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A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment.

artículo científico publicado en 2013

A palmitoylated RING finger ubiquitin ligase and its homologue in the brain membranes

scientific journal article

Cell biology: Tagged tags engage disposal.

artículo científico publicado en 2015

Cleaved PGAM5 is released from mitochondria depending on proteasome-mediated rupture of the outer mitochondrial membrane during mitophagy

scientific article published on 01 January 2019

Constitutive Activation of PINK1 Protein Leads to Proteasome-mediated and Non-apoptotic Cell Death Independently of Mitochondrial Autophagy.

artículo científico publicado en 2016

Different dynamic movements of wild-type and pathogenic VCPs and their cofactors to damaged mitochondria in a Parkin-mediated mitochondrial quality control system.

artículo científico publicado en 2013

Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity.

artículo científico publicado en 2007

Discovery and Optimization of Inhibitors of the Parkinson's Disease Associated Protein DJ-1

scientific article published on 15 August 2018

Diverse effects of pathogenic mutations of Parkin that catalyze multiple monoubiquitylation in vitro

scientific article published on 08 December 2005

Endosomal Rab cycles regulate Parkin-mediated mitophagy.

artículo científico publicado en 2018

Mammalian BCAS3 and C16orf70 associate with the phagophore assembly site in response to selective and non-selective autophagy

artículo científico publicado en 2021

Mechanisms underling the cause of Parkinson's disease: The functions of Parkin/PINK1 ⬇️

artículo científico publicado el 1 de noviembre de 2010

Molecular mechanisms underlying PINK1 and Parkin catalyzed ubiquitylation of substrates on damaged mitochondria.

artículo científico publicado en 2015

Neurodegenerative disorder as "mitochondrial dysfunction disease" ⬇️

artículo científico publicado el 1 de noviembre de 2011

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

artículo científico publicado en 2010

Parkin mediates apparent E2-independent monoubiquitination in vitro and contains an intrinsic activity that catalyzes polyubiquitination.

artículo científico publicado en 2011

Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL

artículo científico publicado en 2019

Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation.

artículo científico publicado en 2013

Parkin-mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes

scientific article published on 10 October 2019

Parkinson's disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro

artículo científico publicado en 2017

Phospho-ubiquitin: upending the PINK-Parkin-ubiquitin cascade

artículo científico publicado en 2016

Phosphorylated ubiquitin chain is the genuine Parkin receptor.

artículo científico publicado en 2015

Proteostasis and neurodegeneration: the roles of proteasomal degradation and autophagy

artículo científico publicado en 2014

Site-specific Interaction Mapping of Phosphorylated Ubiquitin to Uncover Parkin Activation

artículo científico publicado en 2015

Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP30.

artículo científico publicado en 2017

Structural insights into ubiquitin phosphorylation by PINK1

artículo científico publicado en 2018

The PARK2/Parkin receptor on damaged mitochondria revisited-uncovering the role of phosphorylated ubiquitin chains.

artículo científico publicado en 2015

The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation

artículo científico publicado en 2016

UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.

artículo científico publicado en 2005

Ubiquitin ligase activities of Bombyx mori nucleopolyhedrovirus RING finger proteins.

artículo científico publicado en 2003

Ubiquitination of exposed glycoproteins by SCFFBXO27 directs damaged lysosomes for autophagy.

artículo científico publicado en 2017

Unconventional PINK1 localization to the outer membrane of depolarized mitochondria drives Parkin recruitment

artículo científico publicado en 2015

Uncovering the roles of PINK1 and parkin in mitophagy.

artículo científico publicado en 2010

Unexpected mitochondrial matrix localization of Parkinson's disease-related DJ-1 mutants but not wild-type DJ-1.

artículo científico publicado en 2016

Unfolding is the driving force for mitochondrial import and degradation of the Parkinson's disease-related protein DJ-1

artículo científico publicado en 2021

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