Lista de obras - Daniel A Harki - Dominio Público Uruguay

4-Cyanoindole-2'-deoxyribonucleoside (4CIN): A Universal Fluorescent Nucleoside Analogue

artículo científico publicado en 2018

A redox economical synthesis of bioactive 6,12-guaianolides.

artículo científico publicado en 2013

APOBEC Enzymes as Targets for Virus and Cancer Therapy.

artículo científico publicado en 2017

Alkyne Ligation Handles: Propargylation of Hydroxyl, Sulfhydryl, Amino, and Carboxyl Groups via the Nicholas Reaction

artículo científico publicado en 2016

Arsenic exposure accelerates atherogenesis in apolipoprotein E-/-mice

artículo científico publicado en 2003

Bicyclic Cyclohexenones as Inhibitors of NF-κB Signaling ⬇️

artículo científico publicado el 11 de mayo de 2012

Catch and Release DNA Decoys: Capture and Photochemical Dissociation of NF-κB Transcription Factors.

artículo científico publicado en 2016

Cell surface markers of cancer stem cells: diagnostic macromolecules and targets for drug delivery

artículo científico

Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions

artículo científico publicado en 2016

Determinants of Oligonucleotide Selectivity of APOBEC3B

scientific article published on 10 September 2018

Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle

artículo científico publicado en 2015

Differential Inhibition of APOBEC3 DNA-Mutator Isozymes by Fluoro- and Non-Fluoro-Substituted 2'-Deoxyzebularine Embedded in Single-Stranded DNA

scientific article published on 19 December 2019

EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer

artículo científico publicado en 2015

First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G

artículo científico publicado en 2012

Helenalin Analogues Targeting NF-κB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles.

artículo científico publicado en 2018

Immunodetection of human topoisomerase I-DNA covalent complexes

artículo científico publicado en 2016

Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2'-Deoxyzebularine Analogues

scientific article published on 28 November 2018

Inhibition of guanosine monophosphate synthetase by the substrate enantiomer L-XMP.

artículo científico publicado en 2012

Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues.

artículo científico publicado en 2008

Lethal mutagenesis of poliovirus mediated by a mutagenic pyrimidine analogue.

artículo científico publicado en 2007

Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor

artículo científico publicado en 2018

Oxidative Reactivities of 2-Furylquinolines: Ubiquitous Scaffolds in Common High-Throughput Screening Libraries.

artículo científico publicado en 2015

Parthenolide prodrug LC-1 slows growth of intracranial glioma.

artículo científico publicado en 2015

Rapid, Microwave Accelerated Synthesis of [1,2,4]Triazolo[3,4-b][1,3,4]oxadiazoles from 4-Acylamino-1,2,4-Triazoles.

artículo científico publicado en 2016

Reassessing APOBEC3G Inhibition by HIV-1 Vif-Derived Peptides

artículo científico publicado en 2016

SN-38 conjugated gold nanoparticles activated by Ewing sarcoma specific mRNAs exhibit in vitro and in vivo efficacy.

artículo científico publicado en 2018

Signatures of Nucleotide Analog Incorporation by an RNA-Dependent RNA Polymerase Revealed Using High-Throughput Magnetic Tweezers.

artículo científico publicado en 2017

Small-molecule APOBEC3G DNA cytosine deaminase inhibitors based on a 4-amino-1,2,4-triazole-3-thiol scaffold.

artículo científico publicado en 2012

Solution-phase synthesis of pyrrole-imidazole polyamides

artículo científico publicado en 2009

Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B.

artículo científico publicado en 2016

Structural insights into mechanisms of catalysis and inhibition in Norwalk virus polymerase

artículo científico publicado en 2008

Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues.

artículo científico publicado en 2015

Synthesis and antiviral activity of 5-substituted cytidine analogues: identification of a potent inhibitor of viral RNA-dependent RNA polymerases.

artículo científico publicado en 2006

Synthesis and antiviral evaluation of a mutagenic and non-hydrogen bonding ribonucleoside analogue: 1-beta-D-Ribofuranosyl-3-nitropyrrole.

