Lista de obras -

1-[(1-Methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines as mGluR2 Positive Allosteric Modulators for the Treatment of Psychosis ⬇️

artículo científico publicado el 2 de marzo de 2011

3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: a novel series of mGluR2 positive allosteric modulators.

artículo científico publicado en 2008

7-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridines as novel inhibitors of human eosinophil phosphodiesterase.

artículo científico publicado en 1998

Discovering Drugs for the Treatment of Ebola Virus.

artículo científico publicado en 2017

Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vi

artículo científico publicado en 2010

Discovery of a novel Kv7 channel opener as a treatment for epilepsy.

artículo científico publicado en 2015

Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors

artículo científico publicado en 2009

Discovery, synthesis and SAR of azinyl- and azolylbenzamides antagonists of the P2X₇ receptor.

artículo científico publicado en 2011

Galanin function in the central nervous system

artículo científico publicado en 2006

Isoxazolyl, oxazolyl, and thiazolylpropionic acid derivatives as potent alpha(4)beta(1) integrin antagonists

artículo científico publicado en 2001

Mitigating the Impact of Antibacterial Drug Resistance through Host-Directed Therapies: Current Progress, Outlook, and Challenges.

artículo científico publicado en 2018

Modulation of NMDA receptor function by inhibition of D-amino acid oxidase in rodent brain.

artículo científico publicado en 2011

New Steroidal 4-Aminoquinolines Antagonize Botulinum Neurotoxin Serotype A in Mouse Embryonic Stem Cell Derived Motor Neurons in Post-intoxication Model.

artículo científico publicado en 2018

Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535.

artículo científico publicado en 2011

Robust biofilm assay for quantification and high throughput screening applications

scientific article published on 28 February 2019

SAR of a series of 5,6-dihydro-(9H)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-alpha]pyridines as potent inhibitors of human eosinophil phosphodiesterase

artículo científico publicado en 2007

Searching for Therapeutics Against Botulinum Neurotoxins: A True Challenge for Drug Discovery.

artículo científico publicado en 2016

Second generation of diazachrysenes: Protection of Ebola virus infected mice and mechanism of action

artículo científico publicado en 2018

Synthesis of [F]Favipiravir and Biodistribution in C3H/HeN Mice as Assessed by Positron Emission Tomography

artículo científico publicado en 2019

Systematic N-methylation of oxytocin: Impact on pharmacology and intramolecular hydrogen bonding network.

artículo científico publicado en 2016

The Human Cathelicidin Antimicrobial Peptide LL-37 as a Potential Treatment for Polymicrobial Infected Wounds

artículo científico publicado en 2013

Lista de obras de

1-[(1-Methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines as mGluR2 Positive Allosteric Modulators for the Treatment of Psychosis ⬇️

3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: a novel series of mGluR2 positive allosteric modulators.

7-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridines as novel inhibitors of human eosinophil phosphodiesterase.

Discovering Drugs for the Treatment of Ebola Virus.

Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vi

Discovery of a novel Kv7 channel opener as a treatment for epilepsy.

Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors

Discovery, synthesis and SAR of azinyl- and azolylbenzamides antagonists of the P2X₇ receptor.

Galanin function in the central nervous system

Isoxazolyl, oxazolyl, and thiazolylpropionic acid derivatives as potent alpha(4)beta(1) integrin antagonists

Mitigating the Impact of Antibacterial Drug Resistance through Host-Directed Therapies: Current Progress, Outlook, and Challenges.

Modulation of NMDA receptor function by inhibition of D-amino acid oxidase in rodent brain.

New Steroidal 4-Aminoquinolines Antagonize Botulinum Neurotoxin Serotype A in Mouse Embryonic Stem Cell Derived Motor Neurons in Post-intoxication Model.

Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535.

Robust biofilm assay for quantification and high throughput screening applications

SAR of a series of 5,6-dihydro-(9H)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-alpha]pyridines as potent inhibitors of human eosinophil phosphodiesterase

Searching for Therapeutics Against Botulinum Neurotoxins: A True Challenge for Drug Discovery.

Second generation of diazachrysenes: Protection of Ebola virus infected mice and mechanism of action

Synthesis of [F]Favipiravir and Biodistribution in C3H/HeN Mice as Assessed by Positron Emission Tomography

Systematic N-methylation of oxytocin: Impact on pharmacology and intramolecular hydrogen bonding network.

The Human Cathelicidin Antimicrobial Peptide LL-37 as a Potential Treatment for Polymicrobial Infected Wounds