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1,2,4-thiadiazol-5(4H)-ones: a new class of selective inhibitors of Trypanosoma cruzi triosephosphate isomerase. Study of the mechanism of inhibition.

artículo científico publicado en 2012

A guide to the effects of a large portion of the residues of triosephosphate isomerase on catalysis, stability, druggability, and human disease.

artículo científico publicado en 2017

A mechanism of acquired resistance to complement-mediated lysis by Entamoeba histolytica

scientific article published on 01 April 1997

A monoclonal antibody that inhibits Trypanosoma cruzi growth in vitro and its reaction with intracellular triosephosphate isomerase

artículo científico publicado en 2007

An unusual triosephosphate isomerase from the early divergent eukaryote Giardia lamblia.

artículo científico publicado en 2004

Correction to 'Identification of the critical residues responsible for differential reactivation of the triosephosphate isomerases of two trypanosomes'.

artículo científico publicado en 2016

Development of bis-thiazoles as inhibitors of triosephosphate isomerase from Trypanosoma cruzi. Identification of new non-mutagenic agents that are active in vivo

artículo científico publicado en 2015

Differences in the intersubunit contacts in triosephosphate isomerase from two closely related pathogenic trypanosomes

artículo científico publicado en 1998

Different contribution of conserved amino acids to the global properties of triosephosphate isomerases

artículo científico publicado en 2014

Early expression of the receptor for advanced glycation end products in a toxic model produced by 6-hydroxydopamine in the rat striatum.

artículo científico publicado en 2016

Factors that control the reactivity of the interface cysteine of triosephosphate isomerase from Trypanosoma brucei and Trypanosoma cruzi.

artículo científico publicado en 2001

Identification of Amino Acids that Account for Long-Range Interactions in Two Triosephosphate Isomerases from Pathogenic Trypanosomes

artículo científico publicado en 2011

Identification of the critical residues responsible for differential reactivation of the triosephosphate isomerases of two trypanosomes

artículo científico publicado en 2016

Interplay between Protein Thermal Flexibility and Kinetic Stability

artículo científico publicado en 2017

Key residues of loop 3 in the interaction with the interface residue at position 14 in triosephosphate isomerase from Trypanosoma brucei.

artículo científico publicado en 2008

Loosely packed papain prosegment displays inhibitory activity.

artículo científico publicado en 2005

Modeling the interaction between quinolinate and the receptor for advanced glycation end products (RAGE): relevance for early neuropathological processes

artículo científico publicado en 2015

Multi-Anti-Parasitic Activity of Arylidene Ketones and Thiazolidene Hydrazines against Trypanosoma cruzi and Leishmania spp.

artículo científico publicado en 2017

New chemotypes as Trypanosoma cruzi triosephosphate isomerase inhibitors: a deeper insight into the mechanism of inhibition.

artículo científico publicado en 2013

Novel and Selective Triosephosphate Isomerase Inhibitors with Acaricidal Activity

artículo científico publicado en 2018

Polymorphism analysis of the internal transcribed spacer and small subunit of ribosomal RNA genes of Leishmania mexicana.

artículo científico publicado en 2002

Potent and Selective Inhibitors of Trypanosoma cruzi Triosephosphate Isomerase with Concomitant Inhibition of Cruzipain: Inhibition of Parasite Growth through Multitarget Activity.

artículo científico publicado en 2015

Purification of alcohol dehydrogenase from Entamoeba histolytica and Saccharomyces cerevisiae using zinc-affinity chromatography

scientific article published on 01 August 1997

Pyruvate kinase revisited: the activating effect of K+.

artículo científico publicado en 2005

Reactivation of triosephosphate isomerase from three trypanosomatids and human: effect of Suramin

artículo científico publicado el 15 de mayo de 1998

Structural and biochemical characterization of a recombinant triosephosphate isomerase from Rhipicephalus (Boophilus) microplus

artículo científico publicado en 2011

The conserved salt bridge linking two C-terminal beta/alpha units in homodimeric triosephosphate isomerase determines the folding rate of the monomer

artículo científico publicado en 2008

The effect of specific proline residues on the kinetic stability of the triosephosphate isomerases of two trypanosomes.

artículo científico publicado en 2016

The importance of arginine codons AGA and AGG for the expression in E. coli of triosephosphate isomerase from seven different species.

artículo científico publicado en 2017

The importance of polarity in the evolution of the K+ binding site of pyruvate kinase.

artículo científico publicado en 2014

Thermodynamic and kinetic destabilization of triosephosphate isomerase resulting from the mutation of conserved and non-conserved cysteines

artículo científico publicado en 2011

Three unrelated and unexpected amino acids determine the susceptibility of the interface cysteine to a sulfhydryl reagent in the triosephosphate isomerases of two trypanosomes

artículo científico publicado en 2018