Lista de obras -

5'-nucleotidase cN-II emerges as a new predictive biomarker of response to gemcitabine/platinum combination chemotherapy in non-small cell lung cancer

artículo científico publicado en 2018

Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases.

artículo científico publicado en 2013

Bacterial deoxyribonucleoside kinases are poor suicide genes in mammalian cells.

artículo científico publicado en 2009

Beta-hydroxyphosphonate ribonucleoside analogues derived from 4-substituted-1,2,3-triazoles as IMP/GMP mimics: synthesis and biological evaluation.

artículo científico publicado en 2016

CD73 inhibition by purine cytotoxic nucleoside analogue-based diphosphonates

artículo científico publicado en 2018

Calcium channel blockers impair the antitumor activity of anti-CD20 monoclonal antibodies by blocking EGR-1 induction

artículo científico publicado en 2020

Cell proliferation and drug sensitivity of human glioblastoma cells are altered by the stable modulation of cytosolic 5'-nucleotidase II.

artículo científico publicado en 2015

Characterization of a gemcitabine-resistant murine leukemic cell line: reversion of in vitro resistance by a mononucleotide prodrug.

artículo científico publicado en 2004

Characterization of an inhibitory dynamic pharmacophore for the ERCC1-XPA interaction using a combined molecular dynamics and virtual screening approach.

artículo científico publicado en 2009

Cytosolic 5'-Nucleotidase II Silencing in a Human Lung Carcinoma Cell Line Opposes Cancer Phenotype with a Concomitant Increase in p53 Phosphorylation

artículo científico publicado en 2018

Cytosolic 5'-nucleotidase II interacts with the leucin rich repeat of NLR family member Ipaf.

artículo científico publicado en 2015

Deoxycytidine kinase and cN-II nucleotidase expression in blast cells predict survival in acute myeloid leukaemia patients treated with cytarabine.

artículo científico publicado en 2003

Detecting differential allelic expression using high-resolution melting curve analysis: application to the breast cancer susceptibility gene CHEK2.

artículo científico publicado en 2011

Determination and quantification of intracellular fludarabine triphosphate, cladribine triphosphate and clofarabine triphosphate by LC-MS/MS in human cancer cells

artículo científico publicado en 2017

Determination of the enzymatic activity of cytosolic 5'-nucleotidase cN-II in cancer cells: development of a simple analytical method and related cell line models.

artículo científico publicado en 2015

Development of gene therapy in association with clinically used cytotoxic deoxynucleoside analogues.

artículo científico publicado en 2009

Do hENT1 and RRM1 predict the clinical benefit of gemcitabine in pancreatic cancer?

artículo científico

Enhanced migration of breast and lung cancer cells deficient for cN-II and CD73 via COX-2/PGE2/AKT axis regulation

scientific article published on 24 September 2020

Expanding the clinical relevance of the 5'-nucleotidase cN-II/NT5C2

artículo científico publicado en 2018

Expression of domains for protein-protein interaction of nucleotide excision repair proteins modifies cancer cell sensitivity to platinum derivatives and genomic stability.

artículo científico publicado en 2014

F-ara-AMP is a substrate of cytoplasmic 5'-nucleotidase II (cN-II): HPLC and NMR studies of enzymatic dephosphorylation

artículo científico publicado en 2006

Fully validated assay for the quantification of endogenous nucleoside mono- and triphosphates using online extraction coupled with liquid chromatography-tandem mass spectrometry.

artículo científico publicado en 2014

Functions of the multi-interacting protein KIDINS220/ARMS in cancer and other pathologies.

artículo científico publicado en 2017

Further evidences for pharmacogenetic assessment of nucleoside analogue-treated patients ⬇️

artículo científico publicado el 4 de noviembre de 2010

Gemcitabine is active against clinical multiresistant Staphylococcus aureus strains and is synergistic with gentamicin.

artículo científico publicado en 2012

Identification and characterization of inhibitors of cytoplasmic 5'-nucleotidase cN-II issued from virtual screening

artículo científico publicado en 2013

Identification of Noncompetitive Inhibitors of Cytosolic 5'-Nucleotidase II Using a Fragment-Based Approach

artículo científico publicado en 2015

Identification of allosteric inhibitors of the ecto-5'-nucleotidase (CD73) targeting the dimer interface.

