Lista de obras -

Alchemix: a novel alkylating anthraquinone with potent activity against anthracycline- and cisplatin-resistant ovarian cancer.

artículo científico publicado en 2003

Aldehyde Dehydrogenases and Prostate Cancer: Shedding Light on Isoform Distribution to Reveal Druggable Target

scientific article published on 04 December 2020

Aldehyde dehydrogenases in cancer: an opportunity for biomarker and drug development?

artículo científico

Androgen-AR axis in primary and metastatic prostate cancer: chasing steroidogenic enzymes for therapeutic intervention

artículo científico publicado en 2017

Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder.

artículo científico publicado en 2012

CYP2W1 polymorphism: functional aspects and relation to risk for colorectal cancer.

artículo científico publicado en 2013

Chemical and biological explorations of the family of CC-1065 and the duocarmycin natural products.

artículo científico publicado en 2009

Colon cancer-specific cytochrome P450 2W1 converts duocarmycin analogues into potent tumor cytotoxins

artículo científico publicado en 2013

Current challenges and opportunities in treating hypoxic prostate tumors

artículo científico publicado en 2018

Cytochrome P450 Binding and Bioactivation of Tumor-Targeted Duocarmycin Agents

artículo científico publicado en 2022

Cytochrome P450 isoforms 1A1, 1B1 AND 2W1 as targets for therapeutic intervention in head and neck cancer

artículo científico publicado en 2021

DNA mismatch repair deficiency, resistance to cancer chemotherapy and the development of hypersensitive agents.

artículo científico publicado en 2005

Design and synthesis of a DNA-crosslinking azinomycin analogue.

artículo científico publicado en 2005

Design, Synthesis, Biological Evaluation and In Silico Study of Benzyloxybenzaldehyde Derivatives as Selective ALDH1A3 Inhibitors

artículo científico publicado en 2021

Development of nonsymmetrical 1,4-disubstituted anthraquinones that are potently active against cisplatin-resistant ovarian cancer cells.

artículo científico publicado en 2005

Encapsulation and Delivery of Mitoxantrone Using Zirconium-Based Metal–Organic Frameworks (MOFs) and Their Cytotoxic Potential in Breast Cancer Cells

artículo científico publicado en 2024

Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity

scientific article published on 27 June 2019

Expression and regulation of aldehyde dehydrogenases in prostate cancer

artículo científico publicado en 2018

How can the potential of the duocarmycins be unlocked for cancer therapy?

artículo científico publicado en 2020

Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach.

artículo científico publicado en 2017

Insight into the Liposomal Encapsulation of Mono and Bis-Naphthalimides

Intratumoural Cytochrome P450 Expression in Breast Cancer: Impact on Standard of Care Treatment and New Efforts to Develop Tumour-Selective Therapies

artículo científico publicado en 2021

Kinetic analysis of intracellular Hoechst 33342--DNA interactions by flow cytometry: misinterpretation of side population status?

artículo científico publicado en 2012

Microtubule stabilising agents for cancer chemotherapy.

artículo científico publicado en 2009

Minor structural modifications to alchemix influence mechanism of action and pharmacological activity.

artículo científico publicado en 2012

Mitoxantrone and Analogues Bind and Stabilize i-Motif Forming DNA Sequences.

artículo científico publicado en 2016

Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity

artículo científico publicado en 2011

Multigram scale synthesis of polycyclic lactones and evaluation of antitumor and other biological properties

artículo científico publicado en 2019

Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment

artículo científico publicado en 2016

Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid.

artículo científico publicado en 2018

Probing cytochrome P450 (CYP) bioactivation with chloromethylindoline bioprecursors derived from the duocarmycin family of compounds

artículo científico publicado en 2021

Probing cytochrome P450 bioactivation and fluorescent properties with morpholinyl-tethered anthraquinones.

artículo científico publicado en 2018

Probing cytochrome P450-mediated activation with a truncated azinomycin analogue

artículo científico publicado en 2015

Quantitative analysis of cytochrome P450 isoforms in human liver microsomes by the combination of proteomics and chemical probe-based assay

artículo científico publicado en 2014

Rational Development of Novel Activity Probes for the Analysis of Human Cytochromes P450

artículo científico publicado en 2016

Re-engineering of the duocarmycin structural architecture enables bioprecursor development targeting CYP1A1 and CYP2W1 for biological activity.

artículo científico publicado en 2013

Refining the chemical toolbox to be fit for educational and practical purpose for drug discovery in the 21st Century. ⬇️

artículo científico

Solid-Phase Synthesis of Duocarmycin Analogues and the Effect of C-Terminal Substitution on Biological Activity

artículo científico publicado en 2015

Synthesis and biological evaluation of colchicine B-ring analogues tethered with halogenated benzyl moieties

artículo científico publicado en 2012

Synthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation.

artículo científico publicado en 2012

Synthesis and biological evaluation of novel chloroethylaminoanthraquinones with potent cytotoxic activity against cisplatin-resistant tumor cells.

