Lista de obras -

A Glycine-Insulin Autocrine Feedback Loop Enhances Insulin Secretion From Human β-Cells and Is Impaired in Type 2 Diabetes.

artículo científico publicado en 2016

A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.

artículo científico publicado en 2007

A pancreatic islet-specific microRNA regulates insulin secretion

artículo científico publicado en 2004

A post-translational balancing act: the good and the bad of SUMOylation in pancreatic islets

artículo científico publicado en 2018

A role for PKD1 in insulin secretion downstream of P2Y1 receptor activation in mouse and human islets

scientific article published on 01 October 2019

Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism

artículo científico publicado en 2015

Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways.

artículo científico publicado en 2003

Antiaging Glycopeptide Protects Human Islets Against Tacrolimus-Related Injury and Facilitates Engraftment in Mice.

artículo científico publicado en 2015

Autocrine activation of P2Y1 receptors couples Ca (2+) influx to Ca (2+) release in human pancreatic beta cells.

artículo científico publicado en 2014

Calcium increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells.

artículo científico publicado en 2005

Chronic insulin infusion induces reversible glucose intolerance in lean rats yet ameliorates glucose intolerance in obese rats

artículo científico publicado en 2016

Control of secretory granule access to the plasma membrane by PI3 kinase-γ ⬇️

artículo científico publicado el 1 de noviembre de 2009

Controlling insulin secretion: an exciting TASK

scientific article published on 01 October 2014

Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx.

artículo científico publicado en 2017

Corelease and differential exit via the fusion pore of GABA, serotonin, and ATP from LDCV in rat pancreatic beta cells.

artículo científico publicado en 2007

Cystic fibrosis-related diabetes is caused by islet loss and inflammation

artículo científico publicado en 2018

Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice

artículo científico publicado en 2017

Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions

artículo científico

Distinct and opposing roles for the phosphatidylinositol 3-OH kinase catalytic subunits p110α and p110β in the regulation of insulin secretion from rodent and human beta cells

artículo científico publicado en 2013

Functional plasticity of the human infant β-cell exocytotic phenotype.

artículo científico publicado en 2013

GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration

scientific article published on 01 February 2020

Glucagon secretion and signaling in the development of diabetes

artículo científico publicado en 2012

Glucagon-like peptide 1 increases insulin sensitivity in depancreatized dogs

artículo científico publicado en 1999

Glucose-sensing mechanisms in pancreatic beta-cells.

artículo científico publicado en 2005

Human islet function following 20 years of cryogenic biobanking

artículo científico publicado en 2015

Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells.

artículo científico publicado en 2006

Impaired "Glycine"-mia in Type 2 Diabetes and Potential Mechanisms Contributing to Glucose Homeostasis.

artículo científico publicado en 2017

Impaired glucose-stimulated insulin secretion, enhanced intraperitoneal insulin tolerance, and increased beta-cell mass in mice lacking the p110gamma isoform of phosphoinositide 3-kinase.

artículo científico publicado en 2004

Improved glucose tolerance with DPPIV inhibition requires β-cell SENP1 amplification of glucose-stimulated insulin secretion

scientific article published on 01 April 2020

In vivo role of focal adhesion kinase in regulating pancreatic β-cell mass and function through insulin signaling, actin dynamics, and granule trafficking

artículo científico publicado en 2012

Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic beta-cells enhances glucose-dependent insulin secretion.

artículo científico publicado en 2002

Inhibition of beta-cell sodium-calcium exchange enhances glucose-dependent elevations in cytoplasmic calcium and insulin secretion.

artículo científico publicado en 2010

Insulin secretion induced by glucose-dependent insulinotropic polypeptide requires phosphatidylinositol 3-kinase γ in rodent and human β-cells.

artículo científico publicado en 2014

Intraislet SLIT-ROBO signaling is required for beta-cell survival and potentiates insulin secretion

artículo científico publicado en 2013

Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells.

artículo científico publicado en 2008

Kiss-and-run exocytosis and fusion pores of secretory vesicles in human beta-cells.

artículo científico publicado en 2008

Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction.

artículo científico publicado en 2017

LKB1 couples glucose metabolism to insulin secretion in mice.

artículo científico publicado en 2015

Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization

artículo científico publicado en 2023

Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion.

