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A notable example of an evolutionary conserved gene: studies on a putative DNA helicase TIP49

scientific journal article

A pathway for mitotic chromosome formation.

artículo científico publicado en 2018

Acute inactivation of the replicative helicase in human cells triggers MCM8-9-dependent DNA synthesis.

artículo científico publicado en 2017

An auxin-based degron system for the rapid depletion of proteins in nonplant cells.

artículo científico publicado en 2009

Auxin-induced rapid degradation of inhibitor of caspase-activated DNase (ICAD) induces apoptotic DNA fragmentation, caspase activation, and cell death: a cell suicide module

artículo científico publicado en 2014

Auxin-inducible protein depletion system in fission yeast.

artículo científico publicado en 2011

Auxin-mediated rapid degradation of target proteins in hippocampal neurons

artículo científico publicado en 2019

Chk1-mediated Cdc25A degradation as a critical mechanism for normal cell cycle progression

scientific article published on 25 January 2019

Chromatin folding and DNA replication inhibition mediated by a highly antitumor-active tetrazolato-bridged dinuclear platinum(II) complex

artículo científico publicado en 2016

Conditional Budding Yeast Mutants with Temperature-Sensitive and Auxin-Inducible Degrons for Screening of Suppressor Genes

artículo científico publicado en 2016

Conditional Degrons for Controlling Protein Expression at the Protein Level

artículo científico publicado en 2017

Constructing Auxin-Inducible Degron Mutants Using an All-in-One Vector

artículo científico publicado en 2020

Control of homologous recombination by the HROB-MCM8-MCM9 pathway

scientific article published on 29 August 2019

Distinct roles for Sld3 and GINS during establishment and progression of eukaryotic DNA replication forks

artículo científico publicado en 2006

Dynamic Organization of Chromatin Domains Revealed by Super-Resolution Live-Cell Imaging.

artículo científico publicado en 2017

Dynein-Dynactin-NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble

scientific article published on 31 May 2018

Endosomal Rab cycles regulate Parkin-mediated mitophagy.

artículo científico publicado en 2018

Exosomes maintain cellular homeostasis by excreting harmful DNA from cells

artículo científico publicado en 2017

Frontiers of protein expression control with conditional degrons.

artículo científico

Functional analysis after rapid degradation of condensins and 3D-EM reveals chromatin volume is uncoupled from chromosome architecture in mitosis.

artículo científico publicado en 2018

Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo.

artículo científico publicado en 2003

Generation of conditional auxin-inducible degron (AID) cells and tight control of degron-fused proteins using the degradation inhibitor auxinole

scientific article published on 24 April 2019

HsSAS-6-dependent cartwheel assembly ensures stabilization of centriole intermediates

scientific article published on 20 June 2019

In silico protein interaction screening uncovers DONSON’s role in replication initiation

artículo científico publicado en 2023

Inhibiting the MCM8-9 complex selectively sensitizes cancer cells to cisplatin and olaparib

artículo científico publicado en 2019

Ki-67 and condensins support the integrity of mitotic chromosomes through distinct mechanisms

artículo científico publicado en 2018

Knockout-Rescue Embryonic Stem Cell-Derived Mouse Reveals Circadian-Period Control by Quality and Quantity of CRY1.

artículo científico publicado en 2016

Ligand-induced genetic degradation as a tool for target validation

artículo científico publicado en 2018

MCMBP promotes the assembly of the MCM2-7 hetero-hexamer to ensure robust DNA replication in human cells

artículo científico publicado en 2022

Mcm10 plays a role in functioning of the eukaryotic replicative DNA helicase, Cdc45-Mcm-GINS.

artículo científico publicado en 2012

Mcm8 and Mcm9 Form a Complex that Functions in Homologous Recombination Repair Induced by DNA Interstrand Crosslinks

artículo científico publicado el 5 de julio de 2012

Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork.

artículo científico publicado en 2005

Nuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitor

artículo científico publicado en 2014

Perichromosomal protein Ki67 supports mitotic chromosome architecture.

artículo científico publicado en 2016

Publisher Correction: Exosomes maintain cellular homeostasis by excreting harmful DNA from cells

scientific article published in Nature Communications

RAD51 bypasses the CMG helicase to promote replication fork reversal

artículo científico publicado en 2023

RIF1 controls replication initiation and homologous recombination repair in a radiation dose-dependent manner

scientific article published on 20 May 2020

Rapid Depletion of Budding Yeast Proteins via the Fusion of an Auxin-Inducible Degron (AID).

artículo científico

Rapid Protein Depletion in Human Cells by Auxin-Inducible Degron Tagging with Short Homology Donors.

artículo científico publicado en 2016

RecQ4 promotes the conversion of the pre-initiation complex at a site-specific origin for DNA unwinding in Xenopus egg extracts

artículo científico publicado en 2015

Replication stress induces accumulation of FANCD2 at central region of large fragile genes.

artículo científico publicado en 2018

SUG1, a Component of the 26 S Proteasome, Is an ATPase Stimulated by Specific RNAs

artículo científico publicado el 12 de septiembre de 1997

Seh1 targets GATOR2 and Nup153 to mitotic chromosomes.

artículo científico publicado en 2018

Single nucleosome imaging reveals loose genome chromatin networks via active RNA polymerase II

artículo científico publicado en 2019

Sld7, an Sld3-associated protein required for efficient chromosomal DNA replication in budding yeast

artículo científico publicado el 12 de abril de 2011

TAGing for destruction

artículo científico publicado en 2018

TIP49, homologous to the bacterial DNA helicase RuvB, acts as an autoantigen in human

artículo científico publicado en 1998

TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a

artículo científico publicado en 1999

Temporal Regulation of ESCO2 Degradation by the MCM Complex, the CUL4-DDB1-VPRBP Complex, and the Anaphase-Promoting Complex

scientific article published on 09 August 2018

Temporal and Spatial Epigenome Editing Allows Precise Gene Regulation in Mammalian Cells

article

The Elg1 replication factor C-like complex functions in PCNA unloading during DNA replication.

artículo científico publicado en 2013

The RIF1-Long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress

artículo científico publicado en 2020

The auxin-inducible degron 2 technology provides sharp degradation control in yeast, mammalian cells, and mice

artículo científico publicado en 2020

The dimeric Mcm8–9 complex ofXenopus laevislikely has a conserved function for resistance to DNA damage

artículo científico publicado el 15 de abril de 2013

Visualizing looping of two endogenous genomic loci using synthetic zinc-finger proteins with anti-FLAG and anti-HA frankenbodies in living cells

artículo científico publicado en 2021

Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity

artículo científico publicado en 2018