Lista de obras - Tomas Hudlicky - Dominio Público Uruguay

"Organic synthesis—Where now?" is thirty years old. A reflection on the current state of affairs

controversial journal article from 'Angewandte Chemie International Edition' published and promptly retracted (by the journal) in 2020

4-Siloxy-.alpha.-bromocrotonate: a new reagent for [2+3] annulation leading to oxygenated cyclopentenes at low temperatures

article published in 1990

A Formal Approach to Xylosmin and Flacourtosides E and F: Chemoenzymatic Total Synthesis of the Hydroxylated Cyclohexenone Carboxylic Acid Moiety of Xylosmin

scientific article published on 10 February 2017

A beta-carboline-1-one mimic of the anticancer Amaryllidaceae constituent pancratistatin: synthesis and biological evaluation

artículo científico publicado en 2004

A novel synthetic C-1 analogue of 7-deoxypancratistatin induces apoptosis in p53 positive and negative human colorectal cancer cells by targeting the mitochondria: enhancement of activity by tamoxifen ⬇️

artículo científico publicado el 15 de abril de 2011

Applications of biotransformations and biocatalysis to complexity generation in organic synthesis

artículo científico publicado en 2009

Applications of the Wittig-Still Rearrangement in Organic Synthesis

artículo científico publicado en 2017

Benefits of Unconventional Methods in the Total Synthesis of Natural Products

Biocatalytic Syntheses of Protected D-Mannose-d(5), D-Mannose-d(7), D-Mannitol-2,3,4,5,6-d(5), and D-Mannitol-1,1,2,3,4,5,6,6-d(8).

artículo científico publicado en 1996

Cancer Cell Mitochondria Targeting by Pancratistatin Analogs is Dependent on Functional Complex II and III.

artículo científico publicado en 2017

Carnosic acid as a component of rosemary extract stimulates skeletal muscle cell glucose uptake via AMPK activation

artículo científico publicado en 2016

Chemoenzymatic Synthesis of Advanced Intermediates for Formal Total Syntheses of Tetrodotoxin

artículo científico publicado en 2018

Chemoenzymatic Synthesis of All Four Stereoisomers of Sphingosine from Chlorobenzene: Glycosphingolipid Precursors(1)(a).

artículo científico publicado en 1998

Chemoenzymatic Synthesis of Inositols, Conduritols, and Cyclitol Analogues ⬇️

artículo científico publicado el 13 de julio de 2011

Chemoenzymatic Synthesis of Pleiogenone A: An Antiproliferative Trihydroxyalkylcyclohexenone Isolated from Pleiogynium timorense.

artículo científico publicado en 2016

Chemoenzymatic Total Synthesis of (+)-10-Keto-Oxycodone from Phenethyl Acetate

scientific article published on 25 September 2019

Chemoenzymatic Total Synthesis of (+)-Galanthamine and (+)-Narwedine from Phenethyl Acetate

artículo científico publicado en 2016

Chemoenzymatic Total Synthesis of Hydromorphone by an Oxidative Dearomatization/Intramolecular [4 + 2] Cycloaddition Sequence: A Second-Generation Approach

artículo científico publicado en 2016

Chemoenzymatic Total Synthesis of ent-Oxycodone: Second-, Third-, and Fourth-Generation Strategies

scientific article published on 26 June 2019

Chemoenzymatic synthesis of Amaryllidaceae constituents and biological evaluation of their C-1 analogues. The next generation synthesis of 7-deoxypancratistatin and trans-dihydrolycoricidine

artículo científico publicado en 2010

Chiral version of the Burgess reagent and its reactions with oxiranes: application to the formal enantiodivergent synthesis of balanol

artículo científico publicado en 2008

Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast

artículo científico publicado en 2015

Corrigendum: Cancer Cell Mitochondria Targeting by Pancratistatin Analogs is Dependent on Functional Complex II and III.