artículo científico publicado en 2017

Metabolomics applied to islet nutrient sensing mechanisms ⬇️

artículo científico publicado en 2017

Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated insulin secretion

artículo científico publicado en 2014

Molecular and functional profiling of human islets: from heterogeneity to human phenotypes

artículo científico publicado en 2020

Multivesicular exocytosis in rat pancreatic beta cells.

artículo científico publicado en 2011

Novel roles of SUMO in pancreatic β-cells: thinking outside the nucleus.

artículo científico publicado en 2012

Oscillations, intercellular coupling, and insulin secretion in pancreatic beta cells.

artículo científico publicado en 2006

Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.

artículo científico publicado en 1999

PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets.

artículo científico publicado en 2016

Per-arnt-sim (PAS) domain kinase (PASK) as a regulator of glucagon secretion.

artículo científico publicado en 2011

Regulated exocytosis and kiss-and-run of synaptic-like microvesicles in INS-1 and primary rat beta-cells.

artículo científico publicado en 2005

Release of small transmitters through kiss-and-run fusion pores in rat pancreatic beta cells.

artículo científico publicado en 2006

Research-Focused Isolation of Human Islets From Donors With and Without Diabetes at the Alberta Diabetes Institute IsletCore

artículo científico publicado en 2015

Role of phosphatidylinositol 3-kinasegamma in the beta-cell: interactions with glucagon-like peptide-1.

artículo científico publicado en 2006

Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion

artículo científico publicado en 2015

STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation.

artículo científico publicado en 2017

SUMO1 enhances cAMP-dependent exocytosis and glucagon secretion from pancreatic α-cells

artículo científico publicado en 2014

SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells.

artículo científico publicado en 2017

SUMOylation protects against IL-1β-induced apoptosis in INS-1 832/13 cells and human islets.

artículo científico publicado en 2014

SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability

artículo científico publicado en 2009

SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans. ⬇️

artículo científico publicado en 2011

Signal integration at the level of ion channel and exocytotic function in pancreatic β-cells ⬇️

artículo científico publicado el 20 de septiembre de 2011

Stem cells to insulin secreting cells: two steps forward and now a time to pause?

artículo científico publicado en 2014

TRP-ing Down the Path to Insulin Secretion ⬇️

artículo científico publicado el 1 de enero de 2011

Temperature and redox state dependence of native Kv2.1 currents in rat pancreatic beta-cells.

artículo científico publicado en 2003

The cell biology of systemic insulin function.

artículo científico publicado en 2018

The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo- and endocytosis.

artículo científico publicado en 2007

The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function.

artículo científico publicado en 2012

Toward Connecting Metabolism to the Exocytotic Site.

artículo científico publicado en 2016

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors

artículo científico publicado en 2015

Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site.

artículo científico publicado en 2017

Triton X-100 inhibits L-type voltage-operated calcium channels ⬇️

artículo científico publicado el 15 de enero de 2013

Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells

artículo científico publicado en 2018

Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease.

artículo científico publicado en 2016

Voltage-dependent K(+) channels are positive regulators of alpha cell action potential generation and glucagon secretion in mice and humans.

artículo científico publicado en 2010

cAMP-independent effects of GLP-1 on β cells.

artículo científico publicado en 2015

β Cell tone is defined by proglucagon peptides through cAMP signaling

artículo científico publicado en 2019

Lista de obras de

A Glycine-Insulin Autocrine Feedback Loop Enhances Insulin Secretion From Human β-Cells and Is Impaired in Type 2 Diabetes.

A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.

A pancreatic islet-specific microRNA regulates insulin secretion

A post-translational balancing act: the good and the bad of SUMOylation in pancreatic islets

A role for PKD1 in insulin secretion downstream of P2Y1 receptor activation in mouse and human islets

Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism

Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways.

Antiaging Glycopeptide Protects Human Islets Against Tacrolimus-Related Injury and Facilitates Engraftment in Mice.

Autocrine activation of P2Y1 receptors couples Ca (2+) influx to Ca (2+) release in human pancreatic beta cells.

Calcium increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells.

