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Lista de obras de Richard L. Huganir

A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1

scientific journal article

A necessary role for GluR1 serine 831 phosphorylation in appetitive incentive learning

artículo científico publicado en 2008

A role for alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid GluR1 phosphorylation in the modulatory effects of appetitive reward cues on goal-directed behavior

artículo científico publicado en 2008

A selective role for neuronal activity regulated pentraxin in the processing of sensory-specific incentive value

artículo científico publicado en 2007

AMPA receptor and GEF-H1/Lfc complex regulates dendritic spine development through RhoA signaling cascade

scholarly article

AMPA receptor pHluorin-GluA2 reports NMDA receptor-induced intracellular acidification in hippocampal neurons ⬇️

artículo científico publicado el 12 de agosto de 2013

AMPA receptor subunits define properties of state-dependent synaptic plasticity

artículo científico publicado en 2010

AMPA receptor subunits get their share of the pie.

artículo científico publicado en 2009

AMPA receptor trafficking and synaptic plasticity require SQSTM1/p62.

scientific article published on April 2009

AMPARs and synaptic plasticity: the last 25 years

artículo científico publicado en 2013

Activity-Dependent Ubiquitination of GluA1 and GluA2 Regulates AMPA Receptor Intracellular Sorting and Degradation

artículo científico publicado en 2015

Adrenergic gating of Hebbian spike-timing-dependent plasticity in cortical interneurons

artículo científico publicado en 2013

Affected Sib-Pair Analyses Identify Signaling Networks Associated With Social Behavioral Deficits in Autism

artículo científico publicado en 2019

All-or-none disconnection of pyramidal inputs onto parvalbumin-positive interneurons gates ocular dominance plasticity

scientific article published on 01 September 2021

Altered expression and phosphorylation of N-methyl-D-aspartate receptors in piglet striatum after hypoxia-ischemia

artículo científico publicado en 2002

Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking

artículo científico publicado en 2006

An ultrasensitive biosensor for high-resolution kinase activity imaging in awake mice

artículo científico publicado en 2020

Arc Oligomerization Is Regulated by CaMKII Phosphorylation of the GAG Domain: An Essential Mechanism for Plasticity and Memory Formation

scientific article published on 28 May 2019

Automatic Dendritic Length Quantification for High Throughput Screening of Mature Neurons

artículo científico publicado en 2015

BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method

artículo científico publicado en 2017

BioSITe: A Method for Direct Detection and Quantitation of Site-Specific Biotinylation

artículo científico publicado en 2017

Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios

artículo científico publicado en 2005

Brain-specific Drp1 regulates postsynaptic endocytosis and dendrite formation independently of mitochondrial division

scientific article published on 11 October 2019

C75, a Fatty Acid Synthase Inhibitor, Modulates AMP-activated Protein Kinase to Alter Neuronal Energy Metabolism ⬇️

artículo científico publicado el 13 de noviembre de 2003

Calcium-Permeable AMPA Receptor Dynamics Mediate Fear Memory Erasure ⬇️

artículo científico publicado el 28 de octubre de 2010

Calcium-permeable AMPA receptor plasticity is mediated by subunit-specific interactions with PICK1 and NSF.

artículo científico publicado en 2005

Characterization of in vivo Dlg1 deletion on T cell development and function

artículo científico publicado en 2012

Characterization of phosphorylation sites on the glutamate receptor 4 subunit of the AMPA receptors

artículo científico publicado en 1999

Contribution of D1R-expressing neurons of the dorsal dentate gyrus and Cav1.2 channels in extinction of cocaine conditioned place preference

scientific article published on 06 January 2020

Corequirement of PICK1 binding and PKC phosphorylation for stable surface expression of the metabotropic glutamate receptor mGluR7

artículo científico publicado en 2008

D(1) dopamine receptor stimulation increases GluR1 phosphorylation in postnatal nucleus accumbens cultures

artículo científico publicado en 2002

DGKθ Catalytic Activity Is Required for Efficient Recycling of Presynaptic Vesicles at Excitatory Synapses

artículo científico publicado en 2015

DHHC8-dependent PICK1 palmitoylation is required for induction of cerebellar long-term synaptic depression.

artículo científico publicado en 2013

Developmental expression of Ca2+-permeable AMPA receptors underlies depolarization-induced long-term depression at mossy fiber CA3 pyramid synapses.

artículo científico publicado en 2007

Developmental regulation of protein interacting with C kinase 1 (PICK1) function in hippocampal synaptic plasticity and learning

artículo científico publicado en 2010

Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites.

