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A New Application of Parallel Synthesis Strategy for Discovery of Amide-Linked Small Molecules as Potent Chondroprotective Agents in TNF-α-Stimulated Chondrocytes

artículo científico publicado en 2016

A benzamide-linked small molecule HS-Cf inhibits TNF-α-induced interferon regulatory factor-1 in porcine chondrocytes: a potential disease-modifying drug for osteoarthritis therapeutics.

artículo científico publicado en 2011

A salicylate-based small molecule HS-Cm exhibits immunomodulatory effects and inhibits dipeptidyl peptidase-IV activity in human T cells.

artículo científico publicado en 2014

Advanced glycation end products cause collagen II reduction by activating Janus kinase/signal transducer and activator of transcription 3 pathway in porcine chondrocytes.

artículo científico publicado en 2011

Advanced glycation end products induce T cell apoptosis: Involvement of oxidative stress, caspase and the mitochondrial pathway

artículo científico publicado el 1 de noviembre de 2010

Analysis of plasmid pattern in paediatric intensive care unit outbreaks of nosocomial infection due to Enterobacter cloacae

artículo científico publicado el 1 de septiembre de 1991

Biological effects of interleukin-6: Clinical applications in autoimmune diseases and cancers

artículo científico

COX-2 and iNOS are critical in advanced glycation end product-activated chondrocytes in vitro.

artículo científico publicado en 2009

Carvedilol modulates in-vitro granulocyte-macrophage colony-stimulating factor-induced interleukin-10 production in U937 cells and human monocytes.

artículo científico publicado en 2003

Carvedilol, a new antioxidative β-blocker, blocks in vitro human peripheral blood T cell activation by downregulating NF-κB activity

artículo científico publicado el 1 de septiembre de 2003

Chinese herbs as immunomodulators and potential disease-modifying antirheumatic drugs in autoimmune disorders.

artículo científico publicado en 2004

Chondroprotective Effects and Mechanisms of Dextromethorphan: Repurposing Antitussive Medication for Osteoarthritis Treatment.

artículo científico publicado en 2018

Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytes

artículo científico publicado en 2010

Compound K inhibits priming and mitochondria-associated activating signals of NLRP3 inflammasome in renal tubulointerstitial lesions

artículo científico publicado en 2020

Dengue virus infection induces interferon-lambda1 to facilitate cell migration

artículo científico publicado en 2016

Development of prostate-specific antigen promoter-based gene therapy for androgen-independent human prostate cancer

artículo científico publicado el 1 de julio de 1998

Differential effects of triptolide and tetrandrine on activation of COX-2, NF-kappaB, and AP-1 and virus production in dengue virus-infected human lung cells.

artículo científico publicado en 2008

Differential immunomodulatory effects by Tripterygium wilfordii Hook f-derived refined extract PG27 and its purified component PG490 (triptolide) in human peripheral blood T cells: potential therapeutics for arthritis and possible mechanisms explain

artículo científico publicado en 2013

Down-regulation of c-jun N-terminal kinase-activator protein-1 signaling pathway by Ginkgo biloba extract in human peripheral blood T cells.

artículo científico publicado en 2003

Epidemiology of penicillin-resistant Neisseria gonorrhoeae isolated in Taiwan, 1960-1990

artículo científico publicado el 1 de febrero de 1992

Epigallocatechin-3-gallate Reduces Scavenger Receptor A Expression and Foam Cell Formation in Human Macrophages.

artículo científico publicado en 2017

Gentiana scabra Reduces SR-A Expression and Oxidized-LDL Uptake in Human Macrophages

artículo científico publicado en 2016

Ginkgo biloba extract individually inhibits JNK activation and induces c-Jun degradation in human chondrocytes: potential therapeutics for osteoarthritis

artículo científico publicado en 2013

Immunosuppressive Effects and Mechanisms of Leflunomide in Dengue Virus Infection of Human Dendritic Cells

artículo científico publicado el 17 de agosto de 2011

Induction of immunomodulatory monocytes by human mesenchymal stem cell-derived hepatocyte growth factor through ERK1/2.