Chronic insulin infusion induces reversible glucose intolerance in lean rats yet ameliorates glucose intolerance in obese rats

Control of secretory granule access to the plasma membrane by PI3 kinase-γ ⬇️

Controlling insulin secretion: an exciting TASK

Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx.

Corelease and differential exit via the fusion pore of GABA, serotonin, and ATP from LDCV in rat pancreatic beta cells.

Cystic fibrosis-related diabetes is caused by islet loss and inflammation

Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice

Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions

Distinct and opposing roles for the phosphatidylinositol 3-OH kinase catalytic subunits p110α and p110β in the regulation of insulin secretion from rodent and human beta cells

Functional plasticity of the human infant β-cell exocytotic phenotype.

GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration

Glucagon secretion and signaling in the development of diabetes

Glucagon-like peptide 1 increases insulin sensitivity in depancreatized dogs

Glucose-sensing mechanisms in pancreatic beta-cells.

Human islet function following 20 years of cryogenic biobanking

Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells.

Impaired "Glycine"-mia in Type 2 Diabetes and Potential Mechanisms Contributing to Glucose Homeostasis.

Impaired glucose-stimulated insulin secretion, enhanced intraperitoneal insulin tolerance, and increased beta-cell mass in mice lacking the p110gamma isoform of phosphoinositide 3-kinase.

Improved glucose tolerance with DPPIV inhibition requires β-cell SENP1 amplification of glucose-stimulated insulin secretion

In vivo role of focal adhesion kinase in regulating pancreatic β-cell mass and function through insulin signaling, actin dynamics, and granule trafficking

Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic beta-cells enhances glucose-dependent insulin secretion.

Inhibition of beta-cell sodium-calcium exchange enhances glucose-dependent elevations in cytoplasmic calcium and insulin secretion.

Insulin secretion induced by glucose-dependent insulinotropic polypeptide requires phosphatidylinositol 3-kinase γ in rodent and human β-cells.

Intraislet SLIT-ROBO signaling is required for beta-cell survival and potentiates insulin secretion

Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells.

Kiss-and-run exocytosis and fusion pores of secretory vesicles in human beta-cells.

Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction.

LKB1 couples glucose metabolism to insulin secretion in mice.

Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization

Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion.

Metabolomics applied to islet nutrient sensing mechanisms ⬇️

Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated insulin secretion

Molecular and functional profiling of human islets: from heterogeneity to human phenotypes

Multivesicular exocytosis in rat pancreatic beta cells.

Novel roles of SUMO in pancreatic β-cells: thinking outside the nucleus.

Oscillations, intercellular coupling, and insulin secretion in pancreatic beta cells.

Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.

PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets.

Per-arnt-sim (PAS) domain kinase (PASK) as a regulator of glucagon secretion.

Regulated exocytosis and kiss-and-run of synaptic-like microvesicles in INS-1 and primary rat beta-cells.

Release of small transmitters through kiss-and-run fusion pores in rat pancreatic beta cells.

Research-Focused Isolation of Human Islets From Donors With and Without Diabetes at the Alberta Diabetes Institute IsletCore

Role of phosphatidylinositol 3-kinasegamma in the beta-cell: interactions with glucagon-like peptide-1.

Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion

STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation.

SUMO1 enhances cAMP-dependent exocytosis and glucagon secretion from pancreatic α-cells

SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells.

SUMOylation protects against IL-1β-induced apoptosis in INS-1 832/13 cells and human islets.

SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability

SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans. ⬇️

Signal integration at the level of ion channel and exocytotic function in pancreatic β-cells ⬇️

Stem cells to insulin secreting cells: two steps forward and now a time to pause?

TRP-ing Down the Path to Insulin Secretion ⬇️

Temperature and redox state dependence of native Kv2.1 currents in rat pancreatic beta-cells.

The cell biology of systemic insulin function.

The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo- and endocytosis.

The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function.

Toward Connecting Metabolism to the Exocytotic Site.

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors

Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site.

Triton X-100 inhibits L-type voltage-operated calcium channels ⬇️

Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells

Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease.

Voltage-dependent K(+) channels are positive regulators of alpha cell action potential generation and glucagon secretion in mice and humans.

cAMP-independent effects of GLP-1 on β cells.

β Cell tone is defined by proglucagon peptides through cAMP signaling