artículo científico publicado en 2018

Cyclopentene annulation via intramolecular addition of diazoketones to 1,3-dienes. Applications to the synthesis of cyclopentanoid terpenes

article

Design Constraints in Practical Syntheses of Complex Molecules: Current Status, Case Studies with Carbohydrates and Alkaloids, and Future Perspectives

artículo científico publicado en 1996

Enantioselective total synthesis and biological evaluation of (+)-kibdelone A and a tetrahydroxanthone analogue

artículo científico publicado en 2013

Enhancement of apoptotic and autophagic induction by a novel synthetic C-1 analogue of 7-deoxypancratistatin in human breast adenocarcinoma and neuroblastoma cells with tamoxifen

artículo científico publicado en 2012

Exploiting mitochondrial and oxidative vulnerabilities with a synthetic analog of pancratistatin in combination with piperlongumine for cancer therapy

artículo científico publicado en 2017

From discovery to application: 50 years of the vinylcyclopropane-cyclopentene rearrangement and its impact on the synthesis of natural products

artículo científico publicado en 2010

Heteroatom analogues of hydrocodone: synthesis and biological activity

artículo científico publicado en 2013

Introduction to Enzymes in Synthesis ⬇️

artículo científico publicado el 15 de junio de 2011

Investigation of steric and functionality limits in the enzymatic dihydroxylation of benzoate esters. Versatile intermediates for the synthesis of pseudo-sugars, amino cyclitols, and bicyclic ring systems.

artículo científico publicado en 2009

Isolation, Synthesis, and Semisynthesis of Amaryllidaceae Constituents from Narcissus and Galanthus sp.: De Novo Total Synthesis of 2- epi-Narciclasine

scientific article published on 22 May 2018

Morphine Synthesis and Biosynthesis-An Update

New oligomers of conduritol-F and muco-inositol. Synthesis and biological evaluation as glycosidase inhibitors

artículo científico publicado en 2004

On the Practical Limits of Determining Isolated Product Yields and Ratios of Stereoisomers: Reflections, Analysis, and Redemption

article

One-pot conversion of thebaine to hydrocodone and synthesis of neopinone ketal

artículo científico publicado en 2009

Palladium-catalyzed carbonylation of halo arene-cis-dihydrodiols to the corresponding carboxylates. Access to compounds unavailable by toluene dioxygenase-mediated dihydroxylation of the corresponding benzoate esters

artículo científico publicado en 2014

Polyhalogenated Methyl Ethyl Ethers

Reactions of indole derivatives with oxiranes and aziridines on silica. Synthesis of beta-carbolin-1-one mimic of pancratistatin

artículo científico publicado en 2005

Rosmarinic Acid, a Rosemary Extract Polyphenol, Increases Skeletal Muscle Cell Glucose Uptake and Activates AMPK.

artículo científico publicado en 2017

Selective cytotoxicity against human osteosarcoma cells by a novel synthetic C-1 analogue of 7-deoxypancratistatin is potentiated by curcumin

artículo científico publicado en 2011

Several generations of chemoenzymatic synthesis of oseltamivir (Tamiflu): evolution of strategy, quest for a process-quality synthesis, and evaluation of efficiency metrics.

artículo científico publicado en 2011

Symmetry-based design for the chemoenzymatic synthesis of oseltamivir (Tamiflu) from ethyl benzoate.

artículo científico publicado en 2009

Synthesis and biological activity of some structural modifications of pancratistatin

artículo científico publicado en 2004

Synthesis and biological evaluation of unnatural derivatives of narciclasine: 7-aza-nornarciclasine and its N-oxide

artículo científico publicado en 2014

Synthesis of Amaryllidaceae Constituents and Unnatural Derivatives

artículo científico publicado en 2016

Synthesis of C-1 homologues of pancratistatin and their preliminary biological evaluation

artículo científico publicado en 2011

Synthesis of Morphine Alkaloids and Derivatives ⬇️

artículo científico publicado el 1 de enero de 2012

Synthesis of buprenorphine from oripavine via N-demethylation of oripavine quaternary salts

artículo científico publicado en 2011

Synthesis, structure, and biological evaluation of novel N- and O-linked diinositols

artículo científico publicado en 2002

Tetrodotoxin: History, Biology, and Synthesis

artículo científico publicado en 2019

The quest for a practical synthesis of morphine alkaloids and their derivatives by chemoenzymatic methods

artículo científico publicado en 2015

Toluene dioxygenase mediated oxidation of halogen-substituted benzoate esters.

