Lista de obras -

A comparative study of fragment screening methods on the p38α kinase: new methods, new insights ⬇️

artículo científico publicado el 6 de julio de 2011

A new regulatory switch in a JAK protein kinase ⬇️

artículo científico publicado el 1 de febrero de 2011

Crystal structure of vascular endothelial growth factor-B in complex with a neutralising antibody Fab fragment

artículo científico publicado en 2008

Crystallization and quaternary structure analysis of an Lrp-like regulatory protein from the hyperthermophile Pyrococcus furiosus

artículo científico publicado en 2001

Crystallization of RusA Holliday junction resolvase from Escherichia coli.

artículo científico publicado en 2003

Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease

artículo científico publicado en 2013

Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor

scientific article published on 13 November 2018

Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template

artículo científico publicado en 2010

Identification and Investigation of Novel Binding Fragments in the Fatty Acid Binding Protein 6 (FABP6)

artículo científico publicado en 2016

Lead optimization toward proof-of-concept tools for Huntington's disease within a 4-(1H-pyrazol-4-yl)pyrimidine class of pan-JNK inhibitors.

artículo científico publicado en 2015

Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737)

artículo científico publicado en 2016

Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class IIa Histone Deacetylase (HDAC) Inhibitors.

artículo científico publicado en 2015

Structural characterization of a beta-diketone hydrolase from the cyanobacterium Anabaena sp. PCC 7120 in native and product-bound forms, a coenzyme A-independent member of the crotonase suprafamily

artículo científico publicado en 2007

Structure of 6-oxo camphor hydrolase H122A mutant bound to its natural product, (2S,4S)-alpha-campholinic acid: mutant structure suggests an atypical mode of transition state binding for a crotonase homolog

artículo científico publicado en 2004

Structure of mouse IP-10, a chemokine