artículo científico publicado en 2005

Differential vesicular sorting of AMPA and GABAA receptors

artículo científico publicado en 2016

Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization.

artículo científico publicado en 2014

DlgS97/SAP97, a neuronal isoform of discs large, regulates ethanol tolerance

artículo científico publicado en 2012

Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1.

artículo científico publicado en 2003

Dual palmitoylation of NR2 subunits regulates NMDA receptor trafficking

artículo científico publicado en 2009

Dynamic imaging of AMPA receptor trafficking in vitro and in vivo

artículo científico publicado en 2017

Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking

artículo científico publicado en 2007

Enhanced synaptic plasticity in mice with phosphomimetic mutation of the GluA1 AMPA receptor

artículo científico publicado en 2011

Erratum: BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method

artículo científico publicado en 2017

Essential roles of AMPA receptor GluA1 phosphorylation and presynaptic HCN channels in fast-acting antidepressant responses of ketamine

artículo científico publicado en 2016

Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability

scientific journal article

Extensive phosphorylation of AMPA receptors in neurons

artículo científico publicado en 2016

Extinction of Contextual Cocaine Memories Requires Cav1.2 within D1R-Expressing Cells and Recruits Hippocampal Cav1.2-Dependent Signaling Mechanisms.

artículo científico publicado en 2017

GRASP1 Regulates Synaptic Plasticity and Learning through Endosomal Recycling of AMPA Receptors

artículo científico publicado en 2017

GRIP1 and 2 regulate activity-dependent AMPA receptor recycling via exocyst complex interactions

artículo científico publicado en 2010

GRIP1 regulates synaptic plasticity and learning and memory

scientific article published on 18 September 2020

Gain-of-function glutamate receptor interacting protein 1 variants alter GluA2 recycling and surface distribution in patients with autism.

artículo científico publicado en 2011

GluA1 phosphorylation contributes to postsynaptic amplification of neuropathic pain in the insular cortex

artículo científico publicado en 2014

GluA1 subunit ubiquitination mediates amyloid-β-induced loss of surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors

artículo científico publicado en 2017

GluA3-deficiency in mice is associated with increased social and aggressive behavior and elevated dopamine in striatum

artículo científico publicado en 2012

GluA4 is indispensable for driving fast neurotransmission across a high-fidelity central synapse

artículo científico publicado en 2011

GluR1 controls dendrite growth through its binding partner, SAP97.

artículo científico publicado en 2008

Glutamate Receptor Subunit 2 Serine 880 Phosphorylation Modulates Synaptic Transmission and Mediates Plasticity in CA1 Pyramidal Cells ⬇️

artículo científico publicado el 8 de octubre de 2003

Glutamate synapses in human cognitive disorders

artículo científico

High-throughput genetic screen for synaptogenic factors: identification of LRP6 as critical for excitatory synapse development.

scientific article published on 05 December 2013

Homeostatic Scaling Requires Group I mGluR Activation Mediated by Homer1a ⬇️

artículo científico publicado el 22 de diciembre de 2010

Homer1a drives homeostatic scaling-down of excitatory synapses during sleep.

artículo científico publicado en 2017

Identification and characterization of a novel phosphorylation site on the GluR1 subunit of AMPA receptors

artículo científico publicado en 2007

Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.

artículo científico publicado en 2009

Identification of long-lived synaptic proteins by proteomic analysis of synaptosome protein turnover

artículo científico publicado en 2018

Identification of the SNARE complex mediating the exocytosis of NMDA receptors

artículo científico publicado en 2016

Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein

scientific journal article

Interaction of the N-terminal domain of the AMPA receptor GluR4 subunit with the neuronal pentraxin NP1 mediates GluR4 synaptic recruitment

artículo científico publicado en 2007

Involvement of AMPA receptor GluR2 and GluR3 trafficking in trigeminal spinal subnucleus caudalis and C1/C2 neurons in acute-facial inflammatory pain

artículo científico publicado en 2012

Involvement of AMPA receptor phosphorylation in antidepressant actions with special reference to tianeptine

artículo científico publicado en 2007

Involvement of GluR2 and GluR3 subunit C-termini in the trigeminal spinal subnucleus caudalis and C1-C2 neurons in trigeminal neuropathic pain

artículo científico publicado en 2011

Lamina-specific AMPA receptor dynamics following visual deprivation in vivo

artículo científico publicado en 2020

Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression

artículo científico publicado en 2013

Loss of δ-catenin function in severe autism

artículo científico publicado en 2015

Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gating ⬇️

artículo científico publicado el 24 de abril de 2011

Metabotropic glutamate and dopamine receptors co-regulate AMPA receptor activity through PKA in cultured chick retinal neurones: effect on GluR4 phosphorylation and surface expression

artículo científico publicado en 2004

Mice lacking GRIP1/2 show increased social interactions and enhanced phosphorylation at GluA2-S880.