artículo científico publicado en 2014

Infection of human dendritic cells by dengue virus activates and primes T cells towards Th0-like phenotype producing both Th1 and Th2 cytokines.

artículo científico publicado en 2004

Infection of human dendritic cells by dengue virus causes cell maturation and cytokine production.

artículo científico publicado en 2001

Infection with the dengue RNA virus activates TLR9 signaling in human dendritic cells

artículo científico publicado en 2018

Irbesartan inhibits human T-lymphocyte activation through downregulation of activator protein-1.

artículo científico publicado en 2004

JNK/AP-1 activation contributes to tetrandrine resistance in T-cell acute lymphoblastic leukaemia.

artículo científico publicado en 2017

Magnesium lithospermate B mediates anti-inflammation targeting activator protein-1 and nuclear factor-kappa B signaling pathways in human peripheral T lymphocytes.

artículo científico publicado en 2012

Mitochondrial protein CMPK2 regulates IFN alpha-enhanced foam cell formation, potentially contributing to premature atherosclerosis in SLE

artículo científico publicado en 2021

Modulation of both activator protein-1 and nuclear factor-kappa B signal transduction of human T cells by amiodarone

artículo científico publicado en 2014

Modulation of human T cells signaling transduction by lovastatin.

artículo científico publicado en 2008

Monosodium urate crystals induced ICAM-1 expression and cell-cell adhesion in renal mesangial cells: Implications for the pathogenesis of gouty nephropathy

artículo científico publicado en 2018

Operation of mitochondrial machinery in viral infection-induced immune responses

article

PKCδ signalling regulates SR-A and CD36 expression and foam cell formation.

artículo científico publicado en 2012

Physiological concentrations of soluble uric acid are chondroprotective and anti-inflammatory.

artículo científico publicado en 2017

Phytoestrogen bavachin mediates anti-inflammation targeting Ikappa B kinase-I kappaB alpha-NF-kappaB signaling pathway in chondrocytes in vitro.

artículo científico publicado en 2010

Pitavastatin Exerts Potent Anti-Inflammatory and Immunomodulatory Effects via the Suppression of AP-1 Signal Transduction in Human T Cells

artículo científico publicado en 2019

Plant alkaloid tetrandrine downregulates protein kinase C-dependent signaling pathway in T cells

scientific article published on 01 February 1999

Protective roles of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) in dengue virus infection of human lung epithelial cells.

artículo científico publicado en 2013

Retinoic acid blocks pro-inflammatory cytokine-induced matrix metalloproteinase production by down-regulating JNK-AP-1 signaling in human chondrocytes.

artículo científico publicado en 2005

Small-molecule inhibitors for autoimmune arthritis: success, failure and the future.

artículo científico publicado en 2014

Spices and Atherosclerosis

scientific article published on 10 November 2018

Suppression of tissue necrosis factor-alpha or hydrogen peroxide-activated primary human T lymphocytes by Ginkgo biloba extract through down-regulation of activator protein-1 signal transduction.

artículo científico publicado en 2007

Targeting the CD40-CD154 Signaling Pathway for Treatment of Autoimmune Arthritis

scientific article published on 18 August 2019

Translational Implication of Galectin-9 in the Pathogenesis and Treatment of Viral Infection

artículo científico publicado en 2017

Useful biomarkers for assessment of hepatitis C virus infection-associated autoimmune disorders.

scientific article published on March 2014

Useful message in choosing optimal biological agents for patients with autoimmune arthritis

artículo científico publicado en 2019

Western and Chinese antirheumatic drug-induced T cell apoptotic DNA damage uses different caspase cascades and is independent of Fas/Fas ligand interaction.

artículo científico publicado en 2001