artículo científico publicado en 2004

Synthesis and biological properties of aryl methyl sulfones

artículo científico publicado en 2018

Synthesis of DNA-directed pyrrolidinyl and piperidinyl confined alkylating chloroalkylaminoanthraquinones: potential for development of tumor-selective N-oxides

artículo científico publicado en 2006

The changing landscape of cancer drug discovery: a challenge to the medicinal chemist of tomorrow

scientific article published on 26 July 2009

The dual-acting chemotherapeutic agent Alchemix induces cell death independently of ATM and p53.

artículo científico publicado en 2014

Therapeutic antibodies against cancer stem cells: a promising approach

artículo científico

Truncated azinomycin analogues intercalate into DNA.

artículo científico publicado en 2005

Use of the hollow fiber assay for the evaluation of DNA damaging agents.

artículo científico publicado en 2011

Lista de obras de

Alchemix: a novel alkylating anthraquinone with potent activity against anthracycline- and cisplatin-resistant ovarian cancer.

Aldehyde Dehydrogenases and Prostate Cancer: Shedding Light on Isoform Distribution to Reveal Druggable Target

Aldehyde dehydrogenases in cancer: an opportunity for biomarker and drug development?

Androgen-AR axis in primary and metastatic prostate cancer: chasing steroidogenic enzymes for therapeutic intervention

Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder.

CYP2W1 polymorphism: functional aspects and relation to risk for colorectal cancer.

Chemical and biological explorations of the family of CC-1065 and the duocarmycin natural products.

Colon cancer-specific cytochrome P450 2W1 converts duocarmycin analogues into potent tumor cytotoxins

Current challenges and opportunities in treating hypoxic prostate tumors

Cytochrome P450 Binding and Bioactivation of Tumor-Targeted Duocarmycin Agents

Cytochrome P450 isoforms 1A1, 1B1 AND 2W1 as targets for therapeutic intervention in head and neck cancer

DNA mismatch repair deficiency, resistance to cancer chemotherapy and the development of hypersensitive agents.

Design and synthesis of a DNA-crosslinking azinomycin analogue.

Design, Synthesis, Biological Evaluation and In Silico Study of Benzyloxybenzaldehyde Derivatives as Selective ALDH1A3 Inhibitors

Development of nonsymmetrical 1,4-disubstituted anthraquinones that are potently active against cisplatin-resistant ovarian cancer cells.

Encapsulation and Delivery of Mitoxantrone Using Zirconium-Based Metal–Organic Frameworks (MOFs) and Their Cytotoxic Potential in Breast Cancer Cells

Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity

Expression and regulation of aldehyde dehydrogenases in prostate cancer

How can the potential of the duocarmycins be unlocked for cancer therapy?

Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach.

Insight into the Liposomal Encapsulation of Mono and Bis-Naphthalimides

Intratumoural Cytochrome P450 Expression in Breast Cancer: Impact on Standard of Care Treatment and New Efforts to Develop Tumour-Selective Therapies

Kinetic analysis of intracellular Hoechst 33342--DNA interactions by flow cytometry: misinterpretation of side population status?

Microtubule stabilising agents for cancer chemotherapy.

Minor structural modifications to alchemix influence mechanism of action and pharmacological activity.

Mitoxantrone and Analogues Bind and Stabilize i-Motif Forming DNA Sequences.

Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity

Multigram scale synthesis of polycyclic lactones and evaluation of antitumor and other biological properties

Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment

Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid.

Probing cytochrome P450 (CYP) bioactivation with chloromethylindoline bioprecursors derived from the duocarmycin family of compounds

Probing cytochrome P450 bioactivation and fluorescent properties with morpholinyl-tethered anthraquinones.

Probing cytochrome P450-mediated activation with a truncated azinomycin analogue

Quantitative analysis of cytochrome P450 isoforms in human liver microsomes by the combination of proteomics and chemical probe-based assay

Rational Development of Novel Activity Probes for the Analysis of Human Cytochromes P450

Re-engineering of the duocarmycin structural architecture enables bioprecursor development targeting CYP1A1 and CYP2W1 for biological activity.

Refining the chemical toolbox to be fit for educational and practical purpose for drug discovery in the 21st Century. ⬇️

Solid-Phase Synthesis of Duocarmycin Analogues and the Effect of C-Terminal Substitution on Biological Activity

Synthesis and biological evaluation of colchicine B-ring analogues tethered with halogenated benzyl moieties

Synthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation.

Synthesis and biological evaluation of novel chloroethylaminoanthraquinones with potent cytotoxic activity against cisplatin-resistant tumor cells.

Synthesis and biological properties of aryl methyl sulfones

Synthesis of DNA-directed pyrrolidinyl and piperidinyl confined alkylating chloroalkylaminoanthraquinones: potential for development of tumor-selective N-oxides

The changing landscape of cancer drug discovery: a challenge to the medicinal chemist of tomorrow

The dual-acting chemotherapeutic agent Alchemix induces cell death independently of ATM and p53.

Therapeutic antibodies against cancer stem cells: a promising approach

Truncated azinomycin analogues intercalate into DNA.

Use of the hollow fiber assay for the evaluation of DNA damaging agents.