artículo científico publicado en 2017

Mutations in ionotropic AMPA receptor 3 alter channel properties and are associated with moderate cognitive impairment in humans

artículo científico publicado en 2007

N-ethylmaleimide-sensitive factor is required for the synaptic incorporation and removal of AMPA receptors during cerebellar long-term depression

artículo científico publicado en 2004

Narp regulates long-term aversive effects of morphine withdrawal

artículo científico publicado en 2008

Neuromodulators Control the Polarity of Spike-Timing-Dependent Synaptic Plasticity

article by Geun Hee Seol et al published November 2007 in Neuron

Neuromodulators control the polarity of spike-timing-dependent synaptic plasticity

artículo científico publicado en 2007

Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons.

artículo científico publicado en 2017

Neuroscience: Strength in numbers

artículo científico publicado en 2013

Norepinephrine Enhances a Discrete Form of Long-Term Depression during Fear Memory Storage ⬇️

artículo científico publicado el 17 de julio de 2013

Opposing action of nuclear factor κB and Polo-like kinases determines a homeostatic end point for excitatory synaptic adaptation

artículo científico publicado en 2013

PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence

artículo científico publicado en 2014

PICK1 and phosphorylation of the glutamate receptor 2 (GluR2) AMPA receptor subunit regulates GluR2 recycling after NMDA receptor-induced internalization.

artículo científico publicado en 2007

PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance

scientific article (publication date: 2013)

PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression

scientific article published on 05 August 2013

PICK1 loss of function occludes homeostatic synaptic scaling.

artículo científico publicado en 2011

PICK1 regulates incorporation of calcium-permeable AMPA receptors during cortical synaptic strengthening.

artículo científico publicado en 2010

PICK1-ICA69 heteromeric BAR domain complex regulates synaptic targeting and surface expression of AMPA receptors

scientific journal article

PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity

scientific journal article

PKA-GluA1 coupling via AKAP5 controls AMPA receptor phosphorylation and cell-surface targeting during bidirectional homeostatic plasticity

artículo científico publicado en 2014

PKM-ζ is not required for hippocampal synaptic plasticity, learning and memory ⬇️

artículo científico publicado el 2 de enero de 2013

Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R trafficking

artículo científico publicado en 2012

Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1.

artículo científico publicado en 2005

Persistent inflammation induces GluR2 internalization via NMDA receptor-triggered PKC activation in dorsal horn neurons

artículo científico publicado en 2009

Phosphorylation of AMPA receptors is required for sensory deprivation-induced homeostatic synaptic plasticity

artículo científico publicado en 2011

Phosphorylation of the AMPA receptor GluA1 subunit regulates memory load capacity

artículo científico publicado en 2014

Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory

scientific journal article

Plasma membrane insertion of the AMPA receptor GluA2 subunit is regulated by NSF binding and Q/R editing of the ion pore

artículo científico publicado en 2010

Postsynaptic insertion of AMPA receptor onto cortical pyramidal neurons in the anterior cingulate cortex after peripheral nerve injury

artículo científico publicado en 2014

Postsynaptic potentiation of corticospinal projecting neurons in the anterior cingulate cortex after nerve injury

artículo científico publicado en 2014

Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction

artículo científico publicado en 2018

Preserved acute pain and impaired neuropathic pain in mice lacking protein interacting with C Kinase 1

artículo científico publicado en 2011

Protein interacting with C-kinase 1/protein kinase Calpha-mediated endocytosis converts netrin-1-mediated repulsion to attraction.

artículo científico publicado en 2006

Proteomic analysis of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor complexes.

artículo científico publicado en 2012

Pull-push neuromodulation of LTP and LTD enables bidirectional experience-induced synaptic scaling in visual cortex

artículo científico publicado en 2012

Purkinje cell-specific Grip1/2 knockout mice show increased repetitive self-grooming and enhanced mGluR5 signaling in cerebellum

scientific article published on 30 August 2019

Rapid and bi-directional regulation of AMPA receptor phosphorylation and trafficking by JNK

scientific journal article

Ras and Rap Signal Bidirectional Synaptic Plasticity via Distinct Subcellular Microdomains

scientific article published on 26 April 2018

Real-Time Imaging Reveals Properties of Glutamate-Induced Arc/Arg 3.1 Translation in Neuronal Dendrites

artículo científico publicado en 2016

Reduced phosphorylation of GluA1 subunits relates to anxiety-like behaviours in mice

artículo científico publicado en 2013

Reevaluating the role of LTD in cerebellar motor learning

artículo científico publicado en 2011

Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylation

artículo científico publicado en 2009

Regulation of AMPA receptor function by the human memory-associated gene KIBRA.

