in virus replication

artículo científico publicado en 2006

Analysis of the Zidovudine Resistance Mutations T215Y, M41L, and L210W in HIV-1 Reverse Transcriptase

artículo científico publicado en 2015

Apparent defects in processive DNA synthesis, strand transfer, and primer elongation of Met-184 mutants of HIV-1 reverse transcriptase derive solely from a dNTP utilization defect

artículo científico publicado en 2008

Attentive navigation for viewpoint control in virtual environments

artículo científico publicado en 2005

Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia

artículo científico publicado en 2010

Avian bic, a gene isolated from a common retroviral site in avian leukosis virus-induced lymphomas that encodes a noncoding RNA, cooperates with c-myc in lymphomagenesis and erythroleukemogenesis

artículo científico publicado en 2002

Bicyclic 1-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide-containing HIV-1 integrase inhibitors having high antiviral potency against cells harboring raltegravir-resistant integrase mutants

scientific article published on 10 February 2014

Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration

article

Characterization of the polymerase and RNase H activities of human foamy virus reverse transcriptase

artículo científico publicado en 2004

Clonal expansion of CAR T cells harboring lentivector integration in the CBL gene following anti-CD22 CAR T-cell therapy

scientific article published on 01 August 2019

Clonal expansion of SIV-infected cells in macaques on antiretroviral therapy is similar to that of HIV-infected cells in humans

scientific article published on 10 July 2019

Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo

artículo científico publicado en 2016

Combining mutations in HIV-1 reverse transcriptase with mutations in the HIV-1 polypurine tract affects RNase H cleavages involved in PPT utilization

artículo científico publicado en 2006

Construction and characterization of a replication-competent retroviral shuttle vector plasmid

artículo científico publicado en 2002

Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design

artículo científico publicado en 2008

Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: a new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains

artículo científico publicado en 2005

Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097.

artículo científico publicado en 2006

Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors

artículo científico publicado en 2005

D-(+)-iso-methanocarbathymidine: a high-affinity substrate for herpes simplex virus 1 thymidine kinase

artículo científico publicado en 2008

Designing anti-AIDS drugs targeting the major mechanism of HIV-1 RT resistance to nucleoside analog drugs

artículo científico publicado en 2004

Development of tricyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors

artículo científico publicado en 2011

Differential effects of human immunodeficiency virus type 1 capsid and cellular factors nucleoporin 153 and LEDGF/p75 on the efficiency and specificity of viral DNA integration

artículo científico publicado en 2012

Discovery of novel inhibitors of HIV-1 reverse transcriptase through virtual screening of experimental and theoretical ensembles

artículo científico publicado en 2014

Drug resistant integrase mutants cause aberrant HIV integrations

artículo científico publicado en 2016

Effects of mutations in the G tract of the human immunodeficiency virus type 1 polypurine tract on virus replication and RNase H cleavage

artículo científico publicado en 2004

Effects of substitutions at the 4' and 2 positions on the bioactivity of 4'-ethynyl-2-fluoro-2'-deoxyadenosine

artículo científico publicado en 2013

Effects of the Delta67 complex of mutations in human immunodeficiency virus type 1 reverse transcriptase on nucleoside analog excision

artículo científico publicado en 2004

Efficacies of Cabotegravir and Bictegravir against drug-resistant HIV-1 integrase mutants.

artículo científico publicado en 2018

Enhancers are major targets for murine leukemia virus vector integration

artículo científico publicado en 2014

Examination of halogen substituent effects on HIV-1 integrase inhibitors derived from 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-ones and 4,5-dihydroxy-1H-isoindole-1,3(2H)-diones

scientific article published on 28 March 2009

False-positive HIV PCR test following ex vivo lentiviral gene transfer treatment of X-linked severe combined immunodeficiency vector

artículo científico publicado en 2014

Fixed conformation nucleoside analogs effectively inhibit excision-proficient HIV-1 reverse transcriptases

artículo científico publicado en 2005

Flexible use of nuclear import pathways by HIV-1.

