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A mouse model reveals that Mfsd2a is critical for unfolded protein response upon exposure to tunicamycin

artículo científico publicado en 2016

A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants

artículo científico publicado en 2012

A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants.

artículo científico publicado en 2015

ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.

artículo científico publicado en 2008

ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis.

artículo científico publicado en 2009

ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction

artículo científico publicado en 2000

ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney

artículo científico publicado en 2012

Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin.

artículo científico publicado en 2000

Apoptosis signal-regulating kinase 1 (ASK1) induces neuronal differentiation and survival of PC12 cells

artículo científico publicado en 2000

CHOP is a multifunctional transcription factor in the ER stress response

artículo científico publicado el 30 de diciembre de 2011

ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue

scientific article published on 06 February 2020

Endoplasmic reticulum quality control by garbage disposal

artículo científico publicado en 2018

GCN5 is essential for IRF-4 gene expression followed by transcriptional activation of Blimp-1 in immature B cells

artículo científico publicado en 2013

GCN5 is involved in regulation of immunoglobulin heavy chain gene expression in immature B cells.

artículo científico publicado en 2014

GCN5 protects vertebrate cells against UV-irradiation via controlling gene expression of DNA polymerase η.

artículo científico publicado en 2012

Growth/Differentiation Factor-5 Induces Angiogenesisin Vivo

scientific article published on 01 August 1997

Histone acetyltransferase PCAF is involved in transactivation of Bcl-6 and Pax5 genes in immature B cells.

artículo científico publicado en 2015

Histone acetyltransferase p300/CBP-associated factor is an effective suppressor of secretory immunoglobulin synthesis in immature B cells.

artículo científico publicado en 2015

Identification of a novel bone morphogenetic protein-responsive gene that may function as a noncoding RNA.

artículo científico publicado en 1998

Lack of GCN5 remarkably enhances the resistance against prolonged endoplasmic reticulum stress-induced apoptosis through up-regulation of Bcl-2 gene expression

artículo científico publicado en 2015

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

artículo científico publicado en 1998

Molecular mechanism of ER stress-induced pre-emptive quality control involving association of the translocon, Derlin-1, and HRD1.

artículo científico publicado en 2018

Monitoring Lipid Droplet Dynamics in Living Cells by Using Fluorescent Probes

scientific article published on 11 January 2019

Paired box gene 5 isoforms A and B have different functions in transcriptional regulation of B cell development-related genes in immature B cells.

artículo científico publicado en 2015

Paradigm shift from 'Compartment' to 'Zone' in the understanding of organelles

scientific article published on 01 February 2019

Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice.

artículo científico publicado en 2002

Pre-emptive Quality Control Protects the ER from Protein Overload via the Proximity of ERAD Components and SRP

scientific journal article

Protein kinase Cθ gene expression is oppositely regulated by GCN5 and EBF1 in immature B cells

artículo científico publicado en 2014

ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity.

artículo científico publicado en 2005

RbAp48 is essential for viability of vertebrate cells and plays a role in chromosome stability.

artículo científico publicado en 2015

Role of the unfolded protein response in the development of central nervous system.

artículo científico publicado en 2017

Roles of MAPKKK ASK1 in stress-induced cell death.

artículo científico publicado en 2003

SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency

artículo científico publicado en 2013

STT3B-Dependent Posttranslational N-Glycosylation as a Surveillance System for Secretory Protein

artículo científico publicado el 17 de mayo de 2012

Signaling pathways from the endoplasmic reticulum and their roles in disease

artículo científico publicado en 2013

Stress responses from the endoplasmic reticulum in cancer

artículo científico publicado en 2015

Survival and apoptosis signals in ER stress: the role of protein kinases.

artículo científico publicado en 2004

Targeting ASK1 in ER stress-related neurodegenerative diseases.

artículo científico publicado en 2009

The ASK1-specific inhibitors K811 and K812 prolong survival in a mouse model of amyotrophic lateral sclerosis.

artículo científico publicado en 2015

The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis.

artículo científico publicado en 2017

The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization.

artículo científico publicado en 2003

The expression of Fn14 via mechanical stress-activated JNK contributes to apoptosis induction in osteoblasts.

artículo científico publicado en 2014

Tumor growth inhibition by arsenic trioxide (As2O3) in the orthotopic metastasis model of androgen-independent prostate cancer.

artículo científico publicado en 2001

USP14 inhibits ER-associated degradation via interaction with IRE1alpha

artículo científico publicado en 2009

[Identification of receptors for bone morphogenetic proteins]

scientific article published on 01 March 1997

[Molecular mechanisms of ALS-linked mutant SOD1-induced motor neuron death].

artículo científico publicado en 2009