artículo científico publicado en 2011

Regulation of AMPA receptor subunit GluA1 surface expression by PAK3 phosphorylation

artículo científico publicado en 2015

Regulation of AMPA receptor trafficking and synaptic plasticity.

artículo científico publicado en 2012

Regulation of AMPA receptor trafficking by N-cadherin

artículo científico publicado en 2006

Reply to Wilkinson et al.: Concerning the use of pHluorin-tagged GluA2 as a reporter for NMDA-induced AMPA receptor recycling

artículo científico publicado en 2014

Ribosomal S6 kinase 2 interacts with and phosphorylates PDZ domain-containing proteins and regulates AMPA receptor transmission

artículo científico publicado en 2005

Selective Phosphorylation of AMPA Receptor Contributes to the Network of Long-Term Potentiation in the Anterior Cingulate Cortex.

artículo científico publicado en 2017

Signature Fragment Ions of Biotinylated Peptides

artículo científico publicado en 2020

Single-fluorophore biosensors for sensitive and multiplexed detection of signalling activities.

artículo científico publicado en 2018

Sorting Nexin 27 regulates basal and activity-dependent trafficking of AMPARs.

artículo científico publicado en 2014

Specific roles of AMPA receptor subunit GluR1 (GluA1) phosphorylation sites in regulating synaptic plasticity in the CA1 region of hippocampus

artículo científico publicado en 2009

Spinal cord protein interacting with C kinase 1 is required for the maintenance of complete Freund's adjuvant-induced inflammatory pain but not for incision-induced post-operative pain

artículo científico publicado en 2010

Stabilization of Ca2+-permeable AMPA receptors at perisynaptic sites by GluR1-S845 phosphorylation

artículo científico publicado en 2009

Stress induces pain transition by potentiation of AMPA receptor phosphorylation.

artículo científico publicado en 2014

Subcellular dynamics of type II PKA in neurons

scientific journal article

Subunit-Specific Augmentation of AMPA Receptor Ubiquitination by Phorbol Ester

artículo científico publicado en 2020

Surface mobility of postsynaptic AMPARs tunes synaptic transmission

artículo científico publicado en 2008

SynGAP isoforms differentially regulate synaptic plasticity and dendritic development

artículo científico publicado en 2020

SynGAP regulates synaptic plasticity and cognition independently of its catalytic activity

artículo científico publicado en 2024

SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons

artículo científico publicado en 2006

SynGAP splice variants display heterogeneous spatio-temporal expression and subcellular distribution in the developing mammalian brain

artículo científico publicado en 2020

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse

artículo científico publicado en 2019

Synapse-associated protein-97 isoform-specific regulation of surface AMPA receptors and synaptic function in cultured neurons

artículo científico publicado en 2003

Synapse-specific regulation of AMPA receptor function by PSD-95.

artículo científico publicado en 2006

Synaptic incorporation of AMPA receptors during LTP is controlled by a PKC phosphorylation site on GluR1.

artículo científico publicado en 2006

SynaptomeDB: an ontology-based knowledgebase for synaptic genes ⬇️

artículo científico publicado el 27 de enero de 2012

Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression

artículo científico publicado en 2006

The AMPA Receptor Code of Synaptic Plasticity

article

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport.

artículo científico publicado en 2015

The glutamate receptor-interacting protein family of GluR2-binding proteins is required for long-term synaptic depression expression in cerebellar Purkinje cells

artículo científico publicado en 2008

The intellectual disability protein RAB39B selectively regulates GluA2 trafficking to determine synaptic AMPAR composition.

artículo científico publicado en 2015

The role of synaptic GTPase-activating protein in neuronal development and synaptic plasticity

artículo científico publicado en 2003

Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature

artículo científico publicado en 2012

Twenty Years of SynGAP Research: From Synapses to Cognition

artículo científico publicado en 2020

Tyrosine phosphorylation and regulation of the AMPA receptor by SRC family tyrosine kinases.

artículo científico publicado en 2004

Tyrosine phosphorylation of the AMPA receptor subunit GluA2 gates homeostatic synaptic plasticity

artículo científico publicado en 2020

Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors

artículo científico

Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice

artículo científico publicado en 2017

Young and old Pavlovian fear memories can be modified with extinction training during reconsolidation in humans.

artículo científico publicado en 2014

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