artículo científico publicado en 2010

Foamy Retrovirus Integrase Contains a Pol Dimerization Domain Required for Protease Activation ⬇️

artículo científico publicado el 1 de diciembre de 2010

H3K4me3 Interactions with TAF3 Regulate Preinitiation Complex Assembly and Selective Gene Activation ⬇️

artículo científico publicado el 28 de febrero de 2013

HIV-1 Integrase Inhibitors That Are Broadly Effective against Drug-Resistant Mutants.

artículo científico publicado en 2018

HIV-1 Integrase Inhibitors that are active against Drug-Resistant Integrase Mutants

scientific article published on 29 June 2020

HIV-1 Reverse Transcriptase Structure with RNase H Inhibitor Dihydroxy Benzoyl Naphthyl Hydrazone Bound at a Novel Site

artículo científico publicado en 2006

HIV-1 and HIV-2 Reverse Transcriptases: Different Mechanisms of Resistance to Nucleoside Reverse Transcriptase Inhibitors ⬇️

artículo científico publicado el 21 de marzo de 2012

HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excision

artículo científico publicado en 2008

HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor

artículo científico publicado en 2012

High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations

artículo científico publicado en 2008

Human Immunodeficiency Virus Type 1 Capsid Mutation N74D Alters Cyclophilin A Dependence and Impairs Macrophage Infection ⬇️

artículo científico publicado el 1 de febrero de 2012

Human T-cell leukemia virus type 1 integration target sites in the human genome: comparison with those of other retroviruses

artículo científico publicado en 2007

Identification of a 3-aminoimidazo[1,2-a]pyridine inhibitor of HIV-1 reverse transcriptase

artículo científico publicado en 2012

Identification of glycosylation sites in the SU component of the Avian Sarcoma/Leukosis virus Envelope Glycoprotein (Subgroup A) by mass spectrometry

artículo científico publicado en 2004

Improved Baculovirus Vectors for Transduction and Gene Expression in Human Pancreatic Islet Cells

article

In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).

artículo científico publicado en 2005

In vitro analysis of the effects of mutations in the G-tract of the human immunodeficiency virus type 1 polypurine tract on RNase H cleavage specificity

artículo científico publicado en 2006

In vitro characterization of a simian immunodeficiency virus-human immunodeficiency virus (HIV) chimera expressing HIV type 1 reverse transcriptase to study antiviral resistance in pigtail macaques

artículo científico publicado en 2004

In vitro fidelity of the prototype primate foamy virus (PFV) RT compared to HIV-1 RT.

artículo científico publicado en 2007

Insertional activation of <i>STAT3</i> and <i>LCK</i> by HIV-1 proviruses in T cell lymphomas

artículo científico publicado en 2021

Integration in oncogenes plays only a minor role in determining the in vivo distribution of HIV integration sites before or during suppressive antiretroviral therapy

artículo científico publicado en 2021

Integration of rous sarcoma virus DNA: a CA dinucleotide is not required for integration of the U3 end of viral DNA.

artículo científico publicado en 2008

LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes

artículo científico publicado en 2015

Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration

artículo científico publicado en 2010

MK-0536 Inhibits HIV-1 Integrases Resistant to Raltegravir ⬇️

artículo científico publicado el 29 de agosto de 2011

Molecular Dynamics Approaches Estimate the Binding Energy of HIV-1 Integrase Inhibitors and Correlate with In Vitro Activity ⬇️

artículo científico publicado el 28 de octubre de 2011

Multiple Origins of Virus Persistence during Natural Control of HIV Infection

artículo científico

Mutagenesis of Human Immunodeficiency Virus Reverse Transcriptase p51 Subunit Defines Residues Contributing to Vinylogous Urea Inhibition of Ribonuclease H Activity ⬇️

artículo científico publicado el 21 de noviembre de 2011

Mutation of amino acids in the connection domain of human immunodeficiency virus type 1 reverse transcriptase that contact the template-primer affects RNase H activity.