artículo científico publicado en 2012

Total synthesis and biological evaluation of Amaryllidaceae alkaloids: narciclasine, ent-7-deoxypancratistatin, regioisomer of 7-deoxypancratistatin, 10b-epi-deoxypancratistatin, and truncated derivatives

artículo científico publicado en 2002

Total synthesis of (.+-.)-hirsutene

artículo científico publicado en 1980

Total synthesis of 7-deoxypancratistatin-1-carboxaldehyde and carboxylic acid via solvent-free intramolecular aziridine opening: phenanthrene to phenanthridone cyclization strategy.

artículo científico publicado en 2007

Unnatural C-1 homologues of pancratistatin - Synthesis and promising biological activities

artículo científico publicado en 2012

Lista de obras de Tomas Hudlicky

"Organic synthesis—Where now?" is thirty years old. A reflection on the current state of affairs

4-Siloxy-.alpha.-bromocrotonate: a new reagent for [2+3] annulation leading to oxygenated cyclopentenes at low temperatures

A Formal Approach to Xylosmin and Flacourtosides E and F: Chemoenzymatic Total Synthesis of the Hydroxylated Cyclohexenone Carboxylic Acid Moiety of Xylosmin

A beta-carboline-1-one mimic of the anticancer Amaryllidaceae constituent pancratistatin: synthesis and biological evaluation

A novel synthetic C-1 analogue of 7-deoxypancratistatin induces apoptosis in p53 positive and negative human colorectal cancer cells by targeting the mitochondria: enhancement of activity by tamoxifen ⬇️

Applications of biotransformations and biocatalysis to complexity generation in organic synthesis

Applications of the Wittig-Still Rearrangement in Organic Synthesis

Benefits of Unconventional Methods in the Total Synthesis of Natural Products

Biocatalytic Syntheses of Protected D-Mannose-d(5), D-Mannose-d(7), D-Mannitol-2,3,4,5,6-d(5), and D-Mannitol-1,1,2,3,4,5,6,6-d(8).

Cancer Cell Mitochondria Targeting by Pancratistatin Analogs is Dependent on Functional Complex II and III.

Carnosic acid as a component of rosemary extract stimulates skeletal muscle cell glucose uptake via AMPK activation

Chemoenzymatic Synthesis of Advanced Intermediates for Formal Total Syntheses of Tetrodotoxin

Chemoenzymatic Synthesis of All Four Stereoisomers of Sphingosine from Chlorobenzene: Glycosphingolipid Precursors(1)(a).

Chemoenzymatic Synthesis of Inositols, Conduritols, and Cyclitol Analogues ⬇️

Chemoenzymatic Synthesis of Pleiogenone A: An Antiproliferative Trihydroxyalkylcyclohexenone Isolated from Pleiogynium timorense.

Chemoenzymatic Total Synthesis of (+)-10-Keto-Oxycodone from Phenethyl Acetate

Chemoenzymatic Total Synthesis of (+)-Galanthamine and (+)-Narwedine from Phenethyl Acetate

Chemoenzymatic Total Synthesis of Hydromorphone by an Oxidative Dearomatization/Intramolecular [4 + 2] Cycloaddition Sequence: A Second-Generation Approach

Chemoenzymatic Total Synthesis of ent-Oxycodone: Second-, Third-, and Fourth-Generation Strategies

Chemoenzymatic synthesis of Amaryllidaceae constituents and biological evaluation of their C-1 analogues. The next generation synthesis of 7-deoxypancratistatin and trans-dihydrolycoricidine

Chiral version of the Burgess reagent and its reactions with oxiranes: application to the formal enantiodivergent synthesis of balanol

Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast

Corrigendum: Cancer Cell Mitochondria Targeting by Pancratistatin Analogs is Dependent on Functional Complex II and III.