artículo científico publicado en 2002

Synthesis of Guaianolide Analogues with a Tunable α-Methylene-γ-lactam Electrophile and Correlating Bioactivity with Thiol Reactivity

scientific article published on 17 November 2020

Synthesis of a peptide-universal nucleotide antigen: towards next-generation antibodies to detect topoisomerase I-DNA covalent complexes.

artículo científico publicado en 2016

Targeting NF-κB p65 with a Helenalin Inspired Bis-electrophile.

artículo científico publicado en 2016

The Binding Interface between Human APOBEC3F and HIV-1 Vif Elucidated by Genetic and Computational Approaches

artículo científico publicado en 2015

Lista de obras de Daniel A Harki

4-Cyanoindole-2'-deoxyribonucleoside (4CIN): A Universal Fluorescent Nucleoside Analogue

A redox economical synthesis of bioactive 6,12-guaianolides.

APOBEC Enzymes as Targets for Virus and Cancer Therapy.

Alkyne Ligation Handles: Propargylation of Hydroxyl, Sulfhydryl, Amino, and Carboxyl Groups via the Nicholas Reaction

Arsenic exposure accelerates atherogenesis in apolipoprotein E-/-mice

Bicyclic Cyclohexenones as Inhibitors of NF-κB Signaling ⬇️

Catch and Release DNA Decoys: Capture and Photochemical Dissociation of NF-κB Transcription Factors.

Cell surface markers of cancer stem cells: diagnostic macromolecules and targets for drug delivery

Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions

Determinants of Oligonucleotide Selectivity of APOBEC3B

Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle

Differential Inhibition of APOBEC3 DNA-Mutator Isozymes by Fluoro- and Non-Fluoro-Substituted 2'-Deoxyzebularine Embedded in Single-Stranded DNA

EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer

First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G

Helenalin Analogues Targeting NF-κB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles.

Immunodetection of human topoisomerase I-DNA covalent complexes

Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2'-Deoxyzebularine Analogues

Inhibition of guanosine monophosphate synthetase by the substrate enantiomer L-XMP.

Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues.

Lethal mutagenesis of poliovirus mediated by a mutagenic pyrimidine analogue.

Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor

Oxidative Reactivities of 2-Furylquinolines: Ubiquitous Scaffolds in Common High-Throughput Screening Libraries.

Parthenolide prodrug LC-1 slows growth of intracranial glioma.

Rapid, Microwave Accelerated Synthesis of [1,2,4]Triazolo[3,4-b][1,3,4]oxadiazoles from 4-Acylamino-1,2,4-Triazoles.

Reassessing APOBEC3G Inhibition by HIV-1 Vif-Derived Peptides

SN-38 conjugated gold nanoparticles activated by Ewing sarcoma specific mRNAs exhibit in vitro and in vivo efficacy.

Signatures of Nucleotide Analog Incorporation by an RNA-Dependent RNA Polymerase Revealed Using High-Throughput Magnetic Tweezers.

Small-molecule APOBEC3G DNA cytosine deaminase inhibitors based on a 4-amino-1,2,4-triazole-3-thiol scaffold.

Solution-phase synthesis of pyrrole-imidazole polyamides

Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B.

Structural insights into mechanisms of catalysis and inhibition in Norwalk virus polymerase

Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues.

Synthesis and antiviral activity of 5-substituted cytidine analogues: identification of a potent inhibitor of viral RNA-dependent RNA polymerases.

Synthesis and antiviral evaluation of a mutagenic and non-hydrogen bonding ribonucleoside analogue: 1-beta-D-Ribofuranosyl-3-nitropyrrole.

Synthesis of Guaianolide Analogues with a Tunable α-Methylene-γ-lactam Electrophile and Correlating Bioactivity with Thiol Reactivity

Synthesis of a peptide-universal nucleotide antigen: towards next-generation antibodies to detect topoisomerase I-DNA covalent complexes.

Targeting NF-κB p65 with a Helenalin Inspired Bis-electrophile.

The Binding Interface between Human APOBEC3F and HIV-1 Vif Elucidated by Genetic and Computational Approaches