artículo científico publicado en 2003

Mutation of the catalytic domain of the foamy virus reverse transcriptase leads to loss of processivity and infectivity

artículo científico publicado en 2002

Mutations at position 184 of human immunodeficiency virus type-1 reverse transcriptase affect virus titer and viral DNA synthesis

artículo científico publicado en 2004

Mutations in HIV-1 reverse transcriptase affect the errors made in a single cycle of viral replication

artículo científico publicado en 2014

Mutations in HIV-1 reverse transcriptase cause misfolding and miscleavage by the viral protease ⬇️

artículo científico publicado el 11 de julio de 2013

Mutations in human immunodeficiency virus type 1 reverse transcriptase that make it sensitive to degradation by the viral protease in virions are selected against in patients

artículo científico publicado en 2015

Mutations in the 5′ End of the Human Immunodeficiency Virus Type 1 Polypurine Tract Affect RNase H Cleavage Specificity and Virus Titer ⬇️

artículo científico publicado el 1 de octubre de 2003

Mutations in the RNase H domain of HIV-1 reverse transcriptase affect the initiation of DNA synthesis and the specificity of RNase H cleavage in vivo.

artículo científico publicado en 2002

Mutations in the U5 region adjacent to the primer binding site affect tRNA cleavage by human immunodeficiency virus type 1 reverse transcriptase in vivo

artículo científico publicado en 2007

Mutations in the U5 sequences adjacent to the primer binding site do not affect tRNA cleavage by rous sarcoma virus RNase H but do cause aberrant integrations in vivo

artículo científico publicado en 2006

Mutations in the thumb allow human immunodeficiency virus type 1 reverse transcriptase to be cleaved by protease in virions

artículo científico publicado en 2009

Mutations of a residue within the polyproline-rich region of Env alter the replication rate and level of cytopathic effects in chimeric avian retroviral vectors

artículo científico publicado en 2005

Nature, position, and frequency of mutations made in a single cycle of HIV-1 replication

artículo científico publicado en 2010

Nonnucleoside inhibitor binding affects the interactions of the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase with DNA

artículo científico publicado en 2004

Nontemplated base addition by HIV-1 RT can induce nonspecific strand transfer in vitro.

artículo científico publicado en 2002

Nucleoside analog resistance caused by insertions in the fingers of human immunodeficiency virus type 1 reverse transcriptase involves ATP-mediated excision.

artículo científico publicado en 2002

On the detection of multiple-binding modes of ligands to proteins, from biological, structural, and modeling data

artículo científico publicado en 2003

PCR amplification of DNA containing non-standard base pairs by variants of reverse transcriptase from Human Immunodeficiency Virus-1

artículo científico publicado en 2004

Protein delivery using engineered virus-like particles ⬇️

artículo científico publicado el 26 de septiembre de 2011

Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir

artículo científico publicado en 2017

Reduced genotoxicity of avian sarcoma leukosis virus vectors in rhesus long-term repopulating cells compared to standard murine retrovirus vectors

artículo científico publicado en 2008

Reprogramming human T cell function and specificity with non-viral genome targeting

Retrotransposon suicide: formation of Ty1 circles and autointegration via a central DNA flap

artículo científico publicado en 2006

Retrovirus Integration Database (RID): a public database for retroviral insertion sites into host genomes

artículo científico publicado en 2016

Reverse Transcription of Retroviruses and LTR Retrotransposons.