Cyclopentene annulation via intramolecular addition of diazoketones to 1,3-dienes. Applications to the synthesis of cyclopentanoid terpenes

Design Constraints in Practical Syntheses of Complex Molecules: Current Status, Case Studies with Carbohydrates and Alkaloids, and Future Perspectives

Enantioselective total synthesis and biological evaluation of (+)-kibdelone A and a tetrahydroxanthone analogue

Enhancement of apoptotic and autophagic induction by a novel synthetic C-1 analogue of 7-deoxypancratistatin in human breast adenocarcinoma and neuroblastoma cells with tamoxifen

Exploiting mitochondrial and oxidative vulnerabilities with a synthetic analog of pancratistatin in combination with piperlongumine for cancer therapy

From discovery to application: 50 years of the vinylcyclopropane-cyclopentene rearrangement and its impact on the synthesis of natural products

Heteroatom analogues of hydrocodone: synthesis and biological activity

Introduction to Enzymes in Synthesis ⬇️

Investigation of steric and functionality limits in the enzymatic dihydroxylation of benzoate esters. Versatile intermediates for the synthesis of pseudo-sugars, amino cyclitols, and bicyclic ring systems.

Isolation, Synthesis, and Semisynthesis of Amaryllidaceae Constituents from Narcissus and Galanthus sp.: De Novo Total Synthesis of 2- epi-Narciclasine

Morphine Synthesis and Biosynthesis-An Update

New oligomers of conduritol-F and muco-inositol. Synthesis and biological evaluation as glycosidase inhibitors

On the Practical Limits of Determining Isolated Product Yields and Ratios of Stereoisomers: Reflections, Analysis, and Redemption

One-pot conversion of thebaine to hydrocodone and synthesis of neopinone ketal

Palladium-catalyzed carbonylation of halo arene-cis-dihydrodiols to the corresponding carboxylates. Access to compounds unavailable by toluene dioxygenase-mediated dihydroxylation of the corresponding benzoate esters

Polyhalogenated Methyl Ethyl Ethers

Reactions of indole derivatives with oxiranes and aziridines on silica. Synthesis of beta-carbolin-1-one mimic of pancratistatin

Rosmarinic Acid, a Rosemary Extract Polyphenol, Increases Skeletal Muscle Cell Glucose Uptake and Activates AMPK.

Selective cytotoxicity against human osteosarcoma cells by a novel synthetic C-1 analogue of 7-deoxypancratistatin is potentiated by curcumin

Several generations of chemoenzymatic synthesis of oseltamivir (Tamiflu): evolution of strategy, quest for a process-quality synthesis, and evaluation of efficiency metrics.

Symmetry-based design for the chemoenzymatic synthesis of oseltamivir (Tamiflu) from ethyl benzoate.

Synthesis and biological activity of some structural modifications of pancratistatin

Synthesis and biological evaluation of unnatural derivatives of narciclasine: 7-aza-nornarciclasine and its N-oxide

Synthesis of Amaryllidaceae Constituents and Unnatural Derivatives

Synthesis of C-1 homologues of pancratistatin and their preliminary biological evaluation

Synthesis of Morphine Alkaloids and Derivatives ⬇️

Synthesis of buprenorphine from oripavine via N-demethylation of oripavine quaternary salts

Synthesis, structure, and biological evaluation of novel N- and O-linked diinositols

Tetrodotoxin: History, Biology, and Synthesis

The quest for a practical synthesis of morphine alkaloids and their derivatives by chemoenzymatic methods

Toluene dioxygenase mediated oxidation of halogen-substituted benzoate esters.

Total synthesis and biological evaluation of Amaryllidaceae alkaloids: narciclasine, ent-7-deoxypancratistatin, regioisomer of 7-deoxypancratistatin, 10b-epi-deoxypancratistatin, and truncated derivatives

Total synthesis of (.+-.)-hirsutene

Total synthesis of 7-deoxypancratistatin-1-carboxaldehyde and carboxylic acid via solvent-free intramolecular aziridine opening: phenanthrene to phenanthridone cyclization strategy.

Unnatural C-1 homologues of pancratistatin - Synthesis and promising biological activities