Lista de obras -

A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.

artículo científico publicado en 2008

Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda -7/IL-24–mediated toxicity ⬇️

artículo científico publicado el 9 de mayo de 2011

Cardiomyocyte-GSK-3α promotes mPTP opening and heart failure in mice with chronic pressure overload

artículo científico publicado en 2019

Co-administration of the mTORC1/TORC2 inhibitor INK128 and the Bcl-2/Bcl-xL antagonist ABT-737 kills human myeloid leukemia cells through Mcl-1 down-regulation and AKT inactivation.

artículo científico publicado en 2015

Coordinate PI3K pathway and Bcl-2 family disruption in AML.

artículo científico publicado en 2012

Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells

artículo científico publicado en 2018

Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosis

artículo científico publicado en 2014

Depletion of the chromatin remodeler CHD4 sensitizes AML blasts to genotoxic agents and reduces tumor formation

artículo científico publicado en 2015

Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism.

artículo científico publicado en 2012

Functional cooperation between JunD and NF-kappaB in rat hepatocytes.

artículo científico publicado en 2001

Hepatocyte growth factor activates the AP-1 complex: a comparison between normal and transformed rat hepatocytes.

artículo científico publicado en 1999

Induction of Apoptosis in BCR/ABL+ Cells By Histone Deacetylase Inhibitors Involves Reciprocal Effects on the RAF/MEK/ERK and JNK Pathways ⬇️

artículo científico publicado el 1 de septiembre de 2003

Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process

artículo científico publicado en 2012

On the organization of human T-cell receptor loci: log-periodic distribution of T-cell receptor gene segments

artículo científico publicado en 2016

PI3K/mTOR inhibition markedly potentiates HDAC inhibitor activity in NHL cells through BIM- and MCL-1-dependent mechanisms in vitro and in vivo

artículo científico publicado en 2014

Presence of distinct AP-1 dimers in normal and transformed rat hepatocytes under basal conditions and after epidermal growth factor stimulation ⬇️

artículo científico publicado el 1 de diciembre de 1997

Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK- and NF-κB-dependent process ⬇️

artículo científico publicado el 16 de octubre de 2003

Rational combination of dual PI3K/mTOR blockade and Bcl-2/-xL inhibition in AML.

artículo científico publicado en 2014

Studying the ShcD and ERK interaction under acute oxidative stress conditions in melanoma cells

artículo científico publicado en 2019

Synergistic interactions between PLK1 and HDAC inhibitors in non-Hodgkin's lymphoma cells occur in vitro and in vivo and proceed through multiple mechanisms

artículo científico publicado en 2017

The NAE inhibitor pevonedistat interacts with the HDAC inhibitor belinostat to target AML cells by disrupting the DDR.

artículo científico publicado en 2016

The development of MDA-7/IL-24 as a cancer therapeutic ⬇️

artículo científico publicado el 21 de agosto de 2010

The histone deacetylase inhibitor MS-275 interacts synergistically with fludarabine to induce apoptosis in human leukemia cells.

artículo científico publicado en 2004

mda-7/IL-24: A unique member of the IL-10 gene family promoting cancer-targeted toxicity ⬇️

artículo científico publicado el 1 de octubre de 2010

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

artículo científico publicado en 2016

Lista de obras de

A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.

Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda -7/IL-24–mediated toxicity ⬇️

Cardiomyocyte-GSK-3α promotes mPTP opening and heart failure in mice with chronic pressure overload

Co-administration of the mTORC1/TORC2 inhibitor INK128 and the Bcl-2/Bcl-xL antagonist ABT-737 kills human myeloid leukemia cells through Mcl-1 down-regulation and AKT inactivation.

Coordinate PI3K pathway and Bcl-2 family disruption in AML.

Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells

Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosis

Depletion of the chromatin remodeler CHD4 sensitizes AML blasts to genotoxic agents and reduces tumor formation

Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism.

Functional cooperation between JunD and NF-kappaB in rat hepatocytes.

Hepatocyte growth factor activates the AP-1 complex: a comparison between normal and transformed rat hepatocytes.

Induction of Apoptosis in BCR/ABL+ Cells By Histone Deacetylase Inhibitors Involves Reciprocal Effects on the RAF/MEK/ERK and JNK Pathways ⬇️

Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process

On the organization of human T-cell receptor loci: log-periodic distribution of T-cell receptor gene segments

PI3K/mTOR inhibition markedly potentiates HDAC inhibitor activity in NHL cells through BIM- and MCL-1-dependent mechanisms in vitro and in vivo

Presence of distinct AP-1 dimers in normal and transformed rat hepatocytes under basal conditions and after epidermal growth factor stimulation ⬇️

Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK- and NF-κB-dependent process ⬇️

Rational combination of dual PI3K/mTOR blockade and Bcl-2/-xL inhibition in AML.

Studying the ShcD and ERK interaction under acute oxidative stress conditions in melanoma cells

Synergistic interactions between PLK1 and HDAC inhibitors in non-Hodgkin's lymphoma cells occur in vitro and in vivo and proceed through multiple mechanisms

The NAE inhibitor pevonedistat interacts with the HDAC inhibitor belinostat to target AML cells by disrupting the DDR.

The development of MDA-7/IL-24 as a cancer therapeutic ⬇️

The histone deacetylase inhibitor MS-275 interacts synergistically with fludarabine to induce apoptosis in human leukemia cells.

mda-7/IL-24: A unique member of the IL-10 gene family promoting cancer-targeted toxicity ⬇️

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)