artículo científico publicado en 2015

Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 V

article

Roles of viral and cellular proteins in the expression of alternatively spliced HTLV-1 pX mRNAs

artículo científico publicado en 2003

Rous sarcoma virus (RSV) integration in vivo: a CA dinucleotide is not required in U3, and RSV linear DNA does not autointegrate

artículo científico publicado en 2007

Selectivity for strand-transfer over 3'-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme-DNA interactions in the active site

scientific article published on July 2016

Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance

artículo científico publicado en 2009

Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)

artículo científico publicado en 2011

Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures

artículo científico publicado en 2021

Structural basis of HIV-1 resistance to AZT by excision

artículo científico publicado en 2010

Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition

artículo científico publicado en 2008

Structure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active Site

artículo científico publicado en 2009

Structure-Based Non-Nucleoside Inhibitor Design: Developing Inhibitors that Are Effective Against Resistant Mutants

artículo científico publicado en 2020

Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir

artículo científico publicado en 2004

Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.

artículo científico publicado en 2002

Synthesis of conformationally locked carbocyclic nucleoside phosphonates to probe the active site of HIV-1 RT.

scientific article published on January 2008

Synthesis, biological activity, and crystal structure of potent nonnucleoside inhibitors of HIV-1 reverse transcriptase that retain activity against mutant forms of the enzyme

artículo científico publicado en 2007

Taking aim at a moving target: designing drugs to inhibit drug-resistant HIV-1 reverse transcriptases

artículo científico publicado en 2004

The Integrator complex controls the termination of transcription at diverse classes of gene targets

artículo científico publicado en 2015

The M184V mutation reduces the selective excision of zidovudine 5'-monophosphate (AZTMP) by the reverse transcriptase of human immunodeficiency virus type 1

artículo científico publicado en 2002

The effects of RNase H inhibitors and nevirapine on the susceptibility of HIV-1 to AZT and 3TC ⬇️

artículo científico publicado el 9 de septiembre de 2011

The effects of alternate polypurine tracts (PPTs) and mutations of sequences adjacent to the PPT on viral replication and cleavage specificity of the Rous sarcoma virus reverse transcriptase

artículo científico publicado en 2008

The history of N-methanocarbathymidine: the investigation of a conformational concept leads to the discovery of a potent and selective nucleoside antiviral agent

artículo científico publicado en 2006

The level of reverse transcriptase (RT) in human immunodeficiency virus type 1 particles affects susceptibility to nonnucleoside RT inhibitors but not to lamivudine

artículo científico publicado en 2006

The nucleoside analogs 4'C-methyl thymidine and 4'C-ethyl thymidine block DNA synthesis by wild-type HIV-1 RT and excision proficient NRTI resistant RT variants

artículo científico publicado en 2007

The nucleoside analogue D-carba T blocks HIV-1 reverse transcription

artículo científico publicado en 2009

Transduction of rhesus macaque hematopoietic stem and progenitor cells with avian sarcoma and leukosis virus vectors

artículo científico publicado en 2007

Trapping HIV-1 reverse transcriptase before and after translocation on DNA.

artículo científico publicado en 2003

Treatment with suboptimal doses of raltegravir leads to aberrant HIV-1 integrations ⬇️

artículo científico publicado el 19 de agosto de 2013

Two Coselected Distal Mutations in HIV-1 Reverse Transcriptase (RT) Alter Susceptibility to Nonnucleoside RT Inhibitors and Nucleoside Analogs.

artículo científico publicado en 2019

Varicella-zoster virus necrotising retinitis, retinal vasculitis and panuveitis following uncomplicated chickenpox in an immunocompetent child.

artículo científico publicado en 2018

What Integration Sites Tell Us about HIV Persistence

artículo científico publicado en 2016

Why do HIV-1 and HIV-2 use different pathways to develop AZT resistance?

artículo científico publicado en 2006

Lista de obras de

2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-one-based HIV-1 integrase inhibitors

4-amino-1-hydroxy-2-oxo-1,8-naphthyridine-containing compounds having high potency against raltegravir-resistant integrase mutants of HIV-1

