Lista de obras -

6-Alkoxy-5-aryl-3-pyridinecarboxamides, a new series of bioavailable cannabinoid receptor type 1 (CB1) antagonists including peripherally selective compounds

artículo científico publicado en 2013

Analysis of erlotinib and its metabolites in rat tissue sections by MALDI quadrupole time-of-flight mass spectrometry.

artículo científico publicado en 2007

Animal pharmacokinetics and interspecies scaling of Ro 25-6833 and related (lactamylvinyl)cephalosporins

scientific article published on 01 April 1998

Are Biotransformation Studies of Therapeutic Proteins Needed? Scientific Considerations and Technical Challenges

artículo científico publicado en 2019

Biotherapeutics in non-clinical development: Strengthening the interface between safety, pharmacokinetics-pharmacodynamics and manufacturing.

artículo científico publicado en 2018

CD20-TCB with Obinutuzumab Pretreatment as Next-Generation Treatment of Hematologic Malignancies

artículo científico publicado en 2018

Design of experiment (DOE) methods maximize information from a minimal number of animals in special cases of preclinical bioavailability testing

artículo científico publicado en 2003

Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β

artículo científico publicado en 2012

Hematopoietic cells as site of first-pass catabolism after subcutaneous dosing and contributors to systemic clearance of a monoclonal antibody in mice

artículo científico publicado en 2018

High-Throughput, Sensitive LC-MS Quantification of Biotherapeutics and Biomarkers Using Antibody-Free, Peptide-Level, Multiple-Mechanism Enrichment via Strategic Regulation of pH and Ionic and Solvent Strengths

scientific article published on 15 February 2019

Immunogenicity, Inflammation, and Lipid Accumulation in Cynomolgus Monkeys Infused with a Lipidated Tetranectin-ApoA-I Fusion Protein

artículo científico publicado en 2016

In Vivo Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1 Analyzed by Ligand-Binding Mass Spectrometry Combined with Quantitation by ELISA.

artículo científico publicado en 2016

Mechanistic determinants of biotherapeutics absorption following SC administration.

artículo científico publicado en 2012

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration.

artículo científico publicado en 2012

Neonatal Immune Tolerance Induction to Allow Long-Term Studies With an Immunogenic Therapeutic Monoclonal Antibody in Mice

artículo científico publicado en 2015

New challenges and opportunities in nonclinical safety testing of biologics

artículo científico publicado en 2014

Non-clinical Safety Evaluation of Biotherapeutics - Challenges, Opportunities and new Insights

artículo científico publicado en 2016

Non-clinical pharmacokinetic/pharmacodynamic and early clinical studies supporting development of a novel subcutaneous formulation for the monoclonal antibody rituximab

artículo científico

Potential errors in the volume of distribution estimation of therapeutic proteins composed of differently cleared components

artículo científico publicado en 2011

Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody

artículo científico publicado en 2020

Reproductive and developmental toxicology studies with gantenerumab in PS2APP transgenic mice.

artículo científico publicado en 2017

Subcutaneous Administration of Biotherapeutics: An Overview of Current Challenges and Opportunities

scientific article published on 01 October 2018

Subcutaneous absorption of biotherapeutics: knowns and unknowns.

artículo científico publicado en 2014

Subcutaneous versus intravenous administration of rituximab: pharmacokinetics, CD20 target coverage and B-cell depletion in cynomolgus monkeys

artículo científico publicado en 2013

The distribution pattern of radioactivity across different tissues in quantitative whole-body autoradiography (QWBA) studies.

artículo científico publicado en 2006

The effects of interleukin-6 signal blockade on immune system, reproductive and skeletal development in juvenile mice.

artículo científico publicado en 2013

Tissue Distribution of a Therapeutic Monoclonal Antibody Determined by Large Pore Microdialysis

artículo científico publicado en 2017

Lista de obras de

6-Alkoxy-5-aryl-3-pyridinecarboxamides, a new series of bioavailable cannabinoid receptor type 1 (CB1) antagonists including peripherally selective compounds

Analysis of erlotinib and its metabolites in rat tissue sections by MALDI quadrupole time-of-flight mass spectrometry.

Animal pharmacokinetics and interspecies scaling of Ro 25-6833 and related (lactamylvinyl)cephalosporins

Are Biotransformation Studies of Therapeutic Proteins Needed? Scientific Considerations and Technical Challenges

Biotherapeutics in non-clinical development: Strengthening the interface between safety, pharmacokinetics-pharmacodynamics and manufacturing.

CD20-TCB with Obinutuzumab Pretreatment as Next-Generation Treatment of Hematologic Malignancies

Design of experiment (DOE) methods maximize information from a minimal number of animals in special cases of preclinical bioavailability testing

Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β

Hematopoietic cells as site of first-pass catabolism after subcutaneous dosing and contributors to systemic clearance of a monoclonal antibody in mice

High-Throughput, Sensitive LC-MS Quantification of Biotherapeutics and Biomarkers Using Antibody-Free, Peptide-Level, Multiple-Mechanism Enrichment via Strategic Regulation of pH and Ionic and Solvent Strengths

Immunogenicity, Inflammation, and Lipid Accumulation in Cynomolgus Monkeys Infused with a Lipidated Tetranectin-ApoA-I Fusion Protein

In Vivo Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1 Analyzed by Ligand-Binding Mass Spectrometry Combined with Quantitation by ELISA.

Mechanistic determinants of biotherapeutics absorption following SC administration.

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration.

Neonatal Immune Tolerance Induction to Allow Long-Term Studies With an Immunogenic Therapeutic Monoclonal Antibody in Mice

New challenges and opportunities in nonclinical safety testing of biologics

Non-clinical Safety Evaluation of Biotherapeutics - Challenges, Opportunities and new Insights

Non-clinical pharmacokinetic/pharmacodynamic and early clinical studies supporting development of a novel subcutaneous formulation for the monoclonal antibody rituximab

Potential errors in the volume of distribution estimation of therapeutic proteins composed of differently cleared components

Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody

Reproductive and developmental toxicology studies with gantenerumab in PS2APP transgenic mice.

Subcutaneous Administration of Biotherapeutics: An Overview of Current Challenges and Opportunities

Subcutaneous absorption of biotherapeutics: knowns and unknowns.

Subcutaneous versus intravenous administration of rituximab: pharmacokinetics, CD20 target coverage and B-cell depletion in cynomolgus monkeys

The distribution pattern of radioactivity across different tissues in quantitative whole-body autoradiography (QWBA) studies.

The effects of interleukin-6 signal blockade on immune system, reproductive and skeletal development in juvenile mice.

Tissue Distribution of a Therapeutic Monoclonal Antibody Determined by Large Pore Microdialysis