artículo científico publicado en 2018

In vitro susceptibility of CD4+ and CD8+ T cell subsets to fludarabine ⬇️

artículo científico publicado el 1 de diciembre de 2003

Increased expression of the large subunit of ribonucleotide reductase is involved in resistance to gemcitabine in human mammary adenocarcinoma cells.

artículo científico publicado en 2005

Influence of p53 and p21(WAF1) expression on sensitivity of cancer cells to cladribine.

artículo científico publicado en 2003

Intracellular Cytidine Deaminase Regulates Gemcitabine Metabolism in Pancreatic Cancer Cell Lines

scientific article published on 23 December 2019

Lead optimization and biological evaluation of fragment-based cN-II inhibitors

scientific article published on 14 February 2019

Levels of gemcitabine transport and metabolism proteins predict survival times of patients treated with gemcitabine for pancreatic adenocarcinoma

artículo científico publicado en 2012

Liquid chromatographic methods for the determination of endogenous nucleotides and nucleotide analogs used in cancer therapy: a review.

artículo científico publicado en 2010

Nano-encapsulation of vitamin D3 active metabolites for application in chemotherapy: formulation study and in vitro evaluation.

artículo científico publicado en 2012

Neutrophils protect lymphoma cells against cytotoxic and targeted therapies through CD11b/ICAM-1 binding.

artículo científico publicado en 2017

Polymeric nanocapsules as drug carriers for sustained anticancer activity of calcitriol in breast cancer cells

artículo científico publicado en 2018

Preparation, characterization and in vitro evaluation of a new nucleotide analogue prodrug cyclodextrin inclusion complexes.

artículo científico publicado en 2009

Pyrimidine nucleoside analogs in cancer treatment.

artículo científico publicado en 2003

Recent developments to improve the efficacy of cytotoxic nucleoside analogues.

artículo científico publicado en 2006

Regulation and activity of cytosolic 5'-nucleotidase II. A bifunctional allosteric enzyme of the Haloacid Dehalogenase superfamily involved in cellular metabolism.

artículo científico publicado en 2005

Regulation of tumor infiltrated innate immune cells by adenosine

artículo científico publicado en 2020

Resistance to gemcitabine in a human follicular lymphoma cell line is due to partial deletion of the deoxycytidine kinase gene

artículo científico publicado en 2004

Sensitivity and gene expression profile of fresh human acute myeloid leukemia cells exposed ex vivo to AS602868 ⬇️

artículo científico publicado el 16 de septiembre de 2010

Sensitization of ara-C-resistant lymphoma cells by a pronucleotide analogue.

artículo científico publicado en 2003

Simultaneous analysis of eight nucleoside triphosphates in cell lines by liquid chromatography coupled with tandem mass spectrometry.

artículo científico publicado en 2009

Single nucleotide polymorphisms in ABCB1 and CBR1 can predict toxicity to R-CHOP type regimens in patients with diffuse non-Hodgkin lymphoma

artículo científico publicado en 2015

Stably transfected adherent cancer cell models with decreased expression of 5'-nucleotidase cN-II.

artículo científico publicado en 2016

Structural insights into the inhibition of cytosolic 5'-nucleotidase II (cN-II) by ribonucleoside 5'-monophosphate analogues

artículo científico publicado en 2011

Structure-activity relationships of β-hydroxyphosphonate nucleoside analogues as cytosolic 5'-nucleotidase II potential inhibitors: synthesis, in vitro evaluation and molecular modeling studies

artículo científico publicado en 2014

Substrate cycles and drug resistance to 1-beta-D-arabinofuranosylcytosine (araC).

artículo científico publicado en 2005

Synthesis and Preclinical Evaluation of TPA-Based Zinc Chelators as Metallo-β-lactamase Inhibitors

scientific article published on 02 August 2018

Synthesis and biological evaluation of zinc chelating compounds as metallo-β-lactamase inhibitors

scientific article published on 08 March 2019

Synthesis of Substituted 5'-Aminoadenosine Derivatives and Evaluation of Their Inhibitory Potential toward CD73

scientific article published on 25 July 2019

The Antitumor Activity of Combinations of Cytotoxic Chemotherapy and Immune Checkpoint Inhibitors Is Model-Dependent

scientific article published on 09 October 2018

The druggability of intracellular nucleotide-degrading enzymes

artículo científico publicado en 2015

The purine analog fludarabine acts as a cytosolic 5′-nucleotidase II inhibitor

artículo científico publicado en 2015

The ribonucleotide reductase large subunit (RRM1) as a predictive factor in patients with cancer.