4′- C -Methyl-2′-Deoxyadenosine and 4′- C -Ethyl-2′-Deoxyadenosine Inhibit HIV-1 Replication ⬇️

6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors ⬇️

A 4'-C-ethynyl-2',3'-dideoxynucleoside analogue highlights the role of the 3'-OH in anti-HIV active 4'-C-ethynyl-2'-deoxy nucleosides

A Homology Model of HIV-1 Integrase and Analysis of Mutations Designed to Test the Model ⬇️

A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants

A conformationally locked analogue of the anti-HIV agent stavudine. An important correlation between pseudorotation and maximum amplitude

A novel mechanism for inhibition of HIV-1 reverse transcriptase

Activities, Crystal Structures, and Molecular Dynamics of Dihydro-1 H -isoindole Derivatives, Inhibitors of HIV-1 Integrase

Altering the RNase H primer grip of human immunodeficiency virus reverse transcriptase modifies cleavage specificity

Alternate polypurine tracts (PPTs) affect the rous sarcoma virus RNase H cleavage specificity and reveal a preferential cleavage following a GA dinucleotide sequence at the PPT-U3 junction

Alternate polypurine tracts affect rous sarcoma virus integration in vivo

Analysis of amino acids in the beta7-beta8 loop of human immunodeficiency virus type 1 reverse transcriptase for their role in virus replication

Analysis of the Zidovudine Resistance Mutations T215Y, M41L, and L210W in HIV-1 Reverse Transcriptase

Apparent defects in processive DNA synthesis, strand transfer, and primer elongation of Met-184 mutants of HIV-1 reverse transcriptase derive solely from a dNTP utilization defect

Attentive navigation for viewpoint control in virtual environments

Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia

Avian bic, a gene isolated from a common retroviral site in avian leukosis virus-induced lymphomas that encodes a noncoding RNA, cooperates with c-myc in lymphomagenesis and erythroleukemogenesis

Bicyclic 1-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide-containing HIV-1 integrase inhibitors having high antiviral potency against cells harboring raltegravir-resistant integrase mutants

Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration

Characterization of the polymerase and RNase H activities of human foamy virus reverse transcriptase

Clonal expansion of CAR T cells harboring lentivector integration in the CBL gene following anti-CD22 CAR T-cell therapy

Clonal expansion of SIV-infected cells in macaques on antiretroviral therapy is similar to that of HIV-infected cells in humans

Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo

Combining mutations in HIV-1 reverse transcriptase with mutations in the HIV-1 polypurine tract affects RNase H cleavages involved in PPT utilization

Construction and characterization of a replication-competent retroviral shuttle vector plasmid

Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design

Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: a new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains

Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097.

Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors

D-(+)-iso-methanocarbathymidine: a high-affinity substrate for herpes simplex virus 1 thymidine kinase

Designing anti-AIDS drugs targeting the major mechanism of HIV-1 RT resistance to nucleoside analog drugs

Development of tricyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors

Differential effects of human immunodeficiency virus type 1 capsid and cellular factors nucleoporin 153 and LEDGF/p75 on the efficiency and specificity of viral DNA integration

Discovery of novel inhibitors of HIV-1 reverse transcriptase through virtual screening of experimental and theoretical ensembles

Drug resistant integrase mutants cause aberrant HIV integrations

Effects of mutations in the G tract of the human immunodeficiency virus type 1 polypurine tract on virus replication and RNase H cleavage

Effects of substitutions at the 4' and 2 positions on the bioactivity of 4'-ethynyl-2-fluoro-2'-deoxyadenosine

Effects of the Delta67 complex of mutations in human immunodeficiency virus type 1 reverse transcriptase on nucleoside analog excision

Efficacies of Cabotegravir and Bictegravir against drug-resistant HIV-1 integrase mutants.

Enhancers are major targets for murine leukemia virus vector integration

Examination of halogen substituent effects on HIV-1 integrase inhibitors derived from 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-ones and 4,5-dihydroxy-1H-isoindole-1,3(2H)-diones

False-positive HIV PCR test following ex vivo lentiviral gene transfer treatment of X-linked severe combined immunodeficiency vector

Fixed conformation nucleoside analogs effectively inhibit excision-proficient HIV-1 reverse transcriptases

Flexible use of nuclear import pathways by HIV-1.

Foamy Retrovirus Integrase Contains a Pol Dimerization Domain Required for Protease Activation ⬇️

H3K4me3 Interactions with TAF3 Regulate Preinitiation Complex Assembly and Selective Gene Activation ⬇️

HIV-1 Integrase Inhibitors That Are Broadly Effective against Drug-Resistant Mutants.

HIV-1 Integrase Inhibitors that are active against Drug-Resistant Integrase Mutants

HIV-1 Reverse Transcriptase Structure with RNase H Inhibitor Dihydroxy Benzoyl Naphthyl Hydrazone Bound at a Novel Site

HIV-1 and HIV-2 Reverse Transcriptases: Different Mechanisms of Resistance to Nucleoside Reverse Transcriptase Inhibitors ⬇️

HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excision

HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor

High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations

Human Immunodeficiency Virus Type 1 Capsid Mutation N74D Alters Cyclophilin A Dependence and Impairs Macrophage Infection ⬇️

Human T-cell leukemia virus type 1 integration target sites in the human genome: comparison with those of other retroviruses

Identification of a 3-aminoimidazo[1,2-a]pyridine inhibitor of HIV-1 reverse transcriptase

Identification of glycosylation sites in the SU component of the Avian Sarcoma/Leukosis virus Envelope Glycoprotein (Subgroup A) by mass spectrometry

Improved Baculovirus Vectors for Transduction and Gene Expression in Human Pancreatic Islet Cells

In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).

In vitro analysis of the effects of mutations in the G-tract of the human immunodeficiency virus type 1 polypurine tract on RNase H cleavage specificity

In vitro characterization of a simian immunodeficiency virus-human immunodeficiency virus (HIV) chimera expressing HIV type 1 reverse transcriptase to study antiviral resistance in pigtail macaques

In vitro fidelity of the prototype primate foamy virus (PFV) RT compared to HIV-1 RT.

Insertional activation of <i>STAT3</i> and <i>LCK</i> by HIV-1 proviruses in T cell lymphomas

Integration in oncogenes plays only a minor role in determining the in vivo distribution of HIV integration sites before or during suppressive antiretroviral therapy

Integration of rous sarcoma virus DNA: a CA dinucleotide is not required for integration of the U3 end of viral DNA.

LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes

Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration

MK-0536 Inhibits HIV-1 Integrases Resistant to Raltegravir ⬇️

Molecular Dynamics Approaches Estimate the Binding Energy of HIV-1 Integrase Inhibitors and Correlate with In Vitro Activity ⬇️

Multiple Origins of Virus Persistence during Natural Control of HIV Infection

Mutagenesis of Human Immunodeficiency Virus Reverse Transcriptase p51 Subunit Defines Residues Contributing to Vinylogous Urea Inhibition of Ribonuclease H Activity ⬇️

Mutation of amino acids in the connection domain of human immunodeficiency virus type 1 reverse transcriptase that contact the template-primer affects RNase H activity.

Mutation of the catalytic domain of the foamy virus reverse transcriptase leads to loss of processivity and infectivity

Mutations at position 184 of human immunodeficiency virus type-1 reverse transcriptase affect virus titer and viral DNA synthesis

Mutations in HIV-1 reverse transcriptase affect the errors made in a single cycle of viral replication

Mutations in HIV-1 reverse transcriptase cause misfolding and miscleavage by the viral protease ⬇️

Mutations in human immunodeficiency virus type 1 reverse transcriptase that make it sensitive to degradation by the viral protease in virions are selected against in patients