artículo científico publicado en 2010

Therapeutic enhancement of ER stress by insulin-like growth factor I sensitizes myeloma cells to proteasomal inhibitors.

artículo científico publicado en 2013

Therapeutic perspectives for cN-II in cancer.

artículo científico publicado en 2013

Unexpected Growth-Promoting Effect of Oxaliplatin in Excision Repair Cross-Complementation Group 1 Transfected Human Colon Cancer Cells

scientific article published on 26 July 2018

Use of designed experiments for the improvement of pre-analytical workflow for the quantification of intracellular nucleotides in cultured cell lines.

artículo científico publicado en 2015

Zidovudine (AZT) has a bactericidal effect on enterobacteria and induces genetic modifications in resistant strains.

artículo científico publicado en 2011

Lista de obras de

5'-nucleotidase cN-II emerges as a new predictive biomarker of response to gemcitabine/platinum combination chemotherapy in non-small cell lung cancer

Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases.

Bacterial deoxyribonucleoside kinases are poor suicide genes in mammalian cells.

Beta-hydroxyphosphonate ribonucleoside analogues derived from 4-substituted-1,2,3-triazoles as IMP/GMP mimics: synthesis and biological evaluation.

CD73 inhibition by purine cytotoxic nucleoside analogue-based diphosphonates

Calcium channel blockers impair the antitumor activity of anti-CD20 monoclonal antibodies by blocking EGR-1 induction

Cell proliferation and drug sensitivity of human glioblastoma cells are altered by the stable modulation of cytosolic 5'-nucleotidase II.

Characterization of a gemcitabine-resistant murine leukemic cell line: reversion of in vitro resistance by a mononucleotide prodrug.

Characterization of an inhibitory dynamic pharmacophore for the ERCC1-XPA interaction using a combined molecular dynamics and virtual screening approach.

Cytosolic 5'-Nucleotidase II Silencing in a Human Lung Carcinoma Cell Line Opposes Cancer Phenotype with a Concomitant Increase in p53 Phosphorylation

Cytosolic 5'-nucleotidase II interacts with the leucin rich repeat of NLR family member Ipaf.

Deoxycytidine kinase and cN-II nucleotidase expression in blast cells predict survival in acute myeloid leukaemia patients treated with cytarabine.

Detecting differential allelic expression using high-resolution melting curve analysis: application to the breast cancer susceptibility gene CHEK2.

Determination and quantification of intracellular fludarabine triphosphate, cladribine triphosphate and clofarabine triphosphate by LC-MS/MS in human cancer cells

Determination of the enzymatic activity of cytosolic 5'-nucleotidase cN-II in cancer cells: development of a simple analytical method and related cell line models.

Development of gene therapy in association with clinically used cytotoxic deoxynucleoside analogues.

Do hENT1 and RRM1 predict the clinical benefit of gemcitabine in pancreatic cancer?

Enhanced migration of breast and lung cancer cells deficient for cN-II and CD73 via COX-2/PGE2/AKT axis regulation

Expanding the clinical relevance of the 5'-nucleotidase cN-II/NT5C2

Expression of domains for protein-protein interaction of nucleotide excision repair proteins modifies cancer cell sensitivity to platinum derivatives and genomic stability.

F-ara-AMP is a substrate of cytoplasmic 5'-nucleotidase II (cN-II): HPLC and NMR studies of enzymatic dephosphorylation

Fully validated assay for the quantification of endogenous nucleoside mono- and triphosphates using online extraction coupled with liquid chromatography-tandem mass spectrometry.

Functions of the multi-interacting protein KIDINS220/ARMS in cancer and other pathologies.

Further evidences for pharmacogenetic assessment of nucleoside analogue-treated patients ⬇️

Gemcitabine is active against clinical multiresistant Staphylococcus aureus strains and is synergistic with gentamicin.

Identification and characterization of inhibitors of cytoplasmic 5'-nucleotidase cN-II issued from virtual screening

Identification of Noncompetitive Inhibitors of Cytosolic 5'-Nucleotidase II Using a Fragment-Based Approach

Identification of allosteric inhibitors of the ecto-5'-nucleotidase (CD73) targeting the dimer interface.

In vitro susceptibility of CD4+ and CD8+ T cell subsets to fludarabine ⬇️

Increased expression of the large subunit of ribonucleotide reductase is involved in resistance to gemcitabine in human mammary adenocarcinoma cells.

Influence of p53 and p21(WAF1) expression on sensitivity of cancer cells to cladribine.

Intracellular Cytidine Deaminase Regulates Gemcitabine Metabolism in Pancreatic Cancer Cell Lines

Lead optimization and biological evaluation of fragment-based cN-II inhibitors

Levels of gemcitabine transport and metabolism proteins predict survival times of patients treated with gemcitabine for pancreatic adenocarcinoma

Liquid chromatographic methods for the determination of endogenous nucleotides and nucleotide analogs used in cancer therapy: a review.

Nano-encapsulation of vitamin D3 active metabolites for application in chemotherapy: formulation study and in vitro evaluation.

Neutrophils protect lymphoma cells against cytotoxic and targeted therapies through CD11b/ICAM-1 binding.

Polymeric nanocapsules as drug carriers for sustained anticancer activity of calcitriol in breast cancer cells

Preparation, characterization and in vitro evaluation of a new nucleotide analogue prodrug cyclodextrin inclusion complexes.

Pyrimidine nucleoside analogs in cancer treatment.

Recent developments to improve the efficacy of cytotoxic nucleoside analogues.

Regulation and activity of cytosolic 5'-nucleotidase II. A bifunctional allosteric enzyme of the Haloacid Dehalogenase superfamily involved in cellular metabolism.

Regulation of tumor infiltrated innate immune cells by adenosine

Resistance to gemcitabine in a human follicular lymphoma cell line is due to partial deletion of the deoxycytidine kinase gene

Sensitivity and gene expression profile of fresh human acute myeloid leukemia cells exposed ex vivo to AS602868 ⬇️

Sensitization of ara-C-resistant lymphoma cells by a pronucleotide analogue.

Simultaneous analysis of eight nucleoside triphosphates in cell lines by liquid chromatography coupled with tandem mass spectrometry.

Single nucleotide polymorphisms in ABCB1 and CBR1 can predict toxicity to R-CHOP type regimens in patients with diffuse non-Hodgkin lymphoma

Stably transfected adherent cancer cell models with decreased expression of 5'-nucleotidase cN-II.

Structural insights into the inhibition of cytosolic 5'-nucleotidase II (cN-II) by ribonucleoside 5'-monophosphate analogues

Structure-activity relationships of β-hydroxyphosphonate nucleoside analogues as cytosolic 5'-nucleotidase II potential inhibitors: synthesis, in vitro evaluation and molecular modeling studies

Substrate cycles and drug resistance to 1-beta-D-arabinofuranosylcytosine (araC).

Synthesis and Preclinical Evaluation of TPA-Based Zinc Chelators as Metallo-β-lactamase Inhibitors

Synthesis and biological evaluation of zinc chelating compounds as metallo-β-lactamase inhibitors

Synthesis of Substituted 5'-Aminoadenosine Derivatives and Evaluation of Their Inhibitory Potential toward CD73

The Antitumor Activity of Combinations of Cytotoxic Chemotherapy and Immune Checkpoint Inhibitors Is Model-Dependent

The druggability of intracellular nucleotide-degrading enzymes

The purine analog fludarabine acts as a cytosolic 5′-nucleotidase II inhibitor

The ribonucleotide reductase large subunit (RRM1) as a predictive factor in patients with cancer.

Therapeutic enhancement of ER stress by insulin-like growth factor I sensitizes myeloma cells to proteasomal inhibitors.

Therapeutic perspectives for cN-II in cancer.

Unexpected Growth-Promoting Effect of Oxaliplatin in Excision Repair Cross-Complementation Group 1 Transfected Human Colon Cancer Cells

Use of designed experiments for the improvement of pre-analytical workflow for the quantification of intracellular nucleotides in cultured cell lines.

Zidovudine (AZT) has a bactericidal effect on enterobacteria and induces genetic